Paola Parente, Federica Grillo, Alessandro Vanoli, Maria Cristina Macciomei, Maria Raffaella Ambrosio, Nunzia Scibetta, Emanuela Filippi, Ivana Cataldo, Luigi Baron, Giuseppe Ingravallo, Gerardo Cazzato, Laura Melocchi, Barbara Liserre, Carla Giordano, Graziana Arborea, Emanuela Pilozzi, Antonio Scapinello, Maria Costanza Aquilano, Roberta Gafà, Serena Battista, Luca Dal Santo, Michela Campora, Francesco Giuseppe Carbone, Chiara Sartori, Stefano Lazzi, Ester Hanspeter, Valentina Angerilli, Luca Mastracci, Matteo Fassan
BACKGROUND: The DNA Mismatch repair (MMR) system is a highly preserved protein complex recognizing short insertions, short deletions and single base mismatches during DNA replication and recombination. MMR protein status is identified using immunohistochemistry (IHC). Deficit in one or more MMR proteins, configuring deficient MMR status (dMMR), leads to frameshift mutations particularly clustered in microsatellite repeats. Thus, microsatellite instability (MSI) is the epiphenomenon of dMMR...
May 15, 2023: Digestive Diseases