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Journal of Veterinary Internal Medicine

Katherine R Luethcke, Joanne Ekena, Ruthanne Chun, Lauren A Trepanier
INTRODUCTION: Transitional cell carcinoma (TCC) in humans is associated with environmental exposures and variants in glutathione S-transferase (GST) genes. Scottish Terriers have a high breed risk for TCC, but the relationship between genetic and environmental risk in dogs is not fully understood. HYPOTHESES: Scottish Terriers have a higher frequency of GST-theta variants compared to lower risk breeds. Dogs with TCC of any breed have a higher frequency of GST-theta variants along with higher environmental exposures, compared to controls...
April 22, 2019: Journal of Veterinary Internal Medicine
Masahiro Murakami, Hock Gan Heng, Chee Kin Lim, Nolie K Parnell, Nicholas J Rancilio, Tsang L Lin, Mario Sola
BACKGROUND: Gastric wall edema has not been reported as a complication of acute pancreatitis in dogs. OBJECTIVE: To describe the ultrasonographic features of gastric wall thickening in dogs with acute pancreatitis. ANIMALS: Fourteen dogs with ultrasonographic evidence and clinical diagnosis of acute pancreatitis, with ultrasonographic evidence of increased gastric wall thickness (>5 mm). METHODS: A retrospective search in the medical records from 2014 to 2016 was performed to identify dogs that had ultrasonographic evidence of acute pancreatitis, that had increased thickness of the gastric wall and that were diagnosed with acute pancreatitis clinically...
April 22, 2019: Journal of Veterinary Internal Medicine
Anna Bohlin, Claude Saegerman, Emma Hoeberg, Alexandra Sånge, Katarina Nostell, Inge Durie, Louise Husted, Anna Öhman, Gaby van Galen
BACKGROUND: It is highly desirable to assess the probability of survival in sick neonatal foals upon admission. The foal survival score (FSS) is a published scoring system used to estimate the probability of survival in hospitalized neonatal foals <4 days old. HYPOTHESIS/OBJECTIVES: To evaluate the ability of the FSS to predict survival in older foals from a geographically different area compared to the original study. ANIMALS: Five-hundred ninety hospitalized neonatal foals ≤14 days of age...
April 19, 2019: Journal of Veterinary Internal Medicine
Krystle L Reagan, Stanley L Marks, Patricia A Pesavento, Ann Della Maggiore, Bing Y Zhu, Amy M Grooters
Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti-inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids...
April 19, 2019: Journal of Veterinary Internal Medicine
Craig R Breheny, Alisdair Boag, Alice Le Gal, Sven-Erik Hõim, Matteo Cantatore, Davina Anderson, Tim Nuttall, Marjoie L Chandler, Danièlle A Gunn-Moore
BACKGROUND: Esophageal feeding tubes are commonly used to provide enteral nutrition to cats, but their use is associated with adverse effects. OBJECTIVES: To evaluate the complications associated with e-tube placement in cats and to identify factors predisposing to these complications. ANIMALS: Cats that had an esophageal feeding tube placed (n = 248). METHODS: This was a retrospective case review in which clinical records were interrogated across 2 referral centers to identify records of cats that had esophageal tubes placed...
April 18, 2019: Journal of Veterinary Internal Medicine
Clare MacLeod
No abstract text is available yet for this article.
April 18, 2019: Journal of Veterinary Internal Medicine
Ilaria Spalla, Adrian Boswood, David J Connolly, Virginia Luis Fuentes
BACKGROUND: Cats with hypertrophic cardiomyopathy (HCM) have decreased left ventricular (LV) longitudinal deformation detected by mitral annular plane systolic excursion (MAPSE) and speckle tracking echocardiography. People with preclinical HCM have decreased systolic LV longitudinal and radial strain (S) and strain rate (SR), with preserved circumferential S and SR. HYPOTHESIS/OBJECTIVES: Cats with preclinical HCM have decreased systolic LV deformation compared to normal cats...
April 16, 2019: Journal of Veterinary Internal Medicine
S Hertzsch, A Roos, G Wess
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common cardiac disease in cats. However, most cats are not diagnosed until they develop congestive heart failure, arterial thromboembolism (ATE), or sudden cardiac death. Thus, an affordable screening test for early detection of HCM is desirable. HYPOTHESIS/OBJECTIVES: Evaluation of a sensitive cardiac troponin I (cTnI) assay as a screening test for HCM in cats and determination of a cutoff for its early detection...
