Journals AIDS Research and Human Retrov...

AIDS Research and Human Retroviruses
Christian Mangala, Denis Maulot-Bangola, Alain Moutsinga, Anges Gar Wamba, Serge Christian Okolongo Mayani, Joseph Fokam
BACKGROUND: Detection of drug resistance mutations (DRMs) and HIV-1 subtypes ensures effective therapeutic management for HIV-infected individuals. In Gabon, data on DRMs are very little available in the population of people living with HIV (PLHIV) but also among voluntary HIV-positive blood donors. This study aimed to study subtypes and drug resistance mutations (DRMs) in HIV-1 positive volunteer blood donors in Gabon. MATERIAL AND METHODS: A cross-sectional study was carried out at the National Transfusion Center (NBTC) of Gabon...
January 2, 2024: AIDS Research and Human Retroviruses
Eisuke Adachi, Makoto Saito, Amato Otani, Michiko Koga, Hiroshi Yotsuyanagi
Introduction Long-acting cabotegravir plus rilpivirine has revolutionized the concept of antiretroviral therapy, but as the causes of virologic failure and satisfaction can depend on patient background, real-world data are needed. Methods In this single-center study, we reviewed clinical records of people with HIV who received injectable cabotegravir plus rilpivirine between June 2022 and January 2023. We assessed virological and safety outcomes, including injection site reactions and changes in serum creatinine and cystatin C...
January 2, 2024: AIDS Research and Human Retroviruses
Tianfu Li, Kun Qian, Jingwan Han, Yongjian Liu, Lei Jia, Xiaolin Wang, Tianyi Li, Bohan Zhang, Jingyun Li, Hanping Li, Liping Dou, Lin Li
Hematological malignant tumors (HMTs) are serious diseases that threaten human health and life with high mortality. Therefore, it is necessary to develop novel strategies for diagnosis and treatment. Human endogenous retroviruses (HERVs) have recently attracted increasing attention as potential targets for cancer diagnosis and therapy. In this study, we explored the association between HERV-K expression levels and HMTs development. Clinical data and peripheral blood samples were collected from 236 leukemia, 384 lymphoma patients, and 69 healthy controls...
December 21, 2023: AIDS Research and Human Retroviruses
Bhavna H Chohan, Hanley Kingston, Ashley S Tseng, Betsy Sambai, Brandon L Guthrie, Eduan Wilkinson, Jennifer Giandhari, Loice W Mbogo, Aliza Monroe-Wise, Sarah Masyuko, Rose Bosire, Natasha T Ludwig-Barron, William Sinkele, David Bukusi, Tulio de Oliviera, Carey Farquhar, Joshua Herbeck
We evaluated the prevalence and correlates of HIV viral non-suppression and HIV drug resistance (HIV-DR) in a cohort of people who inject drugs living with HIV (PWID-LH) and their sexual and injecting partners living with HIV in Kenya. HIV-DR testing was performed on participants with viral non-suppression. Of 859 PWID-LH and their partners, 623 (72.5%) were on antiretroviral therapy (ART) ≥4 months and 148/623 (23.8%) were not virally suppressed. Viral non-suppression was more common among younger participants and those on ART for a shorter duration...
December 8, 2023: AIDS Research and Human Retroviruses
Sanjay Pujari, Sunil Gaikwad, Suhrud Panchawagh, Abhishek Chitalikar, Kedar Joshi, Chaitrangi Rohekar, Digamber Dabhade, Vivek Bele
Introduction We assessed the effectiveness and safety of switching to generic Dolutegravir/Lamivudine (DTG/3TC) amongst People Living with HIV (PWH) in Western India. Methods In this single-center, retrospective observational study, PWH switched to DTG/3TC were followed for virologic, immunologic, clinical effectiveness and safety including weight changes, hyperglycemia and dyslipidemia. Multivariate linear mixed effects models were used to predict average change in weight adjusted for age, sex, duration of previous ARV regimens and baseline weight...
