Anil Kumar Rana, Supriya Sharma, Rajneesh Kumar, Damanpreet Singh
Menopause is a natural aging process characterized by decreased levels of sex hormones in females. Deprivation of estrogen following menopause results in alterations of dendritic arborization of the neuron that leads to neurobehavioral complications. Hormone replacement therapy is in practice to manage postmenopausal conditions but is associated with a lot of adverse effects. In the present study, the efficacy of buckwheat tartary (Fagopyrum tataricum) whole seed extract was investigated against the neurobehavioral complication in middle-aged ovariectomized rats, which mimic the clinical postmenopausal condition...
May 3, 2023: Metabolic Brain Disease
Sanaz Salaramoli, Hamed Amiri, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
AIM: Parkinson disease (PD) is a prevalent central nervous system degenerative condition that impacts elderly people. Recent clinical and experimental study findings have established oxidative stress as one of the main pathogeneses of PD. Selenium, a trace metals with antioxidant effects, might reverse the neurobehavioral impairments and oxidative stress in rats. Thus, the goal of this study was to ascertain if Selenium Nano Particles (SeNPs) are also effective to protect brain cells from oxidative stress or not...
May 3, 2023: Metabolic Brain Disease
Pei Fan, Yuying Lu, Haidong Wei, Kui Wang, Pengyu Jia, Yuanyuan Zhang, Yan Zhang, Tianyue Wang, Liufei Yang, Jing Zhao, Shuyue Zhang, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhang
Anesthetics such as sevoflurane are commonly administered to infants and children. However, the possible neurotoxicity caused by prolonged or repetitive exposure to it should be a concern. The neuroprotective effects of metformin are observed in many models of neurological disorders. In this study, we investigated whether metformin could reduce the developmental neurotoxicity induced by sevoflurane exposure in neonatal rats and the potential mechanism. Postnatal day 7 (PND 7) Sprague-Dawley rats and neural stem cells (NSCs) were treated with normal saline or metformin before sevoflurane exposure...
April 29, 2023: Metabolic Brain Disease
Mariane Bernardo Duarte, Bianca Zampiroli Medeiros, Isabela da Silva Lemos, Guilherme Lodetti da Silva, Carolina Giassi Alano, Eduardo Ronconi Dondossola, Carolina Antunes Torres, Pauline Souza Effting, Eduardo Pacheco Rico, Emilio Luiz Streck
Maple syrup urine disease (MSUD) is an inherited metabolic disorder caused by a deficiency in branched-chain alpha-ketoacid dehydrogenase complex (BCKAC). The treatment is a standard therapy based on a protein-restricted diet with low branched-chain amino acids (BCAA) content to reduce plasma levels and, consequently, the effects of accumulating their metabolites, mainly in the central nervous system. Although the benefits of dietary therapy for MSUD are undeniable, natural protein restriction may increase the risk of nutritional deficiencies, resulting in a low total antioxidant status that can predispose and contribute to oxidative stress...
April 26, 2023: Metabolic Brain Disease
Vittoria Cianci, Angelo Pascarella, Lucia Manzo, Sara Gasparini, Oreste Marsico, Anna Mammì, Carmelo Massimiliano Rao, Claudio Franzutti, Umberto Aguglia, Edoardo Ferlazzo
BACKGROUND: The GLA c.337T > C (p.Phe113Leu) is a known pathogenic variant associated to late-onset Fabry disease phenotype with predominant cardiac manifestations. A founder effect was demonstrated in a large cohort in the Portuguese region of Guimarães. Herein we report an in-depth phenotype description of a cluster of five Southern Italy families. METHODS: Family pedigrees of five index males with the p.Phe113Leu variant were obtained and all at-risk relatives underwent biochemical and genetical screening test...
April 25, 2023: Metabolic Brain Disease
Song-Tao Wu, Shan-Shan Han, Xi-Ming Xu, Hai-Jun Sun, Hua Zhou, Kun Shang, Zi-Hao Liu, Shu-Juan Liang
BACKGROUND: Postoperative anxiety is a common surgical complication in older patients. Research has recently linked excessive autophagy to several neurological disorders, including anxiety. This study aimed to determine whether 3-Methyladenine (3-MA) administration reduced anxiety-like behaviors in a mouse model following abdominal exploratory laparotomy. METHODS: An abdominal exploratory laparotomy model of postoperative anxiety was established using male C57BL/6 mice aged 20 months...
