journal
https://read.qxmd.com/read/38844583/from-real-world-data-to-real-world-evidence-to-improve-outcomes-in-neuro-ophthalmology
#21
REVIEW
Blake D Colman, Zhuoting Zhu, Ziyi Qi, Anneke van der Walt
Real-world data (RWD) can be defined as all data generated during routine clinical care. This includes electronic health records, disease-specific registries, imaging databanks, and data linkage to administrative databases. In the field of neuro-ophthalmology, the intersection of RWD and clinical practice offers unprecedented opportunities to understand and treat rare diseases. However, translating RWD into real-world evidence (RWE) poses several challenges, including data quality, legal and ethical considerations, and sustainability of data sources...
June 6, 2024: Eye
https://read.qxmd.com/read/38839982/a-survey-of-primary-angle-closure-knowledge-and-application-by-uk-community-based-optometrists
#22
JOURNAL ARTICLE
Anish Jindal, Winifred Nolan
No abstract text is available yet for this article.
June 5, 2024: Eye
https://read.qxmd.com/read/38834842/implementing-teleophthalmology-services-to-improve-cost-effectiveness-of-the-national-eye-care-system
#23
JOURNAL ARTICLE
E P Jørgensen, D V Muttuvelu, T Peto, S Natarajan, J Davies, P A Keane, Lars Holger Ehlers
BACKGROUND AND PURPOSE: Optometrist-assisted and teleophthalmology-enabled referral pathway (OTRP) for community optometry referrals has the potential to improve the capacity and efficiency of eye care delivery systems through risk stratification and limiting the number of improved referrals. This study investigates the expected future costs and benefits of implementing OTRP under various possible organizational set-ups relevant to a Danish context. METHODS: A decision-analytic model (decision tree) with a one-year time horizon was constructed to portray alternative future patient referral pathways for people examined in optometry stores for suspected ocular posterior segment eye disease...
June 4, 2024: Eye
https://read.qxmd.com/read/38831116/infectious-optic-neuropathy-ion-how-to-recognise-it-and-manage-it
#24
REVIEW
Selvakumar Ambika, Padma Lakshmi
Optic neuropathy can be of infectious or non-infectious/idiopathic aetiology. Many infectious organisms can cause optic neuropathy that can be of varied presentation including papillitis, retrobulbar optic neuritis, neuroretinitis, and optic perineuritis. Detailed history, ocular, systemic/neurologic examination along with appropriate laboratory evaluation can help clinicians to identify the infectious agent causing optic neuropathy. In spite of recent advanced techniques in serological testing and molecular diagnostics like polymerase chain reaction (PCR), the identification of these pathogens is still a diagnostic challenge...
June 3, 2024: Eye
https://read.qxmd.com/read/38816570/retinal-macrocysts-in-an-eye-spectacle-configuration
#25
JOURNAL ARTICLE
Yunfei Yang, Sreekala Burgula, Sean Zhou, Anna Few, Francesco Sabatino
No abstract text is available yet for this article.
May 30, 2024: Eye
https://read.qxmd.com/read/38811685/fate-of-trainees-2017-2021
#26
JOURNAL ARTICLE
Zhihang Cheng, Mohammad Zuhair Mustafa
No abstract text is available yet for this article.
May 29, 2024: Eye
https://read.qxmd.com/read/38806699/the-uk-clinical-eye-research-strategy-refreshing-research-priorities-for-clinical-eye-research-in-the-uk
#27
JOURNAL ARTICLE
Rupert R A Bourne, Malik Moledina, Augusto Azuara-Blanco, George M Saleh, James E Self, Sobha Sivaprasad, Srilakshmi M Sharma, Andrew Ross, Rose M Gilbert, Maram E A Abdalla Elsayed, Won Young Moon, Manjo Doug, Pádraig J Mulholland, Alexander C Day, Vito Romano, Geraldine V Hoad, Madina Kara, Ailish Murray, Louise Gow, Faruque Ghanchi, Praveen J Patel, Richard P Gale, Christiana Dinah, Keith Valentine, Cathy Yelf, Vanessa Poustie
OBJECTIVES: To validate and update the 2013 James Lind Alliance (JLA) Sight Loss and Vision Priority Setting Partnership (PSP)'s research priorities for Ophthalmology, as part of the UK Clinical Eye Research Strategy. METHODS: Twelve ophthalmology research themes were identified from the JLA report. They were allocated to five Clinical Study Groups of diverse stakeholders who reviewed the top 10 research priorities for each theme. Using an online survey (April 2021-February 2023), respondents were invited to complete one or more of nine subspecialty surveys...
