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Transfusion Medicine Reviews

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https://read.qxmd.com/read/30910256/extracellular-vesicles-in-red-blood-cell-concentrates-an-overview
#1
REVIEW
Adeline Wannez, Bérangère Devalet, Bernard Chatelain, Christian Chatelain, Jean-Michel Dogné, François Mullier
Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized...
February 23, 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30910255/molecular-detection-of-glycophorins-a-and-b-variant-phenotypes-and-their-clinical-relevance
#2
REVIEW
Siti Nazihahasma Hassan, Kannan Thirumulu Ponnuraj, Suharni Mohamad, Rosline Hassan, Wan Suriana Wan Ab Rahman
Crossover or conversion between the homologous regions of glycophorin A (GYPA) and glycophorin B (GYPB) gives rise to several different hybrid glycophorin genes encoding a number of different glycophorin variant phenotypes which bear low prevalence antigens in the MNS blood group system. GP.Mur is the main glycophorin variant phenotype which causes hemolytic transfusion reaction (HTR) and hemolytic disease of the fetus and newborn (HDFN) in East and Southeast Asians. The detection of glycophorin variant phenotypes using serological methods is limited to phenotyping reagents that are not commercially available...
February 23, 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30948292/risks-and-benefits-of-chimeric-antigen-receptor-t-cell-car-t-therapy-in-cancer-a-systematic-review-and-meta-analysis
#3
REVIEW
Emma J M Grigor, Dean Fergusson, Natasha Kekre, Joshua Montroy, Harold Atkins, Matthew D Seftel, Mads Daugaard, Justin Presseau, Kednapa Thavorn, Brian Hutton, Robert A Holt, Manoj M Lalu
Promising efficacy results of chimeric antigen receptor (CAR) T-cell therapy have been tempered by safety considerations. Our objective was to comprehensively summarize the efficacy and safety of CAR-T cell therapy in patients with relapsed or refractory hematologic or solid malignancies. MEDLINE, Embase, and the Cochrane Register of Controlled Trials (inception - November 21, 2017). Interventional studies investigating CAR-T cell therapy in patients with malignancies were included. Our primary outcome of interest was complete response (defined as the absence of detectable cancer)...
February 14, 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30853167/transfusion-associated-circulatory-overload-a-clinical-perspective
#4
REVIEW
Joachim J Bosboom, Robert B Klanderman, Yazan Migdady, Barbara Bolhuis, Denise P Veelo, Bart F Geerts, Michael F Murphy, Alexander P J Vlaar
For 30 years, transfusion-associated circulatory overload (TACO) has been recognized as a serious transfusion complication. Currently, TACO is the leading cause of transfusion-related morbidity and mortality worldwide which occurs in 1% to 12% of at-risk populations. Despite an incomplete understanding of the underlying pathophysiology, TACO is defined as a collection of signs and symptoms of acute pulmonary edema due to circulatory overload occurring within 6 to 12 hours of transfusion. In the past decade, large observational cohort studies resulted in better insight into the associated transfusion risk factors leading to the development of TACO...
February 7, 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30930009/transfusion-transmitted-infections-reported-to-the-national-healthcare-safety-network-hemovigilance-module
#5
REVIEW
Kathryn A Haass, Mathew R P Sapiano, Alexandra Savinkina, Matthew J Kuehnert, Sridhar V Basavaraju
Transfusion-transmitted infections (TTIs) can be severe and result in death. Transfusion-transmitted viral pathogen transmission has been substantially reduced, whereas sepsis due to bacterial contamination of platelets and transfusion-transmitted babesiosis may occur more frequently. Quantifying the burden of TTI is important to develop targeted interventions. From January 1, 2010, to December 31, 2016, health care facilities participating in the National Healthcare Safety Network Hemovigilance Module monitored transfusion recipients for evidence of TTI and recorded the total number of units transfused...
January 25, 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30814031/role-of-platelet-transfusion-in-the-reversal-of-anti-platelet-therapy
#6
REVIEW
Srikanth Nagalla, Ravi Sarode
Antiplatelet therapy is extensively used in the primary and secondary prophylaxis of arterial thrombotic disorders. Aspirin, the most commonly used antiplatelet agent, is a cyclooxygenase-1 inhibitor and considered a mild to moderate inhibitor of platelet function. Therefore, often a second antiplatelet agent is necessary in certain clinical conditions requiring greater inhibition of platelet function. An adenosine diphosphate (ADP) receptor, P2Y12, is an important target for this purpose; several agents inhibit this receptor providing potent antiplatelet effect...
