Fabrice Micaletti, Jean-Michel Escoffre, Sandrine Kerneis, Ayache Bouakaz, John J Galvin, Luc Boullaud, David Bakhos
Treating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of success. The key is to deliver therapeutics in a way that is minimally invasive, effective, long-lasting, and without adverse effects on vestibular and cochlear function. Microbubble-assisted ultrasound ("sonoporation") is a promising new modality that can be adapted to the inner ear. Combining ultrasound technology with microbubbles in the middle ear can increase the permeability of the round window, enabling therapeutic agents to be delivered safely and effectively to the inner ear in a targeted manner...
November 30, 2023: Advanced Drug Delivery Reviews
Chengqian Zhang, Davide D'Angelo, Francesca Buttini, Mingshi Yang
Inhaled medicines continue to be an essential part of treatment for respiratory diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. In addition, inhalation technology, which is an active area of research and innovation to deliver medications via the lung to the bloodstream, offers potential advantages such as rapid onset of action, enhanced bioavailability, and reduced side effects for local treatments. Certain inhaled macromolecules and particles can also end up in different organs via lymphatic transport from the respiratory epithelium...
November 29, 2023: Advanced Drug Delivery Reviews
Edidiong Udofa, Zongmin Zhao
Since the inception of the concept of "magic bullet", nanoparticles have evolved to be one of the most effective carriers in drug delivery. Nanoparticles improve the therapeutic efficacy of drugs offering benefits to treating various diseases. Unlike free drugs which freely diffuse and distribute through the body, nanoparticles protect the body from the drug by reducing non-specific interactions while also improving the drug's pharmacokinetics. Despite acquiring some FDA approvals, further clinical application of nanoparticles is majorly hindered by its limited ability to overcome biological barriers resulting in uncontrolled biodistribution and high clearance...
November 24, 2023: Advanced Drug Delivery Reviews
Mengjun Zhang, Haoyu Lu, Liangkun Xie, Xulu Liu, Dongmei Cun, Mingshi Yang
In recent years, RNA-based therapies have gained much attention as biomedicines due to their remarkable therapeutic effects with high specificity and potency. Lung diseases offer a variety of currently undruggable but attractive targets that could potentially be treated with RNA drugs. Inhaled RNA drugs for the treatment of lung diseases, including asthma, chronic obstructive pulmonary disease, cystic fibrosis, and acute respiratory distress syndrome, have attracted more and more attention. A variety of novel nanoformulations have been designed and attempted for the delivery of RNA drugs to the lung via inhalation...
November 21, 2023: Advanced Drug Delivery Reviews
Ana Ortiz-Pérez, Miao Zhang, Laurence W Fitzpatrick, Cristina Izquierdo-Lozano, Lorenzo Albertazzi
Despite the enormous potential of nanomedicines to shape the future of medicine, their clinical translation remains suboptimal. Translational challenges are present in every step of the development pipeline, from lack of understanding of patient heterogeneity to insufficient insights on nanoparticle properties and their impact on material-cell interactions. Here, we discuss how the adoption of advanced optical microscopy techniques, such as super-resolution optical microscopies, correlative techniques, and high-content modalities, could aid the rational design of nanocarriers, by characterizing the cell, the nanomaterial, and their interaction with unprecedent spatial and/or temporal detail...
November 17, 2023: Advanced Drug Delivery Reviews
Brianna L Scotland, Jacob R Shaw, Shruti Dharmaraj, Nicholas Caprio, Andrea L Cottingham, Jackline Joy Martín Lasola, Junsik J Sung, Ryan M Pearson
The prevalence of immune-mediated disorders, including autoimmune conditions and allergies, is steadily increasing. However, current therapeutic approaches are often non-specific and do not address the underlying pathogenic condition, often resulting in impaired immunity and a state of generalized immunosuppression. The emergence of technologies capable of selectively inhibiting aberrant immune activation in a targeted, antigen (Ag)-specific manner by exploiting the body's intrinsic tolerance pathways, all without inducing adverse side effects, holds significant promise to enhance patient outcomes...
November 17, 2023: Advanced Drug Delivery Reviews
April Kim, Fang Xie, Omar A Abed, James J Moon
The high prevalence and rising incidence of autoimmune diseases have become a prominent public health issue. Autoimmune disorders result from the immune system erroneously attacking the body's own healthy cells and tissues, causing persistent inflammation, tissue injury, and impaired organ function. Existing treatments primarily rely on broad immunosuppression, leaving patients vulnerable to infections and necessitating lifelong treatments. To address these unmet needs, an emerging frontier of vaccine development aims to restore immune equilibrium by inducing immune tolerance to autoantigens, offering a potential avenue for a cure rather than mere symptom management...
