journal
https://read.qxmd.com/read/38767967/evaluation-of-the-treatment-duration-of-japanese-patients-with-pancreatic-cancer-in-a-real-world-setting-using-a-large-hospital-claims-database-the-suisei-study
#1
JOURNAL ARTICLE
Hideki Ueno, Kyoko Shimizu, Ayako Fukui, Masahiro Nii, Ryo Koto, Michiaki Unno
OBJECTIVES: To clarify the treatment reality of pancreatic cancer in Japan, focusing on treatment duration and time to death. MATERIALS AND METHODS: We retrospectively analyzed Japanese hospital claims data for patients diagnosed with pancreatic cancer between April 2009 and October 2018 to investigate treatment patterns, duration of first-line chemotherapy, and time to death. RESULTS: Of 81,185 eligible patients, 54.2% were male, the mean age was 71...
May 17, 2024: Pancreas
https://read.qxmd.com/read/38758952/real-risk-factors-for-post-ercp-pancreatitis-patients
#2
JOURNAL ARTICLE
Wanjun Wu, Zheng Peng
No abstract text is available yet for this article.
May 17, 2024: Pancreas
https://read.qxmd.com/read/38758943/commentary-on-the-serum-carbohydrate-antigen-19-9-and-metabolite-hypotaurine-are-predictive-markers-for-early-recurrence-of-pancreatic-ductal-adenocarcinoma
#3
JOURNAL ARTICLE
Qiongying Xu, Junwu Zhang, Difeng Chen
No abstract text is available yet for this article.
May 17, 2024: Pancreas
https://read.qxmd.com/read/38743932/genetic-assessment-of-ipmn-for-predicting-concomitant-pancreatic-ductal-adenocarcinoma
#4
JOURNAL ARTICLE
Hideyuki Oi, Yuto Hozaka, Toshiaki Akahane, Kosuke Fukuda, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Michiyo Higashi, Akihide Tanimoto, Takao Ohtsuka
OBJECTIVE: Krüppel-like transcription factor 4(KLF4) mutations are more frequently observed in low-grade lesions than in high-grade lesions of intraductal papillary mucinous neoplasms (IPMN) of the pancreas. However, the role of KLF4 mutations in IPMNs with concomitant pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study clarified the rate and effect of KLF4 mutations in IPMN with concomitant PDAC. METHODS: DNA was extracted from 65 formalin-fixed and paraffin-embedded samples from 52 patients including 13 IPMN with concomitant PDAC and 39 IPMN alone...
May 15, 2024: Pancreas
https://read.qxmd.com/read/38743930/pancreatic-body-and-tail-adenocarcinoma-upfront-resection-versus-neoadjuvant-therapy-a-contemporary-analysis
#5
JOURNAL ARTICLE
Hiro Masuda, Nazim Bhimani, Angela Chou, Anthony J Gill, Jaswinder S Samra, Anubhav Mittal
OBJECTIVES: There is a paucity of data regarding the use of neoadjuvant therapy in pancreatic body or tail ductal adenocarcinomas. Given the differing tumour biology and aggressive nature of pancreatic body or tail adenocarcinomas, patients presenting with these tumours may benefit from upfront resection. METHODS: A retrospective cohort study was performed analysing patients who underwent distal pancreatectomy for pancreatic ductal adenocarcinoma between January 2013 and June 2022...
May 15, 2024: Pancreas
https://read.qxmd.com/read/38739839/primary-angiomyolipoma-of-the-distal-pancreas
#6
JOURNAL ARTICLE
Juliana C Levy, Abby Wong, Huaibin M Ko, John Chabot
No abstract text is available yet for this article.
