journal
https://read.qxmd.com/read/38391160/research-prospects-for-kidney-xenotransplantation-a-bibliometric-analysis
#1
JOURNAL ARTICLE
Shujun Yang, Mingtao Zhang, Hao Wei, Bin Zhang, Jiang Peng, Panfeng Shang, Shengkun Sun
BACKGROUND: Xenograft kidney transplantation has been receiving increasing attention. The purpose of this study is to use bibliometric analysis to identify papers in this research field and explore their current status and development trends. METHODS: Using the data in the Web of Science core database from Clarivate Analytics as the object of study, we used 'TS = Kidney OR Renal AND xenotransplantation' as the search term to find all literature from 1980 to 2 November 2022...
February 23, 2024: Renal Failure
https://read.qxmd.com/read/38390828/association-between-the-levels-of-urinary-cell-cycle-biomarkers-and-non-recovery-of-renal-function-among-critically-ill-geriatric-patients-with-acute-kidney-injury
#2
JOURNAL ARTICLE
Li Cheng, Hui-Miao Jia, Xi Zheng, Yi-Jia Jiang, Xin Xin, Wen-Xiong Li
The lack of early renal function recovery among geriatric patients with acute kidney injury (AKI) in the intensive care unit (ICU) is a commonly observed and acknowledged poor prognostic factor, especially for older adults. However, no reliable prognostic biomarker is available for identifying individuals at risk of renal non-recovery or mortality in older adults. In this prospective observational cohort study, we enrolled critically ill older adults (aged ≥ 60 years) with AKI from the ICU and followed their disease progression...
February 23, 2024: Renal Failure
https://read.qxmd.com/read/38538321/comprehensive-analysis-of-cuproptosis-related-genes-in-immune-infiltration-and-development-of-a-novel-diagnostic-model-for-acute-kidney-injury
#3
JOURNAL ARTICLE
Yajing Li, Yingxue Ding
BACKGROUND: Acute kidney injury (AKI) represents a diverse range of conditions characterized by high incidence and mortality rates, and it is mainly associated with immune-mediated mechanisms and mitochondrial metabolism dysfunction. Cuproptosis, a recently identified form of programmed cell death dependent on copper, is closely linked to mitochondrial respiration and contributes to various diseases. Our study aimed to investigate the involvement of cuproptosis-related genes (CRGs) in AKI...
December 2024: Renal Failure
https://read.qxmd.com/read/38527916/rfxcas13d-mediated-inhibition-of-circ1647-alleviates-renal-fibrosis-via-pi3k-akt-signaling-pathway
#4
JOURNAL ARTICLE
Yufang Ni, Hongmin Zhang, Qianwen Xian, Wenjie Qin, Hongwei Su, Li Wang, Jianchun Li
BACKGROUND: Circular RNAs ( CircRNAs ) have been shown to be involved in the development of chronic kidney disease (CKD). This study aimed to investigate the role of Circ1647 in renal fibrosis, which is a hallmark of CKD. METHODS: In this study, we established a unilateral ureteral obstruction (UUO) model and delivered Circ1647 RfxCas13d knockdown plasmid into renal parenchymal cells via retrograde injection through the ureter followed by electroporation. After that, the pathological changes were determined by Hematoxylin and Eosin...
December 2024: Renal Failure
https://read.qxmd.com/read/38522955/effect-of-angiotensin-converting-enzyme-inhibitors-versus-that-of-angiotensin-receptor-blockers-on-survival-in-patients-undergoing-hemodialysis-a-nationwide-observational-cohort-study
#5
JOURNAL ARTICLE
Seok Hui Kang, Gui Ok Kim, Bo Yeon Kim, Eun Jung Son, Jun Young Do
BACKGROUND: This study aimed to evaluate the patient survival rates based on the use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) in a large cohort of patients undergoing maintenance hemodialysis (HD). METHODS: Data from a national HD quality assessment program were used in this retrospective study. The patients were classified into four groups based on the use of renin-angiotensin system blockers (RASBs) as follows: No group, patients without a prescription of any anti-hypertensive drugs including RASBs; Other group, patients with a prescription of anti-hypertensive drugs excluding RASBs; ACEI group, patients with a prescription of an ACEI; and ARB group, patients with a prescription of an ARB...
