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Lasers in Medical Science

Dario Bertossi, Giorgio Giampaoli, Alessandra Lucchese, Maurizio Manuelli, Massimo Albanese, Riccardo Nocini, Pier Francesco Nocini
Minimally invasive facial rejuvenation procedures reached an all-time high in the 2016. This reveals a growing interest in a smoother, younger, and tighter look accessible using the esthetic medicine tools like botulinum toxin and dermal filler injections, laser, and microdermabrasion. Forty-five patients from 35 to 52 years old (medium age 43.8), 38 women and 7 men underwent 5 sessions of Fraxel laser, 1 session of very low G prime HA, and Microbotox injection treatments from January 2016 and January 2017, were included in this study...
February 14, 2019: Lasers in Medical Science
Airton Luiz Felizatti, Fernando Russo Costa do Bomfim, Julia Leme Bovo, Andrea Aparecida de Aro, Maria Esméria Corezzola do Amaral, Marcelo Augusto Marretto Esquisatto
The aim of this study was to evaluate the effects of low-level laser therapy using the gallium arsenide laser (λ = 830 nm) on the articular cartilage (AC) organization from knee joint in an experimental model of microcrystalline arthritis in adult male Wistar rats. Seventy-two animals were divided into three groups: A (control), B (induced arthritis), and C (induced arthritis + laser therapy). The arthritis was induced in the right knee using 2 mg of Na4 P2 O7 in 0.5 mL of saline solution. The treatments were daily applied in the patellar region of the right knee after 48 h of induction...
February 14, 2019: Lasers in Medical Science
Livia Tosi Trevelin, Beatriz Togoro Ferreira da Silva, Patrícia Moreira de Freitas, Adriana Bona Matos
The purpose of this study was to explore the influence of Er:YAG laser irradiation with different pulse durations on the organic matrix, micromorphology of the hybrid layer (HL), and bond strength over time. Sixty caries-free human molars were cut to obtain flat dentin surfaces which were randomly divided into 4 groups: control (not irradiated-G1) and laser groups (80 mJ/2 Hz) with pulse duration ranging between 50 (G2), 300 (G3), and 600 μs (G4). A self-etch adhesive system (Universal 3M ESPE) was applied on pre-treated dentin surfaces and cylinders of resin composite were built up and stressed in a universal testing machine (μSBS) at 24 h and after12 months (n = 12)...
February 14, 2019: Lasers in Medical Science
D V Pominova, I D Romanishkin, P V Grachev, A V Borodkin, A S Vanetsev, E O Orlovskaya, Yu V Orlovskii, I Sildos, V B Loschenov, A V Ryabova
To improve methods of laser hyperthermia for the treatment of bulk malignant neoplasms, an urgent task is the development of techniques and devices that automatically control heating at a given tissue depth and ensure its uniformity. The article proposes the concept of a system for performing hyperthermia with real-time spectroscopic temperature control and surface cooling, which allows to record spectra of diffusely scattered radiation and fluorescent signal from various depths of biological tissues by the means of the variation of the angle and distance between the fiber source of laser radiation and the receiving fiber...
February 14, 2019: Lasers in Medical Science
Joanna Jackowska, Waldemar Wojnowski, Anna Hashimoto, Bogna Małaczyńska, Krzysztof Piersiala, Piotr Świdziński, Bożena Wiskirska-Woźnica, Małgorzata Wierzbicka
Mechanical debulking of laryngeal papillomas is associated with voice disorders due to impairment of the vocal fold's mucosa. Intraepithelial injection of cidofovir reduces damage to the laryngeal structures and thus improves vocal parameters. The aim of our study was to compare vocal quality before and after cidofovir and CO2 laser treatment by means of objective phoniatric parameters and to obtain evidence concerning voice outcomes. The vocal parameters of 42 patients with RRP were assessed before and after intralesional cidofovir and CO2 laser debulking treatment (Lumenis AcuPulse 40 CO2 laser, wavelength 10...
