Michiko Nakaoka, Hideyuki Chiba, Mikio Kobayashi, Naoya Okada, Jun Arimoto, Jun Tachikawa, Keiichi Ashikari, Hiroki Kuwabara
INTRODUCTION: Despite advances in endoscopic treatment, patients with serrated polyposis syndrome (SPS) occasionally require surgery due to numerous or unresectable polyps, recurrence, and treatment-related adverse events. METHODS: We retrospectively evaluated 43 patients with SPS undergoing diagnosis and treatment at Omori Red Cross Hospital from 2011 to 2022. Resection of all polyps ≥ 3 mm in size was planned during the clearing phase; endoscopic control was defined as complete, endoscopic polyp removal...
November 15, 2023: Digestive Diseases
Sebastian M Staubli, Shahi Ghani, Harriet Walker, Giuseppe K Fusai, Dimitri A Raptis
INTRODUCTION: Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known. METHODS: A systematic review of the information about CP available online using the search term "chronic pancreatitis" in using the search engine Google has been conducted. The quality of the top 100 websites returned from this search term were analysed using the validated Ensuring Quality Information for Patients (EQIP) tool (maximum score 36)...
November 13, 2023: Digestive Diseases
Yoshimasa Miura, Hiroyuki Osawa, Kentaro Sugano
BACKGROUND: The main therapeutic modality of early upper gastrointestinal neoplasms has shifted from surgery to endoscopic therapy. The role of endoscopy has also expanded not only for more accurate diagnosis of neoplasms but for the determination of extent and depth of neoplasms with a combination of multiple electronically modified images acquired with image-enhanced endoscopy (IEE) for assessing the feasibility of endoscopic treatment. SUMMARY: These IEE with or without magnifying endoscopy including narrow band imaging (NBI), blue LASER imaging (BLI) and linked color imaging (LCI) using narrow-band light, has greatly changed the diagnosis for upper gastrointestinal neoplasms...
November 10, 2023: Digestive Diseases
Ai Fujimoto, Tsuyoshi Ishii, Tomomi Hiraoka, Yurie Ogawa, Nobuyuki Sato, Naoko Watanabe, Akira Nogami, Keita Soejima, Kodai Fujii, Aya Hojo, Ryo Shimizu, Yusuke Nishikawa, Nobuhiro Dan, Syunsuke Kobayashi, Yosuke Okamoto, Ryusuke Kimura, Kazuhisa Yamaguchi, Masashi Ono, Takahito Toba, Takahisa Matsuda
INTRODUCTION: We investigated the hemostatic effect and safety of a hemostatic peptide solution for the treatment of gastrointestinal bleeding requiring emergency endoscopy. METHODS: We retrospectively examined the patient backgrounds, hemostatic results, and procedural safety in patients who were treated with a hemostatic peptide solution for hemostasis during emergency endoscopies for gastrointestinal bleeding. All hemostatic procedures were performed by non-expert physicians with less than 10 years of endoscopic experience...
November 10, 2023: Digestive Diseases
Stephanie Hawkins, Meghali Nighot, Shannon Dalessio, Junjia Zhu, Nathan Morris, Kofi Clarke
INTRODUCTION: We sought to evaluate the effect of PPI (proton pump inhibitor) use on the development and severity of iron deficiency anemia (IDA) in celiac disease (CD). METHODS: We conducted a retrospective chart review of patients older than 18 years of age at Milton S. Hershey Medical Center who were diagnosed with CD. We analyzed four cohorts of celiac patients (1) IDA diagnosis with PPI usage, (2) no IDA diagnosis with PPI usage, (3) IDA diagnosis with no PPI usage, and (4) no IDA diagnosis with no PPI usage...
November 8, 2023: Digestive Diseases
Elisabeth Fabian, Oliver Königsbrügge, Guenter J Krejs, Matthias Unseld
BACKGROUND: Palliative care patients frequently present with cinically significant gastrointestinal bleeding. Due to the existence of confounding comorbidities and an often remarkably reduced state of general health, the management of gastrointestinal bleeding in this population is often challenging. SUMMARY: This review summarises and discusses the role of thalidomide in gastrointestinal bleeding with a special focus on palliative care patients. In addition, an illustrative case report is presented...