December 2024: Renal Failure
https://read.qxmd.com/read/38522954/the-association-between-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-chronic-kidney-disease-in-a-chinese-adult-population-a-cross-sectional-study
#6
JOURNAL ARTICLE
Lingling Xu, Dongling Li, Zongwei Song, Jin Liu, Yang Zhou, Junwei Yang, Ping Wen
BACKGROUND: Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. This study aimed to investigate the relationship between MHR and chronic kidney disease (CKD) in a Chinese adult population. METHODS: In this cross-sectional study, 232,775 community-dwelling adults in Binhai who completed health checkups in 2021 were enrolled. Participants were categorized based on the MHR quartiles...
December 2024: Renal Failure
https://read.qxmd.com/read/38522953/recent-advances-in-the-application-of-mendelian-randomization-to-chronic-kidney-disease
#7
REVIEW
Chaofan Wen, Lanlan Chen, Dan Jia, Ziqi Liu, Yidan Lin, Guan Liu, Shuo Zhang, Baoshan Gao
OBJECTIVE: Chronic kidney disease (CKD) is a condition influenced by both genetic and environmental factors and has been a focus of extensive research. Utilizing Mendelian randomization, researchers have begun to untangle the complex causal relationships underlying CKD. This review delves into the advances and challenges in the application of MR in the field of nephrology, shifting from a mere summary of its principles and limitations to a more nuanced exploration of its contributions to our understanding of CKD...
December 2024: Renal Failure
https://read.qxmd.com/read/38515271/cardiopulmonary-bypass-associated-acute-kidney-injury-better-understanding-and-better-prevention
#8
REVIEW
Xutao Yang, Li Zhu, Hong Pan, Yi Yang
Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease recognition methods on research outcomes. Furthermore, we introduce the specialized equipment and procedural intricacies associated with CPB surgeries. Based on recent research, we discuss the potential pathogenesis of AKI that may result from CPB, including compromised perfusion and oxygenation, inflammatory activation, oxidative stress, coagulopathy, hemolysis, and endothelial damage...
December 2024: Renal Failure
https://read.qxmd.com/read/38494199/magnesium-hydride-protects-against-acetaminophen-induced-acute-kidney-injury-by-inhibiting-txnip-nlrp3-nf-%C3%AE%C2%BAb-pathway
#9
JOURNAL ARTICLE
Yachen Si, Lulu Liu, Yinyin Zhang, Hongxia Li, Tingting Zhao, Su Liu, Xuejun Sun, Jin Cheng, Hongtao Lu
Acetaminophen (APAP)-induced acute kidney injury (APAP-AKI) has turned into one of reasons for clinic obtained renal insufficiency. Magnesium hydride (MgH2 ), as a solid-state hydrogen source, might be potentially applied in clinical practice. The current study aimed to investigate the protective effect of MgH2 against APAP-AKI. The results showed that MgH2 improved renal function and histological injury in mice of APAP-AKI. MgH2 also had protective effects on APAP-induced cytotoxicity in HK-2 cells. In addition, the increased level of reactive oxygen species (ROS) and expressions of inflammatory cytokines (TNF-α and IL-1β) and pro-apoptotic factors (Bad, Bax, Caspase3, and CytC) induced by APAP were downregulated with MgH2 treatment...
December 2024: Renal Failure
https://read.qxmd.com/read/38494197/machine-learning-model-and-nomogram-to-predict-the-risk-of-heart-failure-hospitalization-in-peritoneal-dialysis-patients
#10
JOURNAL ARTICLE
Liping Xu, Fang Cao, Lian Wang, Weihua Liu, Meizhu Gao, Li Zhang, Fuyuan Hong, Miao Lin
INTRODUCTION: The study presented here aimed to establish a predictive model for heart failure (HF) and all-cause mortality in peritoneal dialysis (PD) patients with machine learning (ML) algorithm. METHODS: We retrospectively included 1006 patients who initiated PD from 2010 to 2016. XGBoost, random forest (RF), and AdaBoost were used to train models for assessing risk for 1-year and 5-year HF hospitalization and mortality. The performance was validated using fivefold cross-validation...
