journal
https://read.qxmd.com/read/36949240/retraction-note-cyclin-dependent-kinase-4-6-activity-is-a-critical-determinant-of-pre-replication-complex-assembly
#1
W A Braden, A K McClendon, E S Knudsen
No abstract text is available yet for this article.
March 22, 2023: Oncogene
https://read.qxmd.com/read/36944729/epigenomic-mapping-identifies-an-enhancer-repertoire-that-regulates-cell-identity-in-bladder-cancer-through-distinct-transcription-factor-networks
#2
JOURNAL ARTICLE
Hélène Neyret-Kahn, Jacqueline Fontugne, Xiang Yu Meng, Clarice S Groeneveld, Luc Cabel, Tao Ye, Elodie Guyon, Clémentine Krucker, Florent Dufour, Elodie Chapeaublanc, Audrey Rapinat, Daniel Jeffery, Laura Tanguy, Victoria Dixon, Yann Neuzillet, Thierry Lebret, David Gentien, Irwin Davidson, Yves Allory, Isabelle Bernard-Pierrot, François Radvanyi
Muscle-invasive bladder cancer (BLCA) is an aggressive disease. Consensus BLCA transcriptomic subtypes have been proposed, with two major Luminal and Basal subgroups, presenting distinct molecular and clinical characteristics. However, how these distinct subtypes are regulated remains unclear. We hypothesized that epigenetic activation of distinct super-enhancers could drive the transcriptional programs of BLCA subtypes. Through integrated RNA-sequencing and epigenomic profiling of histone marks in primary tumours, cancer cell lines, and normal human urothelia, we established the first integrated epigenetic map of BLCA and demonstrated the link between subtype and epigenetic control...
March 22, 2023: Oncogene
https://read.qxmd.com/read/36932115/hypoxia-responsive-ppargc1a-bambi-acsl5-axis-promotes-progression-and-resistance-to-lenvatinib-in-hepatocellular-carcinoma
#3
JOURNAL ARTICLE
Qiangnu Zhang, Lingfeng Xiong, Teng Wei, Quan Liu, Lesen Yan, Jiaojuan Chen, Lu Dai, Lulin Shi, Wenjian Zhang, Jilin Yang, Stephanie Roessler, Liping Liu
Emerging evidence has indicated that peroxisome proliferator-activated receptor-gamma coactivator-1α (PPARGC1A) is involved in hepatocellular carcinoma (HCC). However, its detailed function and up- and downstream mechanisms are incompletely understood. In this study, we confirmed that PPAGC1A is lowly expressed in HCC and is associated with poor prognosis using large-scale public datasets and in-house cohorts. PPAGC1A was found to impair the progression and sensitivity of HCC to lenvatinib. Mechanistically, PPAGC1A repressed bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) by inhibiting WNT/β-catenin signaling...
March 17, 2023: Oncogene
https://read.qxmd.com/read/36928362/serine-threonine-kinase-tbk1-promotes-cholangiocarcinoma-progression-via-direct-regulation-of-%C3%AE-catenin
#4
JOURNAL ARTICLE
Chong-Qing Gao, Zhen-Zhen Chu, Di Zhang, Yang Xiao, Xing-Yan Zhou, Jun-Ru Wu, Hui Yuan, Yu-Chuan Jiang, Dong Chen, Ji-Chun Zhang, Nan Yao, Kai-Yun Chen, Jian Hong
Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with a poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis and identifying effective therapeutic targets are urgently needed. In this study, we found that TANK-binding kinase 1 (TBK1), a serine/threonine-protein kinase, showed a dynamic increase during the different stages of murine spontaneous CCA carcinogenesis (hyperplasia, dysplasia, and CCA). TBK1 was upregulated in human tissues, including intrahepatic (n = 182) and extrahepatic (n = 40) CCA tissues, compared with nontumor tissues, and the elevated expression of TBK1 was positively correlated with larger tumour diameter, lymph node metastasis, and advanced TNM stage...
March 16, 2023: Oncogene
https://read.qxmd.com/read/36928361/taurodeoxycholic-acid-yap1-upregulates-otx1-in-promoting-gallbladder-cancer-malignancy-through-ifitm3-dependent-akt-activation
#5
JOURNAL ARTICLE
Ruifeng Yang, Linhua Yang, Manmei Long, Fengyao Wu, Yongheng Shi, Ran Xia, Junjie Lv, Yiyin Zhang, Yu Lei, Yang Jiao, Chenchen Zhao, Hui Wang, Wei Wei
Orthodenticle homeobox (OTX1) is reported to be involved in numerous cancers, but the expression level and molecular function of OTX1 in gallbladder cancer (GBC) remain unknown. Here, we found the elevated level of OTX1 associated with poor prognosis in human gallbladder cancer. In vitro and in vivo studies of human gallbladder cancer cell lines demonstrated that overexpression of OTX1 promoted cell proliferation, whereas the downregulation inhibited it. Additionally, we found a tight correlation between the serum level of taurodeoxycholic acid (TDCA) and OTX1 expression...
