journal
https://read.qxmd.com/read/37740007/slc35f2-syvn1-trim59-axis-critically-regulates-ferroptosis-of-pancreatic-cancer-cells-by-inhibiting-endogenous-p53
#1
JOURNAL ARTICLE
Ben Che, Yunyan Du, Rongfa Yuan, Han Xiao, Wenming Zhang, Jun Shao, Hongcheng Lu, Yi Yu, Mingfeng Xiang, Liang Hao, Shouhua Zhang, Xiaohong Du, Xiuxia Liu, Wei Zhou, Kai Wang, Leifeng Chen
Pancreatic cancer cells undergo intricate metabolic reprogramming to sustain their survival and proliferation. p53 exhibits a dual role in tumor cell ferroptosis. However, the precise role and mechanisms underlying wild-type p53 activation in promoting ferroptosis in pancreatic cancer cells remain obscure. In this study, we applied bioinformatics tools and performed an analysis of clinical tissue sample databases and observed a significantly upregulated expression of solute carrier family 35 member F2 (SLC35F2) in pancreatic cancer tissues...
September 22, 2023: Oncogene
https://read.qxmd.com/read/37731056/neoadjuvant-botensilimab-plus-balstilimab-response-pattern-in-locally-advanced-mismatch-repair-proficient-colorectal-cancer
#2
JOURNAL ARTICLE
Pashtoon Murtaza Kasi, Manuel Hidalgo, Mehraneh D Jafari, Heather Yeo, Lea Lowenfeld, Uqba Khan, Alana T H Nguyen, Despina Siolas, Brandon Swed, Jini Hyun, Sahrish Khan, Madeleine Wood, Benjamin Samstein, Juan P Rocca, Allyson J Ocean, Elizabeta C Popa, Daniel H Hunt, Nikhil P Uppal, Kelly A Garrett, Alessio Pigazzi, Xi Kathy Zhou, Manish A Shah, Erika Hissong
In patients with locally advanced cancer without distant metastases, the neoadjuvant setting presents a platform to evaluate new drugs. For mismatch repair proficient/microsatellite stable (pMMR/MSS) colon and rectal cancer, immunotherapy has shown limited efficacy. Herein, we report exceptional responses observed with neoadjuvant botensilimab (BOT), an Fc-enhanced next-generation anti-CTLA-4 antibody, alongside balstilimab (BAL; an anti-PD-1 antibody) in two patients with pMMR/MSS colon and rectal cancer. The histological pattern of rapid immune response observed ("inside-out" (serosa-to-mucosa) tumor regression) has not been described previously in this setting...
September 21, 2023: Oncogene
https://read.qxmd.com/read/37723312/correction-il6-derived-from-cancer-associated-fibroblasts-promotes-chemoresistance-via-cxcr7-in-esophageal-squamous-cell-carcinoma
#3
Y Qiao, C Zhang, A Li, D Wang, Z Luo, Y Ping, B Zhou, S Liu, H Li, D Yue, Z Zhang, X Chen, Z Shen, J Lian, Y Li, S Wang, F Li, L Huang, L Wang, B Zhang, J Yu, Z Qin, Y Zhang
No abstract text is available yet for this article.
September 18, 2023: Oncogene
https://read.qxmd.com/read/37717099/downregulated-circpoke-promotes-breast-cancer-metastasis-through-activation-of-the-usp10-snail-axis
#4
JOURNAL ARTICLE
Yan Luo, Qingyun Zhu, Shasha Xiang, Qi Wang, Jun Li, Xiguang Chen, Wen Yan, Jianbo Feng, Xuyu Zu
Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer-related death among females. Metastasis accounts for the majority of BC related deaths. One feasible strategy to solve this challenging problem is to disrupt the capabilities required for tumor metastasis. Herein, we verified a novel metastasis suppressive circRNA, circPOKE in BC. circPOKE was downregulated in primary and metastatic BC tissues and overexpression of circPOKE inhibited the metastatic potential but not the proliferative ability of BC cells in vitro and in vivo...