December 2024: Renal Failure
https://read.qxmd.com/read/38486504/the-serum-levels-of-gasdermin-d-in-uremic-patients-and-its-relationship-with-the-prognosis-a-prospective-observational-cohort-study
#11
JOURNAL ARTICLE
XiaPing Zhang, Bo Yang
OBJECTIVE: This study aimed to explore the serum levels of gasdermin D (GSDMD) in uremic (end-stage kidney disease, ESKD) patients and their correlation with vascular calcification (VC) and clinical results. METHODS: This prospective observational cohort study enrolled 213 ESKD patients who were undergoing regular maintenance hemodialysis (MHD) for > 3 months in our hospital from August 2019 to July 2022. The abdominal aortic calcification score (AACS) was used to assess the VC condition of patients with ESKD...
December 2024: Renal Failure
https://read.qxmd.com/read/38482886/tak-242-improves-sepsis-associated-acute-kidney-injury-in-rats-by-inhibiting-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#12
JOURNAL ARTICLE
Yan-Mei Xia, Yu-Qian Guan, Ji-Fang Liang, Wei-Dong Wu
OBJECTIVE: This study was designed to observe the effect of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway activity on sepsis-associated acute kidney injury (SA-AKI), thereby providing new considerations for the prevention and treatment of SA-AKI. METHODS: The rats were divided into Sham, cecal ligation and puncture (CLP), CLP + vehicle, and CLP + TAK-242 groups. Except the Sham group, a model of CLP-induced sepsis was established in other groups...
December 2024: Renal Failure
https://read.qxmd.com/read/38482598/tiny-clue-reveals-the-general-trend-a-bibliometric-and-visualized-analysis-of-renal-microcirculation
#13
JOURNAL ARTICLE
Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu
BACKGROUND: Renal microcirculation plays a pivotal role in kidney function by maintaining structural and functional integrity, facilitating oxygen and nutrient delivery, and waste removal. However, a thorough bibliometric analysis in this area remains lacking. Therefore, we aim to provide valuable insights through a bibliometric analysis of renal microcirculation literature using the Web of Science database. METHODS: We collected renal microcirculation-related publications from the Web of Science database from January 01, 1990, to December 31, 2022...
December 2024: Renal Failure
https://read.qxmd.com/read/38482596/the-relationship-between-thiamin-folic-acid-and-cognitive-function-in-a-rat-model-of-uremia
#14
JOURNAL ARTICLE
Yifei Lu, Chenqi Xu, Kewei Xie, Bingru Zhao, Minzhou Wang, Cheng Qian, Xuemei Chen, Leyi Gu, Wangshu Wu, Renhua Lu
End-stage renal disease is a worldwide health burden, but the pathogenesis of uremia-associated cognitive impairment (CI) is poorly recognized. We hypothesized that uremia brings about deficiency of thiamin and folic acid and causes CI by inducing oxidative stress. Therefore, 24 Sprague-Dawley rats were randomly divided into two groups: a 5/6 nephrectomy group ( n  = 12) and a sham-operated group ( n  = 12). The Morris water maze was used to assess the cognitive function eight weeks post-surgery, and serum levels of thiamin, folic acid and homocysteine were detected subsequently...
December 2024: Renal Failure
https://read.qxmd.com/read/38482586/analysis-of-chronic-kidney-disease-epidemiology-in-kazakhstan-using-nationwide-data-for-2014-2020-and-forecasting-future-trends-of-prevalence-and-mortality-for-2030
#15
JOURNAL ARTICLE
Gulnur Zhakhina, Kamilla Mussina, Sauran Yerdessov, Arnur Gusmanov, Yesbolat Sakko, Valdemir Kim, Dmitriy Syssoyev, Meruyert Madikenova, Ainur Assan, Zhanat Kuanshaliyeva, Duman Turebekov, Kuanysh Yergaliyev, Bolat Bekishev, Abduzhappar Gaipov
According to the Global Burden of Disease (GBD) study, chronic kidney disease (CKD) was prevalent in 697.5 million individuals worldwide in 2017. By 2040, it is anticipated that CKD will rank as the fifth most common cause of death. This study aims to examine the epidemiology of CKD in Kazakhstan and to project future trends in CKD prevalence and mortality by 2030. The retrospective analysis was performed on a database acquired from the Unified National Electronic Health System for 703,122 patients with CKD between 2014 and 2020...
