Maryam Mehranpour, Mojtaba Sani, Amirreza Beirami, Maral Hasanzadeh, Mohammad Taghizadeh, Mobina Banihashemi, Meysam Hassani Moghaddam, Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Neda Eskandari, Mohammad-Amin Abdollahifar, Amir-Hossein Bayat, Abbas Aliaghaei, Mohammad Hossain Heidari
Epilepsy significantly reduces the patient's quality of life, and we still need to develop new therapeutic approaches to control it. Transplantation of cells such as Sertoli cells (SCs), having a potent ability to release a variety of growth and immunoprotective substances, have made them a potential candidate to deal with neurological diseases like epilepsy. Hence, this study aims to evaluate whether SCs transplant effectively protects the hippocampus astrocytes and neurons to oppose seizure damage. For this purpose, the effects of bilateral intrahippocampal transplantation of SCs were investigated on the rats with the pentylenetetrazol (PTZ) induced seizure...
October 18, 2023: Metabolic Brain Disease