Juan M Arriaga, Kacey Ronaldson-Bouchard, Florencia Picech, Francisca Nunes de Almeida, Stephanie Afari, Houssein Chhouri, Gordana Vunjak-Novakovic, Cory Abate-Shen
No abstract text is available yet for this article.
April 16, 2024: Oncogene
Maoxiao Feng, Chengwei Chai, Xiaodong Hao, Xiaojiang Lai, Yuanyuan Luo, Hong Zhang, Wenzhu Tang, Ningxin Gao, Guihong Pan, Xiaojie Liu, Yunshan Wang, Wenjing Xiong, Qiang Wu, Jun Wang
Childhood onset of colorectal signet-ring cell carcinoma (CR-SRCC) is extremely rare and featured as highly malignant with poor prognosis. Here we reported a CR-SRCC case of 11-year-old boy with a novel inherited X-linked KDM6AA694T mutation. The H3K27me3 demethylase KDM6A was frequently mutated in varieties of tumors and acts as a tumor suppressor. In vivo H3K27me3 demethylation assay demonstrated that KDM6AA694T had dampened H3K27me3 demethylase activity. Overexpression of KDM6AA694T in SRCC cell line KATO3 promoted cell proliferation, invasion and migration, which were further confirmed in vivo by constructing orthotopic tumor growth and lung metastasis model...
April 15, 2024: Oncogene
Xi Chen, Chenao Ma, Yaming Li, Yiran Liang, Tong Chen, Dianwen Han, Dan Luo, Ning Zhang, Wenjing Zhao, Lijuan Wang, Qifeng Yang
Triple-negative breast cancer (TNBC) is an exceptionally aggressive subtype of breast cancer. Despite the recognized interplay between tumors and tumor-associated macrophages in fostering drug resistance and disease progression, the precise mechanisms leading these interactions remain elusive. Our study revealed that the upregulation of collagen type V alpha 1 (COL5A1) in TNBC tissues, particularly in chemoresistant samples, was closely linked to an unfavorable prognosis. Functional assays unequivocally demonstrated that COL5A1 played a pivotal role in fueling cancer growth, metastasis, and resistance to doxorubicin, both in vitro and in vivo...
April 12, 2024: Oncogene
Nan Cao, Fangmei Zhang, Jiang Yin, Jianlei Zhang, Xiqing Bian, Guopei Zheng, Nan Li, Ying Lin, Liyun Luo
Colorectal cancer (CRC) has a high degree of heterogeneity and identifying the genetic information of individual tumor cells could help enhance our understanding of tumor biology and uncover potential therapeutic targets for CRC. In this study, we identified LPCAT2+ tumor cell populations with less malignancy than LPCAT2- tumor cells in human and mouse CRC tissues using scRNA-seq. Combining in vitro and in vivo experiments, we found that LPCAT2 could inhibit the proliferation of CRC cells by inducing ferroptosis...
April 11, 2024: Oncogene
Laura Bottoni, Alberto Minetti, Giulia Realini, Elena Pio, Daniela Giustarini, Ranieri Rossi, Chiara Rocchio, Lorenzo Franci, Laura Salvini, Orazio Catona, Romina D'Aurizio, Mahdi Rasa, Emanuele Giurisato, Francesco Neri, Maurizio Orlandini, Mario Chiariello, Federico Galvagni
Triple-negative breast cancer (TNBC) is a very aggressive and heterogeneous group of tumors. In order to develop effective therapeutic strategies, it is therefore essential to identify the subtype-specific molecular mechanisms underlying disease progression and resistance to chemotherapy. TNBC cells are highly dependent on exogenous cystine, provided by overexpression of the cystine/glutamate antiporter SLC7A11/xCT, to fuel glutathione synthesis and promote an oxidative stress response consistent with their high metabolic demands...
April 10, 2024: Oncogene
Xianteng Wang, Xingkai Li, Liman Niu, Fang Lv, Ting Guo, Yushun Gao, Yuliang Ran, Weiren Huang, Bing Wang
The focal adhesion kinase (FAK) tyrosine kinase is activated and upregulated in multiple cancer types including small cell lung cancer (SCLC). However, FAK inhibitors have shown limited efficacy in clinical trials for cancer treatment. With the aim of identifying potential therapeutic strategies to inhibit FAK for cancer treatment, we investigated long non-coding RNAs (lncRNAs) that potentially regulate FAK in SCLC. In this study, we identified a long non-coding RNA LINC01089 that binds and inhibits FAK phosphorylation (activation)...
April 9, 2024: Oncogene
Hongmei Jiang, Lijuan Wang, Qiguo Zhang, Sheng Wang, Linchuang Jia, Hao Cheng, Jingya Wang, Xin Li, Ying Xie, Yixuan Wang, Meilin Hu, Jing Guo, Qian Li, Ziyi Peng, Mengqi Wang, Yangyang Xie, Tiantian Li, Yafei Wang, Bill D Geng, Sundararaman Swaminathan, P Leif Bergsagel, Zhiqiang Liu
Ferroptosis has been demonstrated a promising way to counteract chemoresistance of multiple myeloma (MM), however, roles and mechanism of bone marrow stromal cells (BMSCs) in regulating ferroptosis of MM cells remain elusive. Here, we uncovered that MM cells were more susceptible to ferroptotic induction under the interaction of BMSCs using in vitro and in vivo models. Mechanistically, BMSCs elevated the iron level in MM cells, thereby activating the steroid biosynthesis pathway, especially the production of lanosterol, a major source of reactive oxygen species (ROS) in MM cells...
