journal
https://read.qxmd.com/read/38483006/genetic-causes-of-lymphatic-disorders-recent-updates-on-the-clinical-and-molecular-aspects-of-lymphatic-disease
#1
JOURNAL ARTICLE
Catharine Bowman, Stanley G Rockson
PURPOSE OF REVIEW: The lymphatic system facilitates several key functions that limit significant morbidity and mortality. Despite the impact and burden of lymphatic disorders, there are many remaining disorders whose genetic substrate remains unknown. The purpose of this review is to provide an update on the genetic causes of lymphatic disorders, while reporting on newly proposed clinical classifications of lymphatic disease. RECENT FINDINGS: We reviewed several new mutations in genes that have been identified as potential causes of lymphatic disorders including: MDFIC, EPHB4, and ANGPT2...
March 14, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38482858/leaders-need-to-look-in-the-mirror
#2
JOURNAL ARTICLE
Josh Koch
PURPOSE OF REVIEW: There is commonly a discrepancy between optimal physician leader behavior and actual physician leader behavior. Identifying and addressing this discrepancy is essential to optimize culture in high-risk care units. RECENT FINDINGS: Unit culture is directly linked to improving well tolerated and effective care. Adoption of strategies to better address bad behavior is necessary. SUMMARY: To address a toxic culture in a high-risk unit, physician leaders must first look inwards and take personal responsibility for their actions and words...
March 12, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38456429/predictive-utility-of-remnant-cholesterol-in-atherosclerotic-cardiovascular-disease
#3
JOURNAL ARTICLE
Spencer D Proctor, Maggie Wang, Donna F Vine, Paolo Raggi
PURPOSE OF REVIEW: Remnant cholesterol (RC) is the cholesterol carried in lipoproteins derived from the catabolism of chylomicrons and very low-density lipoproteins. Evidence supporting the causal relationship of RC with atherosclerotic cardiovascular disease (ASVD) is accumulating rapidly. The number of impactful contributions to this field are increasing and provide a pathophysiological insight into the current residual cardiovascular risk beyond low-density cholesterol (LDL)-cholesterol (LDL-C)...
March 11, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38482842/pemafibrate-and-other-triglyceride-lowering-therapies-to-reduce-risk-of-cardiovascular-and-metabolic-disease
#4
JOURNAL ARTICLE
Michael Miller
PURPOSE OF REVIEW: Although high triglycerides are consistently associated with elevated risk of cardiovascular disease (CVD), therapies that reduce triglyceride levels have inconsistently translated into reduced CVD risk. RECENT FINDINGS: To date, three clinical trials have tested triglyceride-lowering therapies in patients with hypertriglyceridemia (HTG) and elevated risk of incident/recurrent CVD. In REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial), assignment to IPE, a highly purified eicosapentanoic acid (EPA), resulted in a 25% reduction in nonfatal myocardial infarction), nonfatal stroke, cardiovascular death, coronary revascularization and hospitalization for unstable angina...
March 6, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38456513/resistant-hypertension
#5
JOURNAL ARTICLE
Farnoosh Shariati, Nitin Tandan, Carl J Lavie
PURPOSE OF REVIEW: Resistant hypertension (RH) is characterized by persistently elevated blood pressure despite the concurrent use of three antihypertensive medications, including a diuretic, at optimal doses. This clinical phenomenon poses a significant burden on healthcare systems worldwide due to its association with increased cardiovascular disease morbidity and mortality. RECENT FINDINGS: Ongoing studies on device-based treatment of RH, with aim to reduce sympathetic nervous system outflow, have shown promising evidence in management of RH which may in turn decrease the incidence of composite cardiovascular outcome faced by the affected population...
March 5, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38456474/effects-of-bempedoic-acid-on-markers-of-inflammation-and-lp-a
#6
JOURNAL ARTICLE
Sukhila Reddy, Abhizith Deoker
PURPOSE OF REVIEW: To study the effect of bempedoic acid on markers of inflammation and lipoprotein (a) to help determine if the drug would be useful to treat patients with elevated cardiovascular risks and residual cardiovascular risk despite optimal low-density lipoprotein cholesterol (LDL-C) levels. RECENT FINDINGS: Bempedoic acid is found to cause significant reduction in LDL-C and high-sensitivity C-reactive protein (hs-CRP) in various randomized clinical trials...
