Journal of Gastroenterology and Hepatology | Page 3

Soo-Kyung Park, Sang Hyun Park, Hyo-Joon Yang, Yoon Suk Jung, Jung Ho Park, Chong Il Sohn, Dong Il Park
BACKGROUND AND AIMS: Serrated polyp detection rate (SDR) is a potential quality indicator for preventing colorectal cancer (CRC) associated with the serrated pathway. Using clinically significant SDR (CSSDR) has been suggested based on clinically significant serrated polyp (CSSP) ability to be CRC precursors. Correlations between CSSDR and simpler SDRs, other than proximal SDR, have not yet been studied. We aimed to investigate which simpler SDR indicator is most relevant to CSSDR or adenoma detection rate (ADR) and provide benchmark data...
January 6, 2020: Journal of Gastroenterology and Hepatology
Seung Kak Shin, Kyung-Ok Kim, Se-Hee Kim, Oh Sang Kwon, Cheol Soo Choi, Sung Hwan Jeong, Yun Soo Kim, Ju Hyun Kim, Myung-Hee Chung
BACKGROUND AND AIM: Exogenous 8-hydroxydeoxyguanosine (8-OHdG) was suggested as an inhibitor of Rac1 and NADPH oxidase (NOX). The aim of this study was to evaluate the effects of the exogenous 8-OHdG on hepatic fibrogenesis in vitro and in vivo model of liver fibrosis. METHODS: Adult Sprague-Dawley rats were allocated to sham-operated rats (n=7), rats underwent bile duct ligation (BDL) (n=6), and BDL rats treated with 8-OHdG (60 mg/kg/day by gavage, n=6). All rats were sacrificed on day 21...
January 6, 2020: Journal of Gastroenterology and Hepatology
M Kosaka, Y Kono, M Nakagawa
No abstract text is available yet for this article.
January 4, 2020: Journal of Gastroenterology and Hepatology
Ting-Ting Li, Shuai-Ling Song, Li-Na Xiao, Chun-Hui Wang
BACKGROUND AND AIM: Recently, there has been burgeoning interest in the utilization of fully covered self-expandable metal stents (FCSEMSs) for managing main pancreatic duct strictures (MPDS) in chronic pancreatitis (CP). The primary aim was to investigate stricture resolution and recurrence rates of FCSEMS placement in patients with symptomatic CP complicated with MPDS. METHODS: MEDLINE, EMBASE, ISI Web of Science and Cochrane Library (up to December 2019) were searched to identify eligible studies...
January 3, 2020: Journal of Gastroenterology and Hepatology
Anand Sharma, Ashish Goel, Vinu Moses, Shyamkumar Nidugala Keshava, Uday George Zachariah, Elwyn Elias, Chundamannil Eapen Eapen
AIM: To study incidence of re-bleeding on anticoagulation and survival, of Budd Chiari syndrome (BCS) patients presenting with variceal bleeding METHODS: BCS patients presenting with variceal bleed between 01/01/2007 and 01/05/2019 were retrospectively studied. Patients underwent endoscopic treatment ± endovascular therapy, followed by anti-coagulation. Variceal re-bleed (on anti-coagulation) and survival were studied. RESULTS: Of 376 BCS patients diagnosed during the study period 40(10...
January 3, 2020: Journal of Gastroenterology and Hepatology
May Y W Wong, Geoffrey Hebbard, Peter R Gibson, Rebecca E Burgell
Constipation is both a symptom and a disorder, seen in both functional constipation and irritable bowel syndrome with constipation predominance (IBS-C). Despite the Rome IV criteria distinguishing between these conditions, they share many therapeutic approaches. This review aims to explore the relationship between constipation and abdominal pain, assess the evidence surrounding whether laxation improves abdominal pain, and whether such a response to laxation differs between IBS-C and functional constipation...
January 3, 2020: Journal of Gastroenterology and Hepatology
Liqi Sun, Wei Wang, Yang Wang, Fei Jiang, Lisi Peng, Gang Jin, Zhendong Jin
BACKGROUND AND OBJECTIVES: The European evidence-based guidelines (EEG) and American College of Gastroenterology Guidelines (ACGG) have been published to guide the management of pancreatic cystic lesions. We aim to evaluate the value of both guidelines in predicting advanced PCLs (A-PCLs) with preoperatively imaging suspected cystic mucinous pancreatic neoplasms (cMNs). METHODS: One hundred ninety-eight patients who underwent resections from 2013 to 2019 for suspected cMNs were retrospectively reviewed...