November 17, 2023: Advanced Drug Delivery Reviews
Li Miao, Yaoyao Wei, Xue Lu, Min Jiang, Yixuan Liu, Peishan Li, Yuxin Ren, Hua Zhang, Wen Chen, Bo Han, Wanliang Lu
The cell membrane serves as a barrier against the free entry of foreign substances into the cell. Limited by factors such as solubility and targeting, it is difficult for some drugs to pass through the cell membrane barrier and exert the expected therapeutic effect. Two-dimensional nanomaterial (2D NM) has the advantages of high drug loading capacity, flexible modification, and multimodal combination therapy, making them a novel drug delivery vehicle for drug membrane attachment and intracellular transport...
November 15, 2023: Advanced Drug Delivery Reviews
Natan Roberto de Barros, Canran Wang, Surjendu Maity, Arne Peirsman, Rohollah Nasiri, Anna Herland, Menekse Ermis, Satoru Kawakita, Bruna Gregatti Carvalho, Negar Hosseinzadeh Kouchehbaghi, Rondinelli Donizetti Herculano, Zuzana Tirpáková, Seyed Mohammad Hossein Dabiri, Jean Lucas Tanaka, Natashya Falcone, Auveen Choroomi, RunRun Chen, Shuyi Huang, Elisheva Zisblatt, Yixuan Huang, Ahmad Rashad, Danial Khorsandi, Ankit Gangrade, Leon Voskanian, Yangzhi Zhu, Bingbing Li, Mohsen Akbari, Junmin Lee, Mehmet Remzi Dokmeci, Han-Jun Kim, Ali Khademhosseini
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications. With their potential for personalized therapeutic interventions and high-throughput drug screening, organoids have gained significant attention recently. In this review, we discuss the latest developments in engineering organoids and using materials engineering, biochemical modifications, and advanced manufacturing technologies to improve organoid culture and replicate vital anatomical structures and functions of human tissues...
November 13, 2023: Advanced Drug Delivery Reviews
Tingting Zhang, Xuan Luo, Keming Xu, Wenying Zhong
Transdermal drug delivery presents a less invasive pathway, circumventing the need to pass through the gastrointestinal tract and liver, thereby reducing drug breakdown, initial metabolism, and gastrointestinal discomfort. Nevertheless, the unique composition and dense structure of the stratum corneum present a significant barrier to transdermal delivery. This article presents an overview of the current developments in peptides and nanotechnology to address this challenge. Initially, we sum up peptide-containing nanoformulations for transdermal drug delivery, examining them through the lenses of both inorganic and organic materials...
November 9, 2023: Advanced Drug Delivery Reviews
Mengmeng Qin, Heming Xia, Wenhao Xu, Binlong Chen, Yiguang Wang
The rapid development of nanomedicines is revolutionizing the landscape of cancer treatment, while effectively delivering them into solid tumors remains a formidable challenge. Currently, there is a huge disconnect on therapeutic response between regulatory approved nanomedicines and laboratory reported nanoparticles. The discrepancy is mainly resulted from the failure of using the classic overall pharmacokinetics behaviors of nanomedicines in tumors to predict the antitumor efficacy. Increasing evidence has revealed that the therapeutic efficacy predominantly relies on the intratumoral spatiotemporal distribution of nanomedicines...
November 8, 2023: Advanced Drug Delivery Reviews
Anan Yaghmur, Jesper Østergaard, Huiling Mu
The limitations inherent in conventional cancer treatment methods have stimulated recent efforts towards the design of safe nanomedicines with high efficacy for combating cancer through various promising approaches. A plethora of nanoparticles has been introduced in the development of cancer nanomedicines. Among them, different lipid nanoparticles are attractive for use due to numerous advantages and unique opportunities, including biocompatibility and targeted drug delivery. However, a comprehensive understanding of nano-bio interactions is imperative to facilitate the translation of recent advancements in the development of cancer nanomedicines into clinical practice...
November 7, 2023: Advanced Drug Delivery Reviews
Senta M Kapnick, Corinne A Martin, Christopher M Jewell
Metabolic programming and reprogramming have emerged as pivotal mechanisms for altering immune cell function. Thus, immunometabolism has become an attractive target area for treatment of immune-mediated disorders. Nonetheless, many hurdles to delivering metabolic cues persist. In this review, we consider how biomaterials are poised to transform manipulation of immune cell metabolism through integrated control of metabolic configurations to affect outcomes in autoimmunity, regeneration, transplant, and cancer...
