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Journal of Clinical Biochemistry and Nutrition

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[This corrects the article DOI: 10.3164/jcbn.17-128.].
January 2019: Journal of Clinical Biochemistry and Nutrition
Hitomi Ichikawa, Mitsushige Sugimoto, Yukitoshi Sakao, Shu Sahara, Naro Ohashi, Koji Sano, Shigeru Tadokoro, Hisanori Azekura, Akira Shimomura, Fuyuki Yamashita, Daiki Sugiyama, Ken Fukuta, Takahisa Furuta, Akihiko Kato, Ken Sugimoto, Hideo Yasuda
Plasma ghrelin level is influenced by Helicobacter pylori ( H. pylori ) status and the severity of gastric mucosal atrophy, and the ghrelin level is associated with nutrition status in hemodialysis patients. Here, we investigated the efficacy of H. pylori eradication therapy in improving nutrition status in relation to the ghrelin level in H. pylori -positive hemodialysis patients. Of H. pylori -positive patients receiving hemodialysis at 8 dialysis center, 21 patients underwent gastroduodenoscopy for evaluation of the severity of gastric atrophy, and nutrition markers and plasma ghrelin levels before and 1 year after H...
January 2019: Journal of Clinical Biochemistry and Nutrition
Junichi Iwamoto, Yoshikazu Adachi, Akira Honda, Tadakuni Monma, Yasushi Matsuzaki
The agglutination titers of Brachyspira pilosicoli ( B. pilosicoli ) and Brachyspira aalborgi ( B. aalborgi ) were examined in colitis patients with human intestinal spirochetes. Among three cases of colitis patients, the titer of B. pilosicoli was extremely high in two cases while the titer of B. aalborgi was extremely high in one case. These three cases had symptoms of colitis, such as watery diarrhea, and we diagnosed the case as Brachyspira- related colitis. These findings suggest that the agglutination titers of Brachyspira may be useful in cases of Brachyspira- related colitis...
January 2019: Journal of Clinical Biochemistry and Nutrition
Maki Takami, Wataru Aoi, Hitomi Terajima, Yuko Tanimura, Sayori Wada, Akane Higashi
Although supplementation with several antioxidants has been suggested to improve aerobic metabolism during exercise, whether dietary foods containing such antioxidants can exert the metabolic modulation is unclear. This study aimed to investigate the effect of intake of the specific antioxidant-rich foods coupled with exercise training on energy metabolism. Twenty young healthy, untrained men were assigned to antioxidant and control groups: participants in the antioxidant group were encouraged to consume foods containing catechin, astaxanthin, quercetin, glutathione, and anthocyanin...
January 2019: Journal of Clinical Biochemistry and Nutrition
Min-Seong Ha, Ji-Hyeon Kim, Soo-Min Ha, You-Sin Kim, Do-Yeon Kim
Health issues in elderly individuals are often complex and tend to lead to chronic diseases; such issues can be due to a decline in fitness resulting from lack of physical activity. Aqua exercise and burdock are positive effects on cardiovascular disease and vascular health. This study investigated the changes due to aqua exercise and burdock extract intake in senior fitness, prostaglandin I2 (PGI2 ), and thromboxane A2 (TXA2 ) in elderly women. Forty elderly women (65-80 years) volunteered for this study. After baseline measurements, participants were randomized into control ( n  = 8), aqua exercise ( n  = 11), aqua exercise and burdock extract intake combination ( n  = 11), and burdock extract intake groups ( n  = 10)...
January 2019: Journal of Clinical Biochemistry and Nutrition
Shigeki Sakai, Atsushi Nishida, Masashi Ohno, Osamu Inatomi, Shigeki Bamba, Mitsushige Sugimoto, Masahiro Kawahara, Akira Andoh
Astaxanthin is a xanthophyll carotenoid, which possesses strong scavenging effect on reactive oxygen species. In this study, we examined the effect of astaxanthin on dextran sulfate sodium (DSS)-induced colitis in mice. Experimental colitis was induced by the oral administration of 4% w/v DSS in tap water in C57BL/6J mice. Astaxanthin was mixed with a normal rodent diet (0.02 or 0.04%). Astaxanthin significantly ameliorated DSS-induced body weight loss and reduced the disease activity index. The ameliorating effects was observed in a dose-dependent manner...
