journal
https://read.qxmd.com/read/38636566/targeting-foamy-macrophages-by-manipulating-abca1-expression-to-facilitate-lesion-healing-in-the-injured-spinal-cord
#1
JOURNAL ARTICLE
Xi Wang, Zhijian Cheng, Wenjiao Tai, Mingjun Shi, Maryam Ayazi, Yang Liu, Li Sun, Caiyong Yu, Zhongmin Fan, Bin Guo, Xijing He, Dongming Sun, Wise Young, Yi Ren
Spinal cord injury (SCI) triggers a complex cascade of events, including myelin loss, neuronal damage, neuroinflammation, and the accumulation of damaged cells and debris at the injury site. Infiltrating bone marrow derived macrophages (BMDMϕ) migrate to the epicenter of the SCI lesion, where they engulf cell debris including abundant myelin debris to become pro-inflammatory foamy macrophages (foamy Mϕ), participate neuroinflammation, and facilitate the progression of SCI. This study aimed to elucidate the cellular and molecular mechanisms underlying the functional changes in foamy Mϕ and their potential implications for SCI...
April 16, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38636565/mediterranean-diet-protects-against-a-neuroinflammatory-cortical-transcriptome-associations-with-brain-volumetrics-peripheral-inflammation-social-isolation-and-anxiety-in-nonhuman-primates-macaca-fascicularis
#2
JOURNAL ARTICLE
Brett M Frye, Jacob D Negrey, Corbin S C Johnson, Jeongchul Kim, Richard A Barcus, Samuel N Lockhart, Christopher T Whitlow, Kenneth L Chiou, Noah Snyder-Mackler, Thomas J Montine, Suzanne Craft, Carol A Shively, Thomas C Register
Mediterranean diets may be neuroprotective and prevent cognitive decline relative to Western diets, however the underlying biology is poorly understood. We assessed the effects of Western versus Mediterranean-like diets on RNAseq-generated transcriptional profiles in lateral temporal cortex and their relationships with longitudinal changes in neuroanatomy, circulating monocyte gene expression, and observations of social isolation and anxiety in 38 socially-housed, middle-aged female cynomolgus macaques (Macaca fascicularis)...
April 16, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38636564/spinal-neuronal-activity-and-neuroinflammatory-component-in-a-mouse-model-of-cfa-induced-vestibulodynia
#3
JOURNAL ARTICLE
Serena Boccella, Michela Perrone, Antimo Fusco, Roozbe Bonsale, Rosmara Infantino, Silvia Nuzzo, Giovanni Pecoraro, Federica Ricciardi, Andrea Maria Morace, Gianluca Petrillo, Ilaria Leone, Monica Franzese, Vito de Novellis, Francesca Guida, Marco Salvatore, Sabatino Maione, Livio Luongo
Vestibulodynia is a complex pain disorder characterized by chronic discomfort in the vulvar region, often accompanied by tactile allodynia and spontaneous pain. In patients a depressive behaviour is also observed. In this study, we have used a model of vestibulodynia induced by complete Freund's adjuvant (CFA) focusing our investigation on the spinal cord neurons and microglia. We investigated tactile allodynia, spontaneous pain, and depressive-like behavior as key behavioral markers of vestibulodynia. In addition, we conducted in vivo electrophysiological recordings to provide, for the first time to our knowledge, the characterization of the spinal sacral neuronal activity in the L6-S1 dorsal horn of the spinal cord...
April 16, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38636563/ldl-stimulated-microglial-activation-exacerbates-ischemic-white-matter-damage
#4
JOURNAL ARTICLE
Luo-Qi Zhou, Yun-Hui Chu, Ming-Hao Dong, Sheng Yang, Man Chen, Yue Tang, Xiao-Wei Pang, Yun-Fan You, Long-Jun Wu, Wei Wang, Chuan Qin, Dai-Shi Tian
The role of microglia in triggering the blood-brain barrier (BBB) impairment and white matter damage after chronic cerebral hypoperfusion is unclear. Here we demonstrated that the vessel-adjacent microglia were specifically activated by the leakage of plasma low-density lipoprotein (LDL), which led to BBB breakdown and ischemic demyelination. Interestingly, we found that LDL stimulation enhanced microglial phagocytosis, causing excessive engulfment of myelin debris and resulting in an overwhelming lipid burden in microglia...
