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Immunopharmacology and Immunotoxicology

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https://read.qxmd.com/read/30849257/effect-of-omega-3-fatty-acid-supplementation-on-resolvin-rve1-mediated-suppression-of-inflammation-in-a-mouse-model-of-asthma
#1
Armaan Siddiquee, Mehaben Patel, Sahith Rajalingam, Deven Narke, Mangesh Kurade, Dovenia S Ponnoth
OBJECTIVE: ResolvinE1 (RvE1), an endogenous lipid mediator derived from omega 3 fatty acids contributes to resolution of allergic inflammatory responses. We investigated effects of RvE1 (R) and omega 3 fatty acids (O) on airway reactivity and inflammation using allergic mice. METHODS: Mice were divided into control (nonasthmatic; CON) and allergen sensitized-challenged (asthmatic; SEN) groups, and were sensitized i.p. on days 1, 6 with 0.2 μg ovalbumin (OVA) followed by 5% OVA aerosol challenges on days 11-13...
March 8, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30821556/inhibition-of-tumor-necrosis-factor-alpha-and-increased-of-interleukin-10-by-lactobacillus-a-molecular-mechanism-protection-against-tnbs-induced-ulcerative-colitis-in-chicks
#2
Long Jing, Zhiqiang Yu, Xueli Gao, Chaonan Liu, Xiaoping Lv, Shimin Zheng
The purpose of this study was to evaluate the effects and mechanism of Lactobacillus on ameliorating ulcerative colitis chicks induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). There are three groups in this study, control, Lactobacillus and ulcerative colitis groups. 1-day-old chicks were fed with microcapsules containing Lactobacillus LA-5 daily for Lactobacillus group and clustered with 2,4,6-trinitrobenzene sulfonic acid (TNBS) to make the model of ulcerative colitis at ten-day-old. Chicks in control and ulcerative colitis groups were fed with empty microcapsules daily at 1-day-old and then chicks in ulcerative colitis group were induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) for preparation of ulcerative colitis model at 10-day-old...
March 1, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30821531/agmatine-ameliorates-acetic-acid-induced-colitis-in-rats-involvement-of-nitrergic-system
#3
Amir Rashidian, Hedieh Keshavarz-Bahaghighat, Alireza Abdollahi, Mohsen Chamanara, Hedyeh Faghir-Ghanesefat, Mohsen Hoseini-Ahmadabadi, Ahmad Reza Dehpour
AIM: The aim of the present study is to investigate the anti-inflammatory effect of agmatine through the inhibition of iNOS enzyme in acetic acid-induced rat colitis. METHODS: Acute colitis was induced by administration of 2 mL of diluted acetic acid (4%) solution rectally. Two hours after colitis induction, animals were treated with normal saline, dexamethasone (2 mg/kg), agmatine (2, 5, 10 mg/kg), L-NAME (30 mg/kg), Aminoguanidine (20 mg/kg), agmatine (2 mg/kg) with L-NAME (30 mg/kg) and agmatine (2 mg/kg) with aminoguanidine (20 mg/kg) intraperitoneally and continued for 3 consecutive days...
March 1, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30773959/tachykinin-upregulation-in-atopic-dermatitis
#4
Louise Lönndahl, Aram Rasul, Sol-Britt Lonne-Rahm, Mikael Holst, Björn Johansson, Husameldin El-Nour, Diana Radu Djurfeldt, Klas Nordlind
CONTEXT: Atopic dermatitis (AD) is a chronic, inflammatory, itching skin disorder, which may worsen due to stress, depression and anxiety. Tachykinins may be involved in inflammation signaling as well as they may have a role in stress, depression and anxiety. OBJECTIVE: This study aimed to measure the expression of tachykinin markers, in the skin of patients with AD, and the correlation of these tachykinins with clinical and psychodemographic parameters. MATERIALS AND METHODS: Twenty-eight adult patients with AD were investigated regarding tachykinin expression in skin biopsies, using an immunohistochemical technique...