January 2019: Journal of Clinical Biochemistry and Nutrition
Atsuko Kamiya, Takeshi Hara, Masayuki Tsuda, Emi Tsuru, Yasushi Kuroda, Urara Ota, Takashi Karashima, Hideo Fukuhara, Keiji Inoue, Masahiro Ishizuka, Motowo Nakajima, Tohru Tanaka
5-Aminolevulinic acid, a natural amino acid, activates mitochondrial respiration and induces heme oxygenase-1 expression. Obesity and type 2 diabetes mellitus are associated with age-related mitochondrial respiration defect, oxidative stress and inflammation. The aim of this study is to investigate the effects of 5-aminolevulinic acid with sodium ferrous citrate on early renal damage and hepatic steatosis. 7-Month-old C57BL/6 mice were fed with a standard diet or high fat diet for 9 weeks, which were orally administered 300 mg/kg 5-aminolevulinic acid combined with 47 mg/kg sodium ferrous citrate (5-aminolevulinic acid/sodium ferrous citrate) or vehicle for the last 5 weeks...
January 2019: Journal of Clinical Biochemistry and Nutrition
Masaru Terasaki, Naoya Matsumoto, Ryuichi Hashimoto, Tetsuya Endo, Hayato Maeda, Junichi Hamada, Kazumi Osada, Kazuo Miyashita, Michihiro Mutoh
Fucoxanthin and its major metabolite, fucoxanthinol, have potent anti-cancer properties in carcinogenic model mice and against cancer cells. Evidence has accumulated regarding the diagnostic potential of biological metabolites as invasive and non-invasive obtainable approaches. We recently demonstrated that glycine was an effective predictor of the suppression of sphere formation and epithelial mesenchymal transition by fucoxanthinol in human colorectal cancer stem-like spheroids (colonospheres) under normoxia and hypoxia...
January 2019: Journal of Clinical Biochemistry and Nutrition
Go Yasuda, Hiromu Ito, Hiromi Kurokawa, Masahiko Terasaki, Hideo Suzuki, Yuji Mizokami, Hirofumi Matsui
The Chinese herbal medicine Qing Dai has been traditionally used for the treatment of various inflammatory diseases. We previously reported that reactive oxygen species play an important role in bisphosphonate-induced gastrointestinal injuries and that Qing Dai improved ulcerative colitis by scavenging reactive oxygen species. In this study, we investigated whether Qing Dai prevented bisphosphonate-induced gastric cellular injuries. Risedronate (a bisphosphonate) was added to rat gastric mucosal cells. Risedronate-induced cellular injury, cellular lipid peroxidation, mitochondrial membrane potential, and reactive oxygen species production in rat gastric mucosal cells were examined via viable cell counting, specific fluorescent indicators, and electron spin resonance...
January 2019: Journal of Clinical Biochemistry and Nutrition
Koji Fukui, Shunsuke Okihiro, Yuuka Ohfuchi, Minae Hashimoto, Yugo Kato, Naoki Yoshida, Kaho Mochizuki, Hiroki Tsumoto, Yuri Miura
Reactive oxygen species attack several living organs and induce cell death. Previously, we found axonal/dendrite degeneration before the induction of cell death in hydrogen peroxide-treated neuroblastoma: N1E-115 cells and primary neurons. This phenomenon may be connected with membrane oxidation, microtubule destabilization and disruption of intracellular calcium homeostasis. However, its detailed mechanisms are not fully understood. Here, we identified proteins after treatment with hydrogen peroxide using isolated neurites by liquid chromatography-matrix-assisted laser desorption/ionization-time of flight/time of flight analysis...
