Roger Scherer, Philipp Schreiner, Jean-Benoit Rossel, Thomas Greuter, Emanuel Burri, Catherine Saner, Christoph Schlag, Ekaterina Safroneeva, Alain Schoepfer, Alex Straumann, Luc Biedermann
INTRODUCTION: There is a complex interrelationship between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) potentially promoting the occurrence and modulating severity of each other reciprocally. Presence of Barrett's Esophagus (BE) is a defining factor for the diagnosis of GERD. While several studies investigated the potential impact of concomitant GERD on the presentation and course of EoE, little is known with regards to BE in EoE patients. METHODS: We analyzed prospectively collected clinical, endoscopic and histological data from patients enrolled in the Swiss Eosinophilic Esophagitis Cohort Study (SEECS) regarding differences between EoE patients with (EoE/BE+) vs...
May 24, 2023: Digestive Diseases
Kosuke Nomura, Shu Hoteya, Daisuke Kikuchi, Yusuke Kawai, Yorinari Ochiai, Takayuki Okamura, Yugo Suzuki, Junnosuke Hayasaka, Yutaka Mitsunaga, Masami Tanaka, Kazuhiro Fuchinoue, Hiroyuki Odagiri, Satoshi Yamashita, Akira Matsui
[Objectives] To clarify characteristics of metachronous endoscopic curability C2 cancer (eCura C2) during post-endoscopic submucosal dissection (ESD) follow-up. [Methods] Of 4355 gastric lesions treated by ESD at our hospital during 2005-2021, 657 were metachronous. After excluding lesions found 2 years since the prior examination or in the gastric remnant, the remaining 515 were analyzed. [Study 1] We compared 35 eCura C2 cancers and 480 eCura A-C1 cancers. [Study 2] Endoscopic findings of the 35 lesions were examined to determine why they had been missed...
May 15, 2023: Digestive Diseases
Junnosuke Hayasaka, Satoshi Yamashita, Akira Matsui, Yusuke Kawai, Yorinari Ochiai, Takayuki Okamura, Yugo Suzuki, Yutaka Mitsunaga, Kosuke Nomura, Masami Tanaka, Kazuhiro Fuchinoue, Hiroyuki Odagiri, Daisuke Kikuchi, Yutaka Takazawa, Shu Hoteya
Background Cold snare polypectomy is a high-risk endoscopic procedure with a low delayed post-polypectomy bleeding rate. However, it is unclear whether delayed post-polypectomy bleeding rates increase during continuous antithrombotic treatment. This study aimed to determine the safety of cold snare polypectomy during continuous antithrombotic treatment. Methods This single-center, retrospective cohort study enrolled patients who underwent cold snare polypectomy during antithrombotic treatment between January 2015 and December 2021...
May 15, 2023: Digestive Diseases
Paola Parente, Federica Grillo, Alessandro Vanoli, Maria Cristina Macciomei, Maria Raffaella Ambrosio, Nunzia Scibetta, Emanuela Filippi, Ivana Cataldo, Luigi Baron, Giuseppe Ingravallo, Gerardo Cazzato, Laura Melocchi, Barbara Liserre, Carla Giordano, Graziana Arborea, Emanuela Pilozzi, Antonio Scapinello, Maria Costanza Aquilano, Roberta Gafà, Serena Battista, Luca Dal Santo, Michela Campora, Francesco Giuseppe Carbone, Chiara Sartori, Stefano Lazzi, Ester Hanspeter, Valentina Angerilli, Luca Mastracci, Matteo Fassan
BACKGROUND: The DNA Mismatch repair (MMR) system is a highly preserved protein complex recognizing short insertions, short deletions and single base mismatches during DNA replication and recombination. MMR protein status is identified using immunohistochemistry (IHC). Deficit in one or more MMR proteins, configuring deficient MMR status (dMMR), leads to frameshift mutations particularly clustered in microsatellite repeats. Thus, microsatellite instability (MSI) is the epiphenomenon of dMMR...
May 15, 2023: Digestive Diseases
Jingxuan Quek, Darren Jun Hao Tan, Kai En Chan, Wen Hui Lim, Cheng Han Ng, Yi Ping Ren, Teng Kiat Koh, Readon Teh, Jieling Xiao, Clarissa Fu, Nicholas Syn, Margaret Teng, Mark Muthiah, Kathryn Fowler, Claude B Sirlin, Rohit Loomba, Daniel Q Huang
INTRODUCTION: To achieve early detection and curative treatment options, surveillance imaging for hepatocellular carcinoma (HCC) must remain of quality and without substantial limitations in liver visualization. However, the prevalence of limited liver visualisation during HCC surveillance imaging has not been systematically assessed. Utilizing a systematic review and meta-analytic approach, we aimed to determine the prevalence of limited liver visualization during HCC surveillance imaging...
May 11, 2023: Digestive Diseases
Tiago Capela, Tiago Cúrdia Gonçalves, Bruno Rosa, José Cotter
It's not mentioned in author guidelines' section that is mandatory to write an abstract for a letter to the editor.