January 3, 2020: Journal of Gastroenterology and Hepatology
Jianming Xu, Rui-Hua Xu, Shukui Qin, Hongming Pan, Yuxian Bai, Yihebali Chi, Liwei Wang, Feng Bi, Ying Cheng, Tianshu Liu, Dong Ma, Lin Shen, Yi Ba, Jun Liang, Xin Wang, Thomas C C Yau, Brigette B Ma, Kun-Huei Yeh, Jen-Kou Lin, Christian Kappeler, Jo Ann Shapiro, Joachim Kalmus, Jin Li
BACKGROUND AND AIM: In the phase 3 CONCUR trial (NCT01584830), regorafenib improved overall survival (OS) versus placebo in Asian patients with treatment-refractory metastatic colorectal cancer (mCRC). We conducted a post-hoc subgroup analysis of Chinese patients in CONCUR. METHODS: Adults with mCRC progressing despite at least two prior treatment regimens and Eastern Cooperative Oncology Group performance status 0-1 were randomized 2:1 to regorafenib 160 mg once daily or placebo for the first 3 weeks of each 4-week cycle...
January 3, 2020: Journal of Gastroenterology and Hepatology
Shih-Cheng Yang, Cheng-Kun Wu, Wei-Chen Tai, Chih-Ming Liang, Yu-Chi Li, Wen-Shuo Yeh, Chen-Hsiang Lee, Yao-Hsu Yang, Tzu-Hsien Tsai, Chien-Ning Hsu, Seng-Kee Chuah
BACKGROUND AND AIMS: Colonoscopic polypectomy in end-stage renal disease (ESRD) patients are at risks of post-polypectomy bleeding and perforation but evidences are limited. This study aimed to determine the incident polypectomy complications among ESRD patients. METHODS: In the nationwide ESRD cohort, a propensity score matched case-control study design was conducted to assess risk associated with post-polypectomy bleeding and perforation using the Taiwanese National Health Insurance Research Database from 1997 to 2013 for adults age 40 years and older; 7,011 ESRD and 19,118 non-ESRD patients met with study criteria...
January 3, 2020: Journal of Gastroenterology and Hepatology
H Fujikawa, M Araki
No abstract text is available yet for this article.
January 3, 2020: Journal of Gastroenterology and Hepatology
Kana Daijo, Takashi Nakahara, Yuki Inagaki, Maiko Nanba, Yuno Nishida, Shinsuke Uchikawa, Kenichiro Kodama, Kazuki Oya, Kei Morio, Hatsue Fujino, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, C Nelson Hayes, Michio Imamura, Hiroshi Aikata, Hidenori Ochi, Kazuaki Chayama
BACKGROUND AND AIM: The most important prognostic factor for non-alcoholic steatohepatitis (NASH) is liver fibrosis. The aim of this study is to examine clinical parameters involved in pathological progression in NASH patients who underwent repeated liver biopsy and to analyze the response to treatment with respect to NASH-related single nucleotide polymorphisms (SNPs). We performed longitudinal analysis of genetic and clinical factors associated with progression of NASH. METHODS: Eighty NASH patients who had undergone serial liver biopsies were enrolled in this retrospective cohort study...
January 2, 2020: Journal of Gastroenterology and Hepatology
S Miyamoto, J Ito, H Naruse, R Sugiura, Y Yamamoto, K Hatanaka, K Kinoshita, M Higashino, S Hayasaka, N Tsuchida, N Shimoyama, N Sakamoto
No abstract text is available yet for this article.
December 29, 2019: Journal of Gastroenterology and Hepatology
K Tokumasu, K Harada, F Otsuka
No abstract text is available yet for this article.
December 29, 2019: Journal of Gastroenterology and Hepatology
Masanori Atsukawa, Akihito Tsubota, Koichi Takaguchi, Hidenori Toyoda, Motoh Iwasa, Tadashi Ikegami, Makoto Chuma, Akito Nozaki, Haruki Uojima, Atsushi Hiraoka, Shinya Fukunishi, Keisuke Yokohama, Toshifumi Tada, Keizo Kato, Hiroshi Abe, Joji Tani, Hironao Okubo, Tsunamasa Watanabe, Nobuhiro Hattori, Akemi Tsutsui, Tomonori Senoh, Yuji Yoshida, Tomomi Okubo, Norio Itokawa, Ai Nakagawa-Iwashita, Chisa Kondo, Taeang Arai, Kojiro Michitaka, Etsuko Iio, Takashi Kumada, Yasushito Tanaka, Yoshiyuki Takei, Katsuhiko Iwakiri
BACKGROUND AND AIM: The prognosis of cirrhotic patients with hepatic edema is poor. Although several short-term predictors of tolvaptan (novel diuretic agent) treatment for such patients have been reported, the factors related to long-term survival are still unclear. METHODS: Among 459 patients with hepatic edema enrolled in a retrospective, multicenter collaborative study, we analyzed 407 patients who received tolvaptan. RESULTS: Patients consisted of 266 males and 141 females, with the median age of 68 years (range, 28-93 years)...