October 26, 2023: Digestive Diseases
Zhiyu Yan, Long Zou, Qiang Wang, Shengyu Zhang, Yuhao Jiao, Dingkun Xiong, Qingwei Jiang, Tao Guo, Yunlu Feng, Dongsheng Wu, Yamin Lai, Xuemin Yan, Tao Xu, Weigang Fang, Xi Wu, Weixun Zhou, Aiming Yang
[Introduction] Early gastric cancer with current Helicobacter pylori infection (HpC-EGC) is common but still unclear whether H. pylori eradication therapy (Hp-ET) or endoscopic submucosal dissection (ESD) should be performed first. We evaluated Hp-ET's short-term effects on horizontal boundary delineations of HpC-EGC in ESD. [Methods] Prospectively enrolled HpC-EGC patients were randomly assigned to eradication or control groups. Operation scopes of HpC-EGC lesion were delineated with marking dots at 5 mm out of the endoscopic demarcation line by an independent endoscopist, unaware of eradication status, before formal circumferential incision...
October 13, 2023: Digestive Diseases
Menghan Su, Ting Ye, Wei Wu, Zheyue Shu, Qi Xia
Chronic hepatitis B (CHB) infection is still a major global public health problem, with nearly two billion patients. Although antiviral drugs can inhibit viral replication and reduce hepatitis B virus (HBV) related complications, it is difficult to achieve clinical endpoints due to drug resistance. Immune checkpoint inhibitors (ICIs) are an important strategy to reverse T-cell exhaustion, and rebuilding an effective functional T-cell response is a promising immunomodulatory approach for CHB patients. However, there are still many controversies in the application of ICIs in treating patients with CHB...
October 11, 2023: Digestive Diseases
Qiyun Xiao, Maximilian Eckardt, Awsan Mohamed, Helmut Ernst, Alexander Behrens, Nils Homann, Thomas Hielscher, Georg Kähler, Matthias Ebert, Sebastian Belle, Tianzuo Zhan
Introduction Postprocedural bleeding is a major adverse event after endoscopic resection of colorectal lesions, but the optimal surveillance time after endoscopy is unclear. In this study, we determined onset time and characteristics of postprocedural bleeding events. Methods We retrospectively screened patients who underwent endoscopic resection of colorectal lesions at three German hospitals between 2010 and 2019 for postprocedural bleeding events using billing codes. Only patients who required re-endoscopy were included for analysis...
October 9, 2023: Digestive Diseases
Hirokazu Saito, Hajime Iwasaki, Hisashi Itoshima, Yoshihiro Kadono, Takashi Shono, Kentaro Kamikawa, Atsushi Urata, Jiro Nasu, Masayoshi Uehara, Ikuo Matsushita, Tatsuyuki Kakuma, Shunpei Hashigo, Shuji Tada
UNLABELLED: BIntroduction: Evidence for the outcomes of endoscopic retrograde cholangiopancreatography (ERCP) between a basket catheter and a balloon catheter for endoscopic common bile duct stone (CBDS) removal is lacking. This study aimed to compare ERCP outcomes using a basket catheter and a balloon catheter for endoscopic CBDS removal. METHODS: This multicenter retrospective study included 904 consecutive patients with native papilla who underwent endoscopic stone removal for CBDS ≤10 mm using a basket catheter and/or a balloon catheter at three institutions in Japan...
October 7, 2023: Digestive Diseases
Nimish Vakil
BACKGROUND: The last 40 years have seen a remarkable change in our understanding of reflux disease. SUMMARY: These changes encompass disease definition and impact, pathophysiology, diagnostic testing, regulatory oversight of clinical trials, pharmacotherapy, endoscopic, and surgical treatment. We have also seen a number of promising therapies fail. KEY MESSAGES: The future holds the promise of further advances. Adaptive artificial intelligence will take over diagnostics in manometry and pH impedance testing and patient-driven outcomes may be changed by interactions with artificial intelligence rather than humans...
