journal
https://read.qxmd.com/read/38608823/sp2509-functions-as-a-novel-ferroptosis-inhibitor-by-reducing-intracellular-iron-level-in-vascular-smooth-muscle-cells
#1
JOURNAL ARTICLE
Yi He, Xingbo Wang, Siqi Chen, Hanshen Luo, Bo Huo, Xian Guo, Rui Li, Yue Chen, Xin Yi, Xiang Wei, Ding-Sheng Jiang
Previous studies have shown that ferroptosis of vascular smooth muscle cells (VSMCs) is involved in the development of aortic dissection (AD) and that histone methylation regulates this process. SP2509 acts as a specific inhibitor of lysine-specific demethylase 1 (LSD1), which governs a variety of biological processes. However, the effect of SP2509 on VSMC ferroptosis and AD remains to be elucidated. This aim of this study was to investigate the role and underlying mechanism of SP2509-mediated histone methylation on VSMC ferroptosis...
April 10, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38608822/the-therapeutic-potential-of-thiocyanate-and-hypothiocyanous-acid-against-pulmonary-infections
#2
REVIEW
Nuha Milad Ashtiwi, Susan O Kim, Joshua D Chandler, Balázs Rada
Hypothiocyanous acid (HOSCN) is an endogenous oxidant produced by peroxidase oxidation of thiocyanate (SCN- ), an ubiquitous sulfur-containing pseudohalide synthesized from cyanide. HOSCN serves as a potent microbicidal agent against pathogenic bacteria, viruses, and fungi, functioning through thiol-targeting mechanisms, independent of currently approved antimicrobials. Additionally, SCN- reacts with hypochlorous acid (HOCl), a highly reactive oxidant produced by myeloperoxidase (MPO) at sites of inflammation, also producing HOSCN...
April 10, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38604315/msc-derived-small-extracellular-vesicles-mitigate-diabetic-retinopathy-by-stabilizing-nrf2-through-mir-143-3p-mediated-inhibition-of-neddylation
#3
JOURNAL ARTICLE
Yueqin Chen, Jun Tong, Cong Liu, Chang He, Jinjin Xiang, Genhong Yao, Huayong Zhang, Zhenggao Xie
Diabetic retinopathy (DR) is a highly hazardous and widespread complication of diabetes mellitus (DM). The accumulated reactive oxygen species (ROS) play a central role in DR development. The aim of this research was to examine the impact and mechanisms of mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEV) on regulating ROS and retinal damage in DR. Intravitreal injection of sEV inhibited Cullin3 neddylation, stabilized Nrf2, decreased ROS, reduced retinal inflammation, suppressed Müller gliosis, and mitigated DR...
April 9, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38604314/itaconate-as-a-key-player-in-cardiovascular-immunometabolism
#4
REVIEW
Wenju Shan, Jun Cui, Yujie Song, Dongxu Yan, Linqi Feng, Yuhong Jian, Wei Yi, Yang Sun
Cardiovascular diseases (CVDs) are the leading cause of death globally, resulting in a major health burden. Thus, an urgent need exists for exploring effective therapeutic targets to block progression of CVDs and improve patient prognoses. Immune and inflammatory responses are involved in the development of atherosclerosis, ischemic myocardial damage responses and repair, calcification, and stenosis of the aortic valve. These responses can involve both large and small blood vessels throughout the body, leading to increased blood pressure and end-organ damage...
April 9, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38588903/effect-of-a-personalized-intensive-dietary-intervention-on-base-excision-repair-ber-in-colorectal-cancer-patients-results-from-a-randomized-controlled-trial
#5
JOURNAL ARTICLE
Anne Lene Nordengen, Congying Zheng, Annika Krutto, Ane S Kværner, Dena T Alavi, Hege B Henriksen, Christine Henriksen, Sigbjørn Smeland, Siv K Bøhn, Ingvild Paur, Sergey Shaposhnikov, Andrew R Collins, Rune Blomhoff
DNA repair is essential to maintain genomic integrity and may affect colorectal cancer (CRC) patients' risk of secondary cancers, treatment efficiency, and susceptibility to various comorbidities. Bioactive compounds identified in plant food have the potential to modulate DNA repair mechanisms, but there is limited evidence of how dietary factors may affect DNA repair activity in CRC patients in remission after surgery. The aim of this study was to investigate the effect of a 6 months personalized intensive dietary intervention on DNA repair activity in post-surgery CRC patients (stage I-III)...
