journal
https://read.qxmd.com/read/38760462/sustained-release-drug-delivery-systems
#1
REVIEW
Rachel Williams, Helen Cauldbeck, Victoria Kearns
The design and development of a sustained-release drug delivery system targeting the administration of active pharmaceutical ingredients (APIs) to the eye could overcome the limitations of topically administered eye drops. Understanding how to modify or design new materials with specific functional properties that promote the attachment and release of specific drugs over longer time periods, alongside understanding clinical needs, can lead to new strategic opportunities to improve treatment options. In this paper we discuss two approaches to the design or modification of materials to produce a sustained therapeutic effect...
May 17, 2024: Eye
https://read.qxmd.com/read/38760461/refractive-shifts-in-astronauts-during-spaceflight-mechanisms-countermeasures-and-future-directions-for-in-flight-measurements
#2
JOURNAL ARTICLE
Kelsey Vineyard, Joshua Ong, Benjamin Soares, Daniela Osteicoechea, Cihan Mehmet Kadipasaoglu, Ethan Waisberg, Alireza Tavakkoli, Gianmarco Vizzeri, Andrew G Lee
No abstract text is available yet for this article.
May 17, 2024: Eye
https://read.qxmd.com/read/38750125/clinical-characteristics-and-aetiology-of-uveitis-in-a-viral-haemorrhagic-fever-zone
#3
JOURNAL ARTICLE
Shiama Balendra, Lloyd Harrison-Williams, Jalikatu Mustapha, Zikan Koroma, Alicious Kamara, Bangi Saradugu, Osman Conteh, Theophilus Kanu, Santigie Kamara, Sheku Alhaji Koroma, Matthew Vandy, Laura Ward, Huachun Wang, Tolulope Fashina, Jessica Shantha, Steven Yeh, Alasdair Kennedy
BACKGROUND/OBJECTIVES: Studies on uveitis in Sierra Leone were conducted prior to the Ebola Virus Disease epidemic of 2013-16, which was associated with uveitis in 20% of survivors. They did not include imaging or investigation of tuberculosis and used laboratory services outside the country. We performed a cross-sectional study on patients presenting with uveitis to establish their clinical characteristics and identify the impact of in-country laboratory diagnoses. METHODS: We invited uveitis cases presenting to Eye Clinics in Sierra Leone from March to September 2022 to participate in the study...
May 15, 2024: Eye
https://read.qxmd.com/read/38745084/the-wisconsin-silicone-oil-study-report-1-anatomical-and-functional-outcomes-of-repair-of-retinal-detachment-with-proliferative-vitreoretinopathy
#4
JOURNAL ARTICLE
Kathleen R Schildroth, Maxwell J Wingelaar, Paul S Boeke, Michael S Ip, Jonathan S Chang, Justin L Gottlieb, T Michael Nork, Kyle Peterson, Michael M Altaweel
BACKGROUND: Silicone oil (SO) is a long-term tamponade for repair of complex retinal pathology but has limitations including late redetachment. This study describes our experience with SO tamponade for repair of retinal detachment with proliferative vitreoretinopathy (PVR), with attention to anatomic and functional outcomes. METHODS: Retrospective consecutive case series of eyes with retinal detachment (RD) complicated by proliferative vitreoretinopathy (PVR) receiving SO tamponade at the University of Wisconsin between 2013 and 2019...
May 14, 2024: Eye
https://read.qxmd.com/read/38745083/multimodal-imaging-in-autosomal-dominant-wolfram-syndrome-and-long-term-follow-up-of-laminations-of-the-outer-plexiform-layer
#5
JOURNAL ARTICLE
Peter Kiraly, Felix F Reichel, M Dominik Fischer
No abstract text is available yet for this article.
May 14, 2024: Eye
https://read.qxmd.com/read/38740963/management-of-treatment-resistant-ocular-hypertension-post-eyecee-one-iol-implantation-an-observational-study
#6
JOURNAL ARTICLE
Osman Younus, Huda Al-Hayouti, Douglas Lyall
No abstract text is available yet for this article.
May 14, 2024: Eye
https://read.qxmd.com/read/38740962/reply-to-letter-regarding-descemet-s-membrane-or-confirmation-of-a-novel-corneal-structure-the-layer-of-dua
#7
LETTER
Yannis Athanasiadis, Michael Tsatsos, Panagiota Ntonti, Eirini-Kanella Panagiotopoulou, Georgios Labiris
No abstract text is available yet for this article.
