journal
https://read.qxmd.com/read/37806642/non-coding-rna-profile-for-natural-killer-cell-activity
#21
REVIEW
Soudeh Ghafouri-Fard, Arian Askari, Alireza Zangooie, Hamed Shoorei, Hasan Pourmoshtagh, Mohammad Taheri
Natural killer cells (NK cells) are a type of cytotoxic lymphocytes which are involved in innate immunity, alongside with assisting with adaptive immune response. Since they have cytotoxic effects, disruptions in their functionality and development leads to a variety of conditions, whether malignant or non-malignant. The profile and interaction of these non-coding RNAs and NK cells in different conditions is extensively studied, and it is now approved that if dysregulated, non-coding RNAs have detrimental effects on NK cell activity and can contribute to the pathogenesis of diverse disorders...
October 6, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37802426/identification-of-hub-genes-and-potential-inhibitory-compounds-in-the-process-of-liver-transplantation-through-transcriptome-sequencing
#22
JOURNAL ARTICLE
Chujun Duan, Xiaojun Zhao, Xiao Li, Jiangang Xie, Yi Si, Linxiao Wang, Dan Wu, Yifan Wang, Shanshou Liu, Qianmei Wang, Ran Zhuang, Wen Yin, Junjie Li
Liver transplantation (LT) is the best choice for the patients with end-stage liver diseases. In order to better understand pathophysiological alterations in LT, we aimed to identify potential hub genes and inhibitory compounds involved in the LT process. Four pairs of peripheral blood mononuclear cell (PBMC) samples of the LT recipients before and after surgery were collected and taken for transcriptome sequencing. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed for the screened differentially expressed genes (DEGs) between pre- and post-operation groups...
October 4, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37517598/cdk12-loss-inhibits-cell-proliferation-by-regulating-tbk1-in-non-small-cell-lung-cancer-cells
#23
JOURNAL ARTICLE
Xiaoli Liu, Yangdong Liu, Wenjun Chai, Mingxia Yan, Hui Li, Jing Li, Lei Sun, Yue Cao, Qian Liu, Yuexi Sun, Hongyu Pan
Lung cancer is one of the most common malignant tumors and has a poor prognosis and a low survival rate. Traditional treatments, such as radiotherapy and chemotherapy, still face some challenges because of high drug resistance and toxicity. Therefore, it is necessary to discover a new kind of targeted drug with low toxicity and high efficiency. CDK12 is a cell cycle-dependent kinase whose main function is to activate RNA polymerase II (RNAPII) and promote the transcriptional extension of RNA. However, the role and molecular mechanism of CDK12 in lung cancer are still unclear...
October 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37777021/cancer-associated-fibroblasts-secret-extracellular-vesicles-to-support-cell-proliferation-and-epithelial-mesenchymal-transition-in-laryngeal-squamous-cell-carcinoma
#24
JOURNAL ARTICLE
Tingting Li, Linli Tian, Jing Cao, Ming Liu
As the critical components of tumor microenvironment, cancer-associated fibroblasts (CAFs) support the development of various type of cancers, including laryngeal squamous cell carcinoma (LSCC), but the detailed molecular mechanisms by which cancer-associated fibroblasts interact with LSCC cells to facilitate its progression have not been fully uncovered. In the present study, by analyzing the contents from normal fibroblasts (NFs) and cancer-associated fibroblasts-derived extracellular vesicles (EVs) with Real-Time qPCR analysis, we found that the tumor-initiating LncRNA TUC338 was significantly upregulated in the cancer-associated fibroblasts-derived extracellular vesicles, compared to the normal fibroblasts-secreted extracellular vesicles...
September 28, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37722548/interrelationship-of-hemoglobin-a1c-level-lipid-profile-uric-acid-c-reactive-protein-levels-and-age-in-a-large-hospital-database
#25
JOURNAL ARTICLE
Dlovan Ali Jalal, Barna Vásárhelyi, Béla Blaha, Zoltán Tóth, Tamás Géza Szabó, Béla Gyarmati
INTRODUCTION: Hemoglobin A1c (HbA1c) is used to monitor glucose homeostasis and to identify risk for diabetes. As diabetic patients are frequently present with dyslipidaemia, low-grade inflammation and hyperuricemia, we tested whether HbA1c levels can be estimated having the information about lipid profile, uric acid (UA) and C-reactive protein (CRP) levels. We developed formulas to describe the association of these parameters with HbA1c levels. METHODS: Data of 9599 male and 10,817 female patients, measured between 2008 and 2018, were analysed...
