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Renal Failure

Warumphon Sukkummee, Patcharin Jittisak, Piyanuch Wonganan, Supeecha Wittayalertpanya, Pajaree Chariyavilaskul, Asada Leelahavanichkul
Drug dosing adjustment in sepsis-induced acute kidney injury (sepsis-AKI) is currently adjusted based on renal function. Sepsis is a multiorgan injury, and thus, drug metabolism in sepsis-AKI might be interfered by non-renal factors such as changes in functions of drug-metabolizing enzymes in the liver and functions of intestinal drug transporters. We compared the defect on mouse CYP3A11 (human CYP3A4 representative) in liver and intestine along with several intestinal drug transporters (MDR1a, MRP2, and OATP3) in three mouse models; chronic ischemic reperfusion injury (Chr I/R; 4-week), acute ischemic reperfusion injury (Acute I/R; 24-h), and cecal ligation and puncture (CLP; 24-h) as representative of sepsis-AKI...
November 2019: Renal Failure
Kwazi C Z Ndlovu, Khine Swe Swe-Han, Alain Assounga
INTRODUCTION: Staphylococcal infections can cause significant morbidity in patients undergoing dialysis. This study evaluated the effects of HIV infection on nasal carriage of Staphylococcus aureus, staphylococcal peritonitis, and catheter infection rates in patients with end-stage renal failure managed with continuous ambulatory peritoneal dialysis (CAPD). METHODS: Sixty HIV-positive and 59 HIV-negative CAPD patients were enrolled and followed up for up to 18 months...
November 2019: Renal Failure
Tian Xu, Tao Lin, Jingyuan Xie, Hong Ren, Nan Chen, Weiming Wang
OBJECTIVE: To compare the anti-peritoneal fibrotic effects between a mammalian target of rapamycin complex 1-specific blocker and a phosphatidyl-inositol 3-kinase/mammalian target of rapamycin dual-blocker. METHODS: A total of 40 male Sprague-Dawley rats were randomly divided into five groups with eight animals per group. The normal group (N group) did not receive any intervention. The normal saline group (NS group) received an intraperitoneal injection of normal saline at 1 ml/100 g daily...
November 2019: Renal Failure
Yanlang Yang, Wei Zhou, YuWei Wang, Ru Zhou
OBJECTIVE: To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference. METHODS: A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 . We examined the association between SUA levels and CKD...
November 2019: Renal Failure
Chan Wang, Yun Tang, Yanmei Wang, Guisen Li, Li Wang, Yi Li
Vascular calcification (VC) is a pathological process characterized by abnormal deposition of calcium phosphate, hydroxyapatite and other mineral substances in the vascular wall. Hyperphosphorus is an important risk factor associated with VC in the general population and patients with chronic kidney disease (CKD). However, there is still a lack of early biomarkers for hyperphosphorus induced VC. We established a calcific rat aorta vascular smooth muscle cells (RASMCs) model by stimulating with β-glycerophosphate...
November 2019: Renal Failure
Konstantinos N Adamidis, Maria-Emmanouela Kopaka, Constantina Petraki, Evangelia Charitaki, Theophanis Apostolou, Christallenia Christodoulidou, Nikoleta Nikolopoulou, Alexandra Giatromanolaki, Vassilios Vargemesis, Ploumis Passadakis
PURPOSE: The aim of this study was to examine the expression of matrix metalloproteinases (MMPs) MMP-1, MMP-2, MMP-3, MMP-9, and their specific tissue inhibitor TIMP-1 in kidney biopsies of patients with lupus nephritis (LN) and to investigate the relationship between MMPs, activity index, and renal function at the time of kidney biopsy. METHODS: We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in 58 kidney-biopsy specimens with LN (according to the 2004 ISN/RPS classification) and eight specimens from normal kidney tissue...
November 2019: Renal Failure
Su Mi Lee, Mi Hwa Lee, Young Ki Son, Seong Eun Kim, Yongsoon Park, Seo Hee Rha, Won Suk An
AIM: Stearoyl-CoA desaturase (SCD)-1 and elongase-6 (Elovl-6) are associated with fatty acid (FA) synthesis. We evaluated the effect of omega-3 FA on erythrocyte membrane FA contents through SCD-1 and Elovl-6 expression in the liver and kidney of a cyclosporine (CsA)-induced rat model. METHODS: Male Sprague Dawley rats were divided into control, CsA, and CsA treated with omega-3 FA groups. We measured SCD-1 and Elovl-6 expression levels via western blot and immunohistochemistry analysis...
