journal
https://read.qxmd.com/read/37872767/the-molecular-circadian-clock-is-a-target-of-anti-cancer-translation-inhibitors
#21
JOURNAL ARTICLE
Alexandre Berthier, Céline Gheeraert, Manuel Johanns, Manjula Vinod, Bart Staels, Jérôme Eeckhoute, Philippe Lefebvre
Circadian-paced biological processes are key to physiology and required for metabolic, immunologic, and cardiovascular homeostasis. Core circadian clock components are transcription factors whose half-life is precisely regulated, thereby controlling the intrinsic cellular circadian clock. Genetic disruption of molecular clock components generally leads to marked pathological events phenotypically affecting behavior and multiple aspects of physiology. Using a transcriptional signature similarity approach, we identified anti-cancer protein synthesis inhibitors as potent modulators of the cardiomyocyte molecular clock...
October 23, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37846856/use-of-light-protection-equipment-at-night-reduces-time-until-discharge-from-the-neonatal-intensive-care-unit-a-randomized-interventional-study
#22
JOURNAL ARTICLE
Ana Carolina Odebrecht Vergne de Abreu, Melissa Alves Braga de Oliveira, Tamila Alquati, André Comiran Tonon, Mariana de Novaes Reis, Augusto Camargo Rossi, Fernanda Sbaraini Bonatto, Maria Paz Hidalgo
Newborn infants' circadian systems are not completely developed and rely on external temporal cues for synchronizing their biological rhythms to the environment. In neonatal intensive care units (NICUs), lighting is usually continuous or irregular and infants are exposed to artificial light at night, which can have negative health consequences. Therefore, the aim of this study was to evaluate the impact of the use of individual light protection equipment at night on the development and growth of preterm neonates...
October 17, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37837392/wolfgang-engelmann-passionate-researcher-teacher-and-artist-26-february-1934-to-1-july-2023
#23
JOURNAL ARTICLE
Charlotte Helfrich-Förster
No abstract text is available yet for this article.
October 14, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37819024/friedrich-k-stephan-1941-2023-curt-richter-professor-of-psychology-florida-state-university-1972-2006
#24
JOURNAL ARTICLE
Alec J Davidson, Ralph Mistlberger, Antonio Nunez, Cheryl Sisk
No abstract text is available yet for this article.
October 11, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37786272/the-daily-patterns-of-emergency-medical-events
#25
JOURNAL ARTICLE
Mary E Helander, Margaret K Formica, Dessa K Bergen-Cico
This study examines population-level daily patterns of time-stamped emergency medical service (EMS) dispatches to establish their situational predictability. Using visualization, sinusoidal regression, and statistical tests to compare empirical cumulative distributions, we analyzed 311,848,450 emergency medical call records from the US National Emergency Medical Services Information System (NEMSIS) for years 2010 through 2022. The analysis revealed a robust daily pattern in the hourly distribution of distress calls across 33 major categories of medical emergency dispatch types...
October 2, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37776296/comments-on-block-et-al-pittendrigh-remembered-2023
#26
JOURNAL ARTICLE
Benjamin Rusak
No abstract text is available yet for this article.
September 30, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37750410/circadian-adaptation-of-melatonin-and-cortisol-in-police-officers-working-rotating-shifts
#27
JOURNAL ARTICLE
Anastasi Kosmadopoulos, Philippe Boudreau, Laura Kervezee, Diane B Boivin
Misalignment of behavior and circadian rhythms due to night work can impair sleep and waking function. While both simulated and field-based studies suggest that circadian adaptation to a nocturnal schedule is slow, the rates of adaptation in real-world shift-work conditions are still largely unknown. The aim of this study was to evaluate the extent of adaptation of 24-h rhythms with 6-sulfatoxymelatonin (aMT6s) and cortisol in police officers working rotating shifts, with a special attention to night shifts...
September 26, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37609713/are-we-finding-functional-or-merely-statistically-significant-rhythms
#28
EDITORIAL
Bharath Ananthasubramaniam
No abstract text is available yet for this article.
August 23, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37565646/ambient-temperature-effects-on-the-spring-and-autumn-somatic-growth-trajectory-show-plasticity-in-the-photoneuroendocrine-response-pathway-in-the-tundra-vole
#29
JOURNAL ARTICLE
Mattis Jayme van Dalum, Laura van Rosmalen, Daniel Appenroth, Fernando Cazarez Marquez, Renzo T M Roodenrijs, Lauren de Wit, Roelof A Hut, David G Hazlerigg
Seasonal mammals register photoperiodic changes through the photoneuroendocrine system enabling them to time seasonal changes in growth, metabolism, and reproduction. To a varying extent, proximate environmental factors like ambient temperature (Ta ) modulate timing of seasonal changes in physiology, conferring adaptive flexibility. While the molecular photoneuroendocrine pathway governing the seasonal responses is well defined, the mechanistic integration of nonphotoperiodic modulatory cues is poorly understood...