February 14, 2019: Lasers in Medical Science
Henryk Frelich, Wojciech Ścierski, Magdalena Marków, Jakub Frelich, Hanna Frelich, Misiołek Maciej
The aim of this paper is to present our results and experience in the treatment of snoring using the non-ablative Erbium: Yttrium Aluminum Garnet (Er:YAG) laser. Twenty-four patients (18 male and 6 female) with snoring problems due to soft palate hypertrophy were treated with 3 treatment procedures with Er:YAG 2940-nm laser (long pulse mode, 10 Hz, fluence 1.8-2.0 J/cm2 ) performed at 2-week intervals. The treatment procedures were performed in outpatient settings. One treatment session lasts 15-20 min. Subjective (questionnaires) and objective (polygraph) outcome measures were assessed at baseline and 3 months after the final laser treatment...
February 14, 2019: Lasers in Medical Science
Arteiro Queiroz Menezes, Paulo Francisco Guerreiro Cardoso, Christopher Kengo Nagao, Helio Minamoto, Benoit Jacques Bibas, Isaac de Faria Soares Rodrigues, José Pinhata Otoch, Marisa Dolhnikoff, Mauro Canzian, Marilia Wellichan Mancini, Paulo Manuel Pêgo-Fernandes
To evaluate the feasibility of a 980-nm contact diode laser (CDL) as a method for creating a posterior laryngofissure in live pigs. Twenty-eight Landrace pigs (15-20 kg) were anesthetized, intubated, ventilated, and submitted to a cervical tracheostomy. An anterior and posterior midline longitudinal laryngofissure incision was created according to randomization-control (n = 4), posterior laryngofissure with a scalpel blade; electrocautery (n = 12), posterior laryngofissure by electrocautery (10, 15, 20, 25 W powers); CDL (n = 12), posterior laryngofissure by the CDL (10, 15, 20, 25 W peak powers in pulsed mode)...
February 14, 2019: Lasers in Medical Science
Yiping Zhong, Bin Yang, Lining Huang, Peter M Elias, Mao-Qiang Man
Becker's nevus is a common pigmented dermatosis, usually featured by ipsilateral pigmented patch with hypertrichosis. Becker's nevus is often treated with various types of lasers although other regimens are available. However, clinical outcomes appear inconsistent among studies. To summarize the clinical outcomes of Becker's nevus treated with lasers via literature review. A variety of lasers had been used alone or in combination to treat Becker's nevus. Laser wavelengths used for Becker's nevus ranged from 504 to 10,600 nm, while the number of treatment varied from 1 to 12 sessions...
February 14, 2019: Lasers in Medical Science
Nupur Kapoor Nerurkar, Ruchi Shah
Our study was performed with an aim to analyse the factors responsible for the formation of a carbon granuloma (CG) following transoral laser microlaryngeal cordectomy (TLMC) for early glottic carcinoma. Our study comprises of retrospective data analysis of 78 patients who underwent TLMC for early glottic carcinoma between 2012 and 2017 with the laser settings of an acublade with scanning system, size 1-2 mm, depth 1-3 (250-750 μm), power 10 watts in a repeat mode with time off 0.25 s. A total of 19 patients had undergone type 1 cordectomy, 38 patients a type 2 cordectomy, 20 patients a type 3 cordectomy and 1 type 4 cordectomy...
February 13, 2019: Lasers in Medical Science
Silvana Martins Rodrigues Filipini, Cibele Bruno Campagnolo, Danilo Antônio Milbradt Dutra, Roberto Marinho Maciel, Cristiane Cadermatori Danesi, Karla Zanini Kantorski
The aim of this study was to evaluate the effect of an MB experimental formulation (ethanol 20%) in aPDT used as an adjuvant to scaling and root planing (SRP) in the periodontal treatment of diabetic rats. Forty male Wistar rats received streptozotocin-intraperitonial injections to induce diabetes. After 14 days, 5 animals were allocated in the non-ligate group (NLG), and 35 animals received ligature at the first right mandibular molar to induce periodontitis. After 7 days, the ligature was removed and the animals were randomized into 4 groups: LG (without treatment, n = 5), SRPG (SRP, n = 10), aPDTW (SRP+aPDT-MB/water, n = 10), and aPDTEt (SRP + aPDT-MB/water/ethanol/carboxymethylcellulose, n = 10)...