April 9, 2024: Oncogene
Huachen Chen, Laura Jiyoung Lee, Krista M Vincent, Zhihua Xu, Jiahui Liu, Guihua Zhang, Zorica Nakevska, DuPreez Smith, Cheng-Han Lee, Lynne-Marie Postovit, YangXin Fu
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy in North America. Current therapeutic regimens are ineffective against advanced EOC. A better understanding of the molecular mechanisms that regulate the biology of EOC will be a critical step toward developing more efficacious therapies against EOC. Herein, we demonstrate that elevated expression of transcription factor ZIC2 was associated with lower survival of EOC patients. Knockout of endogenous ZIC2 in EOC cells attenuated the tumorigenic phenotypes associated with both bulk and cancer stem cells in vitro and in vivo, indicating a pro-tumorigenic role of ZIC2 in EOC...
April 9, 2024: Oncogene
Yinan Li, Lei Lv, Meng Ye, Ning Xie, Ladan Fazli, Yuli Wang, Weilun Wang, Shuofei Yang, Qihong Ni, Jiaquan Chen, Xiangjiang Guo, Yiping Zhao, Guanhua Xue, Jianjun Sha, Xuesen Dong, Lan Zhang
Androgen deprivation therapy (ADT) is the first line of treatment for metastatic prostate cancer (PCa) that effectively delays the tumor progression. However, it also increases the risk of venous thrombosis event (VTE) in patients, a leading cause of mortality. How a pro-thrombotic cascade is induced by ADT remains poorly understood. Here, we report that protein disulfide isomerase A2 (PDIA2) is upregulated in PCa cells to promote VTE formation and enhance PCa cells resistant to ADT. Using various in vitro and in vivo models, we demonstrated a dual function of PDIA2 that enhances tumor-mediated pro-coagulation activity via tumor-derived extracellular vehicles (EVs)...
April 8, 2024: Oncogene
Gabriella C Russo, Ashleigh J Crawford, David Clark, Julie Cui, Ryan Carney, Michelle N Karl, Boyang Su, Bartholomew Starich, Tung-Shing Lih, Pratik Kamat, Qiming Zhang, Praful R Nair, Pei-Hsun Wu, Meng-Horng Lee, Hon S Leong, Hui Zhang, Vito W Rebecca, Denis Wirtz
No abstract text is available yet for this article.
April 5, 2024: Oncogene
Gregory D Sepich-Poore, Daniel McDonald, Evguenia Kopylova, Caitlin Guccione, Qiyun Zhu, George Austin, Carolina Carpenter, Serena Fraraccio, Stephen Wandro, Tomasz Kosciolek, Stefan Janssen, Jessica L Metcalf, Se Jin Song, Jad Kanbar, Sandrine Miller-Montgomery, Robert Heaton, Rana Mckay, Sandip Pravin Patel, Austin D Swafford, Tal Korem, Rob Knight
No abstract text is available yet for this article.
April 5, 2024: Oncogene
M Zou, A Bhatia, H Dong, P Jayaprakash, J Guo, D Sahu, Y Hou, F Tsen, C Tong, K O'Brien, A J Situ, T Schmidt, M Chen, Q Ying, T S Ulmer, D T Woodley, W Li
No abstract text is available yet for this article.
April 4, 2024: Oncogene
Astrid S Kahnt, Ann-Kathrin Häfner, Dieter Steinhilber
5-Lipoxygenase (5-LO), a fatty acid oxygenase, is the central enzyme in leukotriene (LT) biosynthesis, potent arachidonic acid-derived lipid mediators released by innate immune cells, that control inflammatory and allergic responses. In addition, through interaction with 12- and 15-lipoxgenases, the enzyme is involved in the formation of omega-3 fatty acid-based oxylipins, which are thought to be involved in the resolution of inflammation. The expression of 5-LO is frequently deregulated in solid and liquid tumors, and there is strong evidence that the enzyme plays an important role in carcinogenesis...
April 4, 2024: Oncogene
Coralie Reger De Moura, Baptiste Louveau, Fanélie Jouenne, Paul Vilquin, Maxime Battistella, Yaelle Bellahsen-Harrar, Aurélie Sadoux, Suzanne Menashi, Nicolas Dumaz, Céleste Lebbé, Samia Mourah
The role of the focal adhesion protein kindlin-3 as a tumor suppressor and its interaction mechanisms with extracellular matrix constitute a major field of investigation to better decipher tumor progression. Besides the well-described role of kindlin-3 in integrin activation, evidence regarding modulatory functions between melanoma cells and tumor microenvironment are lacking and data are needed to understand mechanisms driven by kindlin-3 inactivation. Here, we show that kindlin-3 inactivation through knockdown or somatic mutations increases BRAFV600mut melanoma cells oncogenic properties via collagen-related signaling by decreasing cell adhesion and enhancing proliferation and migration in vitro, and by promoting tumor growth in mice...