May 13, 2024: Pancreas
https://read.qxmd.com/read/38710022/modulation-of-nuclear-receptor-4a1-expression-improves-insulin-secretion-in-a-mouse-model-of-chronic-pancreatitis
#7
JOURNAL ARTICLE
Sheethal Galande, Archana Verma, Raghavendra Mall, Kishore Vl Parsa, Ranjeet K Tokala, Ratnakar Bynigeri, Pavan Kumar Pondugala, Krishna Vemula, S Sai Latha, Divya Tej Sowpati, Surya S Singh, G V Rao, Rupjyoti Talukdar, Thirumala-Devi Kanneganti, D Nageshwar Reddy, Mitnala Sasikala
OBJECTIVES: Diabetes secondary to chronic pancreatitis (CP) presents clinical challenges due to insulin secretory defects and associated metabolic alterations. Owing to lack of molecular understanding, no pharmacotherapies to treat insulin secretory defects have been approved to date. We aimed to delineate the molecular mechanism of β-cell dysfunction in CP. METHODS: Transcriptomic analysis was conducted to identify endocrine specific receptor expression in mice and human CP on microarray...
May 6, 2024: Pancreas
https://read.qxmd.com/read/38710020/phenotypic-genomic-and-transcriptomic-heterogeneity-in-a-pancreatic-cancer-cell-line
#8
JOURNAL ARTICLE
Gengqiang Xie, Liting Zhang, Olalekan H Usman, Sampath Kumar, Chaity Modak, Dhenu Patel, Megan Kavanaugh, Xian Mallory, Yue Julia Wang, Jerome Irianto
OBJECTIVES: To evaluate the suitability of the MIA PaCa-2 cell line for studying pancreatic cancer intratumor heterogeneity, we aim to further characterize the nature of MIA PaCa-2 cells' phenotypic, genomic, and transcriptomic heterogeneity. METHODS: MIA PaCa-2 single-cell clones were established through flow cytometry. For the phenotypic study, we quantified the cellular morphology, proliferation rate, migration potential, and drug sensitivity of the clones. The chromosome copy number and transcriptomic profiles were quantified using SNPa and RNA-seq, respectively...
May 6, 2024: Pancreas
https://read.qxmd.com/read/38696476/essential-fatty-acid-deficiency-is-common-after-total-pancreatectomy-and-islet-autotransplantation
#9
JOURNAL ARTICLE
Elissa M Downs, James S Hodges, Guru Trikudanathan, Martin L Freeman, Srinath Chinnakotla, Varvara Kirchner, Timothy L Pruett, Gregory Beilman, Sarah Jane Schwarzenberg, Melena D Bellin
OBJECTIVES: Total pancreatectomy and islet autotransplantation (TPIAT) for pancreatitis may induce risk for essential fatty acid deficiency (EFAD) due to exocrine pancreatic insufficiency and intestinal alterations. The prevalence of EFAD post-TPIAT is currently unknown. METHODS: We abstracted essential fatty acid (EFA) profiles (n = 332 samples) for 197 TPIAT recipients (72% adult, 33% male). Statistical analyses determined the prevalence of, and associations with, EFAD post-operatively...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696459/syndecan-1-levels-and-early-positive-fluid-balance-are-associated-with-disease-severity-in-acute-pancreatitis
#10
JOURNAL ARTICLE
Antti Turunen, Krista Kuuliala, Antti Kuuliala, Pauli Puolakkainen, Leena Kylänpää, Johanna Hästbacka, Outi Lindström
OBJECTIVES: To study fluid balance and endothelial glycocalyx degradation, reflected by syndedan-1 and heparan sulfate (HS) levels, in early stages of acute pancreatitis (AP). METHODS: This study comprised of 210 AP patients (104 mild, 53 moderately severe, 17 severe). Blood was sampled within 72 h from the onset of symptoms, and plasma syndecan-1 and HS levels were determined using ELISA. Fluid balance up to sampling and up to 4 days was determined retrospectively from medical records...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696457/quality-of-life-following-tpiat-a-patient-experience-survey
#11
JOURNAL ARTICLE
Laura Barthold, Kerrington D Smith, Sushela S Chaidarun, Dawn A Fischer, Timothy B Gardner
