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Brain, Behavior, and Immunity

Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Jane Pei-Chen Chang, Kei Hamazaki, Tamaki Ishima, Yo Sano, Hiroe Ito, Keiich Isaka, Yoshiyuki Tachibana, Shinji Tanigaki, Tomo Suzuki, Kenji Hashimoto, Yutaka J Matsuoka
BACKGROUND: Omega-3 polyunsaturated fatty acids (PUFAs) reduce depressive symptoms through an anti-inflammatory effect, and injection of both omega-3 PUFAs and estradiol (E2) induces antidepressant-like effects in rats by regulating the expression of inflammatory cytokines. The aims of this study were to examine the association of increased E2 during pregnancy with depressive symptoms and with inflammatory cytokines in women who were and were not supplemented with omega-3 PUFAs. METHODS: Pregnant women with Edinburgh Postnatal Depression Scale scores ≥ 9 were recruited at 12-24 weeks of gestation...
February 15, 2019: Brain, Behavior, and Immunity
Alexander Levit, Aaron M Regis, Andrew Gibson, Olivia H Hough, Shikhar Maheshwari, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Brian L Allman, Shawn N Whitehead
Executive dysfunction and white matter inflammation continue to be relatively understudied in rodent models of Alzheimer's disease (AD). Behavioural inflexibility is an important component of executive dysfunction that can be further categorized as perseverative or regressive, which respectively specify whether maladaptive persistence occurs early or late during a behavioural change. Previous studies of the TgAPP21 rat model of AD (expressing pathogenic hAPP) suggested a potentially spontaneous increase of regressive behavioral inflexibility...
February 15, 2019: Brain, Behavior, and Immunity
Bertrand Bryche, Aurélie Dewaele, Audrey Saint-Albin, Claire Le Poupon Schlegel, Patrice Congar, Nicolas Meunier
At the interface of the environment and the nervous system, the olfactory mucosa (OM) is a privileged pathway for environmental toxicants and pathogens towards the central nervous system. The OM is known to produce antimicrobial and immunological components but the mechanisms of action of the immune system on the OM remain poorly explored. IL-17c is a potent mediator of respiratory epithelial innate immune responses, whose receptors are highly expressed in the OM of mice. We first characterized the presence of the IL-17c and its receptors in the OM...
February 15, 2019: Brain, Behavior, and Immunity
T M Lancaster, M J Hill, R Sims, J Williams
Genome-wide association studies (GWAS) suggest that Alzheimer's disease (AD) is partly explained by a burden of risk alleles (single nucleotide polymorphisms; SNPs) with relatively small effects. However, the mechanisms by which these loci cumulatively confer susceptibility remain largely unknown. Accumulating evidence suggests an association between increased AD risk allele burden (measured via a polygenic risk profile score; AD-RPS) with reduced hippocampal volume (HV) across a number of independent cohorts...
February 15, 2019: Brain, Behavior, and Immunity
Yu Zhang, Hang Xu, Fan Zhang, Feng Shao, Bart Ellenbroek, Jiesi Wang, Weiwen Wang
The crucial roles played by the microglia and their release of cytokines in the regulation of brain maturation are increasingly being recognized. Adolescence is a unique period characterized by continued brain maturation, especially in the area of the prefrontal cortex. Our previous studies showed that adolescent social stress (ASS) induced impairment of extradimensional set-shifting (EDS), a core component of cognitive flexibility mediated by the medial prefrontal cortex (mPFC) in adult mice. The present study further determined the role of the microglia and the inflammatory cytokine tumor necrosis factor alpha (TNFα) in cognitive dysfunction...
February 14, 2019: Brain, Behavior, and Immunity
Timothy G Dinan, John F Cryan
No abstract text is available yet for this article.
February 13, 2019: Brain, Behavior, and Immunity
Lisa E Goehler
No abstract text is available yet for this article.
February 12, 2019: Brain, Behavior, and Immunity
Franca R Guerini, Elisabetta Bolognesi, Stefano Sotgiu, Alessandra Carta, Claudia Clerici, Matteo Chiappedi, Alessandro Ghezzo, Michela Zanette, Maria Martina Mensi, Maria Paola Canevini, Milena Zanzottera, Cristina Agliardi, Andrea Saul Costa, Umberto Balottin, Mario Clerici
Recent results show that in mainland Italian children with Autism spectrum disorder (ASD), HLA-G coding alleles distribution is skewed and an association between HLA-G*01:05N and ASD is present. Herein, in an independent cohort of Sardinian ASD (sASD) children and their relatives, we verify whether HLA-G allele association with ASD could be confirmed in this genetically peculiar insular population. One hundred children with a diagnosis of ASD, born in Sardinia and of Sardinian descent, 91 of their mothers, and 40 of their healthy siblings were enrolled...