November 5, 2023: Advanced Drug Delivery Reviews
Longwei Liu, Chi Woo Yoon, Zhou Yuan, Tianze Guo, Yunjia Qu, Peixiang He, Xi Yu, Ziyue Zhu, Praopim Limsakul, Yingxiao Wang
Chimeric Antigen Receptor T cell (CAR-T) therapy has emerged as a transformative therapeutic strategy for hematological malignancies. However, its efficacy in treating solid tumors remains limited. An in-depth and comprehensive understanding of CAR-T cell signaling pathways and the ability to track CAR-T cell biodistribution and activation in real-time within the tumor microenvironment will be instrumental in designing the next generation of CAR-T cells for solid tumor therapy. This review summarizes the signaling network and the cellular and molecular imaging tools and platforms that are utilized in CAR-T cell-based immune therapies, covering both in vitro and in vivo studies...
November 4, 2023: Advanced Drug Delivery Reviews
Yu-Ling Chen, Chun-Jie Bao, Jia-Lun Duan, Ying Xie, Wan-Liang Lu
Virus-like particles (VLPs) have natural structural antigens similar to those found in viruses, making them valuable in vaccine immunization. Furthermore, VLPs have demonstrated significant potential in drug delivery, and emerged as promising vectors for transporting chemical drug, genetic drug, peptide/protein, and even nanoparticle drug. With virus-like permeability and strong retention, they can effectively target specific organs, tissues or cells, facilitating efficient intracellular drug release. Further modifications allow VLPs to transfer across various physiological barriers, thus acting the purpose of efficient drug delivery and accurate therapy...
November 4, 2023: Advanced Drug Delivery Reviews
Qi Zeng, Guanyue Li, Wei Chen
Ultrasound-activatable and skin-associated minimally invasive microdevices (USMIMs) have garnered significant attention in the domains of smart drug delivery and biomedical diagnosis for on-demand healthcare, owing to their outstanding wearability, flexibility, and comfort. In this review, we present a comprehensive overview of the noteworthy advancements in USMIMs, with a specific focus on device design, potential applications, challenges, and future prospects. The classification of such microdevices primarily encompasses biointerfacing microsystems, including skin-perforable US-assisted microneedles (MNs), skin-attachable sonophoresis and their combination with microbubbles, as well as non-biointerfacing microsystems for drug delivery...
November 2, 2023: Advanced Drug Delivery Reviews
Thomas Lee Moore, Giovanna Pannuzzo, Gabriella Costabile, Anna Lisa Palange, Raffaele Spanò, Miguel Ferreira, Adriana Carol Eleonora Graziano, Paolo Decuzzi, Venera Cardile
The brain remains one of the most challenging therapeutic targets due to the low and selective permeability of the blood-brain barrier and complex architecture of the brain tissue. Nanomedicines, despite their relatively large size compared to small molecules and nucleic acids, are being heavily investigated as vehicles to delivery therapeutics into the brain. Here we elaborate on how nanomedicines may be used to treat rare neurodevelopmental disorders, using Krabbe disease (globoid cell leukodystrophy) to frame the discussion...
October 31, 2023: Advanced Drug Delivery Reviews
Ding Wang, Qi Jiang, Zhefan Dong, Tingting Meng, Fuqiang Hu, Jianwei Wang, Hong Yuan
Oral administration is the preferred route of drug delivery in clinical practice due to its noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal tract (GIT) plays a crucial role in facilitating the targeted delivery of oral drugs. However, the GIT presents multiple barriers that impede drug absorption, including the gastric barrier in the stomach and the mucus and epithelial barriers in the intestine. In recent decades, nanotechnology has emerged as a promising approach for overcoming these challenges by utilizing nanocarrier-based drug delivery systems such as liposomes, micelles, polymeric nanoparticles, solid lipid nanoparticles, and inorganic nanoparticles...
October 31, 2023: Advanced Drug Delivery Reviews
Kiyoon Min, Abhishek Sahu, Sae Hyun Jeon, Giyoong Tae
Inflammation is prevalent and inevitable in daily life but can generally be accommodated by the immune systems. However, incapable self-healing and persistent inflammation can progress to chronic inflammation, leading to prevalent or fatal chronic diseases. This review comprehensively covers the topic of emerging drug delivery systems (DDSs) for the treatment of chronic inflammatory diseases (CIDs). First, we introduce the basic biology of the chronic inflammatory process and provide an overview of the main CIDs of the major organs...
October 28, 2023: Advanced Drug Delivery Reviews
Kumar Kulldeep Niloy, Tao L Lowe
Insulin therapy is the mainstay to treat diabetes characterizedd by hyperglycemia. However, its short half-life of only 4-6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and protein engineering have led to several insulin analogue products that have up to 42 h of glycemic control. However, these insulin analogues still require once- or twice-daily injections for optimal glycemic control and have poor patient compliance and adherence issues. To achieve insulin release for more than one day, different injectable delivery systems including microspheres, in situ forming depots, nanoparticles and composite systems have been developed...
October 28, 2023: Advanced Drug Delivery Reviews
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.