August 11, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37553858/vasculature-of-the-suprachiasmatic-nucleus-pathways-for-diffusible-output-signals
#30
JOURNAL ARTICLE
Yifan Yao, Isabella K Green, Alana B Taub, Ruya Tazebay, Joseph LeSauter, Rae Silver
Transplant studies demonstrate unequivocally that the suprachiasmatic nucleus (SCN) produces diffusible signals that can sustain circadian locomotor rhythms. There is a vascular portal pathway between the SCN and the organum vasculosum of the lamina terminalis in mouse brain. Portal pathways enable low concentrations of neurosecretions to reach specialized local targets without dilution in the systemic circulation. To explore the SCN vasculature and the capillary vessels whereby SCN neurosecretions might reach portal vessels, we investigated the blood vessels (BVs) of the core and shell SCN...
August 8, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37539684/chronotype-and-affective-response-to-sleep-restriction-and-subsequent-sleep-deprivation
#31
JOURNAL ARTICLE
Rebecca C Cox, Hannah K Ritchie, Oliver A Knauer, Molly K Guerin, Ellen R Stothard, Kenneth P Wright
Prior research indicates that sleep restriction, sleep deprivation, and circadian misalignment diminish positive affect, whereas effects on negative affect are inconsistent. One potential factor that may influence an individual's affective response to sleep restriction, sleep deprivation, and circadian misalignment is chronotype. Later chronotypes generally report higher negative affect and lower positive affect under typical sleep conditions; however, there is mixed evidence for an influence of chronotype on affective responses to sleep restriction and sleep deprivation...
August 4, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37529986/the-scn-hpa-periphery-circadian-timing-system-mathematical-modeling-of-clock-synchronization-and-the-effects-of-photoperiod-on-jetlag-adaptation
#32
JOURNAL ARTICLE
Yannuo Li, Ioannis P Androulakis
Synchronizing the circadian timing system (CTS) to external light/dark cycles is crucial for homeostasis maintenance and environmental adaptation. The CTS is organized hierarchically, with the central pacemaker located in the suprachiasmatic nuclei (SCN) generating coherent oscillations that are entrained to light/dark cycles. These oscillations regulate the release of glucocorticoids by the hypothalamus-pituitary-adrenal (HPA) axis, which acts as a systemic entrainer of peripheral clocks throughout the body...
August 2, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37515350/roles-for-the-synechococcus-elongatus-rna-binding-protein-rbp2-in-regulating-the-circadian-clock
#33
JOURNAL ARTICLE
Briana M McKnight, Shannon Kang, Tam H Le, Mingxu Fang, Genelyn Carbonel, Esbeydi Rodriguez, Sutharsan Govindarajan, Nitsan Albocher-Kedem, Amanda L Tran, Nicholas R Duncan, Orna Amster-Choder, Susan S Golden, Susan E Cohen
The cyanobacterial circadian oscillator, consisting of KaiA, KaiB, and KaiC proteins, drives global rhythms of gene expression and compaction of the chromosome and regulates the timing of cell division and natural transformation. While the KaiABC posttranslational oscillator can be reconstituted in vitro, the Kai-based oscillator is subject to several layers of regulation in vivo. Specifically, the oscillator proteins undergo changes in their subcellular localization patterns, where KaiA and KaiC are diffuse throughout the cell during the day and localized as a focus at or near the pole of the cell at night...
July 28, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37464775/connecting-the-dots-potential-interactions-between-sex-hormones-and-the-circadian-system-during-memory-consolidation
#34
REVIEW
Hannah M Boyd, Karyn M Frick, Janine L Kwapis
Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the molecular components and action of each of these systems have been fairly well-characterized, but there is a fundamental lack of information about how these systems cooperate. In the circadian system, clock genes function as timekeeping molecules that convey time-of-day information on a well-stereotyped cycle that is governed by the suprachiasmatic nucleus...