December 8, 2023: AIDS Research and Human Retroviruses
Man Zhang, Yingyue Zeng, Fengchao Wang, Huawei Feng, Qingqing Liu, Feng Li, Shan Zhao, Jian Zhao, Zhikui Liu, Fangliang Zheng, Hongsheng Liu
To investigate the effects and underlying molecular mechanisms of the interaction between nonstructural protein (NS1) and nucleolar and coiled-body phosphoprotein 1 (NOLC1) on rRNA synthesis via nucleolar telomeric repeat-binding factor 2 (TRF2) under nucleolar stress in avian influenza A virus infection. The analysis of TRF2 ties into the exploration of ribosomal protein L11 (RPL11) and mouse double minute 2 (MDM2) because TRF2 has been found to interact with NOLC1, and the RPL11-MDM2 pathway plays an important role in nucleolar regulation and cellular processes...
December 7, 2023: AIDS Research and Human Retroviruses
Lydia A Fein, Rebecca Barnett, Tianhao Liu, JoNell E Potter, Nichole R Klatt, Maria L Alcaide, Deborah L Jones
Gender affirmation may reduce stigma and gender-based discrimination that drive increased behaviors that can lead to HIV in transgender women (TW). For many TW, vaginoplasty is gender affirming, yet has not been previously evaluated with regard to likelihood of HIV . This pilot study of TW aimed to evaluate the influence of gender-affirming vaginoplasty on stigma and the drivers of HIV acquisition. Adult TW without HIV were recruited. Interviewer-administered surveys were used to assess demographics, gender identity stigma, psychosocial factors, importance of and satisfaction with gender affirmation, and behaviors that increase the likelihood of HIV in TW who had either undergone gender-affirming vaginoplasty (TWWV) or who had not (TWWOV)...
November 21, 2023: AIDS Research and Human Retroviruses
Zahra Hasanshahi, Behzad Dehghani, Ava Hashempour
It was confirmed that SAMHD1 limits HIV-1 replication. In contrast, Vpx protein in HIV-2 and some simian immunodeficiency viruses (SIVs) can counteract this effect. The possible interaction between SAMHD1 and Vpx was suggested by previous studies, however, there is no data to confirm this interaction. Therefore, this study aimed to study the interaction between two proteins and the properties of Vpx protein for the first time using bioinformatics tools. Vpx and SAMHD1 sequences were obtained from NCBI GenBank...
November 21, 2023: AIDS Research and Human Retroviruses
Shuofan Dong, Xinli Lu, Yingying Wang, Ning An, Meng Liu, Yan Li, Qi Li
The unique recombinant form (URF) of HIV is formed by multiple subtypes which are co-circulating in some area, and the number of HIV recombinants is on the increase worldwide. In this study, we identified a URF named 2019638, composed of CRF01_AE and subtype B, in a man who has sex with men (MSM) in Qinhuangdao, Hebei province, China. The near-full-length genome (NFLG) sequence was confirmed to be a novel URF. within this NFLG, two CRF01_AE fragments were inserted into the pol and vif regions, respectively, using subtype B as the backbone...
November 19, 2023: AIDS Research and Human Retroviruses
Ling Zhang, Miaotian Cai, Bin Su, Yulin Zhang, Yingmin Ma
Tuberculosis (TB) is one of the most common opportunistic infections and is a leading cause of mortality in patients with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). HIV infection causes serious defects in the host immune system and increases the risk of active tuberculosis (TB). TB infection promotes HIV replication and aggravates host damage in patients with HIV/AIDS. Alveolar macrophages (AMs) are essential immune cells during TB and HIV infections. AMs undergo a shift in mitochondrial metabolism during TB or HIV infection, that is, metabolic reprogramming, allowing them to act in the form of classical activated macrophages (M1) and alternative activated macrophages (M2) at different stages of infection...
