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Free Radical Biology & Medicine

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https://read.qxmd.com/read/30776408/the-vicious-circle-between-mitochondrial-oxidative-stress-and-dynamic-abnormality-mediates-triethylene-glycol-dimethacrylate-induced-preodontoblast-apoptosis
#1
Huang Sb, Jin X, Yu Qh, Zhang Xr, Zheng Bb, Wang Kh, Sun Xy, Chen Yt, Ren Xr, Ma Jf, Wu G, Pan Yh
Oxidative stress (OS) plays crucial roles in triethylene glycol dimethacrylate (TEGDMA, a major component in dental resin)-induced apoptosis of dental pulp cells. Mitochondria are important target organelles for regulating the balance of OS, meanwhile, imbalance of the mitochondrial dynamic associated with mitochondrial dysfunction is one major molecular mechanism for oxidative damages. However, whether these mitochondrial dependent pathways were involved in the apoptosis of dental pulp cells induced by TDGDMA remains unclarified...
February 15, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30770168/corrigendum-to-modulation-of-the-rod-outer-segment-aerobic-metabolism-diminishes-the-production-of-radicals-due-to-light-absorption-free-radic-biol-med-117-2018-110-118
#2
Daniela Calzia, Paolo Degan, Federico Caicci, Maurizio Bruschi, Lucia Manni, Luca A Ramenghi, Giovanni Candiano, Carlo Enrico Traverso, Isabella Panfoli
No abstract text is available yet for this article.
February 12, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30769161/antioxidants-bronchopulmonary-dysplasia-beating-the-system-or-beating-a-dead-horse
#3
REVIEW
Gaston Ofman, Trent E Tipple
Preterm birth is a primary cause of worldwide childhood mortality. Bronchopulmonary dysplasia, characterized by impaired alveolar and lung vascular development, affects 25-50% of extremely low birth weight (BW; <1 kg) infants. Abnormalities in lung function persist into childhood in affected infants and are second only to asthma in terms of childhood respiratory disease healthcare costs. While advances in the medical care of preterm infants have reduced mortality, the incidence of BPD has not decreased in the past 10 years...
February 12, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30769160/a-thermodynamically-constrained-mathematical-model-for-the-kinetics-and-regulation-of-nadph-oxidase-2-complex-mediated-electron-transfer-and-superoxide-production
#4
Namrata Tomar, Shima Sadri, Allen W Cowley, Chun Yang, Nabeel Quryshi, Venkat R Pannala, Said H Audi, Ranjan K Dash
Reactive oxygen species (ROS) play an important role in cell signaling, growth, and immunity. However, when produced in excess, they are toxic to the cell and lead to premature aging and a myriad of pathologies, including cardiovascular and renal diseases. A major source of ROS in many cells is the family of NADPH oxidase (NOX), comprising of membrane and cytosolic components. NOX2 is among the most widely expressed and well-studied NOX isoform. Although details on the NOX2 structure, its assembly and activation, and ROS production are well elucidated experimentally, there is a lack of a quantitative and integrative understanding of the kinetics of NOX2 complex, and the various factors such as pH, inhibitory drugs, and temperature that regulate the activity of this oxidase...
February 12, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30769159/thioredoxin-system-as-a-gatekeeper-in-caspase-6-activation-and-nuclear-lamina-integrity-implications-for-alzheimer-s-disease
#5
Md Imamul Islam, Pandian Nagakannan, Olamide Ogungbola, Jelena Djordjevic, Benedict C Albensi, Eftekhar Eftekharpour
Recent reports in pathophysiology of neurodegenerative diseases (ND) have linked nuclear lamina degradation/deficits to neuronal cell death. Lamin-B1 damage is specifically involved in this process leading to nuclear envelope invagination and heterochromatin rearrangement. The underlying mechanisms involved in these events are not yet defined. In this study, while examining the effect of Thioredoxin-1(Trx1) inhibition on cell death in a model of oxidative stress, we noted robust nuclear invagination in SH-SY5Y cells...
February 12, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30763613/chronic-exposure-to-xenobiotic-pollution-leads-to-significantly-higher-total-glutathione-and-lower-reduced-to-oxidized-glutathione-ratio-in-red-blood-cells-of-children-with-autism
#6
Scott Faber, Timothy Fahrenholz, Mesay Mulugeta Wolle, John C Kern, Matt Pamuku, Logan Miller, Jeremiah Jamrom, H M Skip Kingston
Analyses of reduced glutathione (GSH), oxidized glutathione (GSSG), and total glutathione (tGSH) in red blood cell samples from 30 children diagnosed with autism and 30 age, gender, and socioeconomic status matched controls were undertaken. The children's ages ranged from 2-9. Samples were obtained from subjects residing in Western Pennsylvania, an area of the United States greatly affected by high levels of mercury deposition and airborne PM 2.5 particulates. Liquid chromatography - mass spectrometry was utilized by following EPA Method 6800 for sample analyses...