July 19, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37427666/modeling-the-effects-of-napping-and-non-napping-patterns-of-light-exposure-on-the-human-circadian-oscillator
#35
JOURNAL ARTICLE
Shelby R Stowe, Monique K LeBourgeois, Cecilia Diniz Behn
In early childhood, consolidation of sleep from a biphasic to a monophasic sleep-wake pattern, that is, the transition from sleeping during an afternoon nap and at night to sleeping only during the night, represents a major developmental milestone. Reduced napping behavior is associated with an advance in the timing of the circadian system; however, it is unknown if this advance represents a standard response of the circadian clock to altered patterns of light exposure or if it additionally reflects features of the developing circadian system...
July 10, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37382359/the-associations-of-chronotype-and-shift-work-with-rheumatoid-arthritis
#36
JOURNAL ARTICLE
Thomas D Butler, Robert J Maidstone, Martin K Rutter, John T McLaughlin, David W Ray, Julie E Gibbs
The circadian clock regulates multiple aspects of human physiology including immunity. People have a circadian preference termed chronotype. Those with an evening preference may be better suited to shift work, but also carry higher risk of adverse health. Shift work leads to misalignment of circadian rhythms and is associated with increased risk of inflammatory disease such as asthma and cancer. Here, we investigate the association between chronotype, shift work, and rheumatoid arthritis (RA). The associations between exposures of shift work and chronotype on risk of RA were studied in up to 444,210 U...
June 29, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37382061/meta-analysis-of-diurnal-transcriptomics-in-mouse-liver-reveals-low-repeatability-of-rhythm-analyses
#37
JOURNAL ARTICLE
Thomas G Brooks, Aditi Manjrekar, Antonijo Mrcˇela, Gregory R Grant
To assess the consistency of biological rhythms across studies, 57 public mouse liver tissue timeseries totaling 1096 RNA-seq samples were obtained and analyzed. Only the control groups of each study were included, to create comparable data. Technical factors in RNA-seq library preparation were the largest contributors to transcriptome-level differences, beyond biological or experiment-specific factors such as lighting conditions. Core clock genes were remarkably consistent in phase across all studies. Overlap of genes identified as rhythmic across studies was generally low, with no pair of studies having over 60% overlap...
June 29, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37357746/impact-of-simulated-rotating-shift-work-on-mammary-tumor-development-in-the-p53-r270h%C3%A2-wapcre-mouse-model-for-breast-cancer
#38
JOURNAL ARTICLE
Astrid A Streng, Kirsten C G Van Dycke, Conny T M van Oostrom, Daniela C F Salvatori, Gerben Hulsegge, Inês Chaves, Till Roenneberg, Serge A L Zander, Harry van Steeg, Gijsbertus T J van der Horst, Linda W M van Kerkhof
Epidemiological studies associate night shift work with increased breast cancer risk. However, the underlying mechanisms are not clearly understood. To better understand these mechanisms, animal models that mimic the human situation of different aspects of shift work are needed. In this study, we used "timed sleep restriction" (TSR) cages to simulate clockwise and counterclockwise rotating shift work schedules and investigated predicted sleep patterns and mammary tumor development in breast tumor-prone female p53 R270H©/+ WAPCre mice...
June 26, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37357738/circadian-regulation-of-the-neuroimmune-environment-across-the-lifespan-from-brain-development-to-aging
#39
JOURNAL ARTICLE
Ruizhuo Chen, Brandy N Routh, Andrew D Gaudet, Laura K Fonken
Circadian clocks confer 24-h periodicity to biological systems, to ultimately maximize energy efficiency and promote survival in a world with regular environmental light cycles. In mammals, circadian rhythms regulate myriad physiological functions, including the immune, endocrine, and central nervous systems. Within the central nervous system, specialized glial cells such as astrocytes and microglia survey and maintain the neuroimmune environment. The contributions of these neuroimmune cells to both homeostatic and pathogenic demands vary greatly across the day...
June 26, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37350312/impact-of-light-schedules-and-model-parameters-on-the-circadian-outcomes-of-individuals
#40
JOURNAL ARTICLE
Caleb Mayer, Olivia Walch, Daniel B Forger, Kevin Hannay
Key differences exist between individuals in terms of certain circadian-related parameters, such as intrinsic period and sensitivity to light. These variations can differentially impact circadian timing, leading to challenges in accurately implementing time-sensitive interventions. In this work, we parse out these effects by investigating the impact of parameters from a macroscopic model of human circadian rhythms on phase and amplitude outputs. Using in silico light data designed to mimic commonly studied schedules, we assess the impact of parameter variations on model outputs to gain insight into the different effects of these schedules...
June 23, 2023: Journal of Biological Rhythms
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