journal
Journals Alzheimer Disease and Associat...

Alzheimer Disease and Associated Disorders

https://read.qxmd.com/read/37145978/remuneration-and-recruitment-of-study-participants-for-ad-cohort-studies-from-the-general-public-and-from-minority-communities
#1
JOURNAL ARTICLE
Matthew Gabel, Andrea Denny, Jorge Llibre-Guerra, John C Morris, Jennifer Phillips, Ashish Vaidyanathan
INTRODUCTION: Offering remuneration for participation in studies of aging and Alzheimer Disease (AD) may improve recruitment, particularly among minoritized and low-income groups. But remuneration may also raise ethical problems and reduce altruistic motivations for participation. METHODS: A nationally representative sample of Americans (N=2030) with large (N=500) Black and Hispanic oversamples was asked about willingness to participate in a longitudinal AD cohort study after random assignment of remuneration ($0, $50/visit, $100/visit)...
May 8, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37141452/trends-in-alzheimer-disease-mortality-among-american-indian-and-alaska-native-people-between-2011-and-2019
#2
JOURNAL ARTICLE
Solmaz Amiri, Luohua Jiang, Spero M Manson, Dedra S Buchwald
PURPOSE: The number of American Indian and Alaska Native (AI/AN) people living with dementia is expected to increase 5-fold by 2060. Social determinants of health may explain disparities in the incidence of Alzheimer disease (AD) but remain largely overlooked. METHODS: We examined the time trend of AD mortality rates and associations of the percentage of AI/ANs, density of primary care physicians and neurologists, area deprivation index, rurality, and Indian Health Service region with AD mortality in 646 purchased/referred care delivery area counties...
April 28, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37036952/carotid-intima-media-thickness-cimt-and-cognitive-performance-a-population-based-cross-sectional-study-from-north-india-erratum
#3
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 11, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37027496/behavioral-and-brain-correlates-of-emotional-distress-in-older-adults-during-covid-19-quarantine
#4
JOURNAL ARTICLE
Ori Benari, Ramit Ravona Springer, Ganit Almog, Iscka Yore, Maya Zadok, Hung-Mo Lin, Yuxia Ouyang, Mary Sano, Barbara B Bendlin, Abigail Livny, Anthony Heymann, Michal Schnaider Beeri
COVID-19 led to unprecedented lockdowns and changes in older adults' lives, especially those with type 2 diabetes who have high risk of complications and mortality. We investigated the associations of cognitive and motor function and gray matter volumes (GMVs) with COVID-19 lockdown-related emotional distress of type 2 diabetes older adults, participating in the Israel Diabetes and Cognitive Decline Study. We administered a questionnaire to obtain information about anxiety, depression, general well-being, and optimism during a mandated lockdown...
April 1, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36989106/assessing-how-age-sex-race-and-education-affect-the-relationships-between-cognitive-domains-and-odor-identification
#5
JOURNAL ARTICLE
Selena Zhong, Kristen E Wroblewski, Edward O Laumann, Martha K McClintock, Jayant M Pinto
BACKGROUND: The associations between cognitive domains and odor identification are well established, but how sociodemographic variables affect these relationships is less clear. PURPOSE: Using the survey-adapted Montreal Cognitive Assessment instrument (MoCA-SA), we assess how age, sex, race, and education shape these relationships. METHODS: We first used cluster analysis and multidimensional scaling to empirically derive distinct cognitive domains from the MoCA-SA as it is unclear whether the MoCA-SA can be disaggregated into cognitive domains...
March 23, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36988619/the-impact-of-episodes-of-lucidity-on-people-living-with-dementia-and-their-caregivers-a-case-report
#6
JOURNAL ARTICLE
Clark Benson, Jess Fehland, Meghan Botsch, Laura Block, Andrea Gilmore-Bykovskyi
People living with dementia (PLWD) may experience the episodes of lucidity (ELs), defined as a sudden return of abilities presumed to have been lost and presenting as meaningful communication and connection. Early research on ELs in advanced disease stages suggests these are predominantly positive events. This case report draws from 1 outlier case from a descriptive qualitative study on caregivers of PLWDs' experiences with ELs. The caregiver-reported events perceived as an EL being accompanied with unexpected self-awareness, leading to a negative emotional reaction and feelings of loss...
March 20, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36944170/a-virtual-photovoice-study-of-older-african-americans-perceptions-of-neurovascular-clinical-trials
#7
JOURNAL ARTICLE
Ashley R Shaw, Saria Lofton, Eric D Vidoni
BACKGROUND: Alzheimer disease (AD) poses a major public health crisis, especially among African Americans (AAs) who are up to 3 times more likely to develop AD compared with non-Hispanic Whites. Moreover, cardiovascular risk factors represent a precursor to cognitive decline, which contributes to racial/ethnic disparities seen within AD. Despite these disparities, AAs are underrepresented in neurovascular research. The purpose of this qualitative virtual photovoice project is to explore how older Midwestern AAs perceive neurovascular clinical trials...