April 6, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38583680/activation-of-lipophagy-is-required-for-rab7-to-regulate-ferroptosis-in-sepsis-induced-acute-kidney-injury
#6
JOURNAL ARTICLE
Yuanting Yang, Qisheng Lin, Xuying Zhu, Xinghua Shao, Shu Li, Jialin Li, Jingkui Wu, Haijiao Jin, Chaojun Qi, Na Jiang, Kaiqi Zhang, Qin Wang, Leyi Gu, Zhaohui Ni
Sepsis-induced acute kidney injury (S-AKI) is the most common type of acute kidney injury (AKI), accompanied by elevated morbidity and mortality rates. This study investigated the mechanism by which lipid droplets (LDs) degraded via autophagy (lipophagy)required for RAB7 regulated ferroptosis in the pathogenesis of S-AKI. Here, we constructed the S-AKI model in vitro and in vivo to elucidate the potential relationship of lipophagy and ferroptosis, and we first confirmed that the activation of lipophagy promoted renal tubular epithelial cell ferroptosis and renal damage in S-AKI...
April 5, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38582229/tet3-boosts-hepatocyte-autophagy-and-impairs-non-alcoholic-fatty-liver-disease-by-increasing-enpp1-promoter-hypomethylation
#7
JOURNAL ARTICLE
Feng Sun, Yang Yang, Lin Jia, Qi-Qi Dong, Wei Hu, Hui Tao, Chao Lu, Jing-Jing Yang
BACKGROUND: Dysregulated ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family occurs in metabolic reprogramming pathological processes. Nonetheless, the epigenetic mechanisms by which ENPP family impacts NAFLD, also known as metabolic dysfunction-associated steatotic liver disease (MASLD), is poorly appreciated. METHODS: We investigated the causes and consequences of ENPP1 promoter hypomethylation may boost NAFLD using NAFLD clinical samples, as well as revealed the underlying mechanisms using high-fat diet (HFD) + carbon tetrachloride (CCl4 ) induced mouse model of NAFLD and FFA treatment of cultured hepatocyte...
April 4, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38582228/doxorubicin-induces-phosphorylation-of-lamin-a-c-and-loss-of-nuclear-membrane-integrity-a-novel-mechanism-of-cardiotoxicity
#8
JOURNAL ARTICLE
Vikas Tiwari, Paras Gupta, Navya Malladi, Sanjay Salgar, Sanjay K Banerjee
Lamin A/C, essential inner nuclear membrane proteins, have been linked to progeria, a disease of accelerated aging, and many other diseases, which include cardiac disorder. Lamin A/C mutation and its phosphorylation are associated with altering nuclear shape and size. The role of lamin A/C in regulating normal cardiac function was reported earlier. In the present study, we hypothesized that Doxorubicin (Dox) may alter total lamin A/C expression and phosphorylation, thereby taking part in cardiac injury. An in vitro cellular injury model was generated with Dox (0...
April 4, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38580498/corrigendum-to-ampk-pgc1%C3%AE-activation-by-melatonin-attenuates-acute-doxorubicin-cardiotoxicity-via-alleviating-mitochondrial-oxidative-damage-and-apoptosis-free-radic-biol-med-129-2018-59-72
#9
Dong Liu, Zhiqiang Ma, Shouyin Di, Yang Yang, Jingang Yang, Liqun Xu, Russel J Reiter, Shubin Qiao, Jiansong Yuan
No abstract text is available yet for this article.
April 4, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38579938/mitochondrial-quality-control-in-non-exudative-age-related-macular-degeneration-from-molecular-mechanisms-to-structural-and-functional-recovery
#10
JOURNAL ARTICLE
Hernán H Dieguez, Horacio E Romeo, Agustina Alaimo, Nathaly A Bernal Aguirre, Juan S Calanni, Juan S Adán Aréan, Silvia Alvarez, Roberta Sciurano, Ruth E Rosenstein, Damián Dorfman
Non-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause in the elderly. Clinical and experimental evidence supports that early alterations in macular retinal pigment epithelium (RPE) mitochondria play a key role in NE-AMD-induced damage. Mitochondrial dynamics (biogenesis, fusion, fission, and mitophagy), which is under the central control of AMP-activated kinase (AMPK), in turn, determines mitochondrial quality. We have developed a NE-AMD model in C57BL/6J mice induced by unilateral superior cervical ganglionectomy (SCGx), which progressively reproduces the disease hallmarks circumscribed to the temporal region of the RPE/outer retina that exhibits several characteristics of the human macula...