February 18, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30741582/protective-effect-of-a-topical-sunscreen-formulation-fortified-with-melatonin-against-uv-induced-photodermatitis-an-immunomodulatory-effect-via-nf-%C3%AE%C2%BAb-suppression
#5
Nilutpal Sharma Bora, Bhaskar Mazumder, Santa Mandal, Yangchen D Bhutia, Sanghita Das, Sanjeev Karmakar, Pronobesh Chattopadhyay, Sanjai K Dwivedi
OBJECTIVE: Melatonin and pumpkin seed oil, along with US FDA approved UV filters were incorporated into a formulation for enhancement of UV protection by exerting an antioxidant effect. The objective of this study was to assess the protective effect of this formulation against ultraviolet (UV) radiation-induced photo dermatitis in rats, which is an established model to study the aetiopathogenic mechanisms in psoriasis vulgaris, as the former exhibits the same features to those of clinical psoriasis vulgaris in humans...
February 11, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30724633/silica-nanoparticles-as-an-enhancer-in-the-il-1%C3%AE-induced-inflammation-cycle-of-a549-cells
#6
Jing Wu, Yajing Han, Xiaoqian Zou, Kehui Zhu, Zichen Wang, Xiaohong Ye, Yumei Liu, Shirui Dong, Xiaojing Chen, Dandan Liu, Zihao Wen, Yao Wang, Shiqi Huang, Zixing Zhou, Chengli Zeng, Chuican Huang, Shaoling Zheng, Xiuben Du, Xiuxia Huang, Baohuan Zhang, Chunxia Jing, Guang Yang
OBJECTIVE: The industrial production and combustion of coal can produce silica nanoparticles (nano-SiO2 ). It enters the human body mainly through the respiratory tract and exerts a toxic effect. However, whether nano-SiO2 can increase the IL-1β-induced inflammatory expression in A549 cells has not been tested. Therefore, the synergistic toxicity of nano-SiO2 and IL-1β to A549 was observed in our study. MATERIALS AND METHODS: We exposed A549 cells to nano-SiO2 (0, 100, 500, and 1000 μg/ml) for 12 and 24 h...
February 6, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30724631/dehydroxymethylepoxyquinomicin-suppresses-atopic-dermatitis-like-lesions-in-a-stratum-corneum-removed-murine-model-through-nf-%C3%AE%C2%BAb-inhibition
#7
Xiaoxue Jiang, Huan He, Zhehui Xie, Huimin Wen, Xiaoran Li, Xin Li, Jun Ma, Kazuo Umezawa, Yuyang Zhang
BACKGROUND: Dehydroxymethylepoxyquinomicin (DHMEQ) is a specific and potent inhibitor of nuclear factor-kappa B (NF-κB) and has been shown to possess promising potential as an anti-inflammation including anti-atopic dermatitis (AD)-like skin lesions. OBJECTIVE: To further evaluate the activity of DHMEQ in vivo modified AD-like lesion model in BALB/c mice and in vitro AD-like lesion cell model in human keratinocytes. MATERIALS AND METHODS: In this study, in vivo modified AD-like lesion model in BALB/c mice was chronically induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) and oxazolone (OX) on ears, and stratum corneum of the ear skin was additionally stripped off with surgical tapes before each challenge with DNCB/OX...
February 6, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30721636/phillygenin-exhibits-anti-inflammatory-activity-through-modulating-multiple-cellular-behaviors-of-mouse-lymphocytes
#8
Bingyuan Du, Li Zhang, Ying Sun, Guimin Zhang, Jingchun Yao, Mingmin Jiang, Lihong Pan, Chenghong Sun
CONTEXT: Phillygenin (PHI) is an intestinal metabolite of phillyrin from the genus Forsythia. Although the regulatory activity of Forsythia on immune system has been investigated, the effect of PHI on activated lymphocytes is poorly understood. OBJECTIVE: This study was aimed to discuss the possible anti-inflammation potential of PHI on mitogen-activated stimulated lymphocytes in vitro. METHODS: Mice spleen lymphocytes were incubated with PHI for 4 h, and then stimulated with concanavalin A (Con A) or phorbol 12-myristate 13-acetate/ionomycin (PMA + Ion)...