April 16, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38636562/mimicking-bacterial-infection-in-male-mice-changes-sperm-small-rna-profiles-and-multigenerationally-alters-offspring-behavior-and-physiology
#5
JOURNAL ARTICLE
Huan Liao, Da Lu, Sonali N Reisinger, Elizabeth A Kleeman, Nicholas van de Garde, Carolina Gubert, Anthony J Hannan
Paternal pre-conceptual exposures, including stress, diet, substance abuse, parasite infection, and viral immune activation via Poly I:C, have been reported to influence the brains and behavior of offspring through sperm epigenetic changes. However, the effects of paternal (F0) pre-conceptual exposure to bacterial-induced immune activation on the behavior and physiology of F1 and F2 generations remain unexplored. We examined this using C57BL/6J mice. Eight-week-old males (F0) received a single intraperitoneal injection of the bacterial mimetic lipopolysaccharide (LPS: 5 mg/kg) or 0...
April 16, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38608743/alterations-in-gut-microbiota-contribute-to-cognitive-deficits-induced-by-chronic-infection-of-toxoplasma-gondii
#6
JOURNAL ARTICLE
Xiaoying Yang, Yuying Zhou, Shimin Tan, Xiaokang Tian, Xianran Meng, Yiling Li, Beibei Zhou, Guihua Zhao, Xing Ge, Cheng He, Wanpeng Cheng, Yumei Zhang, Kuiyang Zheng, Kun Yin, Yinghua Yu, Wei Pan
Chronic infection with Toxoplasma gondii (T. gondii) emerges as a risk factor for neurodegenerative diseases in animals and humans. However, the underlying mechanisms are largely unknown. We aimed to investigate whether gut microbiota and its metabolites play a role in T. gondii-induced cognitive deficits. We found that T. gondii infection induced cognitive deficits in mice, which was characterized by synaptic ultrastructure impairment and neuroinflammation in the hippocampus. Moreover, the infection led to gut microbiota dysbiosis, barrier integrity impairment, and inflammation in the colon...
April 10, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38608742/association-of-symptom-severity-and-cerebrospinal-fluid-alterations-in-recent-onset-psychosis-in-schizophrenia-spectrum-disorders-an-individual-patient-data-meta-analysis
#7
JOURNAL ARTICLE
Mattia Campana, Vladislav Yakimov, Joanna Moussiopoulou, Isabel Maurus, Lisa Löhrs, Florian Raabe, Iris Jäger, Matin Mortazavi, Michael E Benros, Rose Jeppesen, Gerd Meyer Zu Hörste, Michael Heming, Eloi Giné-Servén, Javier Labad, Ester Boix, Belinda Lennox, Ksenija Yeeles, Johann Steiner, Gabriela Meyer-Lotz, Henrik Dobrowolny, Berend Malchow, Niels Hansen, Peter Falkai, Spyridon Siafis, Stefan Leucht, Sean Halstead, Nicola Warren, Dan Siskind, Wolfgang Strube, Alkomiet Hasan, Elias Wagner
Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorderś(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases...
April 10, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38608741/early-treatment-with-rifaximin-during-epileptogenesis-reverses-gut-alterations-and-reduces-seizure-duration-in-a-mouse-model-of-acquired-epilepsy
#8
JOURNAL ARTICLE
Valentina Kebede, Teresa Ravizza, Silvia Balosso, Rossella Di Sapia, Luca Canali, Sara Soldi, Serena Galletti, Christina Papazlatani, Panagiotis A Karas, Sotirios Vasileiadis, Annalisa Sforzini, Laura Pasetto, Valentina Bonetto, Annamaria Vezzani, Loredana Vesci
The gut microbiota is altered in epilepsy and is emerging as a potential target for new therapies. We studied the effects of rifaximin, a gastrointestinal tract-specific antibiotic, on seizures and neuropathology and on alterations in the gut and its microbiota in a mouse model of temporal lobe epilepsy (TLE). Epilepsy was induced by intra-amygdala kainate injection causing status epilepticus (SE) in C57Bl6 adult male mice. Sham mice were injected with vehicle. Two cohorts of SE mice were fed a rifaximin-supplemented diet for 21 days, starting either at 24 h post-SE (early disease stage) or at day 51 post-SE (chronic disease stage)...