May 13, 2024: Eye
https://read.qxmd.com/read/38740961/the-central-retinal-thickness-and-its-related-genotype-in-abca4-related-retinopathy
#8
JOURNAL ARTICLE
Yimin Wang, Tong Li, Suqin Yu, Yuanyuan Gong, Min Zhang, Yidong Wu, Wenjia Liu, Junran Sun, Jieqiong Chen, Xiaodong Sun
PURPOSE: To further explore the influence of genotype, including mutation type and structural domain, on the severity of macular atrophy, we measured the central retinal thickness (CRT) in patients with ABCA4-related retinopathy. METHODS: A total of 66 patients were included in the cohort. This was a retrospective investigation. The patients were tested using whole exon sequencing and ophthalmic exams, including slip lamp exams, best-corrected visual acuity, optical coherence tomography, fundus photo, and fundus autofluorescence...
May 13, 2024: Eye
https://read.qxmd.com/read/38740960/factors-affecting-anatomical-and-visual-outcomes-in-terson-syndrome-managed-by-surgery-or-observation
#9
JOURNAL ARTICLE
Beatrice Gallo, Ramy Khader, Julia Fajardo-Sanchez, Paul Sullivan, Evgenia Anikina
OBJECTIVES: To investigate visual outcomes and prognostic factors of patients with Terson syndrome (TS) managed with observation or pars plana vitrectomy (PPV). METHODS: retrospective review of medical records of 117 eyes from 81 patients (43 females) with TS. Main outcome measures were final best corrected visual acuity (BCVA), intraoperative findings and long-term sequelae. RESULTS: 46 (39.3%) eyes were managed conservatively and 71 (60...
May 13, 2024: Eye
https://read.qxmd.com/read/38734747/disease-latency-bias-and-the-protective-effect-of-metformin-against-age-related-macular-degeneration
#10
LETTER
Nicholas Beare
No abstract text is available yet for this article.
May 11, 2024: Eye
https://read.qxmd.com/read/38734746/ocular-biomarkers-useful-incidental-findings-by-deep-learning-algorithms-in-fundus-photographs
#11
JOURNAL ARTICLE
Eve Martin, Angus G Cook, Shaun M Frost, Angus W Turner, Fred K Chen, Ian L McAllister, Janis M Nolde, Markus P Schlaich
BACKGROUND/OBJECTIVES: Artificial intelligence can assist with ocular image analysis for screening and diagnosis, but it is not yet capable of autonomous full-spectrum screening. Hypothetically, false-positive results may have unrealized screening potential arising from signals persisting despite training and/or ambiguous signals such as from biomarker overlap or high comorbidity. The study aimed to explore the potential to detect clinically useful incidental ocular biomarkers by screening fundus photographs of hypertensive adults using diabetic deep learning algorithms...
May 11, 2024: Eye
https://read.qxmd.com/read/38729998/confidence-of-emergency-department-doctors-in-managing-ophthalmic-emergencies-a-systematic-review
#12
JOURNAL ARTICLE
Jessica Mendall, Abraham Tolley, Veronica Parisi, Stella Hornby, Ruth Brown, Victoria Nowak
BACKGROUND: Eye emergencies constitute a significant portion of attendances to general Emergency Departments (EDs) in the UK, therefore it is important to assess the confidence of doctors who work in this setting in managing these potentially sight- and life-threatening presentations. This systematic review aims to assess the confidence of UK doctors working in general EDs in managing ophthalmic emergencies. METHODS: MEDLINE (Ovid), EMBASE (Ovid), ProQuest Central and Web of Science databases and grey literature were searched from inception to 1 October 2022 for publications that (1) featured doctors working in UK general EDs, (2) assessed doctors' confidence in managing ophthalmic emergencies, (3) contained original data, (4) were full-text, and (5) written in English...
May 10, 2024: Eye
https://read.qxmd.com/read/38724703/fungal-keratitis-culture-results-from-a-major-commercial-laboratory
#13
JOURNAL ARTICLE
Kaitlin Benedict, Jeremy A W Gold, Shawn R Lockhart, Dallas J Smith
No abstract text is available yet for this article.
May 9, 2024: Eye
https://read.qxmd.com/read/38724702/relationship-between-macular-perfusion-and-lesion-distribution-in-diabetic-retinopathy
#14
JOURNAL ARTICLE
Navid Manafi, Deniz Oncel, Aditya Verma, Giulia Corradetti, Shin Kadomoto, Alireza Mahmoudi, Ahmed Roshdy Alagorie, Naresh Kumar Yadav, Rajeev R Pappuru, Adnan Tufail, Houri Esmaeilkhanian, Muneeswar G Nittala, Rajiv Raman, Srinivas Sadda
BACKGROUND/OBJECTIVES: To assess the relationship between macular vessel density metrics and foveal avascular zone (FAZ) characteristics on optical coherence tomography angiography (OCTA) and lesion distribution in eyes with diabetic retinopathy (DR). SUBJECTS/METHODS: Patients with DR who underwent both Optos ultrawidefield (UWF) pseudocolor imaging and macular OCTA (Cirrus Angioplex, 6 × 6 mm) were included in this cross-sectional observational study...