November 2019: Renal Failure
Lia Roque Assumpção, Isadora de Paula Ramos, Gerson Nunes da Cunha, Cid Manso de Mello Vianna, Maria Cristina Araújo Maya, Denizar Vianna Araújo
BACKGROUND: Few centers in Brazil perform parathyroidectomy (PTX) for recalcitrant secondary hyperparathyroidism (SHPT) generating a long queue. There is little data regarding prioritize criteria besides chronological order and survival. OBJECTIVES: To determine the difference of clinical and laboratory factors between PTX patients and those who remained in the line despite the need for surgery and their survival. METHODS: A retrospective cohort study was conducted in a quaternary hospital in Brazil, where 43 patients with PTX indication due to severe SHPT were followed from 2009 to 2016...
November 2019: Renal Failure
Li-Bo Xie, Xi Chen, Bo Chen, Xian-Ding Wang, Rui Jiang, Yi-Ping Lu
OBJECTIVE: To detect the combination protective effect of bone marrow mesenchymal stem cells (BMSCs) and Klotho gene on the renal ischemia-reperfusion injury (RIRI). METHODS: BMSCs isolated from rats were transfected with Klotho gene to form BMSCKl . We injected BMSCKl to allogenic rat RIRI model. After 24 h and 72 h, we detected the serum creatinine (SCr), malondialdehyde (MDA), and superoxide dismutase (SOD) in renal tissue, Hematoxylin-eosin (HE) staining, and TUNEL of renal pathology...
November 2019: Renal Failure
Dae-Hong Jeon, Ha Nee Jang, Hyun Seop Cho, Tae Won Lee, Eunjin Bae, Se-Ho Chang, Dong Jun Park
Acute kidney injury (AKI) associated with acute pyelonephritis (APN) rarely has been reported. The aim of this study was to evaluate the incidence and risk factors of AKI associated with APN. We retrospectively reviewed the medical records of 403 patients over 18-year old age hospitalized for APN management from October 2009 to September 2014 in tertiary care referral center. Demographic data, clinical symptoms and signs, and laboratory findings were gathered from the medical records and analyzed. The mean age of patients was 57 years and APN commonly occurred in female (87...
November 2019: Renal Failure
Yujun Deng, Lin Wang, Yating Hou, Jianchao Ma, Ruibin Chi, Heng Ye, Yiling Zhai, Danqing Zhang, Lu Gao, Linhui Hu, Tieying Hou, Jinghua Li, Ning Tan, Chunbo Chen
OBJECTIVE: Serum cystatin C (sCysC) used clinically for detecting early acute kidney injury (AKI) was reported to be independently associated with hemoglobin (HbA1c) levels, diabetes, and prediabetes. We aimed to assess the influence of HbA1c levels, diabetes, or prediabetes on the performance of sCysC for AKI detection in critically ill adults. METHODS: A prospective observational study was conducted in a mixed medical-surgical intensive care unit (ICU). Patients were divided into four quartiles based on levels of HbA1c or serum glucose at ICU admission, respectively...
November 2019: Renal Failure
Ryota Yoshitomi, Masaru Nakayama, Teppei Sakoh, Akiko Fukui, Eisuke Katafuchi, Makiko Seki, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono
BACKGROUND: Several studies have shown that the neutrophil/lymphocyte ratio (NLR) is a marker that reflects the state of systemic inflammation. A high NLR was reported to be associated with cardiovascular events and mortality. However, little is known about the association between NLR and kidney disease progression in patients with chronic kidney disease (CKD). Therefore, the aim of the present study was to determine whether NLR is associated with renal outcomes in CKD patients. METHODS: This prospective observational study included 350 consecutive patients with stage 1-4 CKD treated between June 2009 and November 2016...
November 2019: Renal Failure
Yufang Lin, Yanning Zhang
AIM: Exertional heastroke (EHS) can lead to acute kidney injury. Oral rehydration solution III (ORS III), recommended by WHO in 2004, is used to rehydrate children with gastroenteritis. This study aimed to characterize the renoprotective effect of ORS III in EHS rats. METHODS: Rats were randomly divided into Group Control, Group EHS, Group EHS + Water, and Group EHS + ORS. Thirty minutes before the experiment, ORS III was orally administrated to Group EHS + ORS, Water was given to Group EHS + Water...
November 2019: Renal Failure
Yanhong Wang, Zhijing Wu, Jihua Tian, Yang Mi, Xiaojun Ren, Jing Kang, Wan Zhang, Xiaoshuang Zhou, Guiqin Wang, Rongshan Li
Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP) superfamily and a pro-angiogenic factor. In the present study, we identified activation of the Wnt/β-catenin signaling pathway by IMD. Adding CoCl2 HUVECs was used to establish an in vitro model. The migration of HUVECs was measured by wound healing assays and transwell migration assays. Capillary formation was measured using tube formation assays. Immunocytochemistry (ICC) analysis was used to evaluate VEGF and RAMP2 expression in HUVECs...