April 10, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38608740/cannabidiol-improves-maternal-obesity-induced-behavioral-neuroinflammatory-and-neurochemical-dysfunctions-in-the-juvenile-offspring
#9
JOURNAL ARTICLE
Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Vitória Luiza de Camargo Milczarski, Victor Silva Dias, Camila Scheid, Josias de Oliveira Merib, Marcia Giovernardi, Renata Padilha Guedes
Maternal obesity is associated with an increased risk of psychiatric disorders such as anxiety, depression, schizophrenia and autism spectrum disorder in the offspring. While numerous studies focus on preventive measures targeting the mothers, only a limited number provide practical approaches for addressing the damages once they are already established. We have recently demonstrated the interplay between maternal obesity and treatment with cannabidiol (CBD) on hypothalamic inflammation and metabolic disturbances, however, little is known about this relationship on behavioral manifestations and neurochemical imbalances in other brain regions...
April 10, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38608739/dynamic-microglia-alterations-associate-with-hippocampal-network-impairments-a-turning-point-in-amyloid-pathology-progression
#10
JOURNAL ARTICLE
Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez-Rodriguez, Guillermo Vazquez-Cabrera, Simona Laterza, Maria Latorre-Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia Fragkopoulou, André Fisahn, Luis Enrique Arroyo-García
Alzheimer's disease is a progressive neurological disorder causing memory loss and cognitive decline. The underlying causes of cognitive deterioration and neurodegeneration remain unclear, leading to a lack of effective strategies to prevent dementia. Recent evidence highlights the role of neuroinflammation, particularly involving microglia, in Alzheimer's disease onset and progression. Characterizing the initial phase of Alzheimer's disease can lead to the discovery of new biomarkers and therapeutic targets, facilitating timely interventions for effective treatments...
April 10, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38604270/intestinal-madcam-1-imaging-as-biomarker-for-prognostic-in-murine-models-of-multiple-sclerosis
#11
JOURNAL ARTICLE
Erwan Baudron, Sara Martinez de Lizarrondo, Maxime Gauberti, Barbara Delaunay-Piednoir, Antoine P Fournier, Denis Vivien, Fabian Docagne, Isabelle Bardou
INTRODUCTION: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. Recent evidence suggests that lymphocyte trafficking in the intestines could play a key role in its etiology. Nevertheless, it is not clear how intestinal tissue is involved in the disease onset nor its evolution. In the present study, we aimed to evaluate intestinal inflammation dynamic throughout the disease course and its potential impact on disease progression. METHODS: We used tissue immunophenotyping (immunohistofluorescence and flow cytometry) and a recently described molecular magnetic resonance imaging (MRI) method targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1) to assess intestinal inflammation in vivo in two distinct animal models of MS (Experimental Autoimmune Encephalomyelitis - EAE) at several time points of disease progression...