April 25, 2023: Metabolic Brain Disease
Ziying Zhou, Xijia Wang, Qian Hu, Zhigang Yang
BACKGROUND: Circular RNAs (circRNA) have been reported to be involved in the progression of cerebral infarction. The purpose of this study was to reveal the role and potential molecular mechanism of circZfp609 (mmu_circ_0001797) in cerebral infarction. METHODS: C57BL/6J mice was used to construct middle cerebral artery occlusion (MCAO) mice model, and primary mouse astrocytes were treated with oxygen-glucose deprivation/reperfusion (OGD/R) process. The circZfp609, microRNA (miR)-145a-5p and BTB and CNC homology 1 (BACH1) expression levels were detected by quantitative real-time PCR...
April 25, 2023: Metabolic Brain Disease
Xirui He, Yan Yang, Xufang Yuan, Yin Sun, Yongsheng Li
Epilepsy is a serious public health problem in the world. At present, over 30% of affected patients remain refractory to currently available treatment. Medicinal plants as pharmaceuticals and healthcare treatments have been frequently used in the management of epilepsy in China for many centuries. Gastrodia elata-Acous tatarinowii (GEAT), as a classic and most commonly used herb pair in traditional Chinese medicine (TCM), has been employed to control seizures for thousands of years. However, the animal experiment data on its anticonvulsant effect is limited in the literature...
April 12, 2023: Metabolic Brain Disease
Parvin Poorgholam, Parichehreh Yaghmaei, Mehdi Noureddini, Zahra Hajebrahimi
Alzheimer disease (AD) is a common form of dementia associated with loss of memory and disruption of synaptic plasticity. There is a strong correlation between the pathophysiological features of AD and diabetes, including induction of oxidative stress, inflammation, and abnormality in blood vessels. Considering the brain's limited capacity to repair damage and the potential of stem cell-derived neural cells in the repair of neurodegenerative disease, we investigated the effects of artemisinin and TSP‑1‑human endometrial-derived-derived stem cells (TSP‑1‑hEDSCs) on the cognitive function and synaptic plasticity in AD-diabetes rats...
April 12, 2023: Metabolic Brain Disease
Ya-Zhi Bai, Shuang-Qing Zhang
No abstract text is available yet for this article.
April 10, 2023: Metabolic Brain Disease
Zhi-Kun Qiu, Bai-Xian Zhou, Jiali Pang, Wei-Qiang Zeng, Han-Biao Wu, Fan Yang
Alzheimer's Disease is considered as an insidious neurodegenerative progressive disease but its pathogenesis has not been elucidated. Acoritataninowii Rhizoma exhibits anti-dementia effects as a traditional Chinese medicine (TCM), which is linked to its anti- Alzheimer's Disease mechanism. In this study, network pharmacology and molecular docking were used to examine the potential of Acoritataninowii Rhizoma for Alzheimer's Disease. In order to construct PPI networks and drug-component-target-disease networks, disease-related genes and proteins were gathered from the database...
April 10, 2023: Metabolic Brain Disease
Yingjun Liang, Xiaolan Gao, Deyun Lu, Huiwen Zhang, Zhang
BACKGROUND: Mucopolysaccharidosis type IIIC (MPS IIIC; Sanfilippo syndrome C) is a rare lysosomal storage disease caused by mutations in the heparan-α-glucosaminide N-acetyltransferase (HGSNAT) gene, resulting in the accumulation of heparan sulfate. MPS IIIC is characterized by severe neuropsychiatric symptoms and mild somatic symptoms. METHODS: Our study analyzed the clinical presentation and biochemical characteristics of ten Chinese MPS IIIC patients from eight families...
April 4, 2023: Metabolic Brain Disease
Sajad Sahab Negah, Mehrdad Hajinejad, Saeideh Nemati, Seyyed Mohamad Javad Mahdipour Roudbary, Fatemeh Forouzanfar
Neuropathic pain is a chronic condition that causes long-term burning sensations. Despite significant efforts, current treatments for neuropathic pain are ineffective in curing the condition, which means new therapeutic options must be developed. One such option is the use of stem cell therapy in combination with anti-inflammatory herbal components, which has shown promise in treating neuropathic pain. The study aimed to investigate the effects of bone marrow mesenchymal stem cells (BM-MSCs) with luteolin on sensory deficits and pathological changes in a neuropathic model...
April 4, 2023: Metabolic Brain Disease
Nnenna Loveth Anosike, Joy Funsho Adejuwon, Godslove Emeka Emmanuel, Oluwatosin Samuel Adebayo, Hassanat Etti-Balogun, Jannie Nathaniel Nathaniel, Omolabake Ifeoluwa Omotosho, Michael Aschner, Omamuyovwi Meashack Ijomone
Cell death is vital to various organismal developmental processes including brain development. Apoptosis, the most recognized programmed cell death, has been linked to several developmental processes and implicated in pruning cells to provide the ultimate tissue integrity. However, more recently, other forms of non-apoptotic programmed cell death have been identified, of which necroptosis is of predominant interest. Necroptosis is a regulated form of necrosis, activated under apoptotic-deficient conditions...