April 16, 2019: Journal of Veterinary Internal Medicine
Shara A Sheldon, Monica Aleman, Lais R R Costa, Kalie Weich, Quinn Howey, John E Madigan
BACKGROUND: Oral administration of magnesium and boron might have a beneficial effect on headshaking behavior in horses. OBJECTIVE: Evaluate the effects of oral magnesium alone or in combination with boron on headshaking behavior in affected horses. ANIMALS: Twelve geldings (6 healthy controls and 6 affected). METHODS: Prospective randomized controlled dietary trial over 42 days in 12 horses (6 horses diagnosed with trigeminal-mediated headshaking and 6 unaffected healthy controls)...
April 16, 2019: Journal of Veterinary Internal Medicine
Yukitaka Kani, Thomas E Cecere, Kevin Lahmers, Tanya LeRoith, Kurt L Zimmerman, Scott Isom, Fang-Chi Hsu, Waldemar Debinksi, John L Robertson, John H Rossmeisl
BACKGROUND: Stereotactic brain biopsy (SBB) is a technique that allows for definitive diagnosis of brain lesions. Little information is available regarding the diagnostic utility of SBB in dogs with intracranial diseases. OBJECTIVE: To investigate the diagnostic accuracy (DA) of SBB in dogs with brain tumors. ANIMALS: Thirty-one client-owned dogs that underwent SBB followed by surgical resection or necropsy examinations. METHODS: Retrospective observational study...
April 16, 2019: Journal of Veterinary Internal Medicine
Andy E Durham, Nicholas Frank, Cathy M McGowan, Nicola J Menzies-Gow, Ellen Roelfsema, Ingrid Vervuert, Karsten Feige, Kersten Fey
No abstract text is available yet for this article.
April 16, 2019: Journal of Veterinary Internal Medicine
Meriam N Saleh, Jack R Heptinstall, Eileen M Johnson, Lora R Ballweber, David S Lindsay, Stephen Werre, Joel F Herbein, Anne M Zajac
BACKGROUND: An evaluation of currently available in-clinic diagnostic tests for Giardia duodenalis infection of dogs and cats has not been performed. In addition, there is discordance among published diagnostic comparisons. The absence of a true gold standard for detecting Giardia duodenalis also complicates diagnostic evaluations. OBJECTIVES: To evaluate diagnostic tests commercially available in the United States for detecting Giardia duodenalis in dogs and cats, in comparison to a widely used reference test, the direct immunofluorescent assay (IFA), and also to compare the results of 2 methods of analysis: comparison of diagnostic tests to a reference test (IFA) and Bayesian analysis...
April 13, 2019: Journal of Veterinary Internal Medicine
Carol R Reinero, Isabelle Masseau, Megan Grobman, Aida Vientos-Plotts, Kurt Williams
This Perspectives in Veterinary Medicine article seeks to define, describe putative causes, and discuss key diagnostic tests for primary and secondary bronchiolar disorders to propose a classification scheme in cats with support from a literature review and case examples. The small airways (bronchioles with inner diameters <2 mm), located at the transitional zone between larger conducting airways and the pulmonary acinus, have been overlooked as major contributors to clinical syndromes of respiratory disease in cats...
April 13, 2019: Journal of Veterinary Internal Medicine
Bruce W Keene, Clarke E Atkins, John D Bonagura, Philip R Fox, Jens Häggström, Virginia Luis Fuentes, Mark A Oyama, John E Rush, Rebecca Stepien, Masami Uechi
This report, issued by the ACVIM Specialty of Cardiology consensus panel, revises guidelines for the diagnosis and treatment of myxomatous mitral valve disease (MMVD, also known as endocardiosis and degenerative or chronic valvular heart disease) in dogs, originally published in 2009. Updates were made to diagnostic, as well as medical, surgical, and dietary treatment recommendations. The strength of these recommendations was based on both the quantity and quality of available evidence supporting diagnostic and therapeutic decisions...