February 11, 2019: Brain, Behavior, and Immunity
Xuejian Kong, Zhuo Gong, Le Zhang, Xiangdong Sun, Zhenri Ou, Biao Xu, Jingyi Huang, Dahong Long, Xiaosong He, Xiaohong Lin, Qingqing Li, Liping Xu, Aiguo Xuan
Neuroinflammation, considered as a pathological hallmark of Alzheimer'sdisease(AD),has been demonstrated to affect hippocampal neurogenesis and cognitive function. Interleukin-6 (IL-6) is a proinflammatory cytokine known to modulate neurogenesis. However, the mechanisms are still largely unknown. Here, we reported that IL-6 supressed neurogenesis via a JAK2/STAT3 signaling in neural stem cells (NSCs). Importantly, we found that NeuroD1 (Neurogenic differentiation 1) gene expression, which drives NSCs neurodifferentiation, was regulated by TET3 and DNMT1 in a JAK2/STAT3-dependent manner...
February 11, 2019: Brain, Behavior, and Immunity
Julie Lasselin, Michael Ingre, Christina Regenbogen, Mats J Olsson, Maria Garke, Mia Brytting, Rachel Edgar, Mats Lekander, John Axelsson
There is strong experimental support that infections increase the drive for sleep in animals, and it is widely believed that more sleep is part of an adaptive immune response. While respiratory infections (RI) are very prevalent in humans, there is a striking lack of systematic knowledge on how it affects sleep. We recruited 100 people, among whom 28 became sick with an RI during the study period (fulfilling criteria for influenza-like illness, ILI, or acute respiratory infection, ARI). We measured sick participants' sleep at home, both objectively (actigraphy) and subjectively (diary ratings), for one week as well as four weeks later when healthy...
February 8, 2019: Brain, Behavior, and Immunity
Izabela Milaniak, Sara R Jaffee
Recent research suggests that risk for chronic diseases of aging including cardiovascular disease, diabetes, and even cancer can be programmed early in the lifespan as a result of exposure to chronic stressors like low socioeconomic status (SES) that are hypothesized to promote a pro-inflammatory response in immune cells that results in chronic, systemic inflammation. The present paper conducted a metaanalysis to establish whether exposure to low (versus higher) SES in childhood and adolescence is associated with higher levels of inflammation (as measured by C-reactive protein, IL-6, and fibrinogen) concurrently and in adulthood...
February 7, 2019: Brain, Behavior, and Immunity
Zhipeng Li, Shifeng Chu, Wenbin He, Zhao Zhang, Jiaqi Liu, Liyuan Cui, Xu Yan, Defang Li, Naihong Chen
Neuroinflammation is now recognized to be a feature of many neurological disorders. More accumulated evidences suggested chrysin which was contained in honey, propolis, vegetables, fruits and plants can exert biological activities including anti-neuroinflammatory effects. However, the precise molecular mechanisms of anti-neuroinflammatory effects remain unclear. In the present study, we explored a novel molecular mechanism involved in the anti-neuroinflammatory effect of chrysin. Firstly, we investigated the anti-neuroinflammatory effects of chrysin in LPS-induced BV2, primary microglial cells and mice...
February 7, 2019: Brain, Behavior, and Immunity
Deng Xueyang, Fu Jiao, Song Yang, Xu Bingru, Ji Zhouye, Guo Qinglong, Ma Shiping
Depression is highly prevalent among patients with chronic obstructive pulmonary disease (COPD). However, depression with COPD comorbidity is often underdiagnosed and undertreated, and pathogenic research is also insufficient. In the present study, we characterised pulmonary and hippocampal dysfunction by researching the interaction between inflammasome-regulated cytokines and glucocorticoid receptor (GR) signalling by investigating the role of fluoxetine (FLU), one of the most widely used antidepressants in clinical practice...
February 6, 2019: Brain, Behavior, and Immunity
F Dabbah-Assadi, D Alon, I Golani, R Doron, I Kremer, R Beloosesky, A Shamir
Maternal inflammation during pregnancy is associated with a higher incidence of mental disorders (e.g. schizophrenia and autism) in the offspring. In our study, we investigate the involvement of the NRG-ErbB signaling pathway in rodent fetal brains four hours following maternal immune activation (MIA) insult at two different gestational days (i.e. early vs late). Furthermore, we test the long-term behavioral alteration of the exposed MIA mice at juvenile and adulthood. We demonstrate that MIA at late, but not at early gestation day, altered the expression of NRG1, its receptor ErbB4, and the dopamine D2 receptor four hours post injection of viral or bacterial mimic material in fetal brain...