February 5, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30721634/fluconazole-induces-genotoxicity-in-cultured-human-peripheral-blood-mononuclear-cells-via-immunomodulation-of-tnf-%C3%AE-il-6-and-il-10-new-challenges-for-safe-therapeutic-regimens
#9
G S Silva, L Zuravski, M M M F Duarte, M M Machado, L F S Oliveira
CONTEXT: Fluconazole (FNZ) is a drug used in antifungal therapy. However, the minimum FNZ dose to interfering with immune responses or inducing DNA damage is still unknown. OBJECTIVE: This study investigated the toxicological profile of FNZ on cultured human peripheral blood mononuclear cells (PBMCs) treated with different concentrations of this azole. MATERIALS AND METHODS: Cultured PBMCs were exposed to FNZ (6, 12, 30, 60 and 120 μg/mL) and the toxicological profile was assessed by the following parameters: cytotoxic and nuclear division index (necrotic, apoptotic and viable cells), DNA damage (alkaline comet test), mutagenic potential (micronucleus test), cytokine modulation (IL-1, IL-6, IL-10, TNF-α, IFN-γ), and predictive toxicity (Osiris® and LAZAR® programs)...
February 5, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30721100/the-antagonistic-effect-of-tamoxifen-against-d-galactosamine-lipopolysaccharide-induced-acute-liver-failure-is-associated-with-reactivation-of-hepatic-nuclear-factor-%C3%AE%C2%BAb
#10
Liping Liu, Yongsheng Zhao, Yan Lin, Rongshan Zhang, Shi Luo, Ping Ye, Mansheng Luo
CONTEXT: Tamoxifen (TAM) ameliorates D-galactosamine/lipopolysaccharide (Gal/LPS)-induced acute liver failure (ALF) through its antioxidative effect; thus, this study was designed to determine whether the effectiveness of TAM is related to nuclear factor-κB (NF-κB) reactivation. MATERIALS AND METHODS: Experimental mice were injected with TAM once daily for 3 consecutive days intraperitoneally (i.p). Twelve hours after pretreatment, Gal/LPS was given to mice (i...
February 5, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30714456/anti-tnf-effect-of-combined-pravastatin-and-cilostazol-treatment-in-an-in-vivo-mouse-model
#11
Hae-Ri Lee, Min-Kyung Jo, Kyung-Yeon Park, You-Jin Jang, Tae-Hwe Heo
OBJECTIVES: Pravastatin and cilostazol are used as lipid-lowering and antiplatelet agents, respectively. Regarding their well-known anti-inflammatory effects, the additive effect of the two drugs on anti-TNF functions has not yet been investigated. In the present investigation, the beneficial effect of combined pravastatin and cilostazol on their anti-TNF activities was assessed using an in vivo mouse model. METHODS: Mice were pretreated with pravastatin and/or cilostazol (40 mg/kg of each), orally once two hour prior to an LPS (5 mg/kg, i...
February 4, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30714436/survival-of-lymphocytes-is-not-restricted-by-ido-expressing-fibroblast-from-rheumatoid-arthritis-patients
#12
Magdalena Massalska, Ewa Kuca-Warnawin, Iwona Janicka, Magdalena Plebanczyk, Dariusz Pawlak, Tomas Dallos, Anna Olwert, Anna Radzikowska, Pawel Maldyk, Ewa Kontny, Wlodzimierz Maslinski
OBJECTIVE: Rheumatoid arthritis (RA) is characterized by expansion of fibroblast-like synoviocytes (FLS) in inflamed joints and activation of lymphocytes. Tryptophan (trp) is an essential amino acid indispensable for the biosynthesis of proteins and critical for survival of lymphocytes. Indoleamine 2,3-dioxygenase (IDO) that initiates the degradation of trp and tryptophanyl-tRNA synthetase (TTS) essential for tryptophan synthesis, regulate trp bioavailability. Here, we tested the hypothesis that triggered by cytokines, enhanced IDO activity modulate regulatory function of otherwise non-tolerogenic FLS isolated from RA patients...