May 29, 2024: Eye
https://read.qxmd.com/read/38806700/robin-a-randomised-double-masked-placebo-controlled-phase-iia-study-of-the-aoc3-inhibitor-bi-1467335-in-diabetic-retinopathy
#28
JOURNAL ARTICLE
Quan Dong Nguyen, Justis P Ehlers, David S Boyer, Xidong Jin, Andrea Giani, Michael S Ehrlich
OBJECTIVE: To evaluate the safety and efficacy of BI 1467335 in patients with non-proliferative diabetic retinopathy (NPDR). METHODS: ROBIN is a Phase IIa, double-masked, randomised, placebo-controlled study (NCT03238963). Patients with NPDR and without centre-involved diabetic macular oedema were included; all had a best corrected visual acuity letter score of ≥70 Early Treatment Diabetic Retinopathy Study letters in the study eye at screening. Patients received oral BI 1467335 10 mg or placebo once daily for 12 weeks...
May 28, 2024: Eye
https://read.qxmd.com/read/38802486/pushing-the-envelope-the-feasibility-of-using-a-mailed-contrast-sensitivity-test-to-prioritise-cataract-waiting-lists
#29
JOURNAL ARTICLE
Eleonora Bianchi, Peter F Reddingius, Mehal Rathore, Dan Lindfield, David P Crabb, Pete R Jones
BACKGROUND: Cataract waiting lists are growing globally. Pragmatic, cost-effective methods are required to prioritise the most urgent cases. Here we investigate the feasibility of using a third-party pen-and-paper contrast sensitivity, CS, test (SpotChecksTM ), delivered by mail, and performed by patients at home unsupervised, to flag eyes requiring surgery. METHODS: Pen-and-paper CS tests were mailed to 233 people waiting for a cataract assessment, along with a prepaid return envelope (cross-sectional study)...
May 27, 2024: Eye
https://read.qxmd.com/read/38802485/basics-benefits-and-pitfalls-of-pupillometers-assessing-visual-function
#30
REVIEW
Manon Philibert, Dan Milea
Numerous commercially and non-commercially available pupillometers are nowadays able to assess various biological functions in humans, by evaluating pupils' dynamics in response to specific stimuli. However, the use of pupillometers for ophthalmic afferent evaluations (i.e., photoreceptoral responses) in real-world settings is relatively limited. Recent scientific and technological advances, coupled with artificial intelligence methods have improved the performance of such devices to objectively detect, quantify, and classify functional disturbances of the retina and the optic nerve...
May 27, 2024: Eye
https://read.qxmd.com/read/38802484/xr-sans-a-multi-modal-framework-for-analyzing-visual-changes-with-extended-reality-xr-in-spaceflight-associated-neuro-ocular-syndrome-sans
#31
JOURNAL ARTICLE
Ritu Sampige, Joshua Ong, Ethan Waisberg, Nasif Zaman, Prithul Sarker, Alireza Tavakkoli, Andrew G Lee
No abstract text is available yet for this article.
May 27, 2024: Eye
https://read.qxmd.com/read/38789790/improved-feasibility-of-handheld-optical-coherence-tomography-in-children-with-craniosynostosis
#32
JOURNAL ARTICLE
Sohaib R Rufai, Vasiliki Panteli, Robert H Henderson, Catey Bunce, Irene Gottlob, Mervyn G Thomas, Frank A Proudlock, Richard Bowman, Noor Ul Owase Jeelani
No abstract text is available yet for this article.
May 24, 2024: Eye
https://read.qxmd.com/read/38789789/treating-myasthenia-gravis-beyond-the-eye-clinic
#33
REVIEW
Saiju Jacob
Myasthenia gravis (MG) is one of the most well characterised autoimmune disorders affecting the neuromuscular junction with autoantibodies targeting the acetylcholine receptor (AChR) complex. The vast majority of patients present with ocular symptoms including double vision and ptosis, but may progress on to develop generalised fatiguable muscle weakness. Severe involvement of the bulbar muscles can lead to dysphagia, dysarthria and breathing difficulties which can progress to myasthenic crisis needing ventilatory support...