December 2024: Renal Failure
https://read.qxmd.com/read/38482580/efficacy-and-safety-of-mahuang-fuzi-and-shenzhuo-decoction-for-treatment-of-primary-membranous-nephropathy-a-multicenter-prospective-trial
#16
MULTICENTER STUDY
Naiqian Zhang, Hanxue Jiang, Haoran Dai, Shuxian Huang, Qihan Zhao, Na Zhang, Wenbin Liu, Zhaocheng Dong, Yu Gao, Xuan Dong, Yuehong Hu, Fanyu Hou, Hongliang Rui, Qingquan Liu, Baoli Liu
BACKGROUND: This study aims to undertake a comprehensive assessment of the effectiveness and safety profile of Mahuang Fuzi and Shenzhuo Decoction (MFSD) in the management of primary membranous nephropathy (PMN), within the context of a prospective clinical investigation. METHODS: A multicenter, open-label clinical trial was executed on patients diagnosed with PMN. These individuals were subjected to MFSD therapy for a duration of at least 24 months, with primary outcome of clinical remission rates...
December 2024: Renal Failure
https://read.qxmd.com/read/38482569/long-term-mortality-in-patients-with-end-stage-renal-disease-undergoing-hemodialysis-and-peritoneal-dialysis-a-propensity-score-matching-retrospective-study
#17
JOURNAL ARTICLE
Pengjie Zhang, Liru Xun, Nan Bao, Ding Tong, Bin Duan, Du Peng
BACKGROUND: Hemodialysis (HD) and peritoneal dialysis (PD) are effective ways to treat end-stage renal disease (ERSD). This study aimed to investigate the differences in survival and the factors that influence it in patients with end-stage renal disease treated with HD or PD. METHODS: We retrospectively analyzed factors related to all-cause death with renal replacement therapy and compared the long-term mortality between HD and PD strategies in patients with ESRD who started HD or PD treatment in our renal HD center between January 1, 2008, and December 1, 2021...
December 2024: Renal Failure
https://read.qxmd.com/read/38469667/gut-microbiota-in-the-association-between-obesity-and-kidney-function-decline-a-metagenomics-based-study-in-a-rat-model
#18
JOURNAL ARTICLE
Akehu Alemasi, Lijiang Gu, Yilun Zhou
OBJECTIVES: Obesity can induce dysbiosis in the gut microbiota and is considered a separate risk factor for kidney function decline. Nonetheless, the precise function of intestinal microorganisms in facilitating the connection between obesity and kidney function decline remains uncertain. Hence, the objective of this study was to investigate the alterations in the gut microbiota composition that take place during obesity and their correlations with renal function utilizing a rat model...
December 2024: Renal Failure
https://read.qxmd.com/read/38466674/external-validation-of-the-prediction-model-of-intradialytic-hypotension-a-multicenter-prospective-cohort-study
#19
JOURNAL ARTICLE
Yuhe Xiang, Guoting Ma, Qin Yang, Min Cao, Wenbin Xu, Lin Li, Qian Yang
OBJECTIVE: Intradialytic hypotension (IDH) is a common and serious complication in patients with Maintenance Hemodialysis (MHD). The purpose of this study is to externally verify three IDH risk prediction models recently developed by Ma et al. and recalibrate, update and present the optimal model to improve the accuracy and applicability of the model in clinical environment. METHODS: A multicenter prospective cohort study of patients from 11 hemodialysis centers in Sichuan Province, China, was conducted using convenience sampling from March 2022 to July 2022, with a follow-up period of 1 month...
December 2024: Renal Failure
https://read.qxmd.com/read/38466632/coexistence-of-anti-glomerular-basement-membrane-disease-and-iga-nephropathy-an-illustrative-case-and-comprehensive-literature-review
#20
REVIEW
Zewei Chen, Dechao Xu, Fangzheng Cui, Huihui Hou, Zhiguo Mao, Xiang Gao
Anti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with other glomerulonephritis has been reported. Herein, we present the case of a 66-year-old female patient with progressive worsen kidney function and decreased urine output. A renal biopsy revealed crescent glomerulonephritis with lineal IgG deposition along the GBM and mesangial IgA deposition, which supported the diagnosis of concurrent anti-GBM disease and IgA nephropathy (IgAN)...
December 2024: Renal Failure
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