December 27, 2019: Journal of Gastroenterology and Hepatology
Ming Han Lim, Kristina Aluzaite, Michael Schultz, Paul Casey
BACKGROUND AND AIMS: Therapeutic drug monitoring of infliximab (IFX) using the established laboratory based Enzyme-Linked Immunosorbent Assay (ELISA) cannot produce results fast enough to allow IFX dose adjustments prior to each IFX infusion. We investigate the validity of IFX trough levels obtained through the Quantum Blue IFX rapid assay (QB-IFX) compared with the established ELISA. METHODS: Adult inflammatory bowel disease (IBD) patients receiving maintenance IFX infusions at Middlemore Hospital (MMH) and Dunedin Public Hospital (DPH) were prospectively recruited from July to October 2016...
December 27, 2019: Journal of Gastroenterology and Hepatology
Chan Hyuk Park, Se Woo Park, Eunwoo Nam, Jang Han Jung, Jung Hyun Jo
BACKGROUND: Although many studies have reported the efficacy of different stents for endoscopic ultrasonography (EUS)-guided peripancreatic fluid collection (PFC) drainage, they have not completely determined which stent is superior. This network meta-analysis comprehensively evaluated the comparative efficacy of stents used in EUS-guided PFC. METHODS: We searched all relevant studies published up to February 2019 that examined the efficacy of double-pigtail plastic stent (DPPS), fully covered self-expanding metal stent (FCSEMS), and lumen-apposing metal stent (LAMS) in EUS-guided PFC drainage...
December 27, 2019: Journal of Gastroenterology and Hepatology
Thuy-Huong Nguyen, Rebecca Wardell, Shiv Chitturi, Narci Teoh, Geoff Farrell
Liver stiffness measurement (LSM) by Fibroscan-determined transient elastography is a non-invasive approach to estimate liver fibrosis severity. In NAFLD, advanced liver fibrosis is excluded by normal liver stiffness, but a wide range of cut-offs have been used to predict advanced liver fibrosis or cirrhosis. This may be partly because steatosis (measured by controlled attenuation parameter, CAP) contributes to liver stiffness, but also because LSM fluctuates in NAFLD. In a recent pivotal study, one-third of patients with liver stiffness >12...
December 22, 2019: Journal of Gastroenterology and Hepatology
Yasuhiro Morita, Takayuki Imai, Shigeki Bamba, Kenichiro Takahashi, Osamu Inatomi, Takako Miyazaki, Kenji Watanabe, Shiro Nakamura, Atsushi Yoshida, Yutaka Endo, Naoki Ohmiya, Tomoyuki Tsujikawa, Akira Andoh
BACKGROUND/AIM: Ustekinumab is a human monoclonal antibody to the p40 subunit of human IL-12/IL-23. The purpose of this report is to verify the newly developed immunoassays for serum ustekinumab and anti-ustekinumab antibody (AUA) concentrations and assess their clinical utility. PATIENTS AND METHODS: Serum ustekinumab trough levels and AUA levels were measured using new immunoassays in 38 patients with Crohn's disease (CD) under ustekinumab maintenance injection...
December 20, 2019: Journal of Gastroenterology and Hepatology
Yang Li, Yijie Zhang, Tingting Chen, Yun Huang, Yan Zhang, Shiyu Geng, Xu Li
BACKGROUND & AIMS: Emerging evidence suggests aldosterone (aldo) and NLRP3 inflammasome are important factors for HSCs activation and liver fibrosis. However, the interaction between aldo and NLRP3 inflammasome in HSCs activation and liver fibrosis remains largely unknown. The aim of this study is to investigate the relationship between aldo and NLRP3 inflammasome in liver fibrosis. METHODS: Serum and liver specimens collected from 40 patients with or without liver fibrosis were used to test the level of aldo and NLRP3...
December 20, 2019: Journal of Gastroenterology and Hepatology
V Zimmer
No abstract text is available yet for this article.
December 17, 2019: Journal of Gastroenterology and Hepatology
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