Flavia Franco Veiga, Emilli Karine Marcomini, Alana Salvador, Lucas Ulisses Rovigatti Chiavelli, Isabella Letícia Esteves Barros, Lidiane Vizioli de Castro, Diego Luis Lucca, Larissa Miwa Kikuchi Ochikubo, Mauro Luciano Baesso, Armando Mateus Pomini, Terezinha Inez Estivalet Svidzinski, Melyssa Negri
In immunocompetent individuals, Fusarium spp. stands out as the causative agent of onychomycosis, among the non-dermatophyte molds. Despite evidence indicating that Fusarium oxysporum organizes itself in the form of a biofilm causing onychomycosis, there is little literature on the etiopathogenesis of the biofilm on the nail, specifically the signaling molecules present, known as quorum sensing (QS). Thus, this study detected the presence of a molecule related to QS from the ex vivo biofilm of F. oxysporum on human nail and investigated its effect on preformed biofilm in vitro...
December 1, 2023: Molecular Microbiology