April 3, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38579937/peroxiredoxin-6-suppresses-ferroptosis-in-lung-endothelial-cells
#11
JOURNAL ARTICLE
Julia María Torres-Velarde, Kaitlin N Allen, Andrea Salvador-Pascual, Roberto G Leija, Diamond Luong, Diana Daniela Moreno-Santillán, David C Ensminger, José Pablo Vázquez-Medina
Peroxiredoxin 6 (Prdx6) repairs peroxidized membranes by reducing oxidized phospholipids, and by replacing oxidized sn-2 fatty acyl groups through hydrolysis/reacylation by its phospholipase A2 (aiPLA2 ) and lysophosphatidylcholine acyltransferase activities. Prdx6 is highly expressed in the lung, and intact lungs and cells null for Prdx6 or with single-point mutations that inactivate either Prdx6-peroxidase or aiPLA2 activity alone exhibit decreased viability, increased lipid peroxidation, and incomplete repair when exposed to paraquat, hyperoxia, or organic peroxides...
April 3, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38574978/muscle-strength-quantity-and-quality-and-muscle-fat-quantity-and-their-association-with-oxidative-stress-in-patients-with-facioscapulohumeral-muscular-dystrophy-effect-of-antioxidant-supplementation
#12
JOURNAL ARTICLE
Vinicius Dias Wilson, Sébastien Bommart, Emilie Passerieux, Claire Thomas, Joël Pincemail, Marie Christine Picot, Jacques Mercier, Florence Portet, Sandrine Arbogast, Dalila Laoudj-Chenivesse
The purpose of this study was to identify causes of quadriceps muscle weakness in facioscapulohumeral muscular dystrophy (FSHD). To this aim, we evaluated quadriceps muscle and fat volumes by magnetic resonance imaging and their relationships with muscle strength and oxidative stress markers in adult patients with FSHD (n = 32) and healthy controls (n = 7), and the effect of antioxidant supplementation in 20 of the 32 patients with FSHD (n = 10 supplementation and n = 10 placebo) (NCT01596803)...
April 2, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38574977/targeting-nka%C3%AE-1-to-treat-parkinson-s-disease-through-inhibition-of-mitophagy-dependent-ferroptosis
#13
JOURNAL ARTICLE
Xiaoyan Zhang, Guanghong Li, Hanbin Chen, Xiao-Wei Nie, Jin-Song Bian
Dysfunction of the Na+ /K+ -ATPase (NKA) has been documented in various neurodegenerative diseases, yet the specific role of NKAα1 in Parkinson's disease (PD) remains incompletely understood. In this investigation, we utilized NKAα1 haploinsufficiency (NKAα1+/- ) mice to probe the influence of NKAα1 on dopaminergic (DA) neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Our findings reveal that NKAα1+/- mice displayed a heightened loss of DA neurons and more pronounced motor dysfunction compared to the control group when exposed to MPTP...
April 2, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38574976/feasibility-study-of-multimodal-imaging-for-redox-status-and-glucose-metabolism-in-tumor
#14
JOURNAL ARTICLE
Kazuhiro Kato, Hironobu Yasui, Hideo Sato-Akaba, Miho C Emoto, Hirotada G Fujii, Maciej M Kmiec, Periannan Kuppusamy, Yuki Mizuno, Yuji Kuge, Masaki Nagane, Tadashi Yamashita, Osamu Inanami
Understanding the tumor redox status is important for efficient cancer treatment. Here, we noninvasively detected changes in the redox environment of tumors before and after cancer treatment in the same individuals using a novel compact and portable electron paramagnetic resonance imaging (EPRI) device and compared the results with glycolytic information obtained through autoradiography using 2-deoxy-2-[18 F]fluoro-d-glucose ([18 F]FDG). Human colon cancer HCT116 xenografts were used in the mice. We used 3-carbamoyl-PROXYL (3CP) as a paramagnetic and redox status probe for the EPRI of tumors...
April 2, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38574975/mitochondrial-remodeling-underlying-age-induced-skeletal-muscle-wasting-let-s-talk-about-sex
#15
JOURNAL ARTICLE
Alexandra Moreira-Pais, Rui Vitorino, Cláudia Sousa-Mendes, Maria João Neuparth, Alessandro Nuccio, Claudio Luparello, Alessandro Attanzio, Petr Novák, Dmitry Loginov, Rita Nogueira-Ferreira, Adelino Leite-Moreira, Paula A Oliveira, Rita Ferreira, José A Duarte
Sarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood and can be decisive for the optimization of sarcopenia-related interventions. To improve the knowledge regarding the sex differences in skeletal muscle aging, the gastrocnemius muscle of young and old female and male rats was analyzed with a focus on mitochondrial remodeling through the proteome profiling of mitochondria-enriched fractions...