February 11, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30753884/crosstalk-between-tap73-and-tgf-%C3%AE-in-fibroblast-regulates-inos-expression-and-nrf2-dependent-gene-transcription
#7
Aimeric Cabrié, Olivier Guittet, Richard Tomasini, Philippe Vincendeau, Michel Lepoivre
Inducible nitric oxide synthase (iNOS) activity produces anti-tumor and anti-microbial effects but also promotes carcinogenesis through mutagenic, immunosuppressive and pro-angiogenic mechanisms. The tumor suppressor p53 contributes to iNOS downregulation by repressing induction of the NOS2 gene encoding iNOS, thereby limiting NO-mediated DNA damages. This study focuses on the role of the p53 homologue TAp73 in the regulation of iNOS expression. Induction of iNOS by immunological stimuli was upregulated in immortalized MEFs from TAp73-/- mice, compared to TAp73+/+ fibroblasts...
February 9, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30743048/the-molecular-chaperone-sigma-1-receptor-mediates-rescue-of-retinal-cone-photoreceptor-cells-via-modulation-of-nrf2
#8
J Wang, J Zhao, X Cui, B A Mysona, S Navneet, A Saul, M Ahuja, N Lambert, I G Gazaryan, B Thomas, K E Bollinger, S B Smith
Sigma 1 receptor (Sig1R), a putative molecular chaperone, has emerged as a novel therapeutic target for retinal degenerative disease. Earlier studies showed that activation of Sig1R via the high-affinity ligand (+)-pentazocine ((+)-PTZ) induced profound rescue of cone photoreceptor cells in the rd10 mouse model of retinitis pigmentosa; however the mechanism of rescue is unknown. Improved cone function in (+)-PTZ-treated mice was accompanied by reduced oxidative stress and normalization of levels of NRF2, a transcription factor that activates antioxidant response elements (AREs) of hundreds of cytoprotective genes...
February 8, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30743047/interplay-between-ionizing-radiation-effects-and-aging-in-c-elegans
#9
Mira Kuzmic, Simon Galas, Catherine Lecomte-Pradines, Cécile Dubois, Nicolas Dubourg, Sandrine Frelon
Living species are chronically exposed to environmental ionizing radiations from sources that can be overexpressed by nuclear accidents. In invertebrates, reproduction is the most radiosensitive studied endpoint, likely to be connected with aging. Surprisingly, aging is a sparsely investigated endpoint after chronic ionizing radiation, whereas understanding it is of fundamental interest in biology and medicine. Indeed, aging and aging-related diseases (e.g., cancer and degenerative diseases) cause about 90% of deaths in developed countries...
February 8, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30743046/13-hode-9-hode-and-alox15-as-potential-players-in-rett-syndrome-oxinflammation
#10
Alessandra Pecorelli, Carlo Cervellati, Valeria Cordone, Fernanda Amicarelli, Joussef Hayek, Giuseppe Valacchil
Mutations in the MECP2 gene are the main cause of Rett syndrome (RTT), a pervasive neurodevelopmental disorder, that shows also multisystem disturbances associated with a metabolic component. The aim of this study was to investigate whether an increased production of oxidized linoleic acid metabolites, specifically 9- and 13-hydroxyoctadecadienoic acids (HODEs), can contribute to the altered the redox and immune homeostasis, suggested to be involved in RTT. Serum levels of 9- and 13-HODEs were elevated in RTT and associated with the expression of arachidonate 15-Lipoxygenase (ALOX15) in peripheral blood mononuclear cells (PBMCs)...
February 8, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30743045/from-minerals-to-metabolisms-evidence-for-life-before-oxygen-from-the-geological-record
#11
REVIEW
Jena E Johnson
No abstract text is available yet for this article.
February 8, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30738765/how-manganese-empowered-life-with-dioxygen-and-vice-versa
#12
REVIEW
Usha F Lingappa, Danielle R Monteverde, John S Magyar, Joan Selverstone Valentine, Woodward W Fischer
Throughout the history of life on Earth, abiotic components of the environment have shaped the evolution of life, and in turn life has shaped the environment. The element manganese embodies a special aspect of this collaboration; its history is closely entwined with those of photosynthesis and O2 -two reigning features that characterize the biosphere today. Manganese chemistry was central to the environmental context and evolutionary innovations that enabled the origin of oxygenic photosynthesis and the ensuing rise of O2 ...
February 7, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30738155/interaction-of-methyl-viologen-induced-chloroplast-and-mitochondrial-signalling-in-arabidopsis
#13
Fuqiang Cui, Mikael Brosché, Alexey Shapiguzov, Xin-Qiang He, Julia P Vainonen, Johanna Leppälä, Andrea Trotta, Saijaliisa Kangasjärvi, Jarkko Salojärvi, Jaakko Kangasjärvi, Kirk Overmyer
Reactive oxygen species (ROS) are key signalling intermediates in plant metabolism, defence, and stress adaptation. In plants, both the chloroplast and mitochondria are centres of metabolic control and ROS production, which coordinate stress responses in other cell compartments. The herbicide and experimental tool, methyl viologen (MV) induces ROS generation in the chloroplast under illumination, but is also toxic in non-photosynthetic organisms. We used MV to probe plant ROS signalling in compartments other than the chloroplast...