April 11, 2023: Digestive Diseases
Kozue Kakizoe, Takehiro Torisu, Yutaro Ihara, Noboru Harada, Tomoharu Yoshizumi, Shin Fujioka, Masahiro Kondo, Takanari Kitazono
Introduction The proportion of gastroduodenal ulcers caused by drugs is increasing. However, the risk of gastroduodenal ulcer from drugs other than non-steroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin (LDA) is unclear. An association between immunosuppressive drugs and gastroduodenal ulcers has been suggested. We aimed to identify the immunosuppressive drugs and clinical characteristics associated with gastroduodenal ulcers in post-liver transplant patients. Methods The study investigated 119 patients who underwent esophagogastroduodenoscopy after liver transplantation and two patients were excluded...
April 5, 2023: Digestive Diseases
Si-Qi Wang, Yong-Qiang Zhan, Xuan Hu, Yu-Pei Zhuang, Hong-Qian Liu, Ming-Fan Hong, Hao-Jie Zhong
INTRODUCTION: Anemia is a common manifestation of chronic liver diseases. It is a predictor of severe disease, a high risk of complications, and poor outcomes in various liver diseases. However, it remains unclear whether anemia serves as a similar indicator in patients with Wilson disease (WD). Therefore, this study aimed to investigate the relationship between anemia and severity, hepatic complications, and the progression of WD. METHODS: Medical data were collected retrospectively from January 1, 2016, to December 31, 2020...
April 5, 2023: Digestive Diseases
Qing-Yun Zhu, Ruo-Meng Li, Yun-Peng Zhu, Dong-Liang Hao, Yan Liu, Jing Yu, Xue Yang, Yu-Shi Zhang, Tian-Jiao Lin, Xu Yan, Jian-Xin Zuo, Xin-Ting Pan
BACKGROUND: Infected pancreatic necrosis (IPN) accounts for 30% mortality in severe acute pancreatitis (SAP). Early prediction of IPN occurrence is critical for prophylactic measures to be taken. This study aimed to evaluate the predicting value for IPN of combined markers at early stages of SAP. METHODS: The clincial records of 324 SAP patients admitted within 48 hours after disease onset were retrospectively analyzed. As potential predictors, the neutrophil to lymphocyte ratio (NLR), blood procalcitonin concentration (PCT) on the 1st, 4th and 7th day post admission, as well as modified computerized tomography severity index (MCTSI) on the 5 - 7th day post admission, were extracted...
March 30, 2023: Digestive Diseases
Yasuhiko Hamada, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Yuhei Umeda, Yohei Ikenoyama, Hiroki Yukimoto, Junya Tsuboi, Reiko Yamada, Misaki Nakamura, Hayato Nakagawa
INTRODUCTION: Endoscopic submucosal dissection (ESD) for superficial esophageal cancer is technically challenging, and research on predictive factors related to the difficulty in the procedure is limited. This study aimed to investigate the factors predicting the difficulty in esophageal ESD. METHODS: This retrospective study analyzed 303 lesions treated at our institution between April 2005 and June 2021. The following 13 factors were evaluated: sex, age, tumor location, tumor localization, macroscopic type, tumor size, tumor circumference, preoperative diagnosis of histological type, preoperative diagnosis of invasion depth, previous radiotherapy for esophageal cancer, metachronous lesion located close to post ESD scar, operator's skill, and use of a clip-and-thread traction method...
March 29, 2023: Digestive Diseases
Yao-Chun Hsu
Chronic liver disease (CLD) affects approximately 1.5 billion people around the world.1 Non-alcoholic fatty liver disease (NAFLD) is the most common CLD that accounts for 59% of prevalent cases, followed by hepatitis B virus (HBV) infection (29%) and hepatitis C virus infection (9%).2 CLD is a silent killer characterized by insidious progression in hepatic necroinflammation and fibrosis that can culminate in cirrhosis and increase the risk of primary liver cancer. According to the Global Burden of Disease study, there were 2...
March 28, 2023: Digestive Diseases
Jerrald Lau, Ning-Qi Pang, Chermaine Ang, Ker-Kan Tan
Background Colonoscopy is a commonly performed procedure but most patients will not actually be found with colorectal cancer. Subsequent face-to-face consultations to explain post-colonoscopy findings are common despite the time and cost-saving benefits of teleconsultation, especially in a post-COVID-19 era. This exploratory retrospective study examined the proportion of post-colonoscopy follow-up consultations that could have been converted to teleconsultation within a tertiary hospital in Singapore. Methods A retrospective cohort of all patients who underwent colonoscopy in the institution from July to September 2019 was identified...
March 24, 2023: Digestive Diseases
Elizabeth M Garcia, Sanjna N Nerurkar, Eunice X Tan, Shaun Ys Tan, Ern-Wei Peck, Sabrina Xz Quek, Readon Teh, Margaret Teng, Andrew Tran, Ee Jin Yeo, Michael Le, Connie Wong, Ramsey Cheung, Daniel Q Huang
BACKGROUND & AIMS: Due to ageing of the global population, hepatocellular carcinoma (HCC) is increasingly common among elderly patients, but outcomes after curative hepatic resection are unclear. Using a metanalytic approach, we aimed to estimate overall survival (OS), recurrence free survival (RFS) and complication rates in elderly HCC patients undergoing resection. METHODS: We searched PubMed, Embase, and Cochrane databases from inception to Nov 10, 2020 for studies reporting outcomes in elderly (age ≥ 65 years) patients with HCC undergoing curative surgical resection...