March 5, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38456469/clinical-impact-of-genetic-testing-for-lipid-disorders
#7
JOURNAL ARTICLE
Emir Muzurović, Sanja Borozan, Manfredi Rizzo
PURPOSE OF REVIEW: Genetic testing is increasingly becoming a common consideration in the clinical approach of dyslipidemia patients. Advances in research in last decade and increased recognition of genetics in biological pathways modulating blood lipid levels created a gap between theoretical knowledge and its applicability in clinical practice. Therefore, it is very important to define the clinical justification of genetic testing in dyslipidemia patients. RECENT FINDINGS: Clinical indications for genetic testing for most dyslipidemias are not precisely defined and there are no clearly established guideline recommendations...
March 1, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38391284/updates-in-the-management-of-cancer-therapy-related-hypertension
#8
JOURNAL ARTICLE
Prerna Gupta, Mario Enrico Canonico, Christian Faaborg-Andersen, Nicole Prabhu, Lavanya Kondapalli, Raymundo A Quintana
PURPOSE OF REVIEW: To provide a comprehensive review of hypertension among patients with cancer. Several cancer therapies cause hypertension which has resulted in a growing and vulnerable population of patients with difficult to control hypertension which has significant downstream effects. RECENT FINDINGS: Hypertension affects up to 50% of cancer patients and higher comorbidity when compared to the general population. Many anticancer therapies can cause hypertension through their treatment effect...
February 26, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38391276/double-outlet-right-ventricle-the-50-rule-has-always-been-about-the-conus
#9
JOURNAL ARTICLE
Rebecca Josowitz, Lindsay S Rogers
PURPOSE OF REVIEW: There has been much variability in the definition of double outlet right ventricle (DORV) spanning the last century. Historically, emphasis has been placed on the assignment of the great arteries to the right ventricle as a definition of DORV. In this review, we aim to underscore the importance of conal muscle, rather than rules surrounding assignment of great arteries to ventricles. We will be outlining the variability in patient anatomy that results from variations in conal muscle development in DORV, which may not fit perfectly into predefined constructs...
February 26, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38391275/cardiac-rehabilitation-for-heart-failure-progress-and-gaps-in-evidence-and-policy
#10
JOURNAL ARTICLE
Alfred Ngo-Hamilton, Dzhalal Agakishiev, Valmiki Maharaj
PURPOSE OF REVIEW: This review synthesizes recent research on the efficacy, optimal design, and delivery methods of cardiac rehabilitation tailored to heart failure patients. Despite established benefits, cardiac rehabilitation referral and access disparities persist, necessitating elucidation of limitations and solutions. RECENT FINDINGS: Exercise-based cardiac rehabilitation improves long-term mortality and hospitalization rates but not short-term mortality. cardiac rehabilitation further enhances quality of life and medical therapy adherence...
February 26, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38391273/a-deep-dive-into-the-percutaneous-mitral-valve-data
#11
JOURNAL ARTICLE
Ana Paula Tagliari, Rodrigo Petersen Saadi, Gilbert H L Tang
PURPOSE OF REVIEW: This review offers insights into percutaneous mitral valve management, emphasizing pivotal trials that contributed to its evolution. RECENT FINDINGS: Mitral regurgitation (MR) is a highly prevalent heart valve disease, with surgical intervention being the gold standard for managing primary MR. However, a notable proportion of patients face ineligibility criteria or are at high surgical risk, particularly in the setting of secondary MR. To fill this gap, transcatheter therapies have emerged as less invasive alternatives...
February 26, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38386349/the-role-of-genetic-testing-in-marfan-syndrome
#12
JOURNAL ARTICLE
Emanuele Monda, Martina Caiazza, Giuseppe Limongelli
PURPOSE OF REVIEW: This review aims to delineate the genetic basis of Marfan syndrome (MFS) and underscore the pivotal role of genetic testing in the diagnosis, differential diagnosis, genotype-phenotype correlations, and overall disease management. RECENT FINDINGS: The identification of pathogenic or likely pathogenic variants in the FBN1 gene, associated with specific clinical features such as aortic root dilatation or ectopia lentis, is a major diagnostic criterion for MFS...
February 22, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38386340/metabolic-basis-of-cardiac-dysfunction-in-cancer-patients
#13
JOURNAL ARTICLE
Jane C Figueiredo, Neil Adri Bhowmick, Anja Karlstaedt
PURPOSE OF REVIEW: The relationship between metabolism and cardiovascular diseases is complex and bidirectional. Cardiac cells must adapt metabolic pathways to meet biosynthetic demands and energy requirements to maintain contractile function. During cancer, this homeostasis is challenged by the increased metabolic demands of proliferating cancer cells. RECENT FINDINGS: Tumors have a systemic metabolic impact that extends beyond the tumor microenvironment. Lipid metabolism is critical to cancer cell proliferation, metabolic adaptation, and increased cardiovascular risk...