September 20, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37729973/transcription-factor-tead4-facilitates-glycolysis-and-proliferation-of-gastric-cancer-cells-by-activating-pkmyt1
#26
JOURNAL ARTICLE
Lifen Zhan, Wen Wu, Qiongling Yang, Huiqun Shen, Limin Liu, Renzhi Kang
BACKGROUND: Gastric cancer (GC) ranks third for cancer deaths worldwide, and glycolysis is a hallmark of several cancers, including GC. TEAD4 plays a role in establishing an oncogenic cascade in cancers, including GC. Whether TEAD4 can influence the glycolysis of GC cells remains uncovered. Hence, this study attempted to investigate the impact on glycolysis of GC cells by TEAD4. METHODS: By using bioinformatics analysis, differentially expressed mRNAs were screened, and downstream regulatory genes were predicted...
September 18, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37690573/introduced-the-itgb1-dt-as-a-novel-biomarker-associated-with-five-potential-drugs-using-bioinformatics-analysis-of-breast-cancer-proteomics-data-and-rt-pcr
#27
JOURNAL ARTICLE
Zahra Yousefian Naeini, Negin Esfandiari, Mehrdad Hashemi, Kiavash Hushmandi, Sedighe Arbabian, Maliheh Entezari
BACKGROUND: Breast cancer (BC) has been identified as a significant contributor to the rising number of female cancer deaths. As, it has become clear that breast cancer development depends on the interplay of several biological factors against a single molecule. This research aimed to use proteomics to gain a regulatory and metabolic understanding of BC pathophysiology. METHOD: For the study, a breast cancer proteomics dataset was downloaded from ProteomeXchange and then analyzed by employing MaxQuant and Perseus...
September 8, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37683830/exploring-the-role-of-pmepa1-in-gastric-cancer
#28
JOURNAL ARTICLE
Fei Wen, Shangyu Yang, WeiWen Cai, Mengyuan Zhao, Long Qin, Zuoyi Jiao
Although there are several treatments available for gastric cancer (GC), the prognosis of the disease is still poor due to many factors, such as late diagnosis and tumor heterogeneity. To identify potential therapeutic targets, bioinformatics techniques and clinical sample validation were employed and prostate transmembrane protein androgen-induced 1 (PMEPA1) was selected for further study. In the present study, we found that elevated PMEPA1 expression correlates with a worse prognosis and weaker anti-tumor immunity in GC patients...
September 6, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37683829/current-landscape-of-mirnas-and-tgf-%C3%AE-signaling-in-lung-cancer-progression-and-therapeutic-targets
#29
REVIEW
Bashdar Mahmud Hussen, Safeen Jasim Saleem, Snur Rasool Abdullah, Sayran Mohamadtahr, Hazha Jamal Hidayat, Mohammed Fatih Rasul, Mohammad Taheri, Arda Kiani
Lung cancer (LC) is the primary reason for cancer-associated fatalities globally. Due to both tumor-suppressing and tumor-promoting activities, the TGF-β family of growth factors is extremely essential to tumorigenesis. A non-coding single-stranded short RNA called microRNA (miRNA), which is made up of about 22 nt and is encoded by endogenous genes, can control normal and pathological pathways in various kinds of cancer, including LC. Recent research demonstrated that the TGF-β signaling directly can affect the synthesis of miRNAs through suppressor of mothers against decapentaplegic (SMAD)-dependent activity or other unidentified pathways, which could generate allostatic feedback as a result of TGF-β signaling stimulation and ultimately affect the destiny of cancer tissues...
September 6, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37597669/linc02253-promote-the-malignant-phenotype-of-colon-adenocarcinoma-cells-by-up-regulating-wwp1-mediated-smad3-ubiquitination
#30
JOURNAL ARTICLE
Jinfeng Wu, Xianhong Lu, Jinzhong Yu, Pan Li, Xiqiu Yu
OBJECTIVES: Colon adenocarcinoma (COAD) represents a type of common malignant tumor originating in the digestive tract. Long non-coding RNAs (lncRNAs) have been identified to engage in regulating the initiation and development of COAD. LncRNA LINC02253 has been reported abnormal expressed in COAD, but the underlying mechanism has not been discussed so far. This study aimed to determine the role and the molecular biology mechanism of LINC02253 in COAD progression and unearthed its specific molecular mechanism...
