journal
https://read.qxmd.com/read/39024198/neoadjuvant-capecitabine-plus-temozolomide-in-atypical-lung-nets
#1
JOURNAL ARTICLE
Georgios Evangelou, Ioannis Vamvakaris, Irene Konstantopoulou, Konstantinos Syrigos
Neoadjuvant and adjuvant treatment in lung neuroendocrine tumors (NETs) is a field that has not been explored in-depth, with little information on the impact on disease-free survival. This case study highlights the effectiveness of neoadjuvant treatment with capecitabine plus temozolomide (CAPTEM) in a woman with well-differentiated atypical carcinoid. The patient was asymptomatic at diagnosis and was referred to the outpatient NET clinic at Sotiria Hospital in Athens, following an incidental finding on a chest x-ray...
July 8, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38899982/a-rare-case-of-metastatic-spiradenocarcinoma-with-cdkn2a-mutation
#2
JOURNAL ARTICLE
Jonathan Q Trinh, Shristi Upadhyay Banskota, Alissa S Marr
Spiradenocarcinomas are rare malignant skin adnexal tumors. We describe a novel case of a patient with an aggressive CDKN2A-mutated spiradenocarcinoma who responded to a CDK4/6 inhibitor. This case highlights the unique nature of spiradenocarcinomas as well as the potential benefit of targeted therapy.
June 10, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38899981/continued-success-of-venetoclax-in-t-11-14-multiple-myeloma-despite-negative-trials
#3
JOURNAL ARTICLE
Zachary M Avigan, Joshua Richter Md
The June Hot Topics focuses on the challenges venetoclax regimens have faced in multiple myeloma trials.
June 10, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38776517/ai-use-in-prostate-cancer-potential-improvements-in-treatments-and-patient-care
#4
JOURNAL ARTICLE
James B Yu Md Mhs Fastro, Julian C Hong
Artificial intelligence use in prostate cancer encompasses 4 main areas including diagnostic imaging, prediction of outcomes, histopathology, and treatment planning.
May 13, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38776516/synchronous-well-differentiated-papillary-mesothelioma-and-endometrioid-adenocarcinoma-arising-from-endometriosis
#5
JOURNAL ARTICLE
Catherine R Lewis, Jocelyn Uchic-Boccella, Jenna Zimmerman, Eirwen Miller, Sharon Liang, Patrick L Wagner
Well-differentiated papillary mesothelioma (WDPM) is a rare mesothelial tumor of uncertain malignant potential. We present a unique case of a woman with synchronous WDPM and well-differentiated endometrioid adenocarcinoma (EA) arising from extraovarian endometriosis. A 56-year-old postmenopausal woman presented with a several-month history of right lower quadrant abdominal pain. She had a history of supracervical hysterectomy and bilateral salpingo-oophorectomy secondary to endometriosis. Imaging reported a mass in the right lower quadrant originating from the distal ileum...
May 13, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38776515/which-treatment-for-which-patient-rectal-cancer-management-after-prospect-trial
#6
EDITORIAL
Seth Felder, Jessica Frakes, Manju George, Allison Rosen, Ibrahim Halil Sahin
Determining treatment options for patients with locally advanced rectal cancer after the PROSPECT trial data readout adds an important level to the decision-making process.
May 13, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38661513/evaluation-and-management-of-testicular-cancer-after-late-relapse
#7
JOURNAL ARTICLE
Joanna L Langner, Frederick Millard, Vera Vavinskaya, Haiyan Zhang, Nuphat Yodkhunnatham, Aditya Bagrodia
A 41-year-old man presented to his primary care physician with a 1-month history of left neck adenopathy in the context of a history of nonseminomatous germ cell tumors (NSGCTs). In 2011, the patient was treated for stage IB (T2N0M0S0) right-sided NSGCTs of the testis, which were 95% embryonal and 5% yolk sac tumors. He underwent a right radical orchiectomy and was followed until 2022 without recurrence. In the work-up for his adenopathy, laboratory results for human chorionic gonadotropin, lactate dehydrogenase, and α-fetoprotein were normal...
April 11, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38661512/identifying-indications-for-neoadjuvant-therapy-in-cholangiocarcinoma
#8
JOURNAL ARTICLE
Hilary R Keller, Laura Fluke, Jared A Forrester, Ronald F Wolf
The recent Hot Topics section focuses on survival rates for patients with cholangiocarcinoma.
