Journals Journal of Gastroenterology an...

Journal of Gastroenterology and Hepatology
Hiroyoshi Iwagami, Ryu Ishihara, Kazuharu Aoyama, Hiromu Fukuda, Yusaku Shimamoto, Mitsuhiro Kono, Hiroko Nakahira, Noriko Matsuura, Satoki Shichijo, Takashi Kanesaka, Hiromitsu Kanzaki, Tatsuya Ishii, Yasuki Nakatani, Tomohiro Tada
BACKGROUND AND AIMS: Conventional endoscopy for the early detection of esophageal and esophagogastric junctional (EGJ) adenocarcinoma (E/J cancer) is limited because early lesions are asymptomatic and the associated changes in the mucosa are subtle. There are no reports on artificial intelligence (AI) diagnosis for E/J cancer from Asian countries. Therefore, we aimed to develop a computerized image analysis system using deep learning for the detection of E/J cancers. METHODS: A total of 1,172 images from 166 pathologically proven superficial E/J cancer cases and 2,271 images of normal mucosa in EGJ from 219 cases were used as the training image data...
June 8, 2020: Journal of Gastroenterology and Hepatology
Takuya Inoue, Ryu Ishihara, Tsutomu Nishida, Tomofumi Akasaka, Yoshito Hayashi, Dai Nakamatsu, Hideharu Ogiyama, Shinjiro Yamaguchi, Katsumi Yamamoto, Akira Mukai, Kazuo Kinoshita, Takayuki Yakushijin, Hideki Iijima, Tetsuo Takehara
BACKGROUND AND AIM: Prophylactic clipping (PC) after polypectomy has the potential to prevent post-polypectomy bleeding (PPB). We aimed to evaluate the effectiveness of PC in preventing PPB for <20-mm polyps. METHODS: This multicenter, open-labeled, randomized controlled trial conducted from December 2013 to June 2017 at 10 institutions randomly assigned 1080 patients with <20-mm colon polyps to the non-PC and PC groups. Allocation factors were institution, antiplatelet drug use, and polyp number...
June 8, 2020: Journal of Gastroenterology and Hepatology
Gerald Holtmann, Eamonn M Quigley, Ayesha Shah, Michael Camilleri, Victoria Py Tan, Kok Ann Gwee, Kentaro Sugano, Jose D Sollano, Kwong M Fock, Uday C Ghoshal, Minhu Chen, Axel Dignass, Henry Cohen
The available COVID-19 literature has focussed on specific disease manifestations, infection control, and delivery or prioritisation of services for specific patient groups in the setting of the acute COVID-19 pandemic. Local health systems aim to contain the COVID-19 pandemic and hospitals and health care providers rush to provide the capacity for a surge of COVID-19 patients. However, the short, medium- and long-term outcomes of patients with gastrointestinal (GI) diseases without COVID-19 will be affected by the ability to develop locally adapted strategies to meet their service needs in the COVID-19 setting...
June 8, 2020: Journal of Gastroenterology and Hepatology
D B Cao, Y S Wang
No abstract text is available yet for this article.
June 7, 2020: Journal of Gastroenterology and Hepatology
Matthew J Gurka, Jasmine A Mack, Xiaofei Chi, Mark D DeBoer
BACKGROUND AND AIM: Non-alcoholic steatohepatits (NASH), which can lead to liver failure, requires liver biopsies to follow and is difficult to treat. Our goal was to assess metabolic syndrome (MetS) severity as a predictor of treatment success and a marker of response. METHODS: We assessed data from the Pioglitazone, Vitamin-E or Placebo NASH Study (PIVENS), in which individuals with biopsy-confirmed NASH were randomized to receive pioglitazone, vitamin-E or placebo for 96 weeks...
June 7, 2020: Journal of Gastroenterology and Hepatology
Zi Qin Ng, Abdallah Elsabagh, Ruwan Wijesuriya
BACKGROUND AND AIM: Appendicitis after colonoscopy is an exceedingly rare complication. It remains to be explored if this entity is truly a complication of colonoscopy or a coincidental occurrence of appendicitis post-colonoscopy. The aim of this study was to systematically review all the available evidence since it was first described in 1988. METHODS: The literature on post-colonoscopy appendicitis was searched using PubMed, EMBASE, and Cochrane databases. Additional manual search was performed and cross-checked for additional references...