January 25, 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30471867/seroprevalence-of-dengue-and-zika-virus-in-blood-donations-a-systematic-review
#7
REVIEW
Stephanie M Eick, Ariella Perry Dale, Brian McKay, Casey Lawrence, Mark H Ebell, José F Cordero, Michael Welton
The presence of antibodies to Zika virus (ZIKV) and dengue virus (DENV) can be detected in blood donations. Donation-based surveillance provides an alternative strategy to estimate population prevalence by detecting antibodies that are circulating. To estimate population prevalence, we conducted a systematic review of literature on the seroprevalence of ZIKV and DENV antibodies in blood donations. We searched PubMed and Web of Science for studies that reported the seroprevalence of ZIKV and DENV in blood donations...
January 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30122266/impact-of-red-blood-cell-antigen-matching-on-alloimmunization-and-transfusion-complications-in-patients-with-sickle-cell-disease-a-systematic-review
#8
Ross M Fasano, Erin K Meyer, Jane Branscomb, Mia S White, Robert W Gibson, James R Eckman
Red blood cells (RBC) transfusion is critical in managing acute and chronic complications in sickle cell disease (SCD); however, it is complicated by RBC alloimmunization, iron overload, transfusion reactions and infection. Several reports documented an increased incidence of alloantibodies in transfused individuals with SCD, especially for Rh and Kell antigens. As a result, the National Institutes of Health Expert Panel and British Society for Haematology guidelines recommend primary matching for C/c, E/e and K antigens in addition to ABO/RhD for RBC transfusions...
January 2019: Transfusion Medicine Reviews
https://read.qxmd.com/read/30626535/transfusion-safety-the-nature-and-outcomes-of-errors-in-patient-registration
#9
REVIEW
Robert Cohen, Shuoyan Ning, Matthew Tak Sheng Yan, Jeannie Callum
The transfusion chain is susceptible to error at every step. Accurate patient registration is a key first step that links a patient with their historical medical profile, yet patient registration is marked by its own challenges. Registration errors are deviations from standard operating procedures that occur during the process of patient registration. A frequent consequence of registration errors is the obfuscation of historical information and patient misidentification. Through duplicate registrations, patient information can be spread across multiple records and through hybrid registrations information from multiple patients can be combined into a single record...
December 6, 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30528986/peripheral-blood-or-bone-marrow-stem-cells-practical-considerations-in-hematopoietic-stem-cell-transplantation
#10
REVIEW
Afsaneh Amouzegar, Bimalangshu R Dey, Thomas R Spitzer
Although peripheral blood stem cells (PBSC) have worldwide become the predominant source of progenitor cells for hematopoietic stem cell transplantation (HSCT), debate about their role compared with bone marrow (BM) has recently intensified, in large part based on the results of a multicenter Clinical Trials Network study which showed lower incidence of chronic graft-versus-host disease (cGVHD) and improved quality of life in recipients of myeloablative HLA-matched unrelated BM compared with PBSC transplants...
November 12, 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30482420/single-versus-double-unit-umbilical-cord-blood-transplantation-for-hematologic-diseases-a-systematic-review
#11
REVIEW
Li Wang, Zhen-Yang Gu, Shu-Feng Liu, De-Xun Ma, Chao Zhang, Cheng-Jun Liu, Rui Gao, Li-Xun Guan, Cheng-Ying Zhu, Fei-Yan Wang, Chun-Ji Gao, Hua-Ping Wei
Controversial results exist regarding the clinical benefits of single- vs double-unit umbilical cord blood transplantation (UCBT) in patients with hematologic diseases. A systematic review was conducted to evaluate this issue. The PubMed, Embase, and Cochrane Library databases were searched up to May 2018. A total of 25 studies including 6571 recipients were identified. Although double-unit UCB contained higher doses of total nucleated cells and CD34+ cells, it offered no advantages over single-unit UCB in terms of hematologic recovery, including the rate and speed of neutrophil and platelet engraftment...
November 6, 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30177431/thrombocytopenia-in-pregnancy-mechanisms-and-management
#12
REVIEW
Annemarie E Fogerty
Thrombocytopenia is a common hematologic issue encountered by obstetricians and hematologists, detected in about 10% of all pregnancies. In the vast majority of cases, the thrombocytopenia will be attributed to gestational thrombocytopenia (GT), where the thrombocytopenia is mild, does not necessitate active management, and does not introduce maternal or fetal bleeding risk. Although GT is common, the specific mechanism responsible for it is not known with certainty, and therefore, differentiating it from other causes of thrombocytopenia can be challenging...
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30177430/james-blundell-obstetrical-hemorrhage-and-the-origins-of-transfusion-medicine
#13
REVIEW
Sunny Dzik
Although James Blundell is rightly acknowledged as the father of modern transfusion therapy, a review of the events surrounding the initial human-to-human transfusions in the first decades of the 19th century reveals substantial contributions by Blundell's collaborators. Bundell's uncle John Haighton provided substantial support for animal experimentation in the growing field of physiology studies. John Leacock of Barbados provided the essential original experiments that focused the path of investigation on within-species transfusions...