March 13, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36897056/delirium-and-behavioral-symptoms-in-persons-with-dementia-at-hospital-admission-mediating-factors
#8
JOURNAL ARTICLE
Marie Boltz, Ashley Kuzmik, Barbara Resnick, Rhonda BeLue, Ying-Ling Jao, Anju Paudel, Liza Behrens, Doug Leslie, Liron Sinvani, James E Galvin
BACKGROUND: Hospitalized persons with dementia are at risk of delirium with behavioral symptoms, predisposing them to a higher rate of complications and caregiver distress. The purpose of this study was to examine the relationship between delirium severity in patients with dementia upon admission to the hospital and the manifestation of behavioral symptoms, and to evaluate the mediating effects of cognitive and physical function, pain, medications, and restraints. METHODS: This descriptive study used baseline data from 455 older adults with dementia enrolled in a cluster randomized clinical trial that tested the efficacy of family centered function-focused care...
March 13, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37253125/csf1r-related-adult-onset-leukoencephalopathy-the-first-reported-case-in-spain
#9
JOURNAL ARTICLE
Cristina Moreno Loscertales, Paula Canasto Jiménez, Mario Bautista Lacambra, Luisa Tique Rojas, Silvia Izquierdo Álvarez, Eugenia Marta Moreno
Colony-stimulating factor 1 receptor-related adult-onset leukoencephalopathy is a primary microgliopathy characterized by a complex phenotype, which can be easily misdiagnosed with other leukoencephalopathy and neurodegenerative diseases such as frontotemporal dementia. It is estimated to be the most common adult-onset leukodystrophy. Here, we report the case of a 67-year-old man with a history of progressive impairment of behavioral and cognitive functions, including apathy, inhibition, tendency to mutism, and deficits in complex planning skills...
April 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37253124/an-indian-young-onset-dementia-with-parkinsonism-with-double-heterozygous-mutations-in-abca7-and-prkn-identified-through-whole-exome-sequencing
#10
JOURNAL ARTICLE
Dipanwita Sadhukhan, Aishwarya Mallick, Smriti Mishra, Adreesh Mukherjee, Atanu Biswas, Subhra P Hui, Arindam Biswas
Alzheimer disease and Parkinson disease dementia are the 2 most common neurodegenerative diseases have substantial overlap in pathologic, genetic, and clinical manifestation and complex in nature. Here, for the first time, we report an Indian female young patient who presented with clinical manifestation of both Alzheimer disease and Parkinsonism, including dystonia with rapid disease progression. We identified a heterozygous mutation in the ATP-binding cassette transporter A7 gene and double heterozygous mutation in PRKN by whole-exome sequencing...
April 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37253123/caregiver-burden-and-quality-of-life-across-alzheimer-s-disease-severity-stages
#11
JOURNAL ARTICLE
Valérie J van Hezik-Wester, Ron L H Handels, Claire A G Wolfs, Tim A Kanters
INTRODUCTION: The objective is to estimate the caregiver burden in terms of informal care time, health-related quality of life (HRQoL), and societal costs by disease severity (mild, moderate, or severe) and living situation (community-dwelling or institutionalized) of persons with AD (PwAD); and PwAD HRQoL. METHODS: Caregivers were recruited through an online panel provider in the Netherlands. The survey used validated instruments, including iMTA Valuation of Informal Care Questionnaire, CarerQoL, and EQ-5D-5L...
April 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37253122/cognitive-impairment-and-the-associated-factors-among-older-people-in-rural-central-tanzania
#12
JOURNAL ARTICLE
Golden M Masika, Azan Nyundo, Laidi Msisiri
AIM: This study examined the profile of cognitive impairment and associated factors among older people in rural central Tanzania. METHODS: We conducted a cross-sectional study involving 462 community-dwelling older adults. We performed cognitive, psychosocial, and clinical assessments and face-to-face interviews with all older adults. Descriptive, bivariate and multivariate linear regression analyses were performed to determine the participant's cognitive performance and the associated factors...
April 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36820836/nasu-hakola-disease-with-stroke-like-attack-a-case-report
#13
JOURNAL ARTICLE
Azra Rashid Nezhad, Nahid Olfati, Ali Shoeibi, Fariborz Rezaei Talab, Mohsen Soltani Sabi
Homozygous mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are known to cause Nasu-Hakola disease, which is a rare cause of progressive presenile dementia. A 36-year-old woman presented with repetitive seizures, a 5-year history of progressive behavioral and cognitive changes, and an affected sibling. Magnetic resonance imaging of the brain revealed an ischemic lesion in the left medial temporal lobe. Extensive evaluation of juvenile stroke revealed that viral and autoimmune encephalitides, serum lactate and pyruvate levels, and cerebrospinal fluid composition were all normal...