June 5, 2020: Journal of Gastroenterology and Hepatology
Juan D Gomez Cifuentes, Jordan Sparkman, Kati Choi, Robert J Sealock
No abstract text is available yet for this article.
June 5, 2020: Journal of Gastroenterology and Hepatology
K Mandai, K Uno, K Yasuda
No abstract text is available yet for this article.
June 4, 2020: Journal of Gastroenterology and Hepatology
Ichiro Takeuchi, Katsuhiro Arai, Reiko Kyodo, Takuro Sato, Kazuhide Tokita, Yuri Hirano, Hirotaka Shimizu
BACKGROUND AND AIM: Ustekinumab is a human monoclonal antibody targeting the p40 subunit of both interleukin-12 and interleukin-23 with reported efficacy to treat Crohn's disease. However, few studies have reported the use of ustekinumab for pediatric inflammatory bowel disease. This study aimed to assess the clinical efficacy and safety of ustekinumab in children and adolescents with inflammatory bowel disease. METHODS: Medical records of patients aged under 20 years with Crohn's disease or Crohn's disease-like inflammatory bowel disease who had received ustekinumab at a Japanese pediatric inflammatory bowel disease center were retrospectively reviewed for efficacy and safety...
June 4, 2020: Journal of Gastroenterology and Hepatology
Valeria D'Ovidio, Cristina Lucidi, Giovanni Bruno, Lucia Miglioresi, Daniele Lisi, Marco Emilio Bazuro
No abstract text is available yet for this article.
June 4, 2020: Journal of Gastroenterology and Hepatology
Sawangpong Jandee, Panu Wetwittayakhlang, Pattira Boonsri
BACKGROUND AND AIM: Paralytic ileus is a common intestinal dysfunction in critically ill patients, which results in complications and poor hospital outcomes. There are still no established effective medications, except correcting the primary causes and prokinetics trial, which have limited efficacy and potential adverse events. This study aims to evaluate the efficacy of prucalopride on paralytic ileus in critically ill patients. METHODS: A randomized, double-blind, placebo-controlled trial of five consecutive days treatment periods was conducted...
June 1, 2020: Journal of Gastroenterology and Hepatology
Henning Grønbaek, Holger Jon Møller, Fauzi Saliba, Stefan Zeuzem, Agustin Albillos, Xavier Ariza, Isabel Graupera, Elsa Solà, Alex Amoros, Marco Pavesi, Lars Bossen, Rajiv Jalan, Pere Gines, Vicente Arroyo
BACKGROUND AND AIM: Acute-on-chronic liver failure (ACLF) as a sinister prognosis and there is a need for accurate biomarkers and scoring systems to better characterize ACLF patients and predict prognosis. Systemic inflammation and renal failure are hallmarks in ACLF disease development and progression. We hypothesized that the combination of specific inflammatory markers in combination with clinical scores are better predictors of survival than the originally developed CLIF-C acute decompensation (AD) and CLIF-C ACLF scores...
June 1, 2020: Journal of Gastroenterology and Hepatology
Teh-Ia Huo, Po-Hong Liu, Shu-Yein Ho
No abstract text is available yet for this article.
May 31, 2020: Journal of Gastroenterology and Hepatology
Jianhua Wan, Dangyan Wu, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia, Nonghua Lu
INTRODUCTION: Currently, endoscopic drainage (ED) and percutaneous drainage (PD) are both widely used effective interventions in the management of patients with symptomatic pancreatic fluid collections (PFCs). This study aimed to compare the clinical effectiveness and safety of ED to those of PD in the treatment of PFCs. MATERIAL/METHODS: A prospective cohort study of PFC patients who underwent ED or PD was conducted between January 2009 and December 2017. In this study, the initial success rate, adverse events, intervention, requirement of surgical treatment, hospital mortality within 30 days, length of hospital stay and expenses during hospitalization were monitored, and a follow-up investigation of treatment outcome was conducted...
May 30, 2020: Journal of Gastroenterology and Hepatology
Xiangping Wang, Gui Ren, Yibin Xi, Hui Luo, Shuhui Liang, Biaoluo Wang, Qin Tao, Bing Luo, Qian Qin, James J Farrell, Xuegang Guo, Kaichun Wu, Yanglin Pan
BACKGROUND & AIMS: Double-guidewire technique (DWT) has been successfully performed by experts in difficult biliary cannulation as an advanced technique. This study aimed to define the learning curve and safety of DWT by trainees during hands-on endoscopic retrograde cholangiopancreatography (ERCP) training. METHODS: Patients were eligible for inclusion in the study if the biliary cannulation was difficult and the pancreatic duct (PD) was inadvertently cannulated...