January 2019: Journal of Clinical Biochemistry and Nutrition
Tatsuharu Shimokawa, Mai Yoshida, Tatsuya Fukuta, Tamotsu Tanaka, Toshio Inagi, Kentaro Kogure
Decreases in tear volume, unstable tear films and excessive tear evaporation are known to cause desiccation and hyperosmolar stress. These, in turn, induce oxidative stress that is thought to cause dry eye, which is also considered to be age-related disease. We hypothesized that oxidative stress induces up-regulation of age-related markers, and that the antioxidant astaxanthin prepared as a liposomal formulation may be a candidate for the treatment of dry eye. Herein, we examined age-related markers in an in vitro dry eye model, and evaluated the efficacy of high-affinity liposomes containing astaxanthin...
January 2019: Journal of Clinical Biochemistry and Nutrition
Ryohei Umeda, Hiroki Takanari, Kazue Ogata, Shigekiyo Matsumoto, Takaaki Kitano, Katsushige Ono, Osamu Tokumaru
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, are widely used for preventing cardiovascular and cerebrovascular diseases by controlling blood cholesterol level. Additionally, previous studies revealed the scavenging effects of statins on free radicals. We assessed direct scavenging activities of two water-soluble statins, fluvastatin and pravastatin, on multiple free radicals using electron spin resonance spectrometry with spin trapping method. We estimated reaction rate constants ( k fv for fluvastatin, and k pv for pravastatin)...
January 2019: Journal of Clinical Biochemistry and Nutrition
Minako Nyui, Ikuo Nakanishi, Kazunori Anzai, Toshihiko Ozawa, Ken-Ichiro Matsumoto
The reactivity of nitroxyl free radicals, 4-hydroxyl-2,2,6,6-tetramethylpiperidine- N -oxyl (TEMPOL) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine- N -oxyl (CmP), with reactive oxygen species (ROS) were compared as typical 6-membered and 5-membered ring nitroxyl compounds, respectively. The reactivity of the hydroxylamine forms of both these nitroxyl radicals (TEMPOL-H and CmP-H) was also assessed. Two free radical species of ROS, hydroxyl radical (• OH) and superoxide (O2 •- ), were subjected to a competing reaction...
January 2019: Journal of Clinical Biochemistry and Nutrition
Shuya Kasai, Hiromi Yamazaki, Kunikazu Tanji, Máté János Engler, Tomoh Matsumiya, Ken Itoh
Recent investigations have clarified the importance of mitochondria in various age-related degenerative diseases, including late-onset Alzheimer's disease and Parkinson's disease. Although mitochondrial disturbances can be involved in every step of disease progression, several observations have demonstrated that a subtle mitochondrial functional disturbance is observed preceding the actual appearance of pathophysiological alterations and can be the target of early therapeutic intervention. The signals from damaged mitochondria are transferred to the nucleus, leading to the altered expression of nuclear-encoded genes, which includes mitochondrial proteins (i...
January 2019: Journal of Clinical Biochemistry and Nutrition
Yujiro Henmi, Kazuki Kakimoto, Takuya Inoue, Kei Nakazawa, Minori Kubota, Azusa Hara, Takashi Mikami, Yutaka Naka, Yuki Hirata, Yoshimasa Hirata, Taisuke Sakanaka, Sadaharu Nouda, Toshihiko Okada, Ken Kawakami, Toshihisa Takeuchi, Kazunari Tominaga, Kazuhide Higuchi
We investigated the risk factors of and appropriate treatment for cytomegalovirus colitis in patients with ulcerative colitis, using quantitative polymerase chain reaction analysis to detect cytomegalovirus in the colonic mucosa. Between February 2013 and January 2017, patients with exacerbated ulcerative colitis who were admitted to our hospital were consecutively enrolled in this retrospective, single-center study. Patients were evaluated for cytomegalovirus using serology (antigenemia) and quantitative polymerase chain reaction analyses of the colonic mucosa, which were sampled during colonoscopy...
