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Functional Neurology

V Cani
By the 1860s, Paolo Mantegazza was a professor of general pathology at the University of Pavia, where he had graduated in medicine in 1854. There, he founded Italy's first laboratory of experimental pathology and did his first research on pain, the subject of various communications presented to the Istituto Lombardo in Milan. In 1880, Mantegazza published Physiology of Pain, one of the several "physiologies" (of pleasure, of love, of hatred, of woman) that he wrote during his career. In this book, a testament to his scientific versatility, experimental observations supplemented his insights into hygienism and anthropology...
October 2018: Functional Neurology
A Berardi, L Dhrami, M Tofani, Donatella Valente, J Sansoni, G Galeoto
Motor impairments of the upper extremities affect approximately 60% of stroke patients. Rehabilitation is extremely important and can make it possible to identify which manual function is causing difficulty for the patient and hindering daily activities. The Wolf Motor Function Test (WMFT) was recently highly recommended as one of several outcome measures that assess limitations of activities with a high level of psychometrics and clinical utility. The objective of this study was to translate and culturally adapt the WMFT for the Italian population (WMFT-IT) and examine its reliability and validity in Italian post-stroke adults with chronic hemiplegia or hemiparesis...
October 2018: Functional Neurology
Livia Brusa, C Rocchi, V Ponzo, Paolo Stanzione, E Finazzi, A Attanasio
It is well established that non-motor symptoms are a core feature of Parkinson's disease (PD). A dysregulation of the autonomic nervous system seems to be present in PD, supporting the coexistence of urological and cardiovascular non-motor features. We evaluated whether bladder dysfunctions in patients with PD are linked to blood pressure dysregulation. Twenty-eight mild PD patients, previously submitted to a urodynamic evaluation, underwent 24-hour ambulatory blood pressure and heart rate monitoring to allow assessment of their circadian blood pressure profile; the occurrence of postprandial hypotension and orthostatic hypotension was also investigated...
October 2018: Functional Neurology
Q Yu, W Miao, J Han
The ABCD3-I criteria have proved to be effective for use in regular clinical practice to assist in transient ischemic attack (TIA) risk stratification and treatment. In this prospective study we aimed to explore the relationships between risk stratification and arterial stenosis location, carotid plaque morphology and vessel involvement in 90 TIA patients, stratifying risk by ABCD3-I scores. Clinical variables such as total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, homocysteine and high-sensitive C-reactive protein levels were recorded...
October 2018: Functional Neurology
B Aragona, R De Luca, A Piccolo, M Le Cause, M Destro, C Casella, S Filoni, Rocco Salvatore Calabrò
Post-stroke apathy is considered to be one of the clinical consequences of lesions affecting the structures of the prefrontal cortex, basal ganglia, thalamus and limbic system. However, there is no current consensus on the treatment of post-stroke apathy, which mainly depends on the underlying etiology and comorbidities. A 62-year-old man, affected by hemorrhagic stroke in the left thalamus, presented with mood depression, anhedonia, hyporexia and marked apathy. The patient underwent clinical evaluation before and after receiving two different pharmacological therapies: escitalopram and bupropion...
October 2018: Functional Neurology
J S Prusch, A F R Kleiner, A P Salazar, C Pinto, R R Marchese, M Galli, A S Pagnussat
Individuals with Parkinson's disease (PD) and freezing of gait (FOG) have impaired postural control. Recent studies using foot sensory stimulation delivered by means of automated mechanical peripheral stimulation (AMPS) have demonstrated improvements of gait in individuals with PD. This study aimed to investigate the effects of AMPS on postural control in individuals with PD and FOG. Thirty-three subjects participated in this randomized controlled trial. Participants were allocated to two groups: AMPS and AMPS SHAM...
October 2018: Functional Neurology
D De Bartolo, G Morone, A Lupo, F Aloise, A Baricich, D Di Francesco, C Calderone, C Cisari, G Verdecchia, Giorgio Sandrini, C Pistarini, G Antonucci, Nicola Smania, Stefano Paolucci, M Iosa
Even after rehabilitation, post stroke patients remain disabled. The Post Stroke Checklist (PSC) was developed to highlight unmet needs of community-dwelling stroke patients. The present study set out to validate Post Soft Care-App, designed to administer the PSC using smartphones and tablets, in order to monitor unmet needs in chronic patients. Fifty-three patients and fifteen physiotherapists were enrolled. The therapists administered the PSC to patients using the app, and then completed a structured questionnaire on its usability and utility...
October 2018: Functional Neurology
S Portaro, A Naro, M Russo, P Bramanti, P Lauria, Giangaetano D'Aleo, G La Rosa, A Bramanti, Rocco Salvatore Calabrò
Some patients with multiple sclerosis (MS) complain of symptoms, such as myokymia, myotonia, spasms, and stiffness, which have been demonstrated to be due to a concurrent non-dystrophic myotonia, i.e. myotonia congenita or paramyotonia congenita. Beyond the known casual association between MS and non-dystrophic myotonia, a channelopathy representing a primary trait of MS rather than an epiphenomenon of demyelization (i.e., an acquired channelopathy) may exist. Indeed, the finding of MS patients with no genetic evidence of non-dystrophic myotonia but showing a clinical picture resembling this condition would support this hypothesis...