March 16, 2023: Oncogene
https://read.qxmd.com/read/36922679/limk2-promotes-melanoma-tumor-growth-and-metastasis-through-g3bp1-esm1-pathway-mediated-apoptosis-inhibition
#6
JOURNAL ARTICLE
Parmanand Malvi, Dhana Sekhar Reddy, Raj Kumar, Suresh Chava, Sneha Burela, Keshab Parajuli, Xuchen Zhang, Narendra Wajapeyee
Melanoma is the leading cause of skin cancer-related deaths, and current melanoma therapies, including targeted therapies and immunotherapies, benefit only a subset of metastatic melanoma patients due to either intrinsic or acquired resistance. LIM domain kinase 2 (LIMK2) is a serine/threonine kinase that plays an important role in the regulation of actin filament dynamics. Here, we show that LIMK2 is overexpressed in melanoma, and its genetic or pharmacological inhibition impairs melanoma tumor growth and metastasis in both cell culture and mice...
March 16, 2023: Oncogene
https://read.qxmd.com/read/36922683/correction-transgenic-idh2-r172k-and-idh2-r140q-zebrafish-models-recapitulated-features-of-human-acute-myeloid-leukemia
#7
Dandan Wang, Lichuan Zheng, Bowie Yik Ling Cheng, Chun-Fung Sin, Runsheng Li, Sze Pui Tsui, Xinyu Yi, Alvin Chun Hang Ma, Bai Liang He, Anskar Yu Hung Leung, Xuan Sun
No abstract text is available yet for this article.
March 15, 2023: Oncogene
https://read.qxmd.com/read/36922682/correction-alpelisib-and-fulvestrant-in-pik3ca-mutated-hormone-receptor-positive-her2-negative-advanced-breast-cancer-included-in-the-french-early-access-program
#8
D Bello Roufai, A Gonçalves, T De La Motte Rouge, S Akla, C Blonz, J Grenier, J Gligorov, M Saghatchian, C Bailleux, H Simon, I Desmoulins, Z Tharin, E Renaud, M Bertho, M-A Benderra, S Delaloge, L Robert, P Cottu, J Y Pierga, D Loirat, A Bertucci, B Renouf, F C Bidard, F Lerebours
No abstract text is available yet for this article.
March 15, 2023: Oncogene
https://read.qxmd.com/read/36922681/correction-epigenetic-targeting-of-neuropilin-1-prevents-bypass-signaling-in-drug-resistant-breast-cancer
#9
Ammara Abdullah, Saeed Salehin Akhand, Juan Sebastian Paez Paez, Wells Brown, Li Pan, Sarah Libring, Michael Badamy, Emily Dykuizen, Luis Solorio, W Andy Tao, Michael K Wendt
No abstract text is available yet for this article.
March 15, 2023: Oncogene
https://read.qxmd.com/read/36922680/correction-targeting-the-dio3-enzyme-using-first-in-class-inhibitors-effectively-suppresses-tumor-growth-a-new-paradigm-in-ovarian-cancer-treatment
#10
Dotan Moskovich, Yael Finkelshtein, Adi Alfandari, Amit Rosemarin, Tzuri Lifschytz, Avivit Weisz, Santanu Mondal, Harinarayana Ungati, Aviva Katzav, Debora Kidron, Govindasamy Mugesh, Martin Ellis, Bernard Lerer, Osnat Ashur-Fabian
No abstract text is available yet for this article.
March 15, 2023: Oncogene
https://read.qxmd.com/read/36922678/map4k4-promotes-ovarian-cancer-metastasis-through-diminishing-adam10-dependent-n-cadherin-cleavage
#11
JOURNAL ARTICLE
Kelie Chen, Xiaoyu Yuan, Shengchao Wang, Fang Zheng, Zhiqin Fu, Zhangjin Shen, Xiaodong Cheng, Yuwei Wang, Song Tang, Heng Ni, Fang Wang, Guang Lu, Yihua Wu, Dajing Xia, Weiguo Lu
Peritoneal metastasis is a key feature of advanced ovarian cancer, but the critical protein required for ovarian cancer metastasis and progression is yet to be defined. Thus, an unbiased high throughput and in-depth study is warranted to unmask the mechanism. Transcriptomic sequencing of paired primary ovarian tumors and metastases unveiled that MAP4K4, a serine/threonine kinase belongs to the Ste20 family of kinases, was highly expressed in metastatic sites. Increased MAP4K4 expression in metastasis was further validated in other independent patients, with higher MAP4K4 expression associated with poorer survival, higher level of CA125 and more advanced FIGO stage...
