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Journal of Gastroenterology and Hepatology | Page 3

Sang Hyoung Park, Myunghee Hong, Ho-Su Lee, Byong Duk Ye, Sung Wook Hwang, Seulgi Jung, Jiwon Baek, Jungwon Moon, Byoung Mok Kim, Seak Hee Oh, Kyung Mo Kim, Inchul Lee, Chang-Nim Im, Jianjun Liu, Dermot P B McGovern, Suk-Kyun Yang, Kyuyoung Song
BACKGROUND AND AIM: Anti-tumour necrosis factor (TNF) agents, such as infliximab (IFX), have been increasingly used to induce and maintain disease remission in patients with Crohn's disease (CD). Despite a considerable non-response rate, little is known about the genetic predictors of response to anti-TNF therapy in CD. Our aim in this study was to investigate the genetic factors associated with response to anti-TNF therapy in patients with CD. METHODS: We performed a two-stage genome-wide association study (GWAS) to identify loci influencing the response to IFX among Korean patients with CD, comprising 42 good responders with mucosal healing and 70 non-responders...
April 30, 2019: Journal of Gastroenterology and Hepatology
Cheng Zhang, Shuang Ge, Jun Wang, Xiaotong Jing, Hailing Li, Shuyu Mei, Juan Zhang, Ke Liang, Hui Xu, Xiaoying Zhang, Cuijuan Zhang
BACKGROUND: DNA hypermethylation has emerged as a novel molecular biomarker for the diagnosis and prognosis prediction of many cancers. We aimed to identify clinically useful biomarkers regulated by DNA methylation in HCC. METHODS: Genome-wide methylation analysis in HCCs and paired noncancerous tissues was performed using a Illumina Infinium HumanMethylation 450K Bead-Chip array. Methylation-specific PCR (MSP) and pyrosequencing were used to validate the methylation status of selected genes in 100 paired HCCs and noncancerous samples...
April 30, 2019: Journal of Gastroenterology and Hepatology
Ho-Su Lee, Kihyun Kim, Seulgi Jung, Myunghee Hong, Byoung Mok Kim, Dae-Sung Yoo, Jung Won Moon, Jiwon Baek, Sung Wook Hwang, Sang Hyoung Park, Suk-Kyun Yang, Buhm Han, Kyuyoung Song, Byong Duk Ye
BACKGROUND AND AIM: Tobacco smoking is a risk factor for gastrointestinal disorders, causing mucosal damage and impairing immune responses. However, smoking has been found to be protective against ulcerative colitis (UC). Human leukocyte antigen (HLA) is a major susceptibility locus for UC, and HLA-DRB1*15:02 has the strongest effect in Asians. This study investigated the effects of smoking on the association between HLA and UC. METHODS: The study enrolled 882 patients with UC, including 526 never, 151 current, and 205 former smokers, and 3091 healthy controls, including 2124 never, 502 current, and 465 former smokers...
April 30, 2019: Journal of Gastroenterology and Hepatology
Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Yuzo Kawata, Takeshi Mizusawa, Kentaro Tominaga, Junji Yokoyama, Shuji Terai
BACKGROUND AND AIMS: Functional gastrointestinal disorders (FGIDs) are the most common disorders in gastroenterology, and are currently considered as gut-brain interaction disorders with multiple related factors including motility disturbance. However, high-resolution manometry (HRM) had revealed a new disease concept known as minor esophageal motility disorders. This study aimed to investigate the correlation between functional esophageal disorders (FEDs) and minor esophageal motility disorders...
April 29, 2019: Journal of Gastroenterology and Hepatology
Hiroto Kinoshita, Hitomi Nishioka, Aya Ikeda, Kyoko Ikoma, Yoichi Sameshima, Hidehisa Ohi, Mizuki Tatsuno, Junka Kouyama, Chiaki Kawamoto, Tomohiro Mitsui, Yuko Tamura, Yu Hashimoto, Masashi Nishio, Tsuyoshi Ogashiwa, Yusuke Saigusa, Shin Maeda, Hideaki Kimura, Reiko Kunisaki, Kazuhiko Koike
BACKGROUND AND AIM: Oral 5-aminosalicylic acid (5-ASA) is recommended for the therapy of mild to moderate intestinal Behçet's disease (BD). However, the induction remission efficacy and endoscopic outcomes of 5-ASA are unknown. We investigated remission induction at 8 weeks, endoscopic outcomes until 52 weeks, and event-free survival at 52 weeks in patients with intestinal BD treated with 5-ASA. METHODS: Forty-one patients with intestinal BD were treated with oral 5-ASA...