October 2018: Functional Neurology
S Sparla, B Koch, R Bosma, Elsbeth Nagtegaal
The effects of exogenous melatonin on sleep diminish after its long-term use in haemodialysis patients. Our aim was to determine whether melatonin levels accumulate after chronic (at least three months) use of exogenous melatonin, 5 mg daily, and whether discontinuation of this treatment improves endogenous melatonin production and improves the circadian sleep-wake rhythm. In this case series, stable haemodialysis patients discontinued their chronic exogenous melatonin usage for seven days and melatonin concentrations in saliva were analysed...
October 2018: Functional Neurology
Sergio Alejandro Gómez-Ochoa, Blanca Beatriz Espín-Chico, Gabriel David Pinilla-Monsalve, Bonnie M Kaas, Luis Ernesto Téllez-Mosquera
Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome occurring predominantly in elderly females and in the setting of non-ketotic hyperglycemia (NKH). A systematic review was conducted in accordance with the PRISMA statement. Studies published between 1980 and 2018 that reported demographic, clinical, laboratory and imaging features from patients with HCB were screened. 136 studies describing 286 patients were included in the analysis. The patients included had a median age of 72 years; those with ketotic hyperglycemia (KH) were older (p<0...
October 2018: Functional Neurology
A Raglio
No abstract text is available yet for this article.
October 2018: Functional Neurology
Paolo Rossi, S Bruce, M A De Pascual, H Muller, Ewa Kalina Tyminski, E R De La Torre
No abstract text is available yet for this article.
July 2018: Functional Neurology
F Battista, E Tinella, Carlo Colosimo
No abstract text is available yet for this article.
July 2018: Functional Neurology
R G Gatto, S M Mustafi, M Y Amin, T H Mareci, Yu-Chien Wu, R L Magin
Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion technique, has offered new insights for the study of microstructural changes in neurodegenerative diseases. Mainly, the present study aimed to determine the connection between NODDI-derived parameters and changes in white matter (WM) abnormalities at early stages of amyotrophic lateral sclerosis (ALS). Spinal cords from ALS mice (G93A-SOD1 mice) were scanned in a Bruker Avance III HD 17.6T magnet. Fluorescent axonal-tagged mice (YFP, G93A-SOD1 mice) were used for quantitative histological analysis...
July 2018: Functional Neurology
H Famitafreschi, M Karimian
The ventral tegmental area (VTA) is a brain region recently shown to interfere with pain perception. According to previous studies, improvement of antioxidant defense mechanisms reduces pain. The aim of this study was to show that lack of social interaction influences oxidative stress in the VTA and that this results in increased pain tolerance. In this study, 21 male Sprague-Dawley rats were randomly divided into 2 groups: paired and socially isolated (SI). After one week of acclimatization, the SI rats were isolated for 14 days and the other rats were paired for the same period...
July 2018: Functional Neurology
T-D Dimitriou, Eleni Verykouki, John Papatriantafyllou, A Konsta, D Kazis, M Tsolaki
Agitation/aggressive behaviour is a common behavioural and psychological symptom in people with dementia (PwD), occurring with a frequency of between 13-50.4% according to recent studies, and the rate increases as the severity of cognitive decline increases. The burden on caregivers is considerable. This trial is a randomized controlled crossover trial conducted in Greece. The following measures were used: the Mini-Mental State Examination, Addenbrooke's Cognitive Examination Revised, Geriatric Depression Scale, Functional Rating Scale for Symptoms in Dementia and Neuropsychiatric Inventory...
July 2018: Functional Neurology
Ana Francisca Rozin Kleiner, Diana M Cubillos, C Pinto, A P Salazar, R R Marchese, R M L Barros, M Galli, A S Pagnussat
The required coefficient of friction (RCOF) is frequently reported in the literature as an indicator of slip propensity, a consequence of the collisional aspect of legged locomotion. Little is known about the RCOF in pathological gait. Therefore, this study aimed to quantify the RCOF in subjects with Parkinson's disease (PD) and freezing of gait (FOG) during the OFF-pharma phase, and to investigate the interplay between RCOF parameters and ankle kinematic and kinetic gait variables. Fourteen subjects with PD and 14 healthy age-matched subjects were instructed to walk barefoot at self-selected speed over a force platform...
July 2018: Functional Neurology
A Lupo, A M Cinnera, A Pucello, M Iosa, P Coiro, S Personeni, Francesca Gimigliano, Giovanni Iolascon, Stefano Paolucci, G Morone
Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute stroke. The enrolled subjects were randomized into two groups: subjects allocated to the experimental group performed 10 sessions of biofeedback balance training using inertial sensors, whereas subjects allocated to the control group performed 10 sessions of conventional balance training...
July 2018: Functional Neurology
C Geroin, S Tamburin, G Pagano, Marialuisa Gandolfi, Michele Tinazzi
Drugs used for the treatment of chronic lumbosacral radicular pain (LRP) may have frequent adverse effects leading to medication withdrawal. The use of add-on nutraceuticals, which have no side effects, may therefore play a role in LRP treatment. We performed a six-week, single-center, open label prospective uncontrolled clinical study to evaluate the effect of a nutraceutical combination (Noxiall®) used as an add-on therapy in patients with chronic LRP. Fifteen patients were treated with Noxiall® twice a day for 10 consecutive days, followed by once-daily administration up to the end of the six-week treatment...
July 2018: Functional Neurology
Alessio Baricich, S Carda
No abstract text is available yet for this article.
July 2018: Functional Neurology
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