February 20, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36820824/characterization-of-balance-control-and-postural-stability-in-patients-with-alzheimer-disease
#14
JOURNAL ARTICLE
Raymond J So, Kevin Biju, Esther Oh, Paul Rosenberg, Qian-Li Xue, Paul Dash, Muhammad H Burhanullah, Yuri Agrawal
Balance in Alzheimer disease (AD) patients is not rigorously understood. In this study, we characterize balance using qualitative [Berg Balance Scale (BBS)] and quantitative measures (posturography) and assess relationships between qualitative and quantitative balance measures in AD. Patients with mild-moderate AD (n=48) were recruited. BBS scores and posturography metrics, including medial-lateral sway range, anterior-posterior sway range, sway area, and sway velocity, were assessed in eyes-open and eyes-closed conditions...
February 20, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36706328/development-and-validation-of-a-multidimensional-short-version-zarit-burden-interview-zbi-9-for-caregivers-of-persons-with-cognitive-impairment
#15
JOURNAL ARTICLE
Lim Zhi-Xiang, Wee Shiong Lim, Ee-Yuee Chan
BACKGROUND: There is a lack of appreciation of the full dimensionality of the original 22-item Zarit Burden Interview (ZBI) in the development of short versions. Existing short versions are premised upon a 1-factor or 2-factor structure or statistical techniques for item selection. Thus, there is a need for ZBI short versions that considers the multidimensional constructs of role strain, personal strain, and worry about performance (WaP) during item selection to provide a more holistic and comprehensive evaluation...
January 18, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36706325/anticholinergic-drug-burden-and-risk-of-incident-mci-and-dementia-a-population-based-study
#16
JOURNAL ARTICLE
Ariel Gildengers, Gary P Stoehr, Xinhui Ran, Erin Jacobsen, Esther Teverovsky, Chung-Chou H Chang, Mary Ganguli
OBJECTIVE: We investigated whether anticholinergic drug use was related to developing mild cognitive impairment (MCI) or dementia in older adults at the population level. METHODS: We used an Anticholinergic Rating (ACR) scale, Clinical Dementia Rating, APOE genotype, and number of prescription medications. We examined time to incident MCI and incident dementia in a population-based cohort (n=1959). We assessed whether developing MCI or dementia was associated with (1) any anticholinergic drug use, (2) total ACR score, or (3) number of anticholinergic drugs taken...
January 18, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36706322/hypothesis-dementia-diminishes-interdependence-in-health-and-quality-of-life-among-spousal-partners
#17
JOURNAL ARTICLE
Samuel R Nyman, Chloe Casey, Nan Greenwood
No abstract text is available yet for this article.
January 18, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36706321/predictors-of-driving-cessation-in-older-adults-a-12-year-population-based-study
#18
JOURNAL ARTICLE
Isabella Wood, Tejal Bhojak, Yichen Jia, Erin Jacobsen, Beth E Snitz, Chung-Chou H Chang, Mary Ganguli
BACKGROUND: Changes in physical health and cognition during aging can result in some older adults to stop driving. In this population-based longitudinal study, we describe potential predictors of driving cessation in older adults. METHODS: Age-stratified random population cohort of 1982 adults aged 65 years and older drawn from voter registration lists. Participant characteristics were measured using demographics, physical and self-rated health, sleeping habits, driving status, cognitive screening, modified Center for Epidemiologic Studies-Depression scale, clinical dementia rating, and mini-mental state examination...
January 18, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36821178/physical-exercise-as-a-nonpharmacological-intervention-for-the-treatment-of-neuropsychiatric-symptoms-in-persons-with-dementia-a-meta-analysis-of-randomized-controlled-trials
#19
REVIEW
Komanthi Kouloutbani, Fotini Venetsanou, Konstantinos E Karteroliotis, Antonios Politis
BACKGROUND: Neuropsychiatric symptoms (NPS) are prevalent in dementia and affect both patients and caregivers in multiple ways. Because of the complications of drug treatments, nonpharmacological interventions, such as exercise, are of particular value. This study aimed to investigate the effect of exercise on the NPS of dementia and draw recommendations for the disease management. METHODS: Meta-analyses were conducted on the findings of randomized controlled trials identified during an initial systematic review of the literature, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
January 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/36821177/research-priorities-of-individuals-and-caregivers-with-lewy-body-dementia-a-web-based-survey
#20
JOURNAL ARTICLE
Samantha K Holden, Noheli Bedenfield, Angela S Taylor, Ece Bayram, Chris Schwilk, Jori Fleisher, John Duda, Holly Shill, Henry L Paulson, Kelly Stacy, Julia Wood, Pamela Corsentino, Sharon J Sha, Irene Litvan, David J Irwin, Joseph F Quinn, Jennifer G Goldman, Katherine Amodeo, John-Paul Taylor, Bradley F Boeve, Melissa J Armstrong
INTRODUCTION: Lewy body dementia (LBD) is common, yet under-recognized and under-researched. To plan studies with the highest impact, engagement of the community personally affected by these conditions is essential. METHODS: A web-based survey of people living with LBD and current and former caregivers of people with LBD queried research priorities through forced ranking and exploration of burden of LBD symptoms. Specific caregiving needs in LBD and perceptions of research participation were also investigated...
January 2023: Alzheimer Disease and Associated Disorders
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