February 22, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38386339/short-and-long-term-complications-of-hypertensive-disorders-of-pregnancy-lifelong-cardiovascular-risks-we-cannot-ignore
#14
JOURNAL ARTICLE
Cara E Saxon, Julia Bast, Josephine C Chou
PURPOSE OF REVIEW: Hypertensive disorders of pregnancy (HDP) pose a significant threat to maternal cardiovascular health, with emerging research shedding light on the enduring risks beyond the gestational period. This review highlights updates regarding cardiovascular risks associated with HDP and their implications for long-term health. RECENT FINDINGS: Patients with a history of HDP are at an elevated risk of developing chronic hypertension, ischemic heart disease, stroke, valvular heart disease, and heart failure...
February 22, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38375816/sleep-disordered-breathing-in-heart-failure
#15
JOURNAL ARTICLE
Gregory R Jackson, Justin Durland, Frank Hoyland
PURPOSE OF REVIEW: This review addresses the evolving intersection of sleep-disordered breathing (SDB) and heart failure, a topic of increasing clinical significance due to the high prevalence of SDB in heart failure patients and its impact on morbidity and mortality. It reflects recent advancements in diagnostic methodologies and therapeutic strategies. It emphasizes the need for heightened awareness among healthcare providers about the complex relationship between SDB and various forms of heart failure...
February 20, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38362936/decongestion-instead-of-ultrafiltration
#16
JOURNAL ARTICLE
Art Schuermans, Frederik H Verbrugge
PURPOSE OF REVIEW: To summarize the contemporary evidence on decongestion strategies in patients with acute heart failure (AHF). RECENT FINDINGS: While loop diuretic therapy has remained the backbone of decongestive treatment in AHF, multiple randomized clinical trials suggest that early combination with other diuretic classes or molecules with diuretic properties should be considered. Mineralocorticoid receptor antagonists and sodium-glucose co-transporter-2 inhibitors are disease-modifying drugs in heart failure that favourably influence prognosis early on, advocating their start as soon as possible in the absence of any compelling contraindications...
February 19, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38353280/intravenous-iron-in-patients-with-iron-deficiency-and-heart-failure-a-review-of-modern-evidence
#17
JOURNAL ARTICLE
Stormi E Gale, Andrew Willeford, Katherine Sandquist, Kristin Watson
PURPOSE OF REVIEW: Iron deficiency is common in patients with heart failure, affecting up to half of ambulatory patients and an even greater percentage of patients admitted for acute decompensation. Iron deficiency in this population is also associated with poor outcomes, including worse quality of life in addition to increased hospitalizations for heart failure and mortality. Evidence suggests that patients with iron deficiency in heart failure may benefit from repletion with IV iron...
February 15, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38305721/simulating-mitral-repair-lessons-learned
#18
JOURNAL ARTICLE
Abigail White, Anna Zarzycki, Gianluigi Bisleri
PURPOSE OF REVIEW: With the growing complexity of cardiac surgical cases, increased focus on patient safety, and minimally invasive techniques, simulation-based training has experienced a renaissance. This review highlights important elements of simulation-based training, focusing specifically on available simulators for mitral valve repair and the uses for simulation. RECENT FINDINGS: Referring to simulators as being high or low fidelity is oversimplified. Fidelity is a multifactorial concept, and for surgical task trainers, structural and functional fidelity should be discussed...
February 3, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38294187/beyond-weight-loss-the-emerging-role-of-incretin-based-treatments-in-cardiometabolic-hfpef
#19
JOURNAL ARTICLE
Federico Capone, Natasha Nambiar, Gabriele G Schiattarella
PURPOSE OF REVIEW: Incretin-based drugs are potent weight-lowering agents, emerging as potential breakthrough therapy for the treatment of obesity-related phenotype of heart failure with preserved ejection fraction (HFpEF). In this review article, we will discuss the contribution of weight loss as part of the benefits of incretin-based medications in obese patients with HFpEF. Furthermore, we will describe the potential effects of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists on the heart, particularly in relation to HFpEF pathophysiology...
January 31, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38294186/obesity-cardiometabolic-phenotype-of-heart-failure-with-preserved-ejection-fraction-mechanisms-to-recent-trials
#20
REVIEW
Raj Verma, Nitish K Dhingra, Kim A Connelly
PURPOSE OF REVIEW: Heart failure with preserved ejection fraction (HFpEF) is a leading and growing cause of morbidity and mortality globally. Of the various phenotypes identified, the obesity (or cardiometabolic) phenotype appears to be most common. The purpose of this review is to provide the clinician with an abridged understanding of recent developments that have elucidated obesity/visceral adiposity as a central mechanism linking inflammation/immune dysregulation to the development of the HFpEF syndrome...
March 1, 2024: Current Opinion in Cardiology
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