August 17, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37595804/16s-full-length-gene-sequencing-analysis-of-intestinal-flora-in-breast-cancer-patients-in-hainan-province
#31
REVIEW
Yonglan Jiang, Wei Gong, Zhenyong Xian, Weihua Xu, Junjie Hu, Zhichao Ma, Huaying Dong, Chong Lin, Shengmiao Fu, Xinping Chen
Breast cancer has become the number one cancer in the world, and intestinal flora may be closely linked to it. Geographic location also has an important impact on human intestinal flora. We conducted the first study on the intestinal flora of breast cancer patients and non-breast cancer patients in a tropical region - Hainan Province in China. At the same time, Pacbio platform based on third-generation sequencing was used for the first time to conduct 16 S full length sequencing of fecal microorganism DNA...
August 16, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37567322/cd3%C3%AE-as-a-novel-predictive-biomarker-of-pd-1-inhibitor-resistance-in-melanoma
#32
JOURNAL ARTICLE
Zhuo Zhang, Duoli Zhang, Fang Wang, Jiao Liu, Xian Jiang, Songyot Anuchapreeda, Singkome Tima, Zhangang Xiao, Suwit Duangmano
Malignant melanoma is the most lethal form of skin cancer, and its incidence rates are increasing in Europe, America, and Oceania countries. Despite immune checkpoint inhibitors, such as PD-1 inhibitors, have been shown to have significant therapeutic effects on malignant melanoma, many patients are unresponsive to these treatments, even emerged resistance. There is an urgent need to discover novel biomarkers that might distinguish resistant patients from responders. In this study, we used a series of bioinformatics analyses and experimental validation...
August 9, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37567321/a-network-pharmacology-based-approach-to-explore-the-effect-of-dihydromyricetin-on-non-alcoholic-fatty-liver-rats-via-regulating-pparg-and-casp3
#33
JOURNAL ARTICLE
Lu Liu, Sen Sun, Xiaohua Li
BACKGROUND: Non-alcohol fatty liver disease (NAFLD) is the most prevalent hepatopathy in China, with few effective cures currently. This work aimed to confirm the effect of DHM in vivo/vitro and explore the potential mechanism based on a network pharmacology-based approach. METHODS: The rats were fed using a high-fat diet (HFD) to accumulate lipid. DHM at different concentrations was used to treat the HFD rats. The serum total cholesterol (TC), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were detected using ELISA kits...
August 9, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37536457/blood-exosome-marker-mirna-30d-5p-role-and-regulation-mechanism-in-progression-and-gemcitabine-resistance-of-hepatocellular-carcinoma
#34
JOURNAL ARTICLE
Biao Tang, Longhui Xie, Xin Tang, Junjie Tian, Shaofei Xiao
BACKGROUND: Cancer stem cells (CSCs) are different from regular cancer cells because of their self-renewal feature and differentiation potential, which establishes the backbone of the vital role of CSCs in the progress and drug resistance of hepatocellular carcinoma (HCC). The objective of this study was to evaluate the effects of blood exosome-derived miRNA-30d-5p on the stemness and gemcitabine resistance of HCC cells and the underlying mechanisms. METHODS: The expression data of HCC-related miRNAs and mRNAs were downloaded from TCGA database and analyzed for differences...
August 1, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37468079/capg-interference-induces-apoptosis-and-ferroptosis-in-colorectal-cancer-cells-through-the-p53-pathway
#35
JOURNAL ARTICLE
Yingying Zhao, Rui Ma, Chuyue Wang, Rong Hu, Weili Wu, Xiang Sun, Baotao Chen, Wen Zhang, You Chen, Jiajian Zhou, Ping Yuan
PURPOSE: Given the high incidence and mortality rates of colorectal cancer (CRC) and the inadequacy of existing treatments for many patients, this study aimed to explore the potential of Capping Actin Protein (CAPG), a protein involved in actin-related movements, as a novel therapeutic target for CRC. METHODS: Bioinformatic analysis of gene expression was conducted using the UALCAN website. Cell proliferation was measured using the CCK-8 kit. Cell cycle, apoptosis, and ferroptosis were analyzed using flow cytometry...