March 13, 2023: Digestive Diseases
Chenxiao Gan, Xueping Wu, Yu Shen, Zhongsheng Cao, Jiyong Ji, Wensheng Pan
BACKGROUND: Helicobacter pylori infection is strongly associated with gastric cancer. However, there is currently no consensus on the association between H. pylori and gastric cancer prognosis. METHODS: A systematic search was conducted on studies in PubMed, EMBASE, and Web of Science up to March 10, 2022. The quality of all included studies was assessed using the Newcastle-Ottawa Scale. The hazard ratio (HR) and its 95% confidence interval (95%CI) were extracted to analyze the association between H...
March 10, 2023: Digestive Diseases
Lea U Krauß, Andreas-M Brosig, Sophie Schlosser, Vlad Pavel, Alexander Mehrl, Karsten Gülow, Arne Kandulski, Martina Müller, Stephan Schmid
BACKGROUND: Acute severe pancreatitis is associated with high morbidity and mortality. Hypertriglyceridemia is the third most common cause of acute pancreatitis and higher triglyceride levels increase the risk for severe acute pancreatitis. Plasma exchange is an effective treatment method to lower triglycerides. Our study aimed to investigate the efficiency of plasma exchange as a treatment option for acute hypertriglyceridemia-induced pancreatitis (HTGP), the impact on mortality assessed by the SOFA-, SAPS II-, BISAP Score, Ranson's, and Glasgow-Imrie Criteria as well as the overall length of stay in hospital and ICU...
March 4, 2023: Digestive Diseases
Adam Saleh, Shyon Parsa, Manuel Garza, Eamonn M M Quigley, Bincy P Abraham
BACKGROUND: Considerable research supports an important role for the microbiome and/or microbiome-host immune system interactions in the pathogenesis of inflammatory bowel disease (IBD). Consequently, microbiota-modulating interventions, such as fecal microbiota transplantation (FMT), have attracted interest in the management of IBD, including ulcerative colitis (UC). SUMMARY: While the clinical response to FMT in UC has varied between different studies, results to date may offer guidance towards optimal use of FMT...
March 1, 2023: Digestive Diseases
Ja Eun Koo, Hye-Sook Chang, Hye Won Park, Sungwon Park, Inyoung Bae, Ji Young Lee, Jaewon Choe
BACKGROUND: Abdominal obesity increases the risk of gastroesophageal reflux disease (GERD). This study aimed to determine the association between GERD and abdominal fat area quantified by computed tomography (CT). METHODS: We analyzed the effect of abdominal fat area on gastroesophageal reflux symptoms and erosive esophagitis using logistic regression models in 5,338 participants who underwent abdominal fat measurement CT and screening esophagogastroduodenoscopy...
February 24, 2023: Digestive Diseases
Se Peng, Qingrong Wu, Xiaoting Huang, Xuehua He, Zhong Li, Jianfeng Xu, Lei Wang, Jialing Zhuang
BACKGROUND: The assessment of liver fibrosis has been a critical component in the clinical management of liver diseases. We performed a meta-analysis to evaluate serum Golgi protein 73 (GP73) in the diagnosis of liver fibrosis. METHODS: A literature search was performed in eight databases until July 13, 2022. We searched strictly studies according to inclusion and exclusion criteria, extracted data, and than assessed quality. We pooled the sensitivity, specificity and other diagnostic estimates of serum GP73 to assess liver fibrosis...
February 22, 2023: Digestive Diseases
Yugo Suzuki, Kosuke Nomura, Akira Matsui, Daisuke Kikuchi, Kenichi Ohashi, Shu Hoteya
INTRODUCTION: Esophageal cancers other than two types, squamous cell carcinoma (SCC) and adenocarcinoma, are commonly referred to as special type of esophageal cancer (STEC). Studies on STECs have been limited because of its low prevalence. Therefore, we aimed to clarify the clinicopathological findings and the long-term outcomes of STECs that were managed with ESD. METHODS: We reviewed 713 patients with 1089 lesions who underwent ESD for primary esophageal cancer except Barrett's esophageal cancer...
February 9, 2023: Digestive Diseases
Jun Takada, Yukari Uno, Koji Yamashita, Masamichi Arao, Masaya Kubota, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu
BACKGROUND: Cecal intubation during colonoscopy is difficult to achieve in patients with severe sigmoid adhesions. This retrospective observational study assessed the efficacy of using a gastroscope for colonoscopy in patients with severe sigmoid adhesions. Furthermore, the ability of computed tomography (CT) to predict the possibility of cecal intubation using a gastroscope was examined. METHODS: A total of 1,626 patients who underwent colonoscopy for total colon observation by one endoscopist were enrolled...
February 3, 2023: Digestive Diseases
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