OBJECTIVES: Total pancreatectomy with islet autotransplantation (TPIAT) is performed to improve the quality of life (QOL) of patients with chronic pancreatitis. Few reports have documented QOL following TPIAT, with none using the pancreatitis-specific Pancreatitis Quality of Life Instrument (PANQOLI). We surveyed patients at our center who underwent TPIAT to document postoperative QOL. METHODS: We collected survey data from 18 adult patients who underwent TPIAT at our medical center from 2012 to 2020...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696448/endotherapy-for-the-proximal-migration-of-pancreatic-stents-a-systematic-review
#12
JOURNAL ARTICLE
Yi-Li Cai, Fan Wang, Zhao-Shen Li, Liang-Hao Hu
OBJECTIVES: Proximal migration is one of the complications after pancreatic duct stenting. This study aimed to determine the incidence of proximal migration and to analyze the rescue methods. METHODS: A search was performed in MEDLINE/EMBASE database. The literatures included were reviewed and analyzed. Retrieval tools were classified into 3 classes: Class A works by indirectly contacting the outer surface of the stent. Class B works by directly contacting the outer surface...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696443/the-population-level-prevalence-of-exocrine-pancreas-insufficiency-and-the-subsequent-risk-of-pancreatic-cancer
#13
JOURNAL ARTICLE
Oyedotun Babajide, Aakash Desai, Chinelo Eruchalu, Mary Sedarous, Deborah Adekunle, Michael Youssef, Muftah Mahmud, Philip N Okafor
OBJECTIVES: To study the prevalence of exocrine pancreas insufficiency (EPI) at a population level and the subsequent risk of pancreatic ductal adenocarcinoma (PDAC). METHODS: Using TriNetX (a database of over 79 million US residents), we included patients ≥18 years with EPI (identified via ICD-10 codes) and continuous follow-up from 2016-2022. Patients with prior pancreas resection and PDAC before an EPI diagnosis were excluded. The primary outcome was EPI prevalence...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696438/research-progress-on-the-mechanism-of-acute-hypertriglyceridemic-pancreatitis
#14
JOURNAL ARTICLE
Yiteng Meng, Peiyu Han, Xiaoyu Ma, Yiting He, Hetian Chen, Hongbo Ren
The incidence rate of hypertriglyceridemia pancreatitis (HTGP) has experienced a notable increase in recent years, with eclipsing alcohol as the second leading cause of acute pancreatitis (AP). HTGP is often associated with more severe local and systemic complications. Recognized as a metabolic disorder hypertriglyceridemia (HTG), holds significant relevance in the pathogenesis of HTGP, yet its mechanisms are not fully understood. Both primary (genetic) and secondary (acquired) factors contribute to elevated triglyceride (TG) levels, which concurrently influence the progression of HTGP...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696426/severity-of-gallstone-sludge-or-microlithiasis-induced-pancreatitis-all-of-the-same
#15
JOURNAL ARTICLE
Simon Sirtl, Katharina Bretthauer, Mahmood Ahmad, Eric Hohmann, Vanessa F Schmidt, Prince Allawadhi, Marlies Vornhülz, Sarah Klauss, Elisabetta Goni, Jakob Vielhauer, Elisabeth Orgler, Didem Saka, Mathilda Knoblauch, Felix O Hofmann, Jörg Schirra, Christian Schulz, Georg Beyer, Ujjwal M Mahajan, Julia Mayerle, Michal Zorniak
BACKGROUND/AIM: Severity of microlithiasis and sludge-induced pancreatitis in comparison to gallstone-induced pancreatitis has never been studied for a lack of definition. In order to understand whether bile duct obstruction or other mechanisms contribute to biliary pancreatitis severity we performed a monocentric, retrospective cohort study. METHODS: In this retrospective cohort study 263 patients with acute biliary pancreatitis treated at a tertiary care center from 2005 to 2021 were stratified according to the recent consensus definition for microlithiasis and sludge...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696422/aryl-hydrocarbon-receptor-knockout-accelerates-panin-formation-and-fibro-inflammation-in-a-mutant-kras-driven-pancreatic-cancer-model