November 2019: Renal Failure
Sensen Su, Xin Chen, Jia Li, Jinyu Yu, Li Zhang
BACKGROUND: Kimura's disease is a rare disease and its etiology is still unclear. Here we reported a case with lymphadenopathy complicated with secondary membranoproliferative glomerulonephritis. CASE PRESENTATION: A 46-year-old Chinese man presented with bilateral tumor-like nodules over his neck during the past 6 months and developed edema for 15 days. His blood pressure was 145/90 mmHg, multiple 1 × 1 cm masses were found over bilateral post-auricular and submandibular areas, along with trace edema of the lower extremities...
November 2019: Renal Failure
Jieru Cai, Xiaoyan Jiao, Weili Luo, Jing Chen, Xunhui Xu, Yi Fang, Xiaoqiang Ding, Xiaofang Yu
BACKGROUND: A few studies have shown that urinary kidney injury molecule-1 (uKIM-1) levels are increased in acute kidney injury (AKI); however, the correlation between uKIM-1 and histological tubular injury, which is considered to be the gold standard for evaluating renal damage and predicting prognosis, is still unclear. We performed this study to determine whether the predicted value of uKIM-1 is correlated with renal KIM-1 (tKIM-1) expression and tissue damage in AKI patients. METHODS: This retrospective study recruited 14 healthy individuals and 27 biopsy-proven acute tubular injury (ATI) patients...
November 2019: Renal Failure
Bridget A Scoville, Jonathan H Segal, Noha N Salama, Michael Heung, Barry E Bleske, Rachel F Eyler, Bruce A Mueller
PURPOSE: Ranolazine is a novel anti-angina treatment approved in the United States for chronic stable angina. Ranolazine pharmacokinetics have not been studied previously in patients who receive maintenance hemodialysis. This study describes the pharmacokinetics of ranolazine and three major metabolites (CVT-2738, CVT-2512, CVT-2514) in patients receiving thrice weekly hemodialysis. METHODS: Eight participants receiving maintenance hemodialysis completed this prospective, open-label study (study identifier NCT01435174 at Clinicaltrials...
November 2019: Renal Failure
Seishi Aihara, Shunsuke Yamada, Hideaki Oka, Taro Kamimura, Toshiaki Nakano, Kazuhiko Tsuruya, Atsumi Harada
BACKGROUND: Eldecalcitol (ELD) is an active vitamin D3 analog that is widely used in Japan for the treatment of osteoporosis. The most common adverse drug reaction of ELD is hypercalcemia. However, few reports have focused on acute kidney injury (AKI) associated with ELD-induced hypercalcemia. MATERIALS AND METHODS: We retrospectively reviewed the medical records at our hospital for cases of hypercalcemia-induced AKI between April 2013 and February 2018. Among them, we focused on patients who developed AKI secondary to ELD-induced hypercalcemia...
November 2019: Renal Failure
Piotr Domagala, Lukasz Gorski, Michal Wszola, Rafal Kieszek, Piotr Diuwe, Piotr Goralski, Jakub Drozdowski, Agata Ostaszewska, Jolanta Gozdowska, Michal Ciszek, Janusz Trzebicki, Magdalena Durlik, Leszek Paczek, Andrzej Chmura, Artur Kwiatkowski
BACKGROUND: There are many doubts with regards to accepting deceased kidneys with acute kidney injury (AKI) for transplantation. PURPOSE: The aim of this study was to present the 5-years outcome of kidney transplantation cases where deceased donors developed AKI before organ procurement. METHODS: Two hundred twenty-six deceased renal transplants were analyzed. Data regarding donors and recipients were collected. Terminal AKI was defined as terminal serum creatinine concentration higher than 1...
November 2019: Renal Failure
Athanasios Roumeliotis, Stefanos Roumeliotis, Stylianos Panagoutsos, Marios Theodoridis, Christos Argyriou, Anna Tavridou, George S Georgiadis
BACKGROUND: Intima-Media-Thickness of the carotid artery wall (cIMT) is a strong predictor of cardiovascular (CV) disease. The aim of this study was to investigate the significance of cIMT as an independent prognostic factor for CV morbidity and mortality in patients with chronic kidney disease (CKD) and diabetes mellitus type 2 (DM2). METHODS: The study included 142 diabetic patients in different stages of CKD. Patients were categorized into two groups according to low (≤0...
November 2019: Renal Failure
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