April 3, 2024: Oncogene
Mengjie Chen, Cheng Zou, Yu Tian, Wenchao Li, Yingying Li, Dingxiao Zhang
Prostate cancer (PCa) remains a significant cause of morbidity and mortality among men worldwide. A number of genes have been implicated in prostate tumorigenesis, but the mechanisms underlying their dysregulation are still incompletely understood. Evidence has established the competing endogenous RNA (ceRNA) theory as a novel regulatory mechanism for post-transcriptional alterations. Yet, a comprehensive characterization of ceRNA network in PCa lacks. Here we utilize stringent in-silico methods to construct a large ceRNA network across different PCa stages, and provide experimental demonstration for the competing regulation among protumorigenic SEC23A, PHTF2, and their corresponding ceRNA pairs...
April 2, 2024: Oncogene
Vikash Kumar, Xavier Sabaté-Cadenas, Isha Soni, Esther Stern, Carine Vias, Doron Ginsberg, Carlos Romá-Mateo, Rafael Pulido, Martin Dodel, Faraz K Mardakheh, Alena Shkumatava, Eitan Shaulian
Cancer cells employ adaptive mechanisms to survive various stressors, including genotoxic drugs. Understanding the factors promoting survival is crucial for developing effective treatments. In this study, we unveil a previously unexplored long non-coding RNA, JUNI (JUN-DT, LINC01135), which is upregulated by genotoxic drugs through the activation of stress-activated MAPKs, JNK, and p38 and consequently exerts positive control over the expression of its adjacent gene product c-Jun, a well-known oncoprotein, which transduces signals to multiple transcriptional outputs...
April 2, 2024: Oncogene
Qi Wu, Zhihong Wang, Siqi Chen, Xiaowei She, Shengyu Zhu, Pengcheng Li, Lang Liu, Chongchong Zhao, Kangdi Li, Anyi Liu, Changsheng Huang, Yaqi Chen, Fuqing Hu, Guihua Wang, Junbo Hu
Deubiquitinating enzymes (DUBs) are promising targets for cancer therapy because of their pivotal roles in various physiological and pathological processes. Among these, ubiquitin-specific peptidase 26 (USP26) is a protease with crucial regulatory functions. Our study sheds light on the upregulation of USP26 in colorectal cancer (CRC), in which its increased expression correlates with an unfavorable prognosis. Herein, we evidenced the role of USP26 in promoting CRC tumorigenesis in a parkin RBR E3 ubiquitin-protein ligase (PRKN) protein-dependent manner...
April 2, 2024: Oncogene
Yuan Wei, Zhongshao Chen, Yingwei Li, Kun Song
Accumulating studies suggest that splicing factors play important roles in many diseases including human cancers. Our study revealed that WBP11, a core splicing factor, is highly expressed in ovarian cancer (OC) tissues and associated with a poor prognosis. WBP11 inhibition significantly impaired the proliferation and mobility of ovarian cancer cells in vitro and in vivo. Furthermore, FOXM1 transcriptionally activated WBP11 expression by directly binding to its promoter in OC cells. Importantly, RNA-seq and alternative splicing event analysis revealed that WBP11 silencing decreased the expression of MCM7 by regulating intron 4 retention...
April 1, 2024: Oncogene
Yu Dong, Keshu Hu, Jiayu Zhang, Mengxuan Zhu, Mengling Liu, Yitao Yuan, Xun Sun, Zhenghang Xu, Suyao Li, Yanjing Zhu, Chi Zhang, Pengfei Zhang, Tianshu Liu
Gastric carcinoma (GC) is regarded as one of the deadliest cancer characterized by diversity and haste metastasis and suffers limited understanding of the spatial variation between primary and metastatic GC tumors. In this project, transcriptome analysis on 46 primary tumorous, adjacent non-tumorous, and metastatic GC tissues was performed. The results demonstrated that metastatic tumorous tissues had diminished CD8+ T cells compared to primary tumors, which is mechanistically attributed to being due to innate immunity differences represented by marked differences in macrophages between metastatic and primary tumors, particularly those expressing ApoE, where their abundance is linked to unfavorable prognoses...
March 30, 2024: Oncogene
Shengpan Wu, Baojun Wang, Hongzhao Li, Hanfeng Wang, Songliang Du, Xing Huang, Yang Fan, Yu Gao, Liangyou Gu, Qingbo Huang, Jianjun Chen, Xu Zhang, Yan Huang, Xin Ma
While Stimulator-of-interferon genes (STING) is an innate immune adapter cruicial for sensing cytosolic DNA and modulating immune microenvironment, its tumor-promoting role in tumor survival and immune evasion remains largely unknown. Here we reported that renal cancer cells are exceptionally dependent on STING for survival and evading immunosurveillance via suppressing ER stress-mediated pyroptosis. We found that STING is significantly amplified and upregulated in clear cell renal cell carcinoma (ccRCC), and its elevated expression is associated with worse clinical outcomes...
March 28, 2024: Oncogene
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