February 4, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30714433/preclinical-evidences-of-safety-of-a-new-synthetic-adjuvant-to-formulate-with-the-influenza-human-vaccine-absence-of-subchronic-toxicity-and-mutagenicity
#13
Jacquelynne Cervantes-Torres, Isabel Gracia-Mora, René Segura-Velazquez, Regina Montero-Montoya, Javier Espinosa-Aguirre, María E Gonsebatt, Rafael Camacho-Carranza, Marisol Rivera-Huerta, Francisco Sanchez-Bartez, Mabel Tinoco-Méndez, Patricia Ostrosky-Wegman, Gladis Fragoso, Edda Sciutto
CONTEXT: Influenza is a severe, life-threatening viral disease that can be prevented by vaccination. However, the anti-influenza human vaccine failed to show the required efficacy both in infants under 5 years old and in the elder population, who are among those with the highest risk of developing severe complications after influenza infection. Therefore, it is of high importance to improve the vaccine efficacy and ensure its safety in these susceptible populations. GK-1, a novel 18-aa peptide adjuvant, has been proved to increase the immunogenicity of the human influenza vaccine in both young and aged mice...
February 4, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30714422/the-role-of-t-helper-17-and-regulatory-t-cells-in-tumor-microenvironment
#14
Soheil Najafi, Abbas Mirshafiey
T helper 17 (Th17) cells were first described as a novel T helper cell lineage independent from Th1 and Th2 subsets. Th17 cells play vital roles in inflammation and tumor immunity. It causes the dissipation of antitumor immunity and contribution to the survival of tumor cells, worsening tumor growth and metastasis. Tumor-infiltrating Th17 cells were seen innumerous cancers in mice and humans. There has been an association between intratumoral Th17 cell infiltration and both good and bad prognoses. Besides the protumoral roles defined for IL-17 andTh17 cells, several reports have shown that Th17 cells also drive antitumoral immunity...
February 4, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30706742/the-germ-free-mice-monocolonization-with-bacteroides-fragilis-improves-azoxymethane-dextran-sulfate-sodium-induced-colitis-associated-colorectal-cancer
#15
Yen-Peng Lee, Chien-Chao Chiu, Tien-Jen Lin, Shao-Wen Hung, Wen-Ching Huang, Ching-Feng Chiu, Yen-Te Huang, Yi-Hsun Chen, Ter-Hsin Chen, Hsiao-Li Chuang
OBJECTIVE: Inflammatory bowel disease (IBD) is generally considered as a major risk factor in the progression of colitis-associated colorectal cancer (CAC). Previous studies have indicated that the composition of gut microflora may be involved in CAC induction and progress. Bacteroides fragilis (BF) is a Gram-negative anaerobe belonging to colonic symbiotic bacteria of the host. This study was aimed to investigate the protective role of BF in a colorectal cancer (CRC) model induced by azoxymethane (AOM) and dextran sulfate sodium (DSS) in germ-free (GF) mice...
February 1, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30706740/carvacrol-ameliorates-the-progression-of-liver-fibrosis-through-targeting-of-hippo-and-tgf-%C3%AE-signaling-pathways-in-carbon-tetrachloride-ccl-4-induced-liver-fibrosis-in-rats
#16
Roohollah Mohseni, Jamshid Karimi, Heidar Tavilani, Iraj Khodadadi, Mohammad Hashemnia
OBJECTIVE: Little is known about the exact underlying molecular mechanisms of the hepatoprotective effect of carvacrol against liver fibrosis. In the current study, we aimed to investigate the effect of carvacrol on the suppression of liver fibrosis progression via regulation of yes-associated protein (YAP) and transcriptional coactivators with a PDZ-binding motif (TAZ) and transforming growth factor beta (TGF-β) pathway. MATERIALS AND METHODS: To fulfill our target, rats received carbon tetrachloride (CCl4 ) and carvacrol intraperitoneally, and orally, respectively for 10 weeks...