May 30, 2020: Journal of Gastroenterology and Hepatology
Ming-Xing Xia, Yi-Feng Zhou, Ming Zhang, Wei Wang, Jun Wu, Tian-Tian Wang, Xiao-Feng Zhang, Bing Hu
BACKGROUND AND AIM: Fully covered self-expandable metal stents (FCSEMSs) have been increasingly used in the management of benign or malignant biliary disorders. However, the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) with transpapillary placement of the FCSEMS remains controversial. This study therefore aimed to investigate the risk of PEP in patients who received FCSEMS implantation. METHODS: In total, 602 patients who underwent endoscopic transpapillary FCSEMS placement at five Chinese medical centers, between 2011 and 2018, were included in this retrospective study...
May 30, 2020: Journal of Gastroenterology and Hepatology
Tae Hoon Lee, Sung Ill Jang, Jong Ho Moon, Yun Nah Lee, Jae Kook Yang, Jin-Seok Park, Seok Jeong, Don Haeng Lee, Nam Hun Heo, Sang-Heum Park, Dong Ki Lee
BACKGROUNDS AND AIM: Multiple insertions of self-expandable metal stents (SEMS) for advanced malignant hilar obstruction (MHO) is now considered to be an effective palliative method for adequate drainage of liver volume. However, the efficacy of endoscopic reintervention in technically and clinically successful bilateral SEMS is limited. This study investigated the endoscopic revision efficacy in patients who underwent bilateral SEMS in MHO. METHODS: Primary endoscopic revision using plastic or metal stents or an alternative percutaneous approach followed by secondary endoscopic revision was performed in patients who underwent clinically successful deployment of bilateral SEMS...
May 30, 2020: Journal of Gastroenterology and Hepatology
Kazuya Takemura, Etsuko Takizawa, Akihiro Tamori, Mika Nakamae, Hiroshi Kubota, Sawako Uchida-Kobayashi, Masaru Enomoto, Norifumi Kawada, Masayuki Hino
BACKGROUND & AIM: The evaluation of liver fibrosis in patients with chronic hepatitis C virus (HCV) infection is important as it is a risk factor for hepatocellular carcinoma. In the recent years, autotaxin (ATX) has been established as a new non-invasive biomarker to predict liver fibrosis. However, antiviral treatment has been reported to decrease serum ATX, but it is unclear whether post-treatment ATX levels reflect liver fibrosis. In the present study, we analyzed the correlation between ATX and liver fibrosis in pre- and post-treatment patients with HCV infection...
May 26, 2020: Journal of Gastroenterology and Hepatology
Yue Li, Hui-Chan He, Da-Lei Zhou, Qing Liu, Xiao Zhang, Xin-Hua Yang, Zu-Lu Ye, Jun-Ling Peng, Tao Tang, Xuan Su, Cai-Yun He
BACKGROUND AND AIM: Single-nucleotide polymorphisms (SNPs) in long non-coding RNAs (lncRNAs) are potential biomarkers for cancer risk, but their association with hepatocellular carcinoma (HCC) is unclear. We examined the association of lncRNA-related SNPs with HCC susceptibility and explored the optimal genetic models for SNPs. METHODS: Five candidate SNPs linked with digestive tumors were first genotyped in a screening population of 700 HCC and 2800 control cases...
May 26, 2020: Journal of Gastroenterology and Hepatology
Dong Ho Lee, Jin Wook Chung, Ijin Joo, Kyung-Suk Suh, Seong Hoon Kim, Young Hwan Koh, Ju Hee Lee, Yun Ku Cho, Joong-Won Park
To evaluate whether presence of varices on CT could predict treatment outcome for hepatocellular carcinoma (HCC) patients. METHODS: We enrolled 241 patients with single HCC≤5cm treated by surgery. Using preoperative CT/endoscopy, patients were classified into: presence of standard clinically significant portal hypertension (CSPH) surrogate, defined as varices on esophagogastroduodenoscopy and/or thrombocytopenia with splenomegaly (group 1, n=47); Varices on CT without standard CSPH surrogate (group 2, n=45); and none of both (group 3, n=149)...
May 26, 2020: Journal of Gastroenterology and Hepatology
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