October 26, 2023: AIDS Research and Human Retroviruses
Sarah Laper, Corrilynn Olesky Hileman, Graham Block, Kristine M Erlandson, Martin Krsak
OBJECTIVES: We sought to describe the prevalence of and motivation for cannabis use and whether legalization of cannabis impacts the frequency and perceived risks and benefits of use in people living with HIV (PWH). METHODS: The study was based at two HIV clinics located in Cleveland, Ohio, and Aurora, Colorado. Participants responded to a 45-question survey and responses were summarized in aggregate and stratified by frequency of cannabis use and site. RESULTS: 397 participants completed the survey...
October 12, 2023: AIDS Research and Human Retroviruses
Mary Ann Adler Cohen, James Alan Bourgeois
HIV psychiatry may be the missing link to HIV prevention and care. While HIV has been transformed from a fatal illness to a chronic and manageable one, morbidity and mortality from HIV and AIDS continue to persist despite advances in prevention and care. In the 41 years since the HIV pandemic began in 1981, more than 84 million people were infected with HIV and forty million people with HIV have died. In 2021, 1.5 million were newly infected and as of 2022, more than 38 million people were living with HIV.
October 4, 2023: AIDS Research and Human Retroviruses
Pien van Paassen, Maartje Dijkstra, Holly Peay, Casper Rokx, Annelies Verbon, Peter Reiss, Jan Prins, Gail E Henderson, Stuart Rennie, Pythia Nieuwkerk, Godelieve de Bree
BACKGROUND: Starting antiretroviral therapy (ART) same-day, or as soon as possible after HIV diagnosis is advised in guidelines worldwide. Especially during acute HIV infection (AHI), rapid ART start may be more urgent because of a higher risk of transmission or symptoms of acute retroviral syndrome. During this phase, rapid ART start may have additional benefits for viral reservoir size and host immunity. We explored perceptions of rapid ART start among participants of the Netherlands Cohort Study on Acute HIV infection (NOVA study), who started ART rapidly after diagnosis of AHI...
October 4, 2023: AIDS Research and Human Retroviruses
Alessandro Castelli, Massimiliano Lanzafame, Matteo Morra, Marco Bertoldi, Andrea Delama, Daniela Fait, Sandro Vento
The availability of long-acting cabotegravir and rilpivirine injection combination requires some changes in service delivery of outpatient HIV clinics; it is therefore important for clinicians to know the potential number of people living with HIV (PLWH) who are interested in a long-acting antiretroviral treatment. We aimed to determine in an outpatient clinic the number of people living with HIV (PLWH),on dolutegravir/rilpivirine, accepting a switch to an injectable long-acting antiretroviral treatment, and the reasons underlying this choice...
September 30, 2023: AIDS Research and Human Retroviruses
Stephanie Fisher, Jennifer Jao, Lynn M Yee, Lena Serghides, Ellen G Chadwick, Denise Jacobson
Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are vital for fetal metabolic programming and immunomodulation. Higher n-6:n-3 ratios, reflecting a pro-inflammatory eicosanoid profile, are associated with adverse perinatal outcomes. Limited data exist, however, on n-6 and n-3 PUFAs specifically in the context of HIV and pregnancy. Our objective was to assess HIV clinical factors associated with PUFA signatures in pregnant persons with HIV (PWH). In this observational cohort, third trimester plasma PUFA concentrations (six n-6 PUFAs, four n-3 PUFAs) were measured, each as a percent of total fatty acid content, via esterification and gas chromatography in pregnant PWH enrolled from 2009-2011 in the Nutrition sub-study of the Pediatric HIV/AIDS Cohort Study...