April 11, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38517413/rising-prices-and-lower-medicare-reimbursement-rates-create-outrage-among-clinicians
#9
JOURNAL ARTICLE
Nora Janjan Md Mpsa Mba, Patrick J Silva
In a recent Hot Topics article, reimbursement rates for Medicare physicians are discussed, and how it will impact their practice.
March 1, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38517412/extreme-case-of-surgical-port-metastasis-in-ovarian-cancer
#10
JOURNAL ARTICLE
Michał Kostrzanowski, Grzegorz Ziółkowski, Filip Dąbrowski
Ovarian cancer accounts for more deaths than any other malignancy of the female reproductive system. Early diagnosis of this disease is difficult because there are no systematic opportunistic screening methods. At advanced stages, diagnostic laparoscopy is the first step in confirming disease advancement and obtaining samples for genetic and pathologic examination needed to start chemotherapy. Swiftly starting oncological treatment is crucial for increasing the survival rate in these patients. We present the case of a 51-year-old woman with metastatic International Federation of Gynecology and Obstetrics (FIGO) stage IIIC ovarian cancer who had delayed her therapy after initial laparoscopy due to COVID-19 infection and presented with an extreme case of surgical port metastasis...
March 1, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38517411/rising-prices-and-lower-medicare-reimbursement-rates-create-outrage-among-clinicians
#11
JOURNAL ARTICLE
Nora Janjan Md Mpsa Mba, Patrick J Silva
In a recent Hot Topics article, reimbursement rates for Medicare physicians are discussed, and how it will impact their practice.
March 1, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38517410/diagnosing-and-treating-blastic-plasmacytoid-dendritic-cell-neoplasm-in-a-resource-limited-setting
#12
JOURNAL ARTICLE
Fiza Khan, Foorquan Hashmi, Nerses Ghahramanyan, Elen Baloyan, Gevorg Tamamyan, Marina Konopleva, Naveen Pemmaraju, Astghik Voskanyan
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematological malignancy with limited treatment options and poor prognosis. This case report presents the clinical course and management of a 62-year-old man with BPDCN in a resource-limited setting. The patient presented with constitutional symptoms and abnormal complete blood count findings. Initial treatment was performed with an acute lymphoblastic leukemia-based chemotherapy regimen, and the patient achieved complete remission, but the disease recurred 7 months after the initial diagnosis was confirmed in April 2022...
March 1, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38421601/twenty-years-of-advancing-discoveries-and-treatment-of-mantle-cell-lymphoma
#13
JOURNAL ARTICLE
Lymphoma Research Foundation Lymphoma Research Foundation
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphoma characterized by the t(11;14) chromosomal translocation, which leads to the dysregulation of the cell cycle through overexpression of cyclin D1. Although advances in treatment have improved outcomes, in particular the introduction of Bruton tyrosine kinase inhibitors to the treatment armamentarium and more recently chimeric antigen receptor T-cell therapy, MCL often rapidly develops resistance and has a high rate of relapse. In addition, MCL is clinically heterogeneous...
February 5, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38300531/life-experience-of-survivors-of-gynecologic-cancers-a-survey-conducted-in-italy
#14
JOURNAL ARTICLE
Sonia La Spina, Paolo Scollo, Basilio Pecorino, Valentina Lombardo, Annamaria Motta, Rosa Gioia Calderone, Stefania Calì, Helga Lipari, Giuseppa Scandurra
BACKGROUND: The study of health-related quality of life in survivors of gynecologic cancers is becoming increasingly important as 1.5 million survivors of gynecologic cancer in the United States and more are expected due to advances in diagnosis and treatment. This project investigated the perceived needs and lived experiences of survivors of gynecological cancer to help design supportive activities to be implemented in clinical practice. METHODS: Patients were recruited in hospitals or through social media and responded to an online survey that was addressed to patients in Italy, specifically in Sicily, Puglia, and Campania...
January 9, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38300530/building-efficiency-and-scaling-with-a-remote-genetic-counseling-program
#15
JOURNAL ARTICLE
Smita K Rao, L Johnetta Blakely, Kate Small, Stephen Schleicher, Natalie R Dickson Md
Purpose A third-party telemedicine (TM) genetic counseling program was initiated at a large community oncology practice spanning 35 clinical sites with 110 clinicians and 97 advanced practice providers throughout Tennessee and Georgia. Patients and Methods Appropriate patients were referred through the electronic health record (EHR) based on current National Comprehensive Cancer Network guidelines. A combination of TM and genetic counseling assistants enhanced convenience, broadened access, and decreased no-show rates...
