Alexandra Moreira-Pais, Rui Vitorino, Cláudia Sousa-Mendes, Maria João Neuparth, Alessandro Nuccio, Claudio Luparello, Alessandro Attanzio, Petr Novák, Dmitry Loginov, Rita Nogueira-Ferreira, Adelino Leite-Moreira, Paula A Oliveira, Rita Ferreira, José A Duarte
Sarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood and can be decisive for the optimization of sarcopenia-related interventions. To improve the knowledge regarding the sex differences in skeletal muscle aging, the gastrocnemius muscle of young and old female and male rats was analyzed with a focus on mitochondrial remodeling through the proteome profiling of mitochondria-enriched fractions...
April 2, 2024: Free Radical Biology & Medicine