April 2, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38574974/quantifying-redox-transcription-factor-dynamics-as-a-tool-to-investigate-redox-signalling
#16
JOURNAL ARTICLE
Diane J Lind, Kelisa C Naidoo, Lewis E Tomalin, Johann M Rohwer, Elizabeth A Veal, Ché S Pillay
A critical feature of the cellular antioxidant response is the induction of gene expression by redox-sensitive transcription factors. In many cells, activating these transcription factors is a dynamic process involving multiple redox steps, but it is unclear how these dynamics should be measured. Here, we show how the dynamic profile of the Schizosaccharomyces pombe Pap1 transcription factor is quantifiable by three parameters: signal amplitude, signal time and signal duration. In response to increasing hydrogen peroxide concentrations, the Pap1 amplitude decreased while the signal time and duration showed saturable increases...
April 2, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38574973/downregulated-gpx4-in-salivary-gland-epithelial-cells-contributes-to-salivary-secretion-dysfunction-in-sjogren-s-syndrome-via-lipid-ros-pstat4-aqp5-axis
#17
JOURNAL ARTICLE
Jiannan Zhou, Janak L Pathak, Lihong Wu, Bo Chen, Tingting Cao, Wei Wei, Xiaodan Wu, Guiping Chen, Nobumoto Watanabe, Xiaomeng Li, Jiang Li
Sjogren's syndrome (SS) is an autoimmune disease characterized by dysfunction of exocrine glands, such as salivary glands. However, the molecular mechanism of salivary secretion dysfunction in SS is still unclear. Given the significance of glutathione peroxidase 4 (GPX4) in cellular redox homeostasis, we hypothesized that dysregulation of GPX4 may play a pivotal role in the pathogenesis of salivary secretion dysfunction observed in SS. The salivary gland of SS patients and the SS mouse model exhibited reduced expression of the ferroptosis inhibitor GPX4 and the important protein aquaporin 5 (AQP5), which is involved in salivary secretion...
April 2, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38570172/unlocking-the-anticancer-activity-of-gambogic-acid-a-shift-towards-ferroptosis-via-a-gsh-trx-dual-antioxidant-system
#18
JOURNAL ARTICLE
Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding
Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in ferroptosis by regulating the cellular antioxidant response and maintaining redox balance. However, compounds that induce ferroptosis through dual antioxidant pathways based on Nrf2 have not been fully explored. In our study, we investigated the impact of Gambogic acid (GA) on MCF-7 cells and HepG2 cells in vitro. The cytotoxicity, colony formation assay and cell cycle assay demonstrated potent tumor-killing ability of GA, while its effect was rescued by ferroptosis inhibitors...
April 1, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38570171/mapping-the-interplay-of-immunoproteasome-and-autophagy-in-different-heart-failure-phenotypes
#19
REVIEW
Christiane Ott
Proper protein degradation is required for cellular protein homeostasis and organ function. Particularly, in post-mitotic cells, such as cardiomyocytes, unbalanced proteolysis due to inflammatory stimuli and oxidative stress contributes to organ dysfunction. To ensure appropriate protein turnover, eukaryotic cells exert two main degradation systems, the ubiquitin-proteasome-system and the autophagy-lysosome-pathway. It has been shown that proteasome activity affects the development of cardiac dysfunction differently, depending on the type of heart failure...
April 1, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38565400/from-powerhouse-to-regulator-the-role-of-mitoepigenetics-in-mitochondrion-related-cellular-functions-and-human-diseases
#20
REVIEW
Luigi Donato, Domenico Mordà, Concetta Scimone, Simona Alibrandi, Rosalia D'Angelo, Antonina Sidoti
Beyond their crucial role in energy production, mitochondria harbor a distinct genome subject to epigenetic regulation akin to that of nuclear DNA. This paper delves into the nascent but rapidly evolving fields of mitoepigenetics and mitoepigenomics, exploring the sophisticated regulatory mechanisms governing mitochondrial DNA (mtDNA). These mechanisms encompass mtDNA methylation, the influence of non-coding RNAs (ncRNAs), and post-translational modifications of mitochondrial proteins. Together, these epigenetic modifications meticulously coordinate mitochondrial gene transcription, replication, and metabolism, thereby calibrating mitochondrial function in response to the dynamic interplay of intracellular needs and environmental stimuli...
March 31, 2024: Free Radical Biology & Medicine
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