September 29, 2023: Digestive Diseases
Haruki Uojima, Yoshihiko Sakaguchi, Kazuyoshi Gotoh, Takashi Satoh, Hisashi Hidaka, Akira Take, Kazue Horio, Shunji Hayashi, Chika Kusano
BACKGROUND: Limited data are available on the correlation between microbial communities and metabolic dysfunction-associated fatty liver disease (MAFLD). OBJECTIVE: This study aimed to evaluate the influence of MAFLD on distinct microbial communities. METHODS: We recruited 43 patients with a nonviral liver disease. Enrolled patients were divided into two groups according to MAFLD criteria. The fecal microbial composition was evaluated using the variable V3-V4 region of the 16S ribosomal RNA region, which was amplified using polymerase chain reaction...
September 28, 2023: Digestive Diseases
Mira M Yang, Keith Usiskin, Harris A Ahmad, Shabana Ather, Antoine Sreih, James B Canavan, Francis A Farraye, Christopher Ma
BACKGROUND: High-quality colonoscopic surveillance can lead to earlier and increased detection of colorectal neoplasia in patients with inflammatory bowel disease (IBD). In IBD clinical trials, endoscopy is used to assess mucosal disease activity before and after treatment, but also provides an opportunity to surveil for colorectal neoplasia during follow-up. SUMMARY: Best practices for colorectal cancer identification in IBD clinical trials require engagement and collaboration between the clinical trial sponsor, site endoscopist and/or principal investigator, and central read team...
September 27, 2023: Digestive Diseases
Haitao Li, Saihua Yu, Lihong Chen, Hongzhi Liu, Conglong Shen
BACKGROUND: Liver transplantation (LT) is the only effective therapy for end-stage liver diseases, but some patients usually present with serious infection and immune rejection. Those with immune rejection require long-term administration of immunosuppressants, leading to serious adverse effects. Mesenchymal stem cells (MSCs) have various advantages in immune regulation and are promising drugs most likely to replace immunosuppressants. SUMMARY: This study summarized the application of MSCs monotherapy, its combination with immunosuppressants, MSCs genetic modification, and MSCs derivative therapy (cell-free therapy) in LT...
September 20, 2023: Digestive Diseases
Shinya Furukawa, Yasunori Yamamoto, Teruki Miyake, Osamu Yoshida, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Yuka Saeki, Yoichi Hiasa
INTRODUCTION: There is evidence regarding the association between dysmenorrhea and irritable bowel syndrome (IBS), although it is lacking in the Asian population. Therefore, the purpose of this study was to investigate the association between menstrual status and IBS in a young Japanese. METHODS: Overall, 4693 female college students were included in the analysis of this study. Information regarding lifestyle habits, menstrual status (irregularity, pain severity, and medication), and IBS (Rome III criteria) was obtained using a self-reported questionnaire...
September 14, 2023: Digestive Diseases
Darren Tan, Kai En Chan, Zhen Yu Wong, Cheng Han Ng, Jieling Xiao, Wen Hui Lim, Phoebe Tay, Ansel Tang, Clarissa Elysia Fu, Mark Muthiah, Benjamin Nah, Eunice X Tan, Margaret L P Teng, Mohammad Shadab Siddiqui, Yock Young Dan, Seng Gee Lim, Rohit Loomba, Daniel Q Huang
INTRODUCTION: The etiology of liver diseases has changed significantly, but its impact on the comparative burden of cirrhosis between males and females is unclear. We estimated sex differences in the burden of cirrhosis across 204 countries and territories from 2010-2019. METHODS: We analyzed temporal trends in the burden of cirrhosis using the methodology framework of the 2019 Global Burden of Disease study. We estimated annual frequencies and age-standardized rates (ASRs) of cirrhosis incidence, death, and disability-adjusted life-years (DALYs) by sex, region, country, and etiology...