September 16, 2023: Oncogene
https://read.qxmd.com/read/37704784/mesenchymal-stromal-cells-confer-breast-cancer-doxorubicin-resistance-by-producing-hyaluronan
#5
JOURNAL ARTICLE
Zhanhong Liu, Pengbo Hou, Jiankai Fang, Jingyu Zhu, Juanmin Zha, Rui Liu, Yayun Ding, Muqiu Zuo, Peishan Li, Lijuan Cao, Chao Feng, Gerry Melino, Changshun Shao, Yufang Shi
Chemotherapy resistance represents a major cause of therapeutic failure and mortality in cancer patients. Mesenchymal stromal cells (MSCs), an integral component of tumor microenvironment, are known to promote drug resistance. However, the detailed mechanisms remain to be elucidated. Here, we found that MSCs confer breast cancer resistance to doxorubicin by diminishing its intratumoral accumulation. Hyaluronan (HA), a major extracellular matrix (ECM) product of MSCs, was found to mediate the chemoresistant effect...
September 14, 2023: Oncogene
https://read.qxmd.com/read/37704786/correction-fgf19-and-fgfr4-promotes-the-progression-of-gallbladder-carcinoma-in-an-autocrine-pathway-dependent-on-gpbar1-camp-egr1-axis
#6
Tianli Chen, Hongda Liu, Zengli Liu, Kangshuai Li, Ruixi Qin, Yue Wang, Jialiang Liu, Zhipeng Li, Qinglun Gao, Chang Pan, Fan Yang, Wei Zhao, Zongli Zhang, Yunfei Xu
No abstract text is available yet for this article.
September 13, 2023: Oncogene
https://read.qxmd.com/read/37704785/correction-ceacam1-impedes-thyroid-cancer-growth-but-promotes-invasiveness-a-putative-mechanism-for-early-metastases
#7
W Liu, W Wei, D Winer, A -M Bamberger, C Bamberger, C Wagener, S Ezzat, S L Asa
No abstract text is available yet for this article.
September 13, 2023: Oncogene
https://read.qxmd.com/read/37697064/circular-rna-eif3i-promotes-papillary-thyroid-cancer-progression-by-interacting-with-auf1-to-increase-cyclin-d1-production
#8
JOURNAL ARTICLE
Xuelin Yao, Hanyuan Liu, Zhen Wang, Fangting Lu, Wenying Chen, Qing Feng, Yahu Miao, Jie Zhang, Yanlei Wang, Ye Chen, Liping Xue, Yehai Liu, Liang Chen, Qiu Zhang
Circular RNAs (circRNAs) play an important role in regulating the development of human cancers through diverse biological functions. However, the exact molecular mechanisms underlying the role of circRNAs in papillary thyroid cancer (PTC) remain largely unknown. Here, we found that hsa_circ_0011385, designated as circular eukaryotic translation initiation factor 3 subunit I (circEIF3I), preferentially localized in the cytoplasm of PTC cells and was more stable than its linear counterpart, EIF3I. Gain- and loss-of-function studies indicated that circEIF3I promoted PTC progression by facilitating cell proliferation, cell cycle, cell migration, and invasion in vitro, as well as PTC cell proliferation in vivo...
September 11, 2023: Oncogene
https://read.qxmd.com/read/37689827/oncogenic-braf-noncanonically-promotes-tumor-metastasis-by-mediating-vasp-phosphorylation-and-filopodia-formation
#9
JOURNAL ARTICLE
Wenting Pan, Yihao Tian, Qian Zheng, Zelin Yang, Yulong Qiang, Zun Zhang, Nan Zhang, Jie Xiong, Xin Zhu, Lei Wei, Feng Li
BRAF is frequently mutated in various cancer types and contributes to tumorigenesis and metastasis. As an important switch in RAS signaling pathway, BRAF typically enables the activation of MEK and ERK, and its mutation significantly promotes metastasis. However, whether BRAF could stimulate metastasis via a distinct manner is still unknown. Herein, we found that a portion of the BRAF protein localized at the plasma membrane and that the BRAFV600E mutation led to abundant formation of filopodia, which is a hallmark of invasive cancer cells...