November 2018: Journal of Clinical Biochemistry and Nutrition
Takashi Himoto, Koji Fujita, Teppei Sakamoto, Takako Nomura, Asahiro Morishita, Hirohito Yoneyama, Reiji Haba, Tsutomu Masaki
The role of free testosterone, that not bound to sex hormone-binding globulin, in male patients with HCV infection remains uncertain. We investigated whether free testosterone is involved in the progression to hepatic fibrosis/steatosis or insulin resistance in male patients with HCV-related chronic liver disease or not. Free androgen indices, which reflect circulating free testosterone levels, were calculated as 100 × total testosterone levels/sex hormone-binding globulin levels in 30 male patients with HCV-related chronic liver disease...
November 2018: Journal of Clinical Biochemistry and Nutrition
Bing Li, Junqing Zheng, Xia Zhang, Shan Hong
The aim of the present study was to investigate the efficacy of oral administration of probiotic Lactobacillus casei Shirota and amoxicillin-sulbactam in treating childhood fast breathing pneumonia. 518 children diagnosed of fast breathing pneumonia were enrolled and randomly assigned to be administered either amoxicillin-sulbactam +  Lactobacillus casei Shirota or amoxicillin-sulbactam + placebo. Primary outcome was defined as treatment failure before day 3, and secondary outcome was defined as treatment failure during follow-ups on day 6 and 12...
November 2018: Journal of Clinical Biochemistry and Nutrition
Toshihiro Nishizawa, Hidekazu Suzuki, Masahide Arita, Yosuke Kataoka, Kazushi Fukagawa, Daisuke Ohki, Keisuke Hata, Toshio Uraoka, Takanori Kanai, Naohisa Yahagi, Osamu Toyoshima
Nausea and vomiting after esophagogastroduodenoscopy have not been studied in detail. The aim of this study was to evaluate the risk factors for post-endoscopic nausea. We performed a case-control study at the Toyoshima Endoscopy Clinic. Eighteen patients with post-endoscopic nausea and 190 controls without post-endoscopic nausea were analyzed. We conducted univariate and multivariate logistic regression analyses with respect to patient age; sex; body height; body weight; the use of psychotropic drugs as baseline medications; and the dosing amounts of midazolam, pethidine, flumazenil and naloxone...
November 2018: Journal of Clinical Biochemistry and Nutrition
Azusa Hara, Kazuhiro Ota, Toshihisa Takeuchi, Yuichi Kojima, Yuki Hirata, Haruhiko Ozaki, Shinpei Kawaguchi, Yoshiaki Takahashi, Satoshi Harada, Taisuke Sakanaka, Takeshi Ogura, Sadaharu Nouda, Kazuki Kakimoto, Ken Kawakami, Akira Asai, Shinya Fukunishi, Makoto Sanomura, Kazunari Tominaga, Kazuhide Higuchi
Although low-dose aspirin (LDA) is known to induce small intestinal mucosal injury, the effect of dual antiplatelet therapy (DAPT; LDA + clopidogrel) on small intestinal mucosa in patients after percutaneous coronary intervention (PCI) for coronary stenosis is unknown. Fifty-one patients with a history of PCI and LDA use were enrolled, and 45 eligible patients were analyzed. Patients were grouped based on DAPT (DAPT: n  = 10 and non-DAPT: n  = 35) and proton pump inhibitor (PPI) use (PPI user: n  = 22 and PPI-free patients: n  = 23) to compare small intestinal endoscopic findings...
November 2018: Journal of Clinical Biochemistry and Nutrition
Shigeki Sakai, Atsushi Nishida, Masashi Ohno, Osamu Inatomi, Shigeki Bamba, Mitsushige Sugimoto, Masahiro Kawahara, Akira Andoh
We examined the effect of bortezomib, a proteasome inhibitor, on the development of dextran sulfate sodium (DSS)-induced colitis in mice. DSS-colitis was induced by the administration of 3% DSS in water in C57BL/6J mice. Bortezomib was intraperitoneally administered daily for 9 days from the start of DSS. Ubiquitination of IκBα was evaluated by immunoblot. Bortezomib significantly ameliorated DSS-induced body weight loss and reduced the disease activity. The translocation of NF-κBp65 into the nucleus was markedly suppressed in the DSS + bortezomib group compared to the DSS group, but this difference was not detected in submucosal tissue...
November 2018: Journal of Clinical Biochemistry and Nutrition
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