April 11, 2019: Journal of Veterinary Internal Medicine
Melody A de Laat, Dania B Reiche, Martin N Sillence, James M McGree
BACKGROUND: Endocrinopathic laminitis is common in horses and ponies, but the recurrence rate of the disease is poorly defined. OBJECTIVES: To determine the incidence of, and risk factors for, the recurrence of endocrinopathic laminitis. ANIMALS: Privately owned horses and ponies with acute laminitis (n = 317, of which 276 cases with endocrinopathic laminitis were followed up to study completion). METHODS: This prospective cohort study collected data on veterinary-diagnosed cases of acute laminitis for 2 years...
April 10, 2019: Journal of Veterinary Internal Medicine
M E Grobman, K D Hutcheson, T E Lever, F A Mann, C R Reinero
BACKGROUND: Megaesophagus (ME) carries a poor long-term prognosis in dogs. In people, lower esophageal sphincter (LES) achalasia is a rare cause of ME that may respond to targeted intervention. Dogs with lower esophageal sphincter achalasia-like syndrome (LES-AS) have been described recently, warranting investigation of analogous targeted treatment. HYPOTHESIS/OBJECTIVES: Evaluate response of dogs with LES-AS to LES mechanical dilation and botulinum toxin A (BTA) injections, with or without surgical myotomy and fundoplication...
April 9, 2019: Journal of Veterinary Internal Medicine
Martin J Schmidt, Antje Hartmann, Daniela Farke, Klaus Failling, Malgorzata Kolecka
BACKGROUND: One of the remaining questions in treating dogs with internal hydrocephalus is the association between the decrease of ventricular volume and re-expansion of cerebral parenchyma with clinical improvement. HYPOTHESIS: A decrease in ventricular volume and re-expansion of brain tissue occur after ventriculoperitoneal shunting (VPS). Clinical improvement defined by resolution of ≥1 clinical signs is associated with decreased size of cerebral ventricles and that the extent of change in ventricular size is associated with clinical improvement...
April 8, 2019: Journal of Veterinary Internal Medicine
Blake C Guard, Julia B Honneffer, Albert E Jergens, Michelle M Jonika, Linda Toresson, Yuri A Lawrence, Craig B Webb, Steve Hill, Jonathan A Lidbury, Joerg M Steiner, Jan S Suchodolski
BACKGROUND: Mounting evidence from human studies suggests that bile acid dysmetabolism might play a role in various human chronic gastrointestinal diseases. It is unknown whether fecal bile acid dysmetabolism occurs in dogs with chronic inflammatory enteropathy (CE). OBJECTIVE: To assess microbial dysbiosis, fecal unconjugated bile acids (fUBA), and disease activity in dogs with steroid-responsive CE. ANIMALS: Twenty-four healthy control dogs and 23 dogs with steroid-responsive CE...
April 7, 2019: Journal of Veterinary Internal Medicine
Daisuke Hasegawa, Yumi Ohnishi, Eiji Koyama, Satoru Matsunaga, Shouhei Ohtani, Akio Nakanishi, Takanori Shiga, James K Chambers, Kazuyuki Uchida, Norihiko Yokoi, Yuko Fukata, Masaki Fukata
A 7-year-old neutered female domestic shorthaired cat born in Poland and then moved to Japan presented to the local clinic with recent onset of convulsive cluster seizures and status epilepticus. Magnetic resonance imaging revealed bilateral swelling of the hippocampus with T2 hyperintensity and contrast enhancing image, suggesting hippocampal necrosis. The cat completely recovered after treatment with antiepileptic drugs (AED) and administration of prednisolone (1 mg/kg PO q24h for 4 days and tapered)...
April 3, 2019: Journal of Veterinary Internal Medicine
E J Ehrhart, Shukmei Wong, Keith Richter, Victoria Zismann, Carolyn Grimes, William Hendricks, Chand Khanna
BACKGROUND: Polymerase chain reaction for antigen receptor rearrangement (PARR) is a molecular diagnostic tool used for discrimination of lymphoid malignancies in dogs from benign processes. Assay variations have been described and are commercially available, but performance metrics are not uniformly reported. OBJECTIVES: To describe performance (accuracy, sensitivity, specificity) and rigorous benchmarking of a PARR protocol (ePARR) in clinically relevant samples...
April 2, 2019: Journal of Veterinary Internal Medicine
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