February 1, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30706732/hematological-and-immunological-impairment-following-in-utero-and-postnatal-exposure-to-aluminum-sulfate-in-female-offspring-of-albino-rats
#17
Ghada A Omran
AIM: Aluminum (Al) is a ubiquitous element extensively utilized in many products like food additives, pharmaceuticals, and vaccines, but its hematotoxic and immunotoxic effects are not entirely clarified. The present study explored the developmental hematotoxic and immunotoxic properties of aluminum sulfate (AS) in rats' offspring. METHODS: Forty female offspring (10 rats each) were given three incremental AS doses plus a control group, from conception through lactation and after weaning until reached eight weeks old (near adults)...
February 1, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30704333/sclareol-attenuates-the-development-of-atopic-dermatitis-induced-by-2-4-dinitrochlorobenzene-in-mice
#18
Po-Chang Wu, Wen-Ho Chuo, Shih-Chao Lin, Caitlin W Lehman, Christopher Z Lien, Chieh-Shan Wu, Chi-Chien Lin
CONTEXT: Atopic dermatitis is a common chronic inflammatory skin disease affecting up to 20% of children and 1% of adults worldwide. Treatment of atopic dermatitis include corticosteroids and immunosuppressants, such as calcineurin inhibitors and methotrexate. However, these treatments often bring about adverse effects including skin atrophy, osteoporosis, skin cancer, and metabolic syndrome. OBJECTIVE: In this study, we evaluated the therapeutic effects and mechanisms of sclareol, a natural diterpene, on atopic dermatitis (AD)-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in mice...
February 1, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30702002/modulating-acute-neuroinflammation-in-intracerebral-hemorrhage-the-potential-promise-of-currently-approved-medications-for-multiple-sclerosis
#19
Jarred Napier, Lucas Rose, Opeolu Adeoye, Edmond Hooker, Kyle B Walsh
The secondary inflammatory injury following intracerebral hemorrhage (ICH) results in increased morbidity and mortality. White blood cells have been implicated as critical mediators of this inflammatory injury. Currently, no medications have been clinically proven to ameliorate or beneficially modulate inflammation, or to improve outcomes by any mechanism, following ICH. However, other neuroinflammatory conditions, such as multiple sclerosis, have approved pharmacologic therapies that modulate the inflammatory response and minimize the damage caused by inflammatory cells...
January 31, 2019: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/30633591/effects-of-tacrolimus-fk506-and-mycophenolate-mofetil-mmf-on-regulatory-t-cells-and-co-inhibitory-receptors-in-the-peripheral-blood-of-human-liver-allograft-patients
#20
Qiang Zeng, Xiao-Ye Yuan, Wei Li, Bao-Wang Liu, Xin Zhao, Gui-Jun Ren, Yang Wang, Jian Dou, Gui-Ying Wang
CONTEXT: Recent studies have shown that a combination treatment of mycophenolate mofetil (MMF) and tacrolimus (FK506) may be an option for organ transplantation patients. OBJECTIVE: In this study, we detected the effects of FK506 and MMF on the expressions of regulatory T cells (Tregs) and co-inhibitory receptors on Tregs in peripheral blood mononuclear cells (PBMC) of patients with stable phase after liver transplantation. MATERIALS AND METHODS: A total of 35 patients with stable stage after 6 months of liver transplantation were divided into two groups including 20 patients were treated with FK506 monotherapy (FK506 group), and 15 patients with FK506 and MMF combination (FK506 + MMF group)...
January 11, 2019: Immunopharmacology and Immunotoxicology
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