April 9, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38604269/high-fat-diet-consumption-promotes-adolescent-neurobehavioral-abnormalities-and-hippocampal-structural-alterations-via-microglial-overactivation-accompanied-by-an-elevated-serum-free-fatty-acid-concentration
#12
JOURNAL ARTICLE
Xiuting Yao, Chenxi Yang, Xirui Jia, Zhehao Yu, Conghui Wang, Jingyi Zhao, Yuxi Chen, Bingjie Xie, Hong Zhuang, Congli Sun, Qian Li, Xiaomin Kang, Yu Xiao, Lijie Liu
Mounting evidence suggests that high-fat diet (HFD) consumption increases the risk for depression, but the neurophysiological mechanisms involved remain to be elucidated. Here, we demonstrated that HFD feeding of C57BL/6J mice during the adolescent period (from 4 to 8 weeks of age) resulted in increased depression- and anxiety-like behaviors concurrent with changes in neuronal and myelin structure in the hippocampus. Additionally, we showed that hippocampal microglia in HFD-fed mice assumed a hyperactive state concomitant with increased PSD95-positive and myelin basic protein (MBP)-positive inclusions, implicating microglia in hippocampal structural alterations induced by HFD consumption...
April 9, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38599500/association-of-rheumatological-markers-with-neuronal-antibodies-cerebrospinal-fluid-electroencephalography-and-magnetic-resonance-imaging-findings-in-224-patients-with-psychotic-syndromes
#13
JOURNAL ARTICLE
Dominique Endres, Katharina von Zedtwitz, Kathrin Nickel, Kimon Runge, Alexander Maier, Katharina Domschke, Ulrich Salzer, Harald Prüss, Nils Venhoff, Ludger Tebartz van Elst
INTRODUCTION: Psychotic syndromes can have autoimmune-mediated causes in some patients. Thus, this retrospective work aims to investigate the role of rheumatological markers in the development of psychosis. PATIENTS AND METHODS: In total, 224 patients with psychotic syndromes receiving a "rheumatological laboratory screening" (including C-reactive protein [CRP], immunofixation, complement factors, rheumatoid factor [RF], antiphospholipid antibodies [APAs], antineutrophil cytoplasmic antibodies [ANCAs], and antinuclear antibodies [ANAs]) were analyzed...
April 8, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38599499/how-stable-are-psychoneuroimmune-effects-over-time
#14
REVIEW
Lennart Seizer, Christian Schubert
No abstract text is available yet for this article.
April 8, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38599498/unmasking-the-mental-health-scars-of-covid-19-a-longitudinal-investigation-of-children-and-adolescents-in-post-lockdown-china
#15
JOURNAL ARTICLE
Yue Zhu, Yuenan Yu, Yang Wang, Fay Womer, Xiaoyang Qin, Keyin Zhou, Rongxin Zhu, Wei Du, Jie Yang, Kuan-Pin Su, Fei Wang
The long-term mental health consequences of COVID-19 in children and adolescents remain unclear. We investigated the impact of COVID-19 infection on mental health after China's zero-COVID policy relaxation, focusing on symptom-specific and social-family risk factors for mental health issues in children and adolescents. In a longitudinal study, 8348 youths (aged 10-18) were assessed twice (T1: September to October 2022 and T2: April to May 2023). Mental health changes (Δ=T1-T2) were compared between COVID-19-infected (COVID+, n = 4108) and non-infected (COVID-, n = 4240)...
April 8, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38599497/gut-microbiota-dysbiosis-contributes-to-depression-like-behaviors-via-hippocampal-nlrp3-mediated-neuroinflammation-in-a-postpartum-depression-mouse-model
#16
JOURNAL ARTICLE
Qi Xu, Lihong Sun, Qing Chen, Cuicui Jiao, Yuan Wang, Hua Li, Jiaqian Xie, Fangfang Zhu, Jiangling Wang, Wen Zhang, Linghua Xie, Hui Wu, Zhiyi Zuo, Xinzhong Chen
Postpartum depression (PPD) is a severe mental disorder that affects approximately 10---20% of women after childbirth. The precise mechanism underlying PPD pathogenesis remains elusive, thus limiting the development of therapeutics. Gut microbiota dysbiosis is considered to contribute to major depressive disorder. However, the associations between gut microbiota and PPD remain unanswered. Here, we established a mouse PPD model by sudden ovarian steroid withdrawal after hormone-simulated pseudopregnancy-human (HSP-H) in ovariectomy (OVX) mouse...