January 9, 2024: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38133563/genomic-predictors-associated-with-exceptional-response-to-systemic-therapy-in-advanced-pancreatic-cancer
#16
JOURNAL ARTICLE
Suneel Kamath, Joanna Roopkumar, Ying Ni, Minqian Shen, Pablo Bejarano, Daniela Allende, Arun Nagarajan, Tim Nguyen, Bachar Dergham, Dale Shepard, Marc A Shapiro, Michael J McNamara, Bassam N Estfan, Kanika G Nair, Alok A Khorana
INTRODUCTION: Exceptional response to therapy is rare in patients with advanced pancreatic cancer. This study explored potential genomic differences between typical and exceptional responses that could confer more favorable biology. METHODS: We included exceptional responders and controls with advanced pancreatic cancer from Cleveland Clinic from April 2013 to August 2017. Exceptional responders were defined as patients with an overall survival of more than 18 months for metastatic disease and more than 24 months for locally advanced disease...
December 14, 2023: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38133562/danazol-for-the-treatment-of-myelodysplastic-syndromes-a-systematic-review
#17
REVIEW
Sangam Shah, Rukesh Yadav, Abhinav Bhattarai, Sunraj Tharu, Prakash Sharma, Prativa Subedi, Arun Kharel, Pitambar Khanal, Pradeep Khanal Pradeep Khanal Mbbs Md, Sri Kollepara, Krishna Gundabolu
Purpose To study the potential utility of danazol for treating patients with myelodysplastic syndromes, with a focus on efficacy and adverse effects (AEs). Methods MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus were searched for relevant publications from inception June 1, 1950, until June 28, 2022. The studies were screened by title and abstract, followed by full-text screening. The quality of the included studies was assessed via a prespecified set of questionnaires...
December 14, 2023: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38133561/early-access-to-electronic-health-records-may-influence-the-patient-experience
#18
JOURNAL ARTICLE
Mehmet Sitki Copur, Soe Min Tun, Adam J Horn
In a recent Hot Topics column, Mehmet Sitki Copur, MD, FACP, et al discussed the pros and cons of patients receiving test results early through electronic medical records.
December 14, 2023: Oncology (Williston Park, NY)
https://read.qxmd.com/read/38032303/exploring-the-changing-diagnostic-criteria-of-gorlin-goltz-syndrome-a-case-report
#19
JOURNAL ARTICLE
Sahith Kumar Shetty, Vidya G Doddawad, Shyam Sundar, Shivananda S
Gorlin-Goltz syndrome, also known as Gorlin syndrome, basal cell nevus syndrome, and nevoid basal cell carcinoma syndrome, is an autosomal dominant genetic disorder. Its hallmark is an early onset of basal cell carcinoma. Additionally, the syndrome is characterized by a spectrum of distinct clinical attributes encompassing oral, skeletal, ophthalmic, neurological, and developmental aberrations. This condition arises due to anomalies in the Hedgehog signaling pathway, leading to constant pathway activity and uncontrolled growth of tumor cells...
November 8, 2023: Oncology (Williston Park, NY)
https://read.qxmd.com/read/37877807/unusual-clinical-presentation-of-clear-cell-sarcoma-in-a-young-woman
#20
REVIEW
Samia Asif, Brendan J Hurley, Sehr Haroon, Subodh Lele, Bhavina Sharma
Clear cell sarcoma (CCS) is a rare but aggressive malignancy that typically occurs in young adults and is characterized by soft tissue tumors of the extremities. CCS can be difficult to distinguish from metastatic melanoma based solely on histology and immunohistochemistry (IHC) because of the significant overlap between them. However, it is imperative to get an accurate clinical diagnosis, as it informs disease staging and treatment options for patient care. Present in approximately 75% of CCS cases, the EWSR1 gene rearrangement detected by fluorescence in situ hybridization (FISH) can help with establishing a diagnosis; the underlying reciprocal translocation has never been reported in cutaneous melanoma...
October 10, 2023: Oncology (Williston Park, NY)
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