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30177429/microangiopathic-hemolytic-anemia-in-pregnancy
#14
REVIEW
Lucy Neave, Marie Scully
Thrombotic microangiopathies (TMAs) are associated with microangiopathic hemolytic anemia and thrombocytopenia, resulting in microvascular thrombosis and end-organ damage. In pregnancy, this may be the result of pregnancy-related TMAs such as preeclampsia; hemolysis, elevated liver enzymes, and low platelets; or pregnancy-associated TMAs, specifically thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (CM HUS). TTP and CM HUS are rare disorders, and their diagnosis may be missed, no less because features at presentation may be misdiagnosed as a pregnancy-related TMA, such as hypertension, proteinuria, fetal growth restriction, or in utero fetal death...
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30177428/transfusion-medicine-in-obstetrics
#15
EDITORIAL
Barbara A Konkle, Annemarie E Fogerty
No abstract text is available yet for this article.
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30097224/inherited-bleeding-disorders-in-the-obstetric-patient
#16
REVIEW
Bethany Samuelson Bannow, Barbara A Konkle
Inherited bleeding disorders increase the risk of bleeding in the obstetric patient. Randomized controlled trials to compare prophylactic or therapeutic interventions are rare, and guidance documents rely heavily on expert opinion. Here we report the results of a systematic review of the literature for the treatment and prevention of peripartum bleeding in women with an inherited bleeding disorder. The highest-quality evidence is for the use of tranexamic acid in postpartum hemorrhage, which has been shown to decrease bleeding-related mortality in women without bleeding disorders...
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30097223/red-blood-cell-alloimmunization-in-the-pregnant-patient
#17
REVIEW
Jennifer Webb, Meghan Delaney
Alloimmunization to red blood cell (RBC) antigens represents a challenge for physicians caring for women of child bearing potential. Exposure to non-self RBC antigens may occur during transfusion or pregnancy leading to the development of antibodies. If a subsequent fetus bears that antigen, maternal antibodies may attack the fetal red blood cells causing red cell destruction and clinically significant hemolytic disease of the fetus and newborn (HDFN). In the most severe cases, HDFN may result in intrauterine fetal demise due to high output cardiac failure, effusions and ascites, known as "hydrops fetalis"...
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30029813/current-evidence-for-the-use-of-prophylactic-transfusion-to-treat-sickle-cell-disease-during-pregnancy
#18
REVIEW
Bryon Jackson, Ross Fasano, John Roback
The role of prophylactic transfusion therapy for the treatment of sickle cell disease during pregnancy is unclear. An analysis of the existing literature shows a limited number of publications that address this issue and specifically compare clinical outcomes in this population based on a treatment strategy of prophylactic transfusion versus transfusion only for clinical indications (on-demand transfusion). The existing studies show a wide variation in study design and outcomes measured. The results of this analysis suggest that there are insufficient data to support a clinically significant difference in morbidity and mortality outcomes based on transfusion strategy...
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/30025661/transfusion-medicine-in-a-multidisciplinary-approach-to-morbidly-adherent-placenta-preparing-for-and-preventing-the-worst
#19
REVIEW
Robert A DeSimone, Wendy K Leung, Joseph Schwartz
The increasing incidence of placenta accreta has paralleled the rise in its greatest risk factor: cesarean delivery. In placenta accreta, the abnormal invasion of the chorionic villi into the myometrium prevents separation of the placenta at delivery, and the myometrium is unable to contract to prevent hemorrhage. Spontaneous uterine rupture and hemoperitoneum may also occur in the setting of placenta percreta. The average blood loss during a delivery complicated by placenta accreta is 2 to 5 L, compared to less than 0...
October 2018: Transfusion Medicine Reviews
https://read.qxmd.com/read/29934136/transfusion-management-of-obstetric-hemorrhage
#20
REVIEW
Kerry L O'Brien, Scott A Shainker, Evelyn L Lockhart
Obstetric hemorrhage is one of the leading, as well as one of the most treatable, causes of maternal morbidity and mortality worldwide. As obstetric hemorrhage often occurs in patients without risk factors, there is virtually unanimous agreement from obstetric professional societies to establish obstetric hemorrhage protocols in anticipation of these emergencies. These protocols involve multidisciplinary teams in which the transfusion service plays an essential and vital role. This manuscript will examine the epidemiology of obstetric hemorrhage, risk factors that may be present, and recommendations for these protocols, with a focus on massive transfusion protocols, laboratory testing, cell salvage and use of pharmacologic adjuvant therapy including tranexamic acid and factor concentrates...
October 2018: Transfusion Medicine Reviews
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