February 6, 2019: Brain, Behavior, and Immunity
Onésia Cristina Oliveira-Lima, Juliana Carvalho-Tavares, Marcella F Rodrigues, Marcus V Gomez, Antônio C Pinheiro de Oliveira, Rodrigo R Resende, Renato Santiago Gomez, Boniek Gontijo Vaz, Mauro Cunha Xavier Pinto
It is well-established that bacterial lipopolysaccharides (LPS) can promote neuroinflammation through receptor Toll-like 4 and induces sickness behavior in mice. This phenomenon triggers changes in membranes lipid dynamics to promote the intracellular cell signaling. Desorption electrospray ionization mass spectrometry (DESI-MS) is a powerful technique that can be used to image the distribution of lipids in brain tissue directly. In this work, we characterize the LPS-induced neuroinflammation and the lipid dynamics in C57bl/6 mice at 3 and 24 hours after LPS injection...
February 1, 2019: Brain, Behavior, and Immunity
Peng Li, Gang Zhao, Yan Ding, Tianyi Wang, Jerry Flores, Umut Ocak, Pei Wu, Tongyu Zhang, Jun Mo, John H Zhang, Jiping Tang
Neuroinflammation occurs after germinal matrix hemorrhage (GMH) and induces secondary brain injury. Interferon-α (IFN-α) has been shown to exert anti-inflammatory effects in infectious diseases via activating IFNAR and its downstream signaling. We aimed to investigate the anti-inflammatory effects of Recombinant human IFN-α (rh-IFN-α) and the underlying mechanisms in a rat GMH model. Two hundred and eighteen P7 rat pups of both sexes were subjected to GMH by an intraparenchymal injection of bacterial collagenase...
January 31, 2019: Brain, Behavior, and Immunity
Julie E Finnell, Casey M Moffitt, L Ande Hesser, Evelynn Harrington, Michael N Melson, Christopher S Wood, Susan K Wood
Exposure to psychosocial stress is known to precipitate the emergence of stress related psychiatric disorders such as depression and anxiety. While mechanisms by which this occurs remain largely unclear, recent evidence points towards a causative role for inflammation. Neurotransmitters, such as norepinephrine (NE) are capable of regulating expression of proinflammatory cytokines and thus may contribute to the emergence of stress-related disorders. The locus coeruleus (LC) is the major source of norepinephrine (NE) to the brain and therefore the current study utilized N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), an LC selective noradrenergic neurotoxin, to determine the discrete involvement of the LC-NE system in social defeat-induced inflammation in LC projection regions including the central amygdala (CeA), dorsal raphe (DR) and plasma...
January 29, 2019: Brain, Behavior, and Immunity
Minji Bang, Junsol Kim, Suk Kyoon An, Yoosik Youm, Jeanyung Chey, Hyeon Chang Kim, Kyungmee Park, Kee Namkoong, Eun Lee
Increasing evidence suggests that systemic inflammation adversely affects social experiences and behaviors of older adults by changing the functional state of the brain. In this study, we investigated the relationships among systemic inflammation, functional network connectivity (FNC) of the whole brain, and social-network size using complete social-network data of older adults residing in a Korean village. Sixty-one participants were recruited from the Korean Social Life, Health, and Aging Project (KSHAP)...
January 24, 2019: Brain, Behavior, and Immunity
Wenwen Huo, Yue Liu, Yishan Lei, Ying Zhang, Yulin Huang, Yanting Mao, Chenchen Wang, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping Gu
Increasing evidence suggests that T cells participate in the pathology of neuropathic pain, as well as the activation of microglia. However, whether T cells infiltrate into the spinal cord and contribute to the development of bone cancer pain (BCP) remains unknown. Here, we used a mouse model of BCP to show that numbers of T cells infiltrated into the spinal cord after sarcoma cell implantation with increased BCP, and most infiltrating T cells in the spinal cord were CD3+ CD4+ T cells. Both Th17 and Treg subpopulations were analyzed by immunofluorescence...
January 24, 2019: Brain, Behavior, and Immunity
Kristoffer Sølvsten Burgdorf, Betina Trabjerg, Marianne Giørtz Pedersen, Janna Nissen, Karina Banasik, Ole Birger Pedersen, Erik Sørensen, Kaspar René Nielsen, Margit Hørup Larsen, Christian Erikstrup, Peter Bruun-Rasmussen, David Westergaard, Lise Wegner Thørner, Henrik Hjalgrim, Helene Martina Paarup, Søren Brunak, Carsten B Pedersen, E Fuller Torrey, Thomas Werge, Preben Bo Mortensen, Robert Yolken, Henrik Ullum
BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N=2,591), have attempted or committed suicide (N=655), or have had traffic accidents (N=2,724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants...
January 24, 2019: Brain, Behavior, and Immunity
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