February 6, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30735841/how-superoxide-reductases-and-flavodiiron-proteins-combat-oxidative-stress-in-anaerobes
#14
REVIEW
Maria C Martins, C V Romão, Filipe Folgosa, Patrícia T Borges, Carlos Frazão, Miguel Teixeira
Microbial anaerobes are exposed in the natural environment and in their hosts, even if transiently, to fluctuating concentrations of oxygen and its derived reactive species, which pose a considerable threat to their anoxygenic lifestyle. To counteract these stressful conditions, they contain a multifaceted array of detoxifying systems that, in conjugation with cellular repairing mechanisms and in close crosstalk with metal homeostasis, allow them to survive in the presence of O2 and reactive oxygen species...
February 5, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30735840/new-red-shifted-fluorescent-biosensor-for-monitoring-intracellular-redox-changes
#15
Claudia Vanesa Piattoni, Florencia Sardi, Florencia Klein, Sergio Pantano, Mariela Bollati-Fogolin, Marcelo Comini
Maintenance of intracellular redox homeostasis is critical for cell survival, proliferation, differentiation, and signaling. In this regard, major changes in the intracellular redox milieu may lead to cell death whereas subtle increases in the level of certain oxidizing species may act as signals that regulate a plethora of cellular processes. Redox-sensitive variants of green fluorescent proteins (roGFP2 and rxYFP) were developed and proved useful to monitor intracellular redox changes in a non-invasive and online manner...
February 5, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30735839/critical-role-of-h-2-o-2-in-mediating-sanguinarine-induced-apoptosis-in-prostate-cancer-cells-via-facilitating-ceramide-generation-erk1-2-phosphorylation-and-par-4-cleavage
#16
Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil, Sehamuddin Galadari
Natural products are a major source of potential anticancer agents, and in order to develop improved and more effective cancer treatments, there is an immense need in exploring and elucidating their mechanism of action. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid, has been shown to induce cytotoxicity in various human cancers and suppresses various pro-tumorigenic processes such as invasion, angiogenesis, and metastasis in different cancers. Lack of understanding the anticancer mechanism(s) of SNG has impeded the development of this molecule as a potential anticancer agent...
February 5, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30735838/the-free-radical-theory-of-frailty-mechanisms-and-opportunities-for-interventions-to-promote-successful-aging
#17
REVIEW
Jose Viña
The free radical theory of ageing has provided a framework of research into ageing based on Harman's idea that ageing was caused by damage produced by free radicals. However, several experiments have cast doubts on the general validity of the theory. The postulation of the free radical theory of frailty came from two basic facts: first that radicals not only act as damaging molecules, but also as signals to control cell function and second that on many occasions oxidative damage does not correlate with chronological but rather with unsuccessful ageing...
February 5, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30735837/sirt3-mediates-the-protective-effect-of-hydrogen-in-inhibiting-ros-induced-retinal-senescence
#18
Ruichan Li, Yanli Liu, Jing Xie, Xudong Huang, Li Zhang, Hua Liu, Lihua Li
Hydrogen possesses antioxidative effects and cures numerous types of ophthalmopathy, but the mechanism of hydrogen on ROS-induced retinal senescence remains elusive. In this study, retinal morphology revealed that hydrogen reduced the number and size of vitreous black deposits in Bruch's membrane in NaIO3 mice. Hydrogen also reduced ROS levels in the retina as assessed by DHE staining. Moreover, this result was consistent with the downregulation of expression of the oxidative stress hallmark OGG1. These findings suggested that hydrogen can reduce retinal oxidative stress induced by NaIO3, and this result was further verified using the antioxidant ALCAR...
February 5, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30735836/evolutionary-adaptations-that-enable-enzymes-to-tolerate-oxidative-stress
#19
REVIEW
James A Imlay, Ramakrishnan Sethu, Sanjay Kumar Rohaun
Biochemical mechanisms emerged and were integrated into the metabolic plan of cellular life long before molecular oxygen accumulated in the biosphere. When oxygen levels finally rose, they threatened specific types of enzymes: those that use organic radicals as catalysts, and those that depend upon iron centers. Nature has found ways to ensure that such enzymes are still used by contemporary organisms. In some cases they are restricted to microbes that reside in anoxic habitats, but in others they manage to function inside oxygen-filled cells...
February 5, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30735835/geobiological-feedbacks-oxygen-and-the-evolution-of-nitrogenase
#20
REVIEW
Florence Mus, Daniel R Colman, John W Peters, Eric S Boyd
Biological nitrogen fixation via the activity of nitrogenase is arguably one of the most important biological innovations, allowing for an increase in global productivity that eventually permitted the emergence of complex forms of life. The complex metalloenzyme termed nitrogenase contains complex iron-sulfur cofactors. Three versions of nitrogenase exist that differ mainly by the presence or absence of a heterometal at the active site metal cluster (either Mo or V). Mo-dependent nitrogenase is the most common while V-dependent or heterometal independent (Fe-only) are often termed alternative nitrogenases since they have lower activities and are expressed in the absence of Mo...
February 5, 2019: Free Radical Biology & Medicine
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