March 25, 2023: Metabolic Brain Disease
Jalal Gharesouran, Hassan Hosseinzadeh, Ali Naghiloo, Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Mohammad Taheri, Maryam Rezazadeh, Mohammad Samadian
Charcot-Marie-Tooth (CMT) comprises a group of hereditary neuropathies with clinical, epidemiological, and molecular heterogeneity in which variants in more than 80 different genes have been reported. One of the important genes which cause 5% of all CMT cases is Myelin protein zero (P0, MPZ). Variants in this gene have been reported in association with different forms of CMT including classical CMT1, severe DSS (CMT3B), DI-CMT, CMT2I and CMT2J with autosomal dominant (AD) inheritance. To our knowledge, MPZ variants have not been described in autosomal recessive (AR) form of CMT in previous studies...
March 23, 2023: Metabolic Brain Disease
Xi Jiang, Qizhi Yan, Wendie Lao, Qian Lin, Haoran Cao, Lei Chen, Jin Chen, Xuefeng Yu, Fuhe Liu
This study aims to investigate the effect of irisin on ethanol-induced behavioral deficits and explore the underlying mechanisms. A mouse model of ethanol addiction/withdrawal was constructed through chronic ethanol administration. Depressive-like behaviors were evaluated by the tail suspension test and forced swimming test, and anxiety-like behaviors were evaluated by the marble-burying test and elevated plus maze test. The expression of Nrf2 was measured by western blotting. Levels of inflammatory mediators (NF-κB, TNF-α, IL-1β and IL-6) and oxidative stress factors (ROS, MDA, GSH and SOD) were detected by ELISA...
March 22, 2023: Metabolic Brain Disease
Parul Sood, Varinder Singh, Richa Shri
Mounting evidence shows that dietary intake of fruits with polyphenols is beneficial to improve impaired memory functions. This study explored the preventive as well as therapeutic effects of diet enriched with Morus alba fruits extract (DEMA) in streptozotocin (STZ) induced mouse model of memory impairment. The study consisted of two facets: one aspect consisted of pretreatment of animals with DEMA for two weeks followed by STZ (i.c.v) intervention and the second phase involved induction of dementia with STZ (i...
March 22, 2023: Metabolic Brain Disease
Chunwang Zhou, Mengyuan Li, Yingxin Chu, Liyan Zheng, Shubo Zhang, Xiujiang Gao, Ping Gao
Ischemic stroke is a disabling and fatal disease caused by the insufficient blood supply to the brain. Stellate ganglion block (SGB) is a type of anesthesia commonly used to relieve pain. Here, we sought to identify the effects of SGB on cerebral ischemia-reperfusion (I/R) injury. The middle cerebral artery occlusion (MCAO) model was established in rats. The brain injury was assessed using the 2,3,5-triphenyl-tetrazolium-chloride (TTC) staining assay and neurological score. Ferroptosis was analyzed by detecting cell death, Fe2+ content, glutathione (GSH), malonic dialdehyde (MDA), superoxide dismutase (SOD), and ferroptosis-related factors...
March 16, 2023: Metabolic Brain Disease
Rongrong Lv, Fang Lu, Shanshan Xu
Circular RNAs (circRNAs) can regulate the progression of neuroblastoma (NB) via miRNA/mRNA axis. This study aimed to investigate the functional mechanism of hsa_circ_0001361 in NB. Hsa_circ_0001361, miR-490-5p and tripartite motif 2 (TRIM2) were detected through reverse transcription-quantitative polymerase chain reaction. The proliferation ability was examined using cell counting kit-8 assay, colony formation assay and ethynyl-2'-deoxyuridine assay. Cell migration and invasion were assessed via transwell assay and wound healing assay...
March 15, 2023: Metabolic Brain Disease
Liang Meng, Yuefei Wang, Qin Tu, Yuan Zhu, Xiaoqin Dai, Ji Yang
BACKGROUND: Histone deacetylase (HDAC) inhibitor-based therapeutic drug tolerance is a major obstacle to glioblastoma (GBM) treatment. Meanwhile, non-coding RNAs have been reported to be involved in the regulation of HDAC inhibitor (SAHA) tolerance in some human tumors. However, the relationship between circular RNAs (circRNAs) and SAHA tolerance is still unknown. Herein, we explored the role and mechanism of circ_0000741 on SAHA tolerance in GBM. METHODS: Circ_0000741, microRNA-379-5p (miR-379-5p), and tripartite motif-containing 14 (TRIM14) level were detected by real-time quantitative polymerase chain reaction (RT-qPCR)...
March 11, 2023: Metabolic Brain Disease
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