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International Journal of Geriatric Psychiatry

Helen Brooker, Keith A Wesnes, Clive Ballard, Adam Hampshire, Dag Aarsland, Zunera Khan, Rob Stenton, Maria Megalogeni, Anne Corbett
OBJECTIVE: Establishing affordable lifestyle interventions that might preserve cognitive function in the aging population and subsequent generations is a growing area of research focus. Data from the PROTECT study has been utilised to examine whether number puzzle use is related to cognitive function in older adults. METHODS: Data from 19,078 healthy volunteers aged 50 to 93 years old enrolled on the online PROTECT study were evaluated for self-reported frequency of performing number puzzles...
February 11, 2019: International Journal of Geriatric Psychiatry
Richard Cheston, Emily Dodd, India Hart, Gary Christopher
OBJECTIVE: Thought suppression may not work effectively when people have a cognitive impairment. This study tests whether participants with dementia showed lessened or enhanced recall and recognition of dementia-related words compared to a control population. METHODS: Fifty participants living with dementia with mild levels of cognitive impairment and a control group of fifty-two participants without a diagnosis of dementia took part. A list of 12 words, composed of six dementia-related and six neutral words matched for frequency and length, was read out on four occasions, with the word order being varied for each presentation...
February 7, 2019: International Journal of Geriatric Psychiatry
Min Hae Park, Sarah C Smith, A A Jolijn Hendriks, Nick Black
OBJECTIVES: We aimed to describe 1) the burden and HRQL of informal caregivers of new patients attending a memory assessment service (MAS), 2) changes in these outcomes over two years and 3) satisfaction with services. METHODS: Informal caregivers of patients attending one of 73 MASs throughout England completed questionnaires at the patient's first appointment, and 6 and 12 months later. Participants from 30 of these MASs were also followed up at 24 months. Questionnaires covered caregivers' sociodemographic characteristics, Zarit Burden Interview, EQ-5D-3L and satisfaction with services...
February 7, 2019: International Journal of Geriatric Psychiatry
Maria J Marques, Bob Woods, Louise Hopper, Hannah Jelley, Kate Irving, Liselot Kerpershoek, Gabriele Meyer, Anja Bieber, Astrid Stephan, Anders Sköldunger, Britt-Marie Sjölund, Geir Selbaek, Janne Rosvik, Orazio Zanetti, Elisa Portolani, Marjolein de Vugt, Frans Verhey, Manuel Gonçalves-Pereira
OBJECTIVE: Quality of life of people with dementia and their family carers is strongly influenced by interpersonal issues and personal resources. In this context, relationship quality (RQ) and sense of coherence (SOC) potentially protect and promote health. We aimed to identify what influences RQ in dyads of people with dementia and their carers and to examine differences in their perspectives. METHODS: Cross-sectional data from the Actifcare cohort study of 451 community-dwelling people with dementia and their primary carers in eight European countries...
February 7, 2019: International Journal of Geriatric Psychiatry
Ann M Mayo, Guerry M Peavy
OBJECTIVE: Compromised functional abilities in older adults with dementia with Lewy bodies (DLB) represent a significant burden to families and frequently lead to institutionalization. Contributing factors to this compromise are poorly understood. METHODS: Using data collected at a first study visit, multiple regression modeling was used to examine the associations between Braak staged Alzheimer's disease (AD) pathology, Apolipoprotein E (ApoE) status, Parkinsonian gait, cognition and functional status from a cohort of 102 cases with an autopsy-confirmed diagnosis of dementia stemming from combined Lewy body and AD pathology...
February 6, 2019: International Journal of Geriatric Psychiatry
Angelina R Sutin, Yannick Stephan, Antonio Terracciano
OBJECTIVE: Verbal fluency is a common neuropsychological test that is impaired in dementia. We test whether verbal fluency is a prospective risk factor for incident dementia, cognitive impairment not dementia (CIND), and conversion from CIND to dementia. METHODS: Participants (N=18,189) from the Health and Retirement Study were administered a standard test of verbal fluency and were assessed for cognitive status every two years between baseline and six years follow-up...
February 6, 2019: International Journal of Geriatric Psychiatry
Emmanuelle Belanger, Kali S Thomas, Richard N Jones, Gary Epstein-Lubow, Vincent Mor
OBJECTIVES: The objective of this study was to assess the measurement properties of the self-reported Patient Health Questionnaire-9 (PHQ-9) and its 10-item observer-version (PHQ-10OV) among nursing home residents. METHODS: We conducted a retrospective study of Minimum Dataset 3.0 assessments for national cohorts of Medicare Fee-for-Service beneficiaries who were newly admitted or incident long-stay residents in 2014-2015 at US Nursing Homes Certified by the Center for Medicare and Medicaid Services...