February 8, 2019: Lasers in Medical Science
Fernando Anschau, Jacqueline Webster, Marcelo Eduardo Zanella Capra, André Luis Ferreira de Azeredo da Silva, Airton Tetelbom Stein
Review effectiveness of low-level laser therapy (LLLT) in the curative treatment of oral mucositis (OM) in patients receiving cancer therapy. A systematic review with meta-analysis was performed using Medline, Embase, and Cochrane Library databases according to PRISMA guidelines, to identify randomized controlled trials (RCT) on OM in patients during and/or after cancer therapy and in which the therapeutic approach was LLLT, with wavelengths between 632 and 970 nm. We considered grade of OM as a dichotomous variable (such as an improvement or not in severe OM on the seventh day of therapy), with the analysis of subgroups of adult patients or children and adolescents and as a continuous variable with determination of the time for the complete resolution and the subgroup analysis occurred with the strata of the samples by treatment only with chemotherapy or chemotherapy and radiotherapy...
February 7, 2019: Lasers in Medical Science
Pierre Augusto Victor da Silva, Lúcia Mara Januário Dos Anjos, Thais Fraga Abduch, Rafael Pereira, Adenilson de Souza da Fonseca, Fávia de Paoli
Photobiomodulation (PBM) by low-level laser has demonstrated excellent results for inflammatory treatments, promoting repair of injured tissues. Knowledge regarding the molecular mechanisms involved in this process has been increasing, but its effect on cell death/survival-related gene expression after laser irradiation with different doses is not well understood. So, it is important to know these effects in order to guarantee the safety of therapeutic protocols based on PBM. This study aimed to investigate the mRNA levels of genes related to proteins involved in cell death/survival pathways of healthy tissues from talocrural joint of mice after PBM...
February 5, 2019: Lasers in Medical Science
Natália Aguiar Moraes Vitoriano, Daniela Gardano Bucharles Mont'Alverne, Maria Iara Socorro Martins, Priscila Sampaio Silva, Cristiany Azevedo Martins, Hortência Diniz Teixeira, Camylla Bandeira Miranda, Leila Maria Machado Bezerra, Renan Magalhães Montenegro, José Carlos Tatmatsu-Rocha
To compare the influence of laser and LED on tissue repair and neuropathic symptoms during treatment of diabetic foot. An intervention survey conducted in a health center located in Brazil, contemplating ten sessions, twice a week, with randomization in two groups. In one group, the wounds were treated with GaAlAs laser, with a wavelength of 830 nm, 30 mW, and power density 0.84 W/cm2 , the other group by LED 850 nm, 48 mW, and power density 1.05 W/cm2 . For the analysis of wound size, photographic records analyzed by the ImageJ® software were used, and the neuropathy evaluation card examined...
February 4, 2019: Lasers in Medical Science
Daíse Raquel Maldaner, Verônica Farina Azzolin, Fernanda Barbisan, Moisés Henrique Mastela, Cibele Ferreira Teixeira, Alexandre Dihel, Thiago Duarte, Neida Luiza Pellenz, Luiz Fernando Cuozzo Lemos, Carla Maria Uggeri Negretto, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte
Skin aging is a complex biological process induced by intrinsic and extrinsic factors which is characterized by clinical and cellular changes, especially dermal fibroblasts. It is possible that, some procedures, such as low-level laser therapy (LLLT), could decelerate this process. To test this hypothesis, this study evaluated the in vitro LLLT on dermal fibroblast cell line (HFF-1) with premature senescence H2 O2 -induced. HFF-1 cells were cultured in standardized conditions, and initially H2 O2 exposed at different concentrations...