July 17, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37459905/dnmt1-mediated-dna-methylation-in-toll-like-receptor-4-tlr4-inactivates-nf-%C3%AE%C2%BAb-signal-pathway-triggered-pyroptotic-cell-death-and-cellular-inflammation-to-ameliorate-lipopolysaccharides-lps-induced-osteomyelitis
#36
JOURNAL ARTICLE
Muguo Song, Junyi Li, Jian Sun, Xiaoyong Yang, Xijiao Zhang, Kehan Lv, Yongqing Xu, Jian Shi
Toll-like receptor 4 (TLR4) plays a critical role in various human diseases, and was associated with pyroptotic cell death and inflammatory responses. DNA methylation, which has stable and reversible properties, has been reported to alter the expression of target genes, including TLR4. However, the role of methylated TLR4 in osteomyelitis (OM) and the underlying molecular mechanisms remain unclear. RNA sequencing was used to identify differentially expressed genes and associated signaling pathways. RT-qPCR, Western blot, emzyme-linked immunosorbent assay (ELISA), cell counting kit-8 (CCK-8) and LDH assay kit were used to detect mRNA and protein expression of relevant genes, cell viability and the LDH activity, respectively...
July 15, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37454877/formin-related-protein-1-facilitates-proliferation-and-aggressive-phenotype-of-clear-cell-renal-cell-carcinoma-through-mapk-mmp2-pathway
#37
JOURNAL ARTICLE
Gui Ma, Bin Zhang, Shengjun Fu, Jianzhong Lu, Lili Zhang, Panfeng Shang, Zhongjin Yue
BACKGROUND: Formin-related protein-1(FRL1) has reportedly been overexpressed in a variety of malignancies, such as clear cell renal cell carcinoma (ccRCC). However, the clinical value and molecular mechanisms underlying ccRCC tumorigenesis and progression in association with FRL1 remain poorly understood. METHODS: Immunohistochemical analysis was performed on 119 paraffin-embedded RCC tissue samples to detect FRL1 expression and analyze its prognostic value. Colony formation, the CCK-8 assay, flow cytometry, and in vivo nude mice subcutaneous experiments were used to identify the effects of FRL1 on growth and proliferation...
July 14, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37454876/cote-1-promotes-the-proliferation-and-invasion-of-small-cell-lung-cancer-by-regulating-autophagy-activity-via-the-ampk-mtor-signaling-pathway
#38
JOURNAL ARTICLE
Yuhui Ma, Huijing Feng, Yuxuan Wang, Lina Hu, Xuan Su, Nan Li, Xu Li
BACKGROUND: COTE-1 has been found to promote the proliferation and invasion of non-small cell lung cancer. However, the mechanism of COTE-1 in SCLC is still unclear. Exploring the role of COTE-1 in SCLC is expected to provide a potential target for the prognosis and treatment of SCLC. METHODS: The expression of COTE-1 and ki-67 was detected by immunohistochemical staining. PCR detected COTE-1 expression level. Cell proliferation activity was detected by CCK8 assay...
July 14, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37442529/circcpsf6-promotes-hepatocellular-carcinoma-cancer-progression-by-regulating-map4k4-through-sponging-mir-145-5p
#39
JOURNAL ARTICLE
Fei Lu, Jing Gao, Yang Luo, Wei-Lin Jin, Haiping Wang, Chuan-Xing Li, Xun Li
BACKGROUND: Aberrant expression of circRNAs is involved in the progression of hepatocellular carcinoma (HCC). This study aimed at screening the pro-tumorigenic circular RNAs (circRNAs) in HCC and the mechanisms of circCPSF6 expression influencing HCC characteristics. METHOD: circCPSF6 was identified in HCC tissues using high-throughput sequencing data, and its expression was verified in both HCC tissues and cell lines using quantitative real-time PCR (qRT-PCR). CCK-8 and Transwell assays were used to evaluate the effects of circCPSF6 on HCC proliferation and migration...
July 11, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37364690/venous-thromboembolism-related-genetic-determinant-f11-rs4253417-is-a-potential-prognostic-factor-in-ischaemic-stroke
#40
JOURNAL ARTICLE
Valéria Tavares, Joana Assis, Ricardo Pinto, Margarida Freitas-Silva, Rui Medeiros
Ischaemic stroke (IS) and venous thromboembolism (VTE) are two forms of thromboembolism that, although distinct, seem to share numerous risk factors. Concerning genetic risk factors, while many VTE genetic markers have been reported, inclusively by genome-wide association studies (GWAS), the identification and validation of genetic determinants underlying IS pathogenesis have been challenging. Considering that IS and VTE shared biological pathways and aetiological factors, the severity of IS might be also influenced by VTE-related genetic variants...
June 24, 2023: Molecular and Cellular Probes
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