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Toxicology in Vitro: An International Journal Published in Association with BIBRA

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https://read.qxmd.com/read/30763609/corrigendum-to-lusens-a-keratinocyte-based-are-reporter-gene-assay-for-use-in-integrated-testing-strategies-for-skin-sensitization-hazard-identification-by-ramirez-et-al-toxicol-in-vitro-2014-dec-28-8-1482-97-doi-10-1016-j-tiv-2014-08-002
#1
https://read.qxmd.com/read/30763608/human-small-bowel-as-model-for-poisoning-with-organophosphorus-compounds
#2
Katharina Marquart, Olga Prokopchuk, Dirk Wilhelm, Franz Worek, Horst Thiermann, Marc E Martignoni, Timo Wille
In previous experiments, human and rat small bowel samples have been successfully used to study the spasmolytic effect of (potential) therapeutics in carbamate-constricted bowel specimens. Additionally, transferability from rat to human data was shown in the previous study. In the present study, the effects of atropine, scopolamine, MB327, HI-6 as well as obidoxime were examined in organophosphorus-poisoned human small bowel specimens. All substances were tested with at least seven concentrations in samples previously exposed to the nerve agent sarin...
February 11, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30742918/assessment-of-human-estrogen-receptor-agonistic-antagonistic-effects-of-veterinary-drugs-used-for-livestock-and-farmed-fish-by-oecd-in-vitro-stably-transfected-transcriptional-activation-assays
#3
Hee-Seok Lee, Na-Yeon Kim, YoungSun Song, Gyeong-Yong Oh, Da-Woon Jung, Da-Hyun Jeong, Hui-Seung Kang, Hyun-Sook Oh, Yooheon Park, Jeong Sup Hong, Yong Eui Koo
The presence of veterinary drug residues in foods and the environment could potentially cause adverse effects on humans and wildlife. Several veterinary drugs were reported to exhibit endocrine disrupting effects via binding affinities to sexual hormone receptors such as estrogen and androgen receptors. Therefore, we confirmed the human estrogen receptor (ER) agonistic/antagonistic effects of 135 chemicals that were used as veterinary drugs in Korea by the official Organization for Economic Cooperation and Development (OECD) in vitro ER transcriptional activation (TA) assay using the VM7Luc4E2 cell line...
February 8, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30738890/primary-human-bronchial-epithelial-cell-responses-to-diesel-and-biodiesel-emissions-at-an-air-liquid-interface
#4
Annalicia Vaughan, Svetlana Stevanovic, Mohammad Jafari, Rayleen V Bowman, Kwun M Fong, Zoran D Ristovski, Ian A Yang
INTRODUCTION: Diesel emissions have a high level of particulate matter which can cause inflammation and oxidative stress in the airways. A strategy to reduce diesel particulate matter and the associated adverse effects is the use of biodiesels and fuel additives. However, very little is known about the biological effects of these alternative emissions. The aim of this study is to compare the effect of biodiesel and triacetin/biodiesel emissions on primary human bronchial epithelial cells (pHBECs) compared to diesel emissions...
February 7, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30738889/development-of-a-non-radioactive-screening-assay-to-detect-chemicals-disrupting-the-human-sodium-iodide-symporter-activity
#5
Hongyan Dong, Ella Atlas, Michael G Wade
Adequate concentration of iodide ions within thyroid epithelial cells, which is mediated by the sodium iodide symporter (NIS), is essential for proper thyroid hormone synthesis. Inhibition of NIS activity represents a potential mechanism by which goitrogens/toxicants can disrupt thyroid hormone physiology. It is necessary to develop a rapid, simple, inexpensive and sensitive screening assay to identify chemicals affecting NIS function. The current study compares the sensitivities of non-radioactive Sandell-Kolthoff (SK) reaction and radioactive iodide uptake (RAIU) in a previously described NIS assay...
February 7, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30738888/regarding-the-references-for-reference-chemicals-of-alternative-methods
#6
S N Kolle, E Hill, H Raabe, R Landsiedel, R Curren
The selection of reference and proficiency chemicals is an important component of method validation and proficiency evaluations. Reference chemicals are a set of test substances used by a method developer to evaluate the reliability and relevance of a new method, in comparison to reference data (usually to a validated reference method). Proficiency chemicals, as defined in OECD Guidance Document on Good In Vitro Method Practices, are defined post validation as a subset of the reference chemicals or other chemicals with sufficient supporting data that are used by naïve laboratories to demonstrate technical competence with a validated test method...
February 7, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30738887/sirt1-suppresses-p53-dependent-apoptosis-by-modulation-of-p21-in-osteoblast-like-mc3t3-e1-cells-exposed-to-fluoride
#7
Xiaolong Gu, Zhi Wang, Jian Gao, Dandan Han, Limei Zhang, Peng Chen, Guangjian Luo, Bo Han
Fluoride is very crucial for development of teeth and bones. Excessive fluoride, however, causes damage to teeth and bones resulting in serious public health problem. SIRT1 regulates physiological and pathological processes such as apoptosis and cell cycle. Although SIRT1 inhibits p53-mediated transactivation, how SIRT1 regulates p53 in fluorosis remains unclear. This study aims to investigate the involvement of SIRT1 in fluoride-induced cell cycle arrest and apoptosis in MC3T3-E1 cells and the underlying mechanism...