September 13, 2023: Digestive Diseases
Dominika Boldovjakova, Islam El-Abbassy, Inari Alarcon, Mamoun El-Saify, Juen Hao Chan, Morag Harley, Craig Parnaby, Angus Watson, George Ramsay
INTRODUCTION: Inflammatory bowel disease (IBD) often requires surgical resection, such as subtotal colectomy operations to alleviate symptoms. However, IBD also has an inherently increased risk of colorectal dysplasia and cancer. Despite the well-accepted surveillance guidelines for IBD patients with an intact colon, contemporaneous decision-making models on rectal stump surveillance is sparse. This study looks at the fate of rectal stumps in IBD patients following subtotal colectomy...
September 8, 2023: Digestive Diseases
Junnosuke Hayasaka, Daisuke Kikuchi, Naoki Ishii, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Jun Omori, Takashi Ikeya, Taiki Aoyama, Naoyuki Tominaga, Yoshinori Sato, Takaaki Kishino, Tsunaki Sawada, Masaki Murata, Akinari Takao, Kazuhiro Mizukami, Ken Kinjo, Shunji Fujimori, Takahiro Uotani, Minoru Fujita, Hiroki Sato, Sho Suzuki, Toshiaki Narasaka, Tomohiro Funabiki, Yuzuru Kinjo, Akira Mizuki, Shu Kiyotoki, Tatsuya Mikami, Ryosuke Gushima, Hiroyuki Fujii, Yuta Fuyuno, Naohiko Gunji, Yosuke Toya, Kazuyuki Narimatsu, Noriaki Manabe, Koji Nagaike, Tetsu Kinjo, Yorinobu Sumida, Sadahiro Funakoshi, Kiyonori Kobayashi, Tamotsu Matsuhashi, Yuga Komaki, Kuniko Miki, Kazuhiro Watanabe, Hiroyuki Odagiri, Shu Hoteya, Mitsuru Kaise, Naoyoshi Nagata
Introduction Weekend admissions showed increased mortality in several medical conditions. This study aimed to examine the weekend effect on acute lower gastrointestinal bleeding (ALGIB) and its mortality and other outcomes. Methods This retrospective cohort study (CODE BLUE-J Study) was conducted at 49 Japanese hospitals between January 2010 and December 2019. In total, 8120 outpatients with acute hematochezia were enrolled and divided into weekend admissions and weekday admissions groups. Multiple imputation (MI) was used to handle missing values, followed by propensity score matching (PSM) to compare outcomes...
September 5, 2023: Digestive Diseases
Guillermo Bastida Paz, Olga Merino Ochoa, Mariam Aguas Peris, Manuel Barreiro-de Acosta, Yamile Zabana, Daniel Ginard Vicens, Daniel Ceballos Santos, Fernando Muñoz Núñez, David Monfort I Miquel, Ignacio Catalán-Serra, Valle García Sánchez, Carmen Loras Alastruey, Alfredo Lucendo Villarín, Jose Maria Huguet, Cristóbal de la Coba Ortiz, Xavier Aldeguer Manté, Antonio Palau Canós, Eugeni Domènech Morral, Pilar Nos
BACKGROUND: Crohn's disease (CD) is characterized by the development of complications over the course of the disease. It is crucial to identify predictive factors of disabling disease, in order to target patients for early intervention. We evaluated risk factors of disabling CD and developed a prognostic model. METHODS: In total, 511 CD patients were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to identify demographic, clinical, and biological risk factors...
August 23, 2023: Digestive Diseases
Theodoros Androutsakos, Konstantinos Dimitriadis, Konstantinos Revenas, Chrysovalantis Vergadis, Dimitrios-Dorotheos Papadakis, Stratigoula Sakellariou, Christos Vallilas, Gregorios Hatzis
INTRODUCTION: A variety of liver disorders are associated with characteristic histopathological findings that help in their diagnosis and treatment. However, percutaneous liver biopsy (PLB) is prone to limitations and complications. We evaluated all PLBs done in our hospital in a 13-year period, aiming to assess PLB's utility and complications. METHODS: All PLBs conducted in an internal medicine department of a tertiary university hospital in Athens, Greece, during a 13-year period were reviewed...
August 23, 2023: Digestive Diseases
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