September 9, 2023: Oncogene
https://read.qxmd.com/read/37684408/glucose-induced-and-chrebp-mlx-mediated-lipogenic-program-promotes-hepatocellular-carcinoma-development
#10
JOURNAL ARTICLE
Aijuan Yu, Pengcheng Yu, Yuwen Zhu, Rui Zhu, Renqiang Sun, Dan Ye, Fa-Xing Yu
The Carbohydrate Response Element (ChoRE) Binding Protein (ChREBP) and its binding partner Max-like protein X (MLX) mediate transcription of lipogenic genes under glucose-rich conditions. Dysregulation of glucose and lipid metabolism frequently occurs in cancers, including Hepatocellular Carcinomas (HCCs). However, it is currently unclear whether the glucose-induced lipogenic program plays a role in the development of HCCs. Here, we show that MLX expression is elevated in HCC specimens and downregulation of MLX expression inhibits proliferation of HCC cells...
September 9, 2023: Oncogene
https://read.qxmd.com/read/37684411/correction-activation-of-nfat-by-hgf-and-igf-1-via-arf6-and-its-effector-asap1-promotes-uveal-melanoma-metastasis
#11
Jackson R Richards, Donghan Shin, Rob Pryor, Lise K Sorensen, Zhonglou Sun, Won Mi So, Garam Park, Roger Wolff, Amanda Truong, Martin McMahon, Allie H Grossmann, J William Harbour, Weiquan Zhu, Shannon J Odelberg, Jae Hyuk Yoo
No abstract text is available yet for this article.
September 8, 2023: Oncogene
https://read.qxmd.com/read/37684410/correction-targeting-erbb-2-nuclear-localization-and-function-inhibits-breast-cancer-growth-and-overcomes-trastuzumab-resistance
#12
R I Cordo Russo, W Béguelin, M C Díaz Flaqué, C J Proietti, L Venturutti, N Galigniana, M Tkach, P Guzmán, J C Roa, N A O'Brien, E H Charreau, R Schillaci, P V Elizalde
No abstract text is available yet for this article.
September 8, 2023: Oncogene
https://read.qxmd.com/read/37684409/correction-activation-of-erbb-2-via-a-hierarchical-interaction-between-erbb-2-and-type-i-insulin-like-growth-factor-receptor-in-mammary-tumor-cells
#13
Maria Eugenia Balañá, Leticia Labriola, Mariana Salatino, Federico Movsichoff, Giselle Peters, Eduardo H Charreau, Patricia V Elizalde
No abstract text is available yet for this article.
September 8, 2023: Oncogene
https://read.qxmd.com/read/37684407/translation-of-ai-into-oncology-clinical-practice
#14
REVIEW
Issam El Naqa, Aleksandra Karolak, Yi Luo, Les Folio, Ahmad A Tarhini, Dana Rollison, Katia Parodi
Artificial intelligence (AI) is a transformative technology that is capturing popular imagination and can revolutionize biomedicine. AI and machine learning (ML) algorithms have the potential to break through existing barriers in oncology research and practice such as automating workflow processes, personalizing care, and reducing healthcare disparities. Emerging applications of AI/ML in the literature include screening and early detection of cancer, disease diagnosis, response prediction, prognosis, and accelerated drug discovery...
September 8, 2023: Oncogene
https://read.qxmd.com/read/37670020/the-role-of-non-coding-rnas-in-extracellular-vesicles-in-breast-cancer-and-their-diagnostic-implications
#15
REVIEW
Mark Samuels, William Jones, Benjamin Towler, Charlotte Turner, Stephen Robinson, Georgios Giamas
Breast Cancer (BC) is the most common form of cancer worldwide, responsible for 25% of cancers in women. Whilst treatment is effective and often curative in early BC, metastatic disease is incurable, highlighting the need for early detection. Currently, early detection relies on invasive procedures, however recent studies have shown extracellular vesicles (EVs) obtained from liquid biopsies may have clinical utility. EVs transport diverse bioactive cargos throughout the body, play major roles in intercellular communication and, importantly, mirror their cell of origin...