February 7, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30738203/preventive-effect-of-tio-2-nanoparticles-on-heavy-metal-pb-induced-toxicity-in-human-lung-epithelial-a549-cells
#8
Maqusood Ahamed, Mohd Javed Akhtar, Hisham A Alhadlaq
Wide application of TiO2 nanoparticles (nTiO2 ) and ubiquitous lead (Pb) pollution in natural environment enhance the chance of co-exposure of humans to Pb and nTiO2 . We investigated the effects of nTiO2 on Pb-induced toxicity in human lung epithelial (A549) cells. Results showed that nTiO2 was not toxic to A549 cells. Conversely, Pb-induced cytotoxicity and oxidative stress in A549 cells were evidenced by cell viability reduction, cell membrane damage, reactive oxygen species generation and depletion of antioxidants...
February 6, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30711601/measurement-of-the-agonistic-activities-of-monohydroxylated-polychlorinated-biphenyls-at-the-retinoid-x-and-retinoic-acid-receptors-using-recombinant-yeast-cells
#9
Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
The possibility that a wide variety of polychlorinated biphenyls (PCBs) and their derivatives are present in the environment necessitates detailed evaluation of their toxicities. A number of PCBs and monohydroxylated PCBs (OH-PCBs) have been reported to have affinities for several nuclear receptors, and some of these compounds have been shown to have harmful effects in animals. In this study, we focused on the retinoid X receptor (RXR) and the retinoic acid receptor (RAR), which play critical roles in development and homeostasis...
January 31, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30710624/diterpene-pekinenal-from-euphorbia-pekinensis-radix-induced-iec-6-cells-apoptosis-mediated-by-mitochondria-and-death-receptors
#10
Fang Yao, Dongjing Jiang, Fangfang Cheng, Weifeng Yao, Peidong Chen, Shuchen Guo, Yudan Cao, Li Zhang
Pekinenal, a diterpenoid from the roots of Euphorbia pekinensis Rupr., can cause serious intestinal toxicity. However, its toxic mechanism hasn't been comprehensively understood. This present study aims to clarify its toxic effects and investigate the potential mechanism. In vitro effects of pekinenal on cell proliferation, cell cycle and apoptosis were examined by performing experiments on rat intestinal crypt epithelial cells (IEC-6). Proteins and enzymes involved in cell apoptotic pathways were detected by Western blot and enzyme-linked immunosorbent assay (ELISA), and related mRNAs were detected by RT-PCR...
January 30, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30707927/biological-impact-of-metal-nanomaterials-in-relation-to-their-physicochemical-characteristics
#11
Henriqueta Louro, Andreia Saruga, Joana Santos, Mariana Pinhão, Maria João Silva
No abstract text is available yet for this article.
January 29, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30703532/cytotoxicity-and-mitochondrial-dysfunction-caused-by-the-dietary-supplement-l-norvaline
#12
Kate Samardzic, Kenneth J Rodgers
In addition to the 20 protein amino acids that are encoded for protein synthesis, hundreds of other naturally occurring amino acids, known as non-proteinogenic amino acids (NPAAs) exist. It is well known that some NPAAs are toxic through their ability to mimic protein amino acids, either in protein synthesis or in other metabolic pathways, and this property is utilised by some plants to inhibit the growth of other plants or kill herbivores. L-norvaline is an NPAA readily available for purchase as a dietary supplement...
January 28, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30686568/corrigendum-to-the-biological-effects-of-long-term-exposure-of-human-bronchial-epithelial-cells-to-total-particulate-matter-from-a-candidate-modified-risk-tobacco-product-published-in-toxicology-in-vitro-volume-50-august-2018-pages-95-108
#13
Marco van der Toorn, Alain Sewer, Diego Marescotti, Stephanie Johne, Karin Baumer, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Elena Scotti, Claudius Pak, Patrice Leroy, Emmanuel Guedj, Nikolai Ivanov, Florian Martin, Manuel Peitsch, Julia Hoeng, Karsta Luettich
No abstract text is available yet for this article.
January 24, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30685479/in-vitro-evaluation-of-cytotoxic-and-genotoxic-effects-of-di-2-ethylhexyl-phthalate-dehp-on-european-sea-bass-dicentrarchus-labrax-embryonic-cell-line
#14
Chiara Molino, Silvia Filippi, Gerardo Antonio Stoppiello, Roberta Meschini, Dario Angeletti
Marine litter is extensively distributed in the marine environment, and plastic debris, of which litter is mostly composed, can be a major source of pollutants. Among them, Di(2-ethylhexyl)-phthalate (DEHP) is the most abundantly used plastic additive, and it has been reported to affect biochemical processes both in humans and wildlife; however, studies on its toxicological effects on marine organisms are still scarce. In this survey, we studied the cytotoxic, genotoxic, and mutagenic effects of DEHP in European sea bass embryonic cell line (DLEC) by applying specific in vitro tests...