March 15, 2023: Oncogene
https://read.qxmd.com/read/36922677/lncrna-xist-regulates-breast-cancer-stem-cells-by-activating-proinflammatory-il-6-stat3-signaling
#12
JOURNAL ARTICLE
Yuxi Ma, Yongyou Zhu, Li Shang, Yan Qiu, Na Shen, Jonathan Wang, Tiffany Adam, Wei Wei, Qingxuan Song, Jun Li, Max S Wicha, Ming Luo
Aberrant expression of XIST, a long noncoding RNA (lncRNA) initiating X chromosome inactivation (XCI) in early embryogenesis, is a common feature of breast cancer (BC). However, the roles of post-XCI XIST in breast carcinogenesis remain elusive. Here we identify XIST as a key regulator of breast cancer stem cells (CSCs), which exhibit aldehyde dehydrogenase positive (ALDH+ ) epithelial- (E) and CD24lo CD44hi mesenchymal-like (M) phenotypes. XIST is variably expressed across the spectrum of BC subtypes, and doxycycline (DOX)-inducible knockdown (KD) of XIST markedly inhibits spheroid/colony forming capacity, tumor growth and tumor-initiating potential...
March 15, 2023: Oncogene
https://read.qxmd.com/read/36922676/the-platelet-pannexin-1-il-1%C3%AE-axis-orchestrates-pancreatic-ductal-adenocarcinoma-invasion-and-metastasis
#13
JOURNAL ARTICLE
Hao Li, Wang Jiang, Shi-Rong Zhang, Peng-Cheng Li, Tian-Jiao Li, Wei Jin, Hua-Xiang Xu, Xian-Jun Yu, Liang Liu
We aimed to investigate the protumor mechanisms of platelets in pancreatic ductal adenocarcinoma (PDAC). Serum samples were collected from 656 PDAC patients and 3105 healthy people, and a Panx1 knockout tumor model and an adoptive platelet transfusion mouse model were established. We showed that the blood platelet counts were not significantly different between stage III/IV and stage I/II patients, while the number of the CD41+/CD62P+ platelets was significantly elevated in stage III/IV patients, indicating that CD41+/CD62P+ platelets are associated with a poor prognosis...
March 15, 2023: Oncogene
https://read.qxmd.com/read/36922675/kif14-promotes-proliferation-lymphatic-metastasis-and-chemoresistance-through-g3bp1-ybx1-mediated-nf-%C3%AE%C2%BAb-pathway-in-cholangiocarcinoma
#14
JOURNAL ARTICLE
Wangjie Jiang, Jifei Wang, Xiao Yang, Jijun Shan, Yaodong Zhang, Xiaoli Shi, Yuming Wang, Anlan Chenyan, Jiang Chang, Yirui Wang, Yue Yu, Changxian Li, Xiangcheng Li
Cholangiocarcinoma (CCA), a highly lethal and fetal cancer derived from the hepatobiliary system, is featured by aggressive growth and early lymphatic metastasis. Elucidating the underlying mechanism and identifying the effective therapy are critical for advanced CCA patients. In the study, we detected that KIF14 was upregulated in CCA samples, especially in patients with lymph node metastasis and vascular invasion. CCA patients with higher KIF14 were associated with worse overall survival and recurrence-free survival after surgery...
March 15, 2023: Oncogene
https://read.qxmd.com/read/36906655/uhrf1-ube2l6-ubr4-mediated-ubiquitination-regulates-ezh2-abundance-and-thereby-melanocytic-differentiation-phenotypes-in-melanoma
#15
JOURNAL ARTICLE
Gamze Kuser-Abali, Youfang Zhang, Pacman Szeto, Peinan Zhao, Samar Masoumi-Moghaddam, Clare G Fedele, Isobel Leece, Cheng Huang, Jen G Cheung, Malaka Ameratunga, Fumihito Noguchi, Miles C Andrews, Nicholas C Wong, Ralf B Schittenhelm, Mark Shackleton
Cellular heterogeneity in cancer is linked to disease progression and therapy response, although mechanisms regulating distinct cellular states within tumors are not well understood. We identified melanin pigment content as a major source of cellular heterogeneity in melanoma and compared RNAseq data from high-pigmented (HPCs) and low-pigmented melanoma cells (LPCs), suggesting EZH2 as a master regulator of these states. EZH2 protein was found to be upregulated in LPCs and inversely correlated with melanin deposition in pigmented patient melanomas...