April 8, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38579936/stress-induced-mucin-13-reductions-drive-intestinal-microbiome-shifts-and-despair-behaviors
#17
JOURNAL ARTICLE
Courtney R Rivet-Noor, Andrea R Merchak, Caroline Render, Naudia M Gay, Rebecca M Beiter, Ryan Brown, Austin Keeler, G Brett Moreau, Sihan Li, Deniz G Olgun, Alexandra D Steigmeyer, Rachel Ofer, Tobey Mihn Huu Phan, Kiranmayi Vemuri, Lei Chen, Keira E Mahoney, Jung-Bum Shin, Stacy A Malaker, Chris Deppmann, Michael Verzi, Alban Gaultier
Depression is a prevalent psychological condition with limited treatment options. While its etiology is multifactorial, both chronic stress and changes in microbiome composition are associated with disease pathology. Stress is known to induce microbiome dysbiosis, defined here as a change in microbial composition associated with a pathological condition. This state of dysbiosis is known to feedback on depressive symptoms. While studies have demonstrated that targeted restoration of the microbiome can alleviate depressive-like symptoms in mice, translating these findings to human patients has proven challenging due to the complexity of the human microbiome...
April 3, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38579935/correspondence-to-antici-et-al-salivary-crp-predicts-treatment-response-to-virtual-reality-exposure-therapy-for-social-anxiety-disorder
#18
LETTER
Restu Dwi Ariyanto, Indriyana Rachmawati, Wahyu Nanda Eka Saputra, Rikas Saputra, Nora Yuniar Setyaputri
The study by Antici et al. (2024) investigates the effects of virtual reality exposure therapy on social anxiety disorder (SAD), focusing on the relationship between C-reactive protein (CRP) levels in saliva and therapy outcomes. Findings indicate that this therapy not only reduces SAD symptoms and discomfort but also correlates with decreased systemic inflammation, as evidenced by lowered CRP levels. Remarkably, higher baseline CRP levels predicted a greater reduction in anxiety symptoms, suggesting a unique response pattern in SAD compared to other psychological disorders...
April 3, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38570102/tnfr1-p38%C3%AE-mapk-signaling-in-nex%C3%A2-%C3%A2-supraspinal-neurons-regulates-estrogen-dependent-chronic-neuropathic-pain
#19
JOURNAL ARTICLE
Kathryn A Swanson, Kayla L Nguyen, Shruti Gupta, Jerome Ricard, John R Bethea
Upregulation of soluble tumor necrosis factor (sTNF) cytokine signaling through TNF receptor 1 (TNFR1) and subsequent neuronal hyperexcitability are observed in both animal models and human chronic neuropathic pain (CNP). Previously, we have shown that estrogen modulates sTNF/TNFR1 signaling in CNP, which may contribute to female prevalence of CNP. The estrogen-dependent role of TNFR1-mediated supraspinal neuronal circuitry in CNP remains unknown. In this study, we interrogated the intersect between supraspinal TNFR1 mediated neuronal signaling and sex specificity by selectively removing TNFR1 in Nex + neurons in adult mice (NexCreERT2 ::TNFR1f/f )...
April 1, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38570101/microglial-scap-deficiency-protects-against-diabetes-associated-cognitive-impairment-through-inhibiting-nlrp3-inflammasome-mediated-neuroinflammation
#20
JOURNAL ARTICLE
Wenwen Zhu, Haoqiang Zhang, Tong Niu, Kunyu Liu, Huzaifa Fareeduddin Mohammed Farooqui, Ruoyu Sun, Xiu Chen, Yang Yuan, Shaohua Wang
Hyperglycemia-induced pathological microglial responses and subsequent neuronal damage- are notable characteristics of diabetes-associated cognitive impairment (DACI). Cholesterol accumulation in the brain is a prevalent consequence of diabetes mellitus (DM), exacerbating pathological microglial responses. Regarding disordered glucose and lipid metabolism, the Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP), a cholesterol sensor, exhibits increased expression and abnormal translocation from the endoplasmic reticulum to the Golgi, amplifying the inflammatory response...
April 1, 2024: Brain, Behavior, and Immunity
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