April 24, 2019: Journal of Gastroenterology and Hepatology
Shun Kaneko, Masayuki Kurosaki, Nobuharu Tamaki, Jun Itakura, Tsuguru Hayashi, Sakura Kirino, Leona Osawa, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Mayu Higuchi, Kenta Takaura, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Mamoru Watanabe, Namiki Izumi
BACKGROUND: Tenofovir alafenamide (TAF) is a new prodrug of tenofovir, enabling treatment of patients with hepatitis B virus (HBV) infection at a lower dose than tenofovir disoproxil fumarate (TDF), via more efficient delivery of tenofovir to the hepatocytes. We compared the efficacy and safety of TDF and TAF and investigated switching from TDF to TAF therapy. METHODS: Consent for TDF and TAF therapy was obtained from 117 and 67 patients from August 2014 to January 2018...
April 24, 2019: Journal of Gastroenterology and Hepatology
Irena Kasacka, Żaneta Piotrowska, Michał Niezgoda, Wojciech Łebkowski
BACKGROUND AND AIM: Although the stomach has been identified as important source of leptin, detailed biosynthesis sites of leptin in human gastrointestinal tract has not been fully elucidated. The study objective was to compare leptin distribution and expression in the stomach and its serum level between healthy men and women. METHODS: Nineteen subjects (organ donors; 10 men and 9 women) with normal gastric mucosa histology were recruited. Research material contained gastric samples from the cardia, fundus and pyloric regions...
April 24, 2019: Journal of Gastroenterology and Hepatology
Qin Xiang, Dishu Zhou, Xiaoqian He, Jiangxia Fan, Jun Tang, Zhu Qiu, Yan Zhang, Jingfu Qiu, Yongzhu Xu, Guoqi Lai
BACKGROUND AND AIM: The high mortality and poor prognosis of hepatocellular carcinoma (HCC) have raised the public attention. Gene therapy is considered as a promising treatment option for cancer; thus, finding a new therapeutic target for hepatocellular carcinoma is urgently needed. GATA4 is a tumor suppressor gene in multiple cancers, but its role in HCC is unclear. In this study, we explored the function of GATA4 in HCC. METHODS: RT-PCR (Reverse Transcription-Polymerase chain reaction) and qPCR (quantitative PCR) were used to detect the mRNA expression of GATA4 in HCC cells and tissues...
April 17, 2019: Journal of Gastroenterology and Hepatology
L Hardy, H Hessamodini, I Yusoff
No abstract text is available yet for this article.
April 10, 2019: Journal of Gastroenterology and Hepatology
Hugh Watson, Monica Guevara, Hendrik Vilstrup, Pere Ginès
BACKGROUND AND AIM: Hyponatremia, a cause of brain dysfunction and risk factor for hepatic encephalopathy, is frequent in patients with advanced cirrhosis and ascites. The interdependence of liver failure and hyponatremia makes it difficult to separate the effects of each on cognitive function. The objective was to assess whether an increase in plasma sodium in patients with cirrhosis and ascites leads to an improvement in cognitive function. METHODS: This is a post-hoc analysis of 250 cirrhosis patients without overt hepatic encephalopathy randomized to receive either placebo or satavaptan, a vasopressin V2 antagonist...
April 9, 2019: Journal of Gastroenterology and Hepatology
Kristel K Leung, Usman Khan, Mei Zhang, Jeffrey D McCurdy, Paul D James
BACKGROUND AND AIM: This study aimed to assess the clinical utility of computed tomography enterography (CTE) and identify factors associated with a diagnostic CTE for patients with obscure gastrointestinal bleeding (OGIB). METHODS: A retrospective observational study was performed at a Canadian tertiary care centre from 2005-2015. A total of 138 patients underwent a CTE for OGIB. Univariate and multivariate logistic regression were performed to determine factors associated with a diagnostic CTE...
April 9, 2019: Journal of Gastroenterology and Hepatology
Xia Yang, Liqi Sun, Jiefang Guo, Li Gao, Chengyong Qin, Zhendong Jin
BACKGROUND AND OBJECTIVE: Brush cytology is widely applied to diagnosis indeterminate biliary stricture but suffer from low sensitivity. Changes in DNA content is a character of malignant cell and can be detected by DNA image cytometry (DNA-ICM). The study aimed to estimate the value of routine cytology (RC), DNA-ICM, and their combination in diagnosing indeterminate biliary strictures. METHODS: A total of 362 patients who underwent both RC and DNA-ICM tests were analysis...
April 8, 2019: Journal of Gastroenterology and Hepatology
S S Rana, A Savlania, R Gupta, P Dey
No abstract text is available yet for this article.
April 7, 2019: Journal of Gastroenterology and Hepatology
X Ding, T Huang, X Zou
No abstract text is available yet for this article.