May 24, 2024: Eye
https://read.qxmd.com/read/38789788/managing-idiopathic-intracranial-hypertension-in-the-eye-clinic
#34
JOURNAL ARTICLE
Laura Bonelli, Vaishnavi Menon, Anthony C Arnold, Susan P Mollan
Idiopathic intracranial hypertension (IIH) is a neuro-ophthalmological condition characterised by a raised intracranial pressure and papilloedema that causes disabling headaches. The main risk factors of female sex and living with obesity have been known for some time, however the knowledge of the underlying pathophysiology is evolving. Papilloedema can impact the visual function, and the majority of people are offered acetazolamide. Those with sight threatening disease need urgent management, though there is little high quality evidence to recommend any particular surgical intervention...
May 24, 2024: Eye
https://read.qxmd.com/read/38789787/ocular-injuries-among-patients-with-major-trauma-in-england-and-wales-from-2004-to-2021
#35
JOURNAL ARTICLE
Mohammed Talha Bashir, Omar Bouamra, James F Kirwan, Fiona E Lecky, Rupert R A Bourne
BACKGROUND: Ocular trauma is a significant cause of blindness and is often missed in polytrauma. No contemporary studies report eye injuries in the setting of severe trauma in the UK. We investigated ocular injury epidemiology and trends among patients suffering major trauma in England and Wales from 2004 to 2021. METHODS: We conducted a retrospective study utilising the Trauma Audit and Research Network (TARN) registry. Major trauma cases with concomitant eye injuries were included...
May 24, 2024: Eye
https://read.qxmd.com/read/38789786/accelerated-aging-in-space-and-the-ocular-surface
#36
JOURNAL ARTICLE
Ritu Sampige, Joshua Ong, Ethan Waisberg, John Berdahl, Andrew G Lee
No abstract text is available yet for this article.
May 24, 2024: Eye
https://read.qxmd.com/read/38783086/flicker-electroretinogram-in-preterm-infants
#37
JOURNAL ARTICLE
Aylin F Taner, James V M Hanson, Caroline Weber, Dirk Bassler, Daphne L McCulloch, Christina Gerth-Kahlert
BACKGROUND: Infants born prematurely are at risk of developing retinopathy of prematurity, which is associated with abnormalities in retinal function as measured using electroretinography. The aim of this study was to record non-invasive flicker electroretinograms (ERGs) in preterm infants and compare function of moderate and very or extremely preterm infants. METHODS: In this non-randomized, cross-sectional study, 40 moderate preterm (gestational age (GA) 34 0/7 to 36 6/7 weeks, Group A) and 40 very or extremely preterm infants (GA ≤ 31 weeks, Group B) were recruited for flicker ERG recording through closed eyelids using the RETeval® device and skin electrodes...
May 23, 2024: Eye
https://read.qxmd.com/read/38783085/mog-antibody-associated-optic-neuritis
#38
REVIEW
Niroshan Jeyakumar, Magdalena Lerch, Russell C Dale, Sudarshini Ramanathan
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a demyelinating disorder, distinct from multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MOGAD most frequently presents with optic neuritis (MOG-ON), often with characteristic clinical and radiological features. Bilateral involvement, disc swelling clinically and radiologically, and longitudinally extensive optic nerve hyperintensity with associated optic perineuritis on MRI are key characteristics that can help distinguish MOG-ON from optic neuritis due to other aetiologies...
May 23, 2024: Eye
https://read.qxmd.com/read/38783084/imaging-the-brain-diagnosis-aided-by-structural-features-on-neuroimaging-studies
#39
REVIEW
Sanja Cejvanovic, Zahir Sheikh, Steffen Hamann, Prem S Subramanian
The use of neuroimaging allows the ophthalmologist to identify structural lesions in the orbit or along the neuroaxis that allow for more accurate diagnosis and treatment of patients with neuro-ophthalmic diseases. The primary imaging tools include computed tomography (CT) and magnetic resonance imaging (MRI), both of which can be used to evaluate the brain, spinal cord and canal, and orbits. Neurovascular structures, both arterial and venous, also can be imaged in high resolution with modern CT and MR angiography and CT and MR venography...
May 23, 2024: Eye
https://read.qxmd.com/read/38783083/independent-sector-cataract-training
#40
EDITORIAL
Sarah Maling, Mike Adams
No abstract text is available yet for this article.
May 23, 2024: Eye
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