January 24, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30684567/arsenic-induces-gender-difference-of-estrogen-receptor-in-aecii-cells-from-icr-fetal-mice
#15
Wangjun Che, Mengping Yang, Yaling Cheng, Mei Wu, Yajia Lan, Hao Zhang
Arsenic is a confirmed human lung carcinogen with estrogenic activity. There are gender differences in the incidence of lung cancer. Estrogen receptors (ER) play an important role in the process of the development of lung cancer. In order to understand the gender difference effects of ER during carcinogenesis of lung induced by arsenic, the effects of arsenic and estrogen receptor antagonist (ICI182780) on expression levels of estrogen receptor beta (ERβ), extracellular regulated protein kinase (ERK1/2) and nuclear factor κB (NF-κB/P65) in type II alveolar epithelial cells (AECII) from different sex ICR fetal mice lung were detected...
January 23, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30682495/evidences-for-involvement-of-estrogen-receptor-induced-erk1-2-activation-in-ovarian-cancer-cell-proliferation-by-cadmium-chloride
#16
Negar Ataei, Mahmoud Aghaei, Mojtaba Panjehpour
Cadmium (Cd) as a human carcinogen and one of the most toxic industrial and environmental pollutant mimics the estrogenic effects in cell proliferation. So, it might have a role in the incidence and etiology of hormone-related cancers such as ovarian cancer as the most lethal gynecologic malignancy. This study aimed to evaluate the estrogenic effect and underlying mechanism of Cd in ovarian cancer cell line proliferation. OVCAR3 and SKOV3 cell lines were treated with different concentrations of CdCl2 (0- 50 μM)...
January 22, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30682494/catalpol-and-panax-notoginseng-saponins-synergistically-alleviate-triptolide-induced-hepatotoxicity-through-nrf2-are-pathway
#17
Zhe Feng, Cong Zhou, Sheng Dong, Zhangpu Liu, Tianyang Liu, Lingling Zhou, Xueping Zhou
Triptolide (TP), as the main component of Tripterygium wilfordii (TW), could induce significant hepatic damage when exerting the therapeutic effect. However, The previous studies have shown that catalpol (CAT) and panax notoginseng saponins (PNS) have synergistic protecting effect against hepatotoxicity induced by TP. This study aims to address the role of the nuclear factor erythroid-2-related factor-2 (Nrf2)/antioxidant response element (ARE) pathway in their protecting effect, and to explore their synergistic mechanisms...
January 22, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30682493/oxidative-stress-induced-by-oxime-reactivators-of-acetylcholinesterase-in-vitro
#18
L Muckova, N Vanova, J Misik, D Herman, J Pejchal, D Jun
In this study, we determined the effect of methoxime (MMB-4), asoxime (HI-6), obidoxime (LüH-6), trimedoxime (TMB-4), and pralidoxime (2-PAM) on redox homeostasis in vitro. Cultured human hepatoma cells (HepG2) were exposed to oximes at concentrations equivalent to their IC50 (assessed using MTT assay) and evaluated 1, 4 and 24 h after incubation. Additionally, intact, early and late apoptotic and necrotic cells were quantified by microcapillary flow cytometry. Intracellular levels of oxygen/nitrogen species were determined using two fluorescent probes (2',7'-dichlorodihydrofluorescein diacetate and dihydroethidium)...
January 22, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30677511/involvement-of-estrogen-receptor-and-gper-in-bisphenol-a-induced-proliferation-of-vascular-smooth-muscle-cells
#19
Fei Gao, Yunchao Huang, Liang Zhang, Wei Liu
Aortic aneurysm (AA) is a common disease that is associated with the proliferation and apoptosis of vascular smooth muscle cells (VSMCs). VSMC cells can be directly exposed to environmental endocrine disruptors (EEDs) such as bisphenol A (BPA). However, the effects of BPA on the biological functions of VSMC are not well studied. Our present study found that nanomolar bisphenol A (BPA) can increase the proliferation of VSMC, which was further evidenced by the results that BPA can increase the expression of proliferating cell nuclear antigen (PCNA)...
January 21, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/30654088/ascorbic-acid-prevents-chloroquine-induced-toxicity-in-inner-glial-cells
#20
Karen Renata Herculano Matos Oliveira, Larissa Medeiros Dos Anjos, Ana Paula Sousa Araújo, Waldo Lucas Luz da Silva, Nayara Kauffmann, Danielle Valente Braga, Adelaide da Conceição Fonseca Passos, Suellen Alessandra Soares de Moraes, Evander de Jesus Oliveira Batista, Anderson Manoel Herculano
Ototoxicity is a collateral effect of prolonged treatment with chloroquine which is a widely utilized as an anti-lupus and anti-malarial drug. Glial cells of inner ear are responsible for maintenance of neuronal cells homeostasis in auditory system. In the current study we have evaluated chloroquine-induced toxicity and protective effect of ascorbic acid treatment on Schwann glial cell cultures of inner ear. Glial cells were cultured from organ of Corti of mice cochlear structure. Purity of Schwann glial cell was confirmed by S100 protein staining...
January 14, 2019: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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