April 3, 2019: Journal of Gastroenterology and Hepatology
Ke-Shu Hu, Bei Tang, Jia Yuan, Shen-Xin Lu, Miao Li, Rong-Xin Chen, Lan Zhang, Zheng-Gang Ren, Xin Yin
BACKGROUND AND AIM: Patients with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma are heterogeneous population, and the classifications available could not predict the prognosis accurately. Herein, we proposed a new sub-stage classification method, Scoring Method for Intermediate Stage, for precise classification and clinical guidance in hepatocellular carcinoma patients within Barcelona Clinic Liver Cancer stage B. METHODS: 1026 stage B patients of hepatocellular carcinoma who underwent transcatheter arterial chemoembolization as first line treatment in liver cancer institute, Zhongshan hospital, Fudan University were retrospectively enrolled...
April 1, 2019: Journal of Gastroenterology and Hepatology
Ka Shing Cheung, Lijia Chen, Wai Kay Seto, Wai K Leung
BACKGROUND AND AIMS: Population-based studies on post-colonoscopy colorectal cancer (CRC) from Asia are sparse. We aimed to determine the characteristics and predictive factors and survival of post-colonoscopy CRC in Hong Kong. METHODS: This is a territory-wide retrospective cohort study. Patients aged ≥40 years with colonoscopies performed between 2005 and 2013 without history of CRCs, inflammatory bowel disease and prior colectomy were included. Post-colonoscopy colorectal cancer for an interval of 3 years (PCCRC-3y) was defined as CRC diagnosed between 6 and 36 months after index colonoscopy, whereas CRC diagnosed within 6 months of index colonoscopy was regarded as "detected CRC"...
April 1, 2019: Journal of Gastroenterology and Hepatology
Shoichiro Kawai, Hideki Iijima, Shinichiro Shinzaki, Satoshi Hiyama, Toshio Yamaguchi, Manabu Araki, Shuko Iwatani, Eri Shiraishi, Akira Mukai, Takahiro Inoue, Yoshiki Tsujii, Yoshito Hayashi, Masahiko Tsujii, Tetsuo Takehara
BACKGROUND AND AIM: Transabdominal ultrasonography (US) examination for the intestine is often difficult, and its precedence for intestinal examination depends on accessibility to experienced ultrasonographers. Real-time virtual sonography (RVS) assists examination of US as a fusion method by synchronizing US images with pre-captured computed tomography or magnetic resonance images. We aimed to evaluate the feasibility to use RVS for the examination of the intestine. METHODS: The time to scan three parts of the intestine was compared between conventional US and RVS in seven participants without intestinal diseases...
April 1, 2019: Journal of Gastroenterology and Hepatology
Chen-Hua Liu, Yu-Lueng Shih, Sheng-Shun Yang, Chih-Lin Lin, Yu-Jen Fang, Pin-Nan Cheng, Chi-Yi Chen, Cheng-Yuan Peng, Tsai-Yuan Hsieh, Yen-Cheng Chiu, Tung-Hung Su, Chun-Jen Liu, Hung-Chih Yang, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
BACKGROUND AND AIM: Data regarding the efficacy and safety of paritaprevir/ritonavir, ombitasvir plus dasabuvir (PrOD) for East-Asian non-cirrhotic hepatitis C virus genotype 1b (HCV GT1b) patients receiving hemodialysis were limited. METHODS: Forty-six HCV GT1b non-cirrhotic patients receiving hemodialysis who received PrOD for 12 weeks were prospectively enrolled 7 academic centers in Taiwan. The primary efficacy endpoint was sustained virologic response 12 weeks off-therapy (SVR12 )...
April 1, 2019: Journal of Gastroenterology and Hepatology
Rapat Pittayanon, Panida Piyachaturawat, Rungsun Rerknimitr, Piyapan Prueksapanich, Supakarn Chaitongrat, Vorarit Lertsuwunseri, Suphot Srimahachota, Varocha Mahachai
BACKGROUND: Long-term use of dual antiplatelets is increasing, and most patients need primary peptic ulcer prophylaxis. The long-term use of proton pump inhibitors (PPIs) is associated with adverse events. We evaluated the efficacy of rebamipide for peptic ulcer prevention. METHODS: This RCT was conducted between July 2014 and November 2017. Patients receiving dual antiplatelets for ≥1 year with no history of peptic ulcer bleeding or perforation were recruited and randomly assigned to the rebamipide (300 mg/day) group or the placebo group...
March 28, 2019: Journal of Gastroenterology and Hepatology
A C Hopp, B D Nguyen
No abstract text is available yet for this article.
March 25, 2019: Journal of Gastroenterology and Hepatology
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