September 29, 2023: AIDS Research and Human Retroviruses
Natanias Macson da Silva, Nícolas Patrícius de Medeiros Leite, Amanda Estevam Carvalho, Valéria Duarte de Almeida, Isis Kelly Dos Santos, José Rodolfo Lopes de Paiva Cavalcanti, Thales Allyrio Araújo de Medeiros Fernandes, Ellany Gurgel Cosme do Nascimento, Micassio Andrade
HIV infection is still an important public health problem, which justifies the research of new therapies to combat it. Recent studies show that Extracellular Traps (ETs) are cellular mechanisms useful in the capture and destruction of some viruses, such as the Human Immunodeficiency Virus (HIV). Here, we show that neutrophils from peripheral blood, genital tissues and placenta are activated when exposed to HIV-1 and release Neutrophil Extracellular Traps (NETs). The NETs can capture, neutralize, and inactivate the virus and, also, protect other target cells from HIV infection, as long as the DNA and other constituents of the NETs remain intact...
September 29, 2023: AIDS Research and Human Retroviruses
Solen Secher, Maxime Hentzien, Lise Cuzin, Christine Jacomet, Laurent Hocqueloux, David Rey, Amélie Menard, Cédric Arvieux, François Raffi, Firouzé Bani-Sadr
Among 34,351 PLHIV with available HLA- B*57:01 included in the Dat'AIDS cohort, 194 patients (0.56%) had a history of progressive multifocal leukoencephalopathy (PML) and 1746 (5.08%) were carriers of HLA-B*57:01. The frequency of HLA-B*57:01 was similar among patients with history of PML compared to patients without a history of PML (6.19% [95% CI 2.8%; 9.6%] versus 5.08% [95% CI 4.8%; 5.3%]; p=0.48). Among patients with PML, clinical and biological characteristics at PML diagnosis and the PML outcome were not different according to HLA-B*57:01 status...
September 27, 2023: AIDS Research and Human Retroviruses
Alexandra Maria Malciolu, Cristiana Costescu, Cornel Popescu, Simin Florescu, Cristiana Oprea
Monkeypox virus (Mpox), a double-stranded DNA virus belonging to the Orthopox genus, can affect vulnerable anatomic sites, including the eyes, causing a monkeypox-related ophthalmic disease. The Mpox virus may enter the eye via autoinoculation and cause multiple problems from mild lesions including conjunctivitis, blepharitis, keratitis, to severe ones such as corneal ulcers, corneal scarring, and rarely loss of vision. The aim of this article is to aggregate from an ophthalmologic point of view what is presently known about Mpox related ophthalmic disease (MpoxROD) and to present a particular case of a 41-year-old, white, bisexual, HIV positive male, with severe ocular complications...
September 27, 2023: AIDS Research and Human Retroviruses
Gundolf Schuettfort, Caroline Roether, Annemarie Berger, Emmanouil Fokas, Ingeborg Fraunholz, Ana Groh, Annette Haberl, Pavel Khaykin, Daniel Martin, Claus Roedel, Maria Vehreschild, Christoph Stephan
BACKGROUND: Incidence of anal carcinoma (AC) in people living with HIV (PLWH) is increased compared to the general population. Adverse effects of chemoradiotherapy (CRT) on the immune system are associtated with a significant detrimental prognosis on overall survival in patients receiving CRT for solid tumors. The aim of this study was to evaluate immunological factors, in particular the differences in recovery of CD4+ and CD8+ cell counts before and after chemoradiotherapy (CRT) for AC in PLWH...
September 27, 2023: AIDS Research and Human Retroviruses
Laven Mavarani, Nico Reinsch, Sarah Albayrak-Rena, Anja Potthoff, Martin Hower, Sebastian Dolff, Dirk Schadendorf, Karl-Heinz Jöckel, Börge Schmidt, Stefan Esser
Traditional cardiovascular risk scores underestimate the incidence of cardiovascular diseases (CVD) in people living with HIV (PLH). This study compared the effect of HIV-specific cardiovascular risk factors (CRF) with traditional CRF at baseline for their association with incident CVD in PLH. The ongoing, prospective HIV HEART Aging (HIVH) study assesses CVD in PLH in the German Ruhr Area since 2004. PLH from the HIVH study with at least 5 years of follow-up were examined with the help of Cox proportional hazards models using inverse probability-of-censoring weights...
September 7, 2023: AIDS Research and Human Retroviruses
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