February 2, 2019: Lasers in Medical Science
Lijun Zhou, Victor Chong, Kunbei Lai, Chuangxin Huang, Fabao Xu, Yajun Gong, Maimaitiaili Youlidaxi, Tao Li, Lin Lu, Chenjin Jin
To compare the efficacy of 50% threshold power with 25% threshold power of 577-nm subthreshold micropulse laser (SMPL) for acute central serous chorioretinopathy (CSC). Prospective, interventional, non-randomized, comparative case series. A total of 54 patients (54 eyes) with acute CSC were enrolled. Twenty-four eyes received 25% threshold power and 30 eyes received 50% threshold power of 577-nm SMPL. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and complete absorption of subretinal fluid (SRF) were evaluated at 1 month and 3 months...
February 2, 2019: Lasers in Medical Science
Zhao Zhang, Hua-Jun Yu, Hui Huang, Bei Wan, Shang Wu, Hai-Yang Liu, Hai-Tao Zhang
Corrole is a kind of new and promising photosensitizer (PS) in cancer photodynamic therapy (PDT). However, the protein molecular mechanism of PDT activity for corrole under light irradiation is still not clear. In this paper, water-soluble cationic sulfonated corrole (1) and its metal complexes (1-Fe, 1-Mn, and 1-Cu) were prepared, and the photodynamic anti-cancer activity against various tumor cells was investigated by MTT assay. The potential molecular mechanism of PDT activity was elucidated by fluorescence microscope, flow cytometry, molecular docking, and western blotting analysis...
February 2, 2019: Lasers in Medical Science
Javier Moreno-Moraga, Mihail L Pascu, Justo M Alcolea, Adriana Smarandache, Josefina Royo, Fernández David, Mario A Trelles
Sclerotherapy continues to be the treatment of choice for varicose veins in the legs. However, isolated treatment using microfoam or lasers requires a high number of sessions to eliminate them. In 2013, we published results about the efficacy and safety 3 years after the combined treatment with microfoam injections and subsequent application of Nd:YAG laser. The aim of this paper is to clinically evaluate the treatment of varices in a control visit after 5 years, when polidocanol microfoam is used and is immediately irradiated in the tissue with 1064-nm Nd:YAG laser beam...
February 1, 2019: Lasers in Medical Science
Kao-Hui Liu, Donald Liu, Yu-Tsung Chen, Szu-Ying Chin
The purpose of this review is to explore the effectiveness of low-level laser therapy (LLLT) in the treatment of adult androgenic alopecia (AGA). A systematic search of studies on LLLT for AGA was conducted mainly in Pubmed, Embase, and Cochrane Systematic Reviews. The standardized mean difference (SMD) in the changes of hair density treated by LLLT versus sham devices was analyzed. The meta-analysis included 8 studies comprising a total of 11 double-blinded randomized controlled trials. The quantitative analysis showed a significant increase in hair density for those treated by LLLT versus sham group (SMD 1...
January 31, 2019: Lasers in Medical Science
ZiZheng Yang, Yang Lv, Feng Yue, DongSheng Cao
To determine the combined therapeutic effect of fractional carbon dioxide laser and silicone gel on fresh traumatic scars using a rabbit ear hypertrophic scar (EHS) model, as well as on human subjects. The rabbit EHS model was established by punching four circular wounds in each ear and respectively treated with carbon dioxide laser, silicone gel, and the combination of both, while one wound was left untreated. In addition, a validation group of five rabbits was also included wherein the wounds were treated with triamcinolone, IFN-α, and normal saline, with one untreated control...
January 25, 2019: Lasers in Medical Science
N S Zaki, R F Hilal, R M Essam
Unfortunately, there are two mistakes in the published article. The first mistake is found in the Results section, Clinical improvement subsection. The last sentence "There was no statistical difference between both sides (P=0.008)." should be corrected to "There was statistical difference between both sides (P=0.008)."
January 24, 2019: Lasers in Medical Science
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