May 9, 2024: Eye
https://read.qxmd.com/read/38714837/assessing-the-value-of-the-water-drinking-test-in-glaucoma-a-systematic-review-and-meta-analysis
#15
REVIEW
Eric Jin, Claire Xin Yi Goh, Bjorn Kaijun Betzler, Choon Pooh Heng, Bryan Chin Hou Ang
This systematic review and meta-analysis examines the relationship between intraocular pressure (IOP) parameters derived from the water drinking test (WDT) and diurnal IOP monitoring, and evaluates the reproducibility of the WDT and its association with future glaucomatous visual field (VF) loss. A literature search was performed on PubMed, EMBASE, and Cochrane Library from inception to 31 March 2023. Cohort, cross-sectional and observational studies reporting WDT results in glaucoma patients were included...
May 7, 2024: Eye
https://read.qxmd.com/read/38714836/drug-induced-macular-oedema
#16
JOURNAL ARTICLE
Yoshiyasu Takefuji
No abstract text is available yet for this article.
May 7, 2024: Eye
https://read.qxmd.com/read/38710940/increased-late-onset-glaucoma-risk-following-vitrectomy-for-macular-pucker-or-hole
#17
JOURNAL ARTICLE
Yung-Sung Lee, Yu-Chi Chen, Tsung-En Huang, Chu-Yen Huang, Yih-Shiou Hwang, Wei-Chi Wu, Eugene Yu-Chuan Kang, Kuang-Hung Hsu
OBJECTIVES: The long-term risk of developing glaucoma after vitrectomy remains uncertain. This retrospective population-based cohort study aimed to explore this risk following vitrectomy for macular pucker or hole. METHODS: Utilizing Taiwan's National Health Insurance Research Database (NHIRD), we included patients who were older than 18 years and had undergone vitrectomy surgery between 2011 and 2019. Exclusions were made for patients with prior diagnoses of glaucoma, congenital or secondary glaucoma, as well as those who had received previous vitreoretinal treatments or had undergone multiple vitrectomies...
May 6, 2024: Eye
https://read.qxmd.com/read/38710939/impact-of-treat-and-extend-criteria-on-proportions-that-can-be-extended-after-loading-phase-of-2%C3%A2-mg-aflibercept-therapy-for-neovascular-age-related-macular-degeneration-precise-report-5
#18
JOURNAL ARTICLE
Sridevi Thottarath, Sarega Gurudas, Swati Chandak, Praveen J Patel, Ajay Kotagiri, Ian Pearce, Martin McKibbin, Geeta Menon, Benjamin J L Burton, James Talks, Anna Grabowska, Faruque Ghanchi, Richard Gale, Eleni Karatsai, Shruti Chandra, Sobha Sivaprasad
OBJECTIVE: To study the impact of definitions of various treatment extension criteria on the proportion of patients who could be extended at their first visit after the loading phase of 2 mg aflibercept therapy for neovascular age related macular degeneration (nAMD). METHODS: Patients with nAMD initiated on the loading phase of three intravitreal doses of 2 mg aflibercept in routine clinical practice were recruited from December 2019 to August 2021...
May 6, 2024: Eye
https://read.qxmd.com/read/38710938/response-to-optical-coherence-tomography-biomarkers-in-preterm-infants-with-and-without-retinopathy-of-prematurity-fallacies-and-facts
#19
LETTER
Akash Belenje, Subhadra Jalali
No abstract text is available yet for this article.
May 6, 2024: Eye
https://read.qxmd.com/read/38710937/medications-for-attention-deficit-hyperactivity-disorder-associated-with-increased-risk-of-developing-glaucoma
#20
JOURNAL ARTICLE
Rami Darwich, Mahyar Etminan, Bonnie He, Brennan D Eadie
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) therapies including atomoxetine, methylphenidate, and amphetamines are some of the most prescribed medications in North America. Due to their sympathomimetic action, these drugs are contraindicated in patients with a history of angle closure glaucoma (ACG). This study aims to determine the risk of ACG and open angle glaucoma (OAG) among users of these treatments. METHODS: This is a retrospective cohort study with a case control analysis using the PharMetrics Plus Database (IQVIA, USA)...
May 6, 2024: Eye
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