#16
JOURNAL ARTICLE
Morgan T Walcheck, Patrick B Schwartz, Noah D Carrillo, Kristina A Matkowsky, Manabu Nukaya, Christopher A Bradfield, Sean M Ronnekleiv-Kelly
OBJECTIVES: The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the development of several cancers, and can be targeted for therapeutic effect. However, its involvement in the pathogenesis of PDAC remains unclear. To address this gap, we evaluated the role of AHR in the development of PDAC pre-cancerous lesions in vivo. METHODS: We created a global AHR-null, mutant Kras-driven PDAC mouse model (A-/-KC) and evaluated the changes in PDAC precursor lesion formation (Pan-IN 1, 2, and 3) and associated fibro-inflammation between KC and A-/-KC at 5 months of age...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696420/regarding-the-risk-of-hypertriglyceridemic-acute-pancreatitis
#17
JOURNAL ARTICLE
Beibei Wang, Zheng Peng
No abstract text is available yet for this article.
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696385/screening-of-amino-acids-as-a-safe-energy-source-for-isolated-rat-pancreatic-acini
#18
JOURNAL ARTICLE
Anastasiia M Zub, Bohdan O Manko, Volodymyr V Manko
OBJECTIVES: Amino acids play an essential role in protein synthesis, metabolism and survival of pancreatic acini. Adequate nutritional support is important for acute pancreatitis treatment. However, high concentrations of arginine and lysine may induce acute pancreatitis. The study aimed to identify the most suitable L-amino acids as safe energy sources for pancreatic acinar cells. METHODS: Pancreatic acini were isolated from male Wistar rats. Effects of amino acids (0...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696382/lipase-to-amylase-ratio-for-the-prediction-of-clinically-relevant-postoperative-pancreatic-fistula-following-pancreaticoduodenectomy
#19
JOURNAL ARTICLE
Juanita N Chui, William A Ziaziaris, Christopher B Nahm, Talia Fuchs, Sumit Sahni, Christopher S H Lim, Anthony J Gill, Jaswinder S Samra DPhil, Anubhav Mittal
AIM: Postoperative pancreatic fistula(POPF) represents a leading cause of morbidity and mortality following major pancreatic resections. This study aimed to evaluate the use of post-operative drain fluid lipase-to-amylase ratio(LAR) for the prediction of clinically relevant fistulae(CR-POPF). METHODS: Consecutive patients undergoing pancreaticoduodenectomy between 2017-2021 at a tertiary centre were retrospectively reviewed. Univariable and multivariable analyses were performed to identify predictors for CR-POPF(ISGPS Grades B/C)...
May 1, 2024: Pancreas
https://read.qxmd.com/read/38696363/early-hypophosphatemia-as-a-prognostic-marker-in-acute-pancreatitis
#20
JOURNAL ARTICLE
Connor F Stewart, Esther A Adeniran, Dhiraj Yadav, Fred S Gorelick, Rodger A Liddle, Bechien Wu, Stephen J Pandol, Christie Y Jeon
OBJECTIVES: Acute pancreatitis (AP) is a complex disease representing a significant portion of gastrointestinal-related hospitalizations in the U.S. Understanding risk factors of AP might provide attractive therapeutic targets. We evaluated hypophosphatemia as a risk factor for worse outcomes in AP. METHODS: We performed a retrospective review of electronic health records of patients with AP admissions from 01/01/2012-12/31/2021 at Cedars-Sinai Medical Center, evaluating patients with serum phosphate measured within 48 hours of admission...
May 1, 2024: Pancreas
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