March 11, 2023: Oncogene
https://read.qxmd.com/read/36906654/lncrna-cacclnc-promotes-chemoresistance-of-colorectal-cancer-by-modulating-alternative-splicing-of-rad51
#16
JOURNAL ARTICLE
Xinyu Zhang, Dan Ma, Baoqin Xuan, Debing Shi, Jie He, Minhao Yu, Hua Xiong, Yanru Ma, Chaoqin Shen, Fangfang Guo, Yingying Cao, Yuqing Yan, Ziyun Gao, Tianying Tong, Xiaoqiang Zhu, Jing-Yuan Fang, Haoyan Chen, Jie Hong
Long non-coding RNAs (lncRNAs) play important roles in carcinogenesis. However, the effect of lncRNA on chemoresistance and RNA alternative splicing remains largely unknown. In this study, we identified a novel lncRNA, CACClnc, which was upregulated and associated with chemoresistance and poor prognosis in colorectal cancer (CRC). CACClnc promoted CRC resistance to chemotherapy via promoting DNA repair and enhancing homologous recombination in vitro and in vivo. Mechanistically, CACClnc specifically bound to Y-box binding protein 1 (YB1, a splicing factor) and U2AF65 (a subunit of U2AF splicing factor), promoting the interaction between YB1 and U2AF65, and then modulated alternative splicing (AS) of RAD51 mRNA, and consequently altered CRC cell biology...
March 11, 2023: Oncogene
https://read.qxmd.com/read/36890279/retraction-note-ptbp3-splicing-factor-promotes-hepatocellular-carcinoma-by-destroying-the-splicing-balance-of-neat1-and-pre-mir-612
#17
Xisheng Yang, Shibin Qu, Lin Wang, Hongtao Zhang, Zhaoxu Yang, Jianlin Wang, Bin Dai, Kaishan Tao, Runze Shang, Zhengcai Liu, Xiao Li, Zhuochao Zhang, Congcong Xia, Ben Ma, Wei Liu, Haimin Li, Kefeng Dou
No abstract text is available yet for this article.
March 8, 2023: Oncogene
https://read.qxmd.com/read/36882525/trim28-promotes-luminal-cell-plasticity-in-a-mouse-model-of-prostate-cancer
#18
JOURNAL ARTICLE
Ashutosh S Yende, Emily C Williams, Andrew Pletcher, Alexandra Helfand, Helen Ibeawuchi, Tanya M North, Patricia S Latham, Anelia Horvath, Maho Shibata
The Tripartite motif-containing 28 (TRIM28) transcriptional cofactor is significantly upregulated in high-grade and metastatic prostate cancers. To study the role of TRIM28 in prostate cancer progression in vivo, we generated a genetically-engineered mouse model, combining prostate-specific inactivation of Trp53, Pten and Trim28. Trim28 inactivated NPp53T mice developed an inflammatory response and necrosis in prostate lumens. By conducting single-cell RNA sequencing, we found that NPp53T prostates had fewer luminal cells resembling proximal luminal lineage cells, which are cells with progenitor activity enriched in proximal prostates and prostate invagination tips in wild-type mice with analogous populations in human prostates...
March 8, 2023: Oncogene
https://read.qxmd.com/read/36882524/c4orf19-inhibits-colorectal-cancer-cell-proliferation-by-competitively-binding-to-keap1-with-trim25-via-the-usp17-elk-1-cdk6-axis
#19
JOURNAL ARTICLE
Shirui Huang, Jizhen Li, Shuang Wu, Zhijian Zheng, Cong Wang, Hongyan Li, Lingling Zhao, Xiaodong Zhang, Haishan Huang, Chuanshu Huang, Qipeng Xie
Colorectal cancer (CRC) is one of the most common malignant tumors in the gastrointestinal tract, and has been attracted a great deal attention and extensive investigation due to its high morbidity and mortality rates. The C4orf19 gene encodes a protein with uncharacterized function. Our preliminary exploration of the TCGA database indicated that C4orf19 is markedly downregulated in CRC tissues in comparison to that observed in normal colonic tissues, suggesting its potential association with CRC behaviors...
March 7, 2023: Oncogene
https://read.qxmd.com/read/36882523/e3-ligase-maea-mediated-ubiquitination-and-degradation-of-phd3-promotes-glioblastoma-progression
#20
JOURNAL ARTICLE
Peijun Zhou, Xingzhi Peng, Siyuan Tang, Kun Zhang, Zhikai Tan, Dan Li, Liangfang Shen, Jinwu Peng, Lifang Yang
Glioblastoma (GBM) is the most common malignant glioma, with a high recurrence rate and a poor prognosis. However, the molecular mechanism behind the malignant progression of GBM is still unclear. In the present study, through the tandem mass tag (TMT)-based quantitative proteomic analysis of clinical primary and recurrent glioma samples, we identified that aberrant E3 ligase MAEA was expressed in recurrent samples. The results of bioinformatics analysis showed that the high expression of MAEA was related to the recurrence and poor prognosis of glioma and GBM...
March 7, 2023: Oncogene
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