September 5, 2023: Oncogene
https://read.qxmd.com/read/37666938/a-first-in-class-fully-modified-version-of-mir-34a-with-outstanding-stability-activity-and-anti-tumor-efficacy
#16
JOURNAL ARTICLE
Ahmed M Abdelaal, Ikjot S Sohal, Shreyas Iyer, Kasireddy Sudarshan, Harish Kothandaraman, Nadia A Lanman, Philip S Low, Andrea L Kasinski
Altered by defects in p53, epigenetic silencing, and genomic loss, the microRNA miR-34a represents one of the most clinically relevant tumor-suppressive microRNAs. Without question, a striking number of patients with cancer would benefit from miR-34a replacement, if poor miR-34a stability, non-specific delivery, and delivery-associated toxicity could be overcome. Here, we highlight a fully modified version of miR-34a (FM-miR-34a) that overcomes these hurdles when conjugated to a synthetically simplistic ligand...
September 5, 2023: Oncogene
https://read.qxmd.com/read/37666939/clinical-morphologic-and-molecular-heterogeneity-of-hpv-associated-oropharyngeal-cancer
#17
REVIEW
Yvonne X Lim, Michelle L Mierzwa, Maureen A Sartor, Nisha J D'Silva
The incidence of human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) is rising rapidly and has exceeded cervical cancer to become the most common HPV-induced cancer in developed countries. Since patients with HPV + OPSCC respond very favorably to standard aggressive treatment, the emphasis has changed to reducing treatment intensity. However, recent multi-center clinical trials failed to show non-inferiority of de-escalation strategies on a population basis, highlighting the need to select low-risk patients likely to respond to de-intensified treatments...
September 4, 2023: Oncogene
https://read.qxmd.com/read/37660182/n7-methylguanosine-methylation-of-trnas-regulates-survival-to-stress-in-cancer
#18
JOURNAL ARTICLE
Raquel García-Vílchez, Ana M Añazco-Guenkova, Judith López, Sabine Dietmann, Mercedes Tomé, Sonia Jimeno, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika Gonzalez-Lopez, Ana M Aransay, Manuel A Sánchez-Martín, Pablo Huertas, Raúl V Durán, Sandra Blanco
Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity of cancer cells and their capacity to respond to stress. The higher plasticity of cancer cells highlights the need for identifying targetable molecular pathways that challenge cancer cell survival. Here, we show that N7 -guanosine methylation (m7 G) of tRNAs, mediated by METTL1, regulates survival to stress conditions in cancer cells. Mechanistically, we find that m7 G in tRNAs protects them from stress-induced cleavage and processing into 5' tRNA fragments...
September 2, 2023: Oncogene
https://read.qxmd.com/read/37658192/rna-binding-motif-protein-45-mediated-phosphorylation-enhances-protein-stability-of-asct2-to-promote-hepatocellular-carcinoma-progression
#19
JOURNAL ARTICLE
Danyu Du, Mengyao Qin, Li Shi, Chan Liu, Jingwei Jiang, Zhengguang Liao, Hongxv Wang, Zhibo Zhang, Li Sun, Hui Fan, Zhengrui Liu, Hong Yu, Hongyang Li, Jun Peng, Shengtao Yuan, Mei Yang, Jing Xiong
Targeting metabolic remodeling represents a potentially promising strategy for hepatocellular carcinoma (HCC) therapy. In-depth understanding on the regulation of the glutamine transporter alanine-serine-cysteine transporter 2 (ASCT2) contributes to the development of novel promising therapeutics. As a developmentally regulated RNA binding protein, RBM45 is capable to shuttle between nucleus and cytoplasm, and directly interacts with proteins. By bioinformatics analysis, we screened out that RBM45 was elevated in the HCC patient specimens and positively correlated with poor prognosis...
September 1, 2023: Oncogene
https://read.qxmd.com/read/37658191/greb1-isoform-4-is-specifically-transcribed-by-mitf-and-required-for-melanoma-proliferation
#20
JOURNAL ARTICLE
Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura, Keisuke Nimura, Masahito Ikawa, Tomoyoshi Soga, Akira Kikuchi
Growth regulation by estrogen in breast cancer 1 (GREB1) is involved in hormone-dependent and -independent tumor development (e.g., hepatoblastoma). In this study, we found that a GREB1 splicing variant, isoform 4 (Is4), which encodes C-terminal half of full-length GREB1, is specifically expressed via microphthalmia-associated transcription factor (MITF) in melanocytic melanoma, and that two MITF-binding E-box CANNTG motifs at the 5'-upstream region of GREB1 exon 19 are necessary for GREB1 Is4 transcription...
September 1, 2023: Oncogene
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