February 6, 2019: International Journal of Geriatric Psychiatry
Laurna Bullock, John Bedson, Joanne L Jordan, Bernadette Bartlam, Carolyn A Chew-Graham, Paul Campbell
OBJECTIVES: To describe the current literature on pain assessment and pain treatment for community-dwelling people with dementia. METHOD: A comprehensive systematic search of the literature with narrative synthesis was conducted. Eight major bibliographic databases were searched in October 2018. Titles, abstracts, and full-text articles were sequentially screened. Standardised data extraction and quality appraisal exercises were conducted. RESULTS: 32 studies were included in the review, 11 reporting findings on pain assessment tools or methods, and 27 reporting findings on treatments for pain...
February 6, 2019: International Journal of Geriatric Psychiatry
Linda Clare, Aleksandra Kudlicka, Jan R Oyebode, Roy W Jones, Antony Bayer, Iracema Leroi, Michael Kopelman, Ian A James, Alison Culverwell, Jackie Pool, Andrew Brand, Catherine Henderson, Zoe Hoare, Martin Knapp, Bob Woods
OBJECTIVES: To determine whether individual goal-oriented cognitive rehabilitation (CR) improves everyday functioning for people with mild-to-moderate dementia. DESIGN AND METHODS: Parallel group multi-centre single-blind randomised controlled trial (RCT) comparing CR added to usual treatment (CR) with usual treatment alone (TAU) for people with an ICD-10 diagnosis of Alzheimer's, vascular or mixed dementia and mild-to-moderate cognitive impairment (MMSE score ≥ 18), and with a family member willing to contribute...
February 6, 2019: International Journal of Geriatric Psychiatry
Nazire E Akarsu, Martin Prince, Vanessa Lawrence, Jayati Das-Munshi
OBJECTIVES: Systematic review and meta-analysis to determine the effectiveness of interventions in reducing depressive symptoms in ethnic minority carers of people with dementia. METHODS: We systematically searched EMBASE, CINAHL, MEDLINE, PsycINFO, PsycARTICLES, Applied Social Sciences Index and Abstracts (ASSIA), The Cochrane Central Register of Controlled Trials (CENTRAL), Sociological Abstracts and Social Policy and Practices databases from 1990 to 2015, supplemented by a grey literature search, hand searches of bibliographies and contacting authors...
February 4, 2019: International Journal of Geriatric Psychiatry
Roseanne D Dobkin, Sarah L Mann, Alejandro Interian, Michael A Gara, Matthew Menza
OBJECTIVE: Depression is among the most common and debilitating non-motor complaints in Parkinson's disease (PD), yet there is a paucity of controlled research to guide treatment. Little research has focused on the extent to which specific depressive symptom profiles may dictate unique clinical recommendations to ultimately improve treatment outcomes. The current study examined the impact of Cognitive-Behavioral Therapy (CBT) on different types of depressive symptoms in PD. It was hypothesized that the cognitive (e...
February 4, 2019: International Journal of Geriatric Psychiatry
George S Vlachos, Stephanie Consentino, Mary H Kosmidis, Costas A Anastasiou, Mary Yannakoulia, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Eva Ntanasi, Nikolaos Scarmeas
OBJECTIVES: We studied the prevalence of subjective cognitive decline (SCD) and its determinants in a sample of 1456 cognitively normal Greek adults ≥65 years old. METHODS/DESIGN: Subjects were evaluated by a multi-disciplinary team on their neurological, medical, neuropsychological and lifestyle profile to reach consensus diagnoses. We investigated various types of SCD, including single-question, general memory decline, specific subjective memory decline based on a list of questions and three types of subjective naming, orientation and calculation decline...
February 3, 2019: International Journal of Geriatric Psychiatry
Sneha Mantri, Chinwe Nwadiogbu, Whitney Fitts, Nabila Dahodwala
OBJECTIVES: Screening tests of global cognition detect racial differences in scores even after adjustment for educational attainment. Differential educational environments in adolescence may affect individual cognitive function. This study examines the impact of high school educational quality on late-life cognition among community-dwelling older adults. METHODS/DESIGN: Data were collected from community-dwelling individuals from the Philadelphia Healthy Brain Aging (PHBA) cohort at the University of Pennsylvania Health System...
February 3, 2019: International Journal of Geriatric Psychiatry
Rory Durcan, Paul Donaghy, Curtis Osborne, John-Paul Taylor, Alan J Thomas
OBJECTIVES: The aim of this review was to provide an overview of the literature on imaging in prodromal Dementia with Lewy bodies (DLB). DESIGN: Systematic PubMed search and literature review. RESULTS: Diagnostic classification of the prodromal DLB stage remains to be established but is likely to require imaging biomarkers to improve diagnostic accuracy. In subjects with mild cognitive impairment with Lewy body disease (MCI-LB) (here synonymous with prodromal DLB) and REM sleep behaviour disorder, a high risk condition for future conversion to a synucleinopathy, imaging modalities have assessed early structural brain changes, striatal dopaminergic integrity, metabolic brain and cerebral perfusion alterations...
February 3, 2019: International Journal of Geriatric Psychiatry
Jeewon Suh, Young Ho Park, Hang-Rai Kim, Jae-Won Jang, Min Ju Kang, Jimin Yang, Min Jae Baek, SangYun Kim
BACKGROUND: Approximately 10 to 30% of Alzheimer's disease (AD) patients progress rapidly in severity and become more dependent on caregivers. Although several studies have investigated whether imaging biomarkers such as medial temporal atrophy (MTA) and posterior atrophy (PA) are useful for predicting the rapid progression of AD, their results have been inconsistent. OBJECTIVE: To investigate the association of visually rated MTA and PA with rapid disease progression in AD...
February 3, 2019: International Journal of Geriatric Psychiatry
Ira Driscoll, Beverly M Snively, Mark A Espeland, Sally A Shumaker, Stephen R Rapp, Joseph S Goveas, Ramon L Casanova, Jean Wactawski-Wende, JoAnn E Manson, Rebecca Rossom, Janet Brooks, Dena G Hernandez, Andrew B Singleton, Susan M Resnick
OBJECTIVE: While a number of single nucleotide polymorphisms (SNPs) associated with Alzheimer's disease (AD) or cognitive impairment have been identified, independent replications remain the only way to validate proposed signals. We investigated SNPs in candidate genes associated with either cognitive impairment or AD pathogenesis and their relationships with probable dementia (PD) in the Women's Health Initiative Memory Study (WHIMS). METHODS: We analyzed 96 SNPs across five genes (APOE/TOMM40, BDNF, COMT, SORL1, and KIBRA) in 2857 women (ages ≥ 65) from the WHIMS randomized trials of hormone therapy using a custom Illumina GoldenGate assay; 19% of the sample were MCI (N=165) or PD (N=387), and the remaining 81% were free of cognitive impairment...
January 31, 2019: International Journal of Geriatric Psychiatry
Torstein F Habiger, Wilco P Achterberg, Elisabeth Flo, Bettina S Husebo
OBJECTIVE: To investigate the characteristics of nursing home residents with psychosis and the association with potential underlying factors, such as pain, sleep disturbances, and antipsychotic medication. METHOD: 545 residents with and without dementia from 67 Norwegian nursing home units were included in the cross sectional analyses. Psychosis was the main outcome measure in our study; other outcome measures include quality of life (QoL), ADL function, cognitive function, pain, and antipsychotic medication...
January 31, 2019: International Journal of Geriatric Psychiatry
Sara Balouch, Enas Rifaat, Henglien Lisa Chen, Naji Tabet
OBJECTIVES: Modifiable lifestyle risk factors are of great interest in the prevention and management of Alzheimer's disease (AD). Loneliness and social networks may influence onset of AD, but little is known about this relationship in people with AD. The current study aimed to explore the relationship between loneliness and social networks (social measures) and cognitive and psychopathology decline (AD outcomes) in people with AD. METHODS: Ninety-three participants with mild-moderate AD were recruited from memory clinics, in a cross-sectional study...
January 31, 2019: International Journal of Geriatric Psychiatry
Jane Fossey, Lucy Garrod, Christina Tolbol Froiland, Clive Ballard, Vanessa Lawrence, Ingelin Testad
OBJECTIVES: To understand the factors that care home staff felt enabled or hindered them in continuing to use the WHELD psychosocial approach in their care home and investigate whether there was sustained activity nine - twelve months after the study ended. METHODS: This qualitative study is part of a wider clinical trial which demonstrated effectiveness of a psychosocial intervention on quality of life outcomes and neuropsychiatric symptoms for residents. 47 care home staff within nine care homes in the UK participated in focus groups, between nine and 12 months after the intervention had finished...
January 31, 2019: International Journal of Geriatric Psychiatry
Nicolas Farina, Gina Sherlock, Serena Thomas, Ruth G Lowry, Sube Banerjee
OBJECTIVES: Measuring physical activity is complicated particularly in people with dementia, where activity levels are low and subjective measures are susceptible to inaccurate recall. Activity monitors are increasingly being used within research, however, it is unclear how people with dementia view wearing such devices, and what aspects of the device effect wear time. The aim of the study was to evaluate the acceptability and feasibility of people with dementia wearing activity monitors...
January 30, 2019: International Journal of Geriatric Psychiatry
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