Journal of Gastroenterology and Hepatology | Page 3

Masaki Takinami, Naomi Kakushima, Masao Yoshida, Keiko Sasaki, Kohei Takizawa, Yohei Yabuuchi, Noboru Kawata, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
BACKGROUND AND AIM: It is imperative to distinguish superficial non-ampullary duodenal carcinomas (NADCs) between intramucosal and submucosal invasive carcinoma for treatment selection. The aim of this study was to evaluate the clinicopathological differences of intramucosal and submucosal carcinoma. METHODS: This was a retrospective, single-center study comprising 134 patients with 137 superficial NADCs during May 2005 and March 2018. Clinicopathological characteristics and treatment outcomes data were used to perform a comparative analysis of endoscopic findings, preoperative diagnoses of depth of cancer and treatment outcomes of histologically diagnosed intramucosal and submucosal carcinoma...
October 16, 2019: Journal of Gastroenterology and Hepatology
Lei Ye, Yaping Yu, Yanping Zhao
BACKGROUND: Hepatic fibrosis is the final endpoint for most chronic liver diseases and remains a significant public health problem worldwide. Icariin, a naturally occurring flavonol glucoside, has been reported to exhibit protective effects on liver injury and alleviate liver fibrosis. However, the underlying detail molecular mechanism is not fully revealed. METHODS: Mouse primary hepatic stellate cells (HSCs) and carbon tetrachloride (CCL4 )-induced liver fibrosis model in mice were used as in vitro and in vivo models in this study...
October 16, 2019: Journal of Gastroenterology and Hepatology
Alex Barnes, Richard J Woodman, Paul Kleinig, Michael Briffa, Timothy To, Alan J Wigg
BACKGROUND AND AIMS: Palliative care referral for end stage liver disease (ESLD) is uncommon and usually occurs late. We aimed to review the rate of early palliative care referral (EPCR) in ESLD patients, its associations, and its impacts on resource utilisation and survival. METHODS: A retrospective review of all patients with ESLD admitted to a single hepatology unit between 2013 and 2016. Inclusion criteria for study entry were at least two admissions for decompensated liver disease within a six month period and not eligible for liver transplantation...
October 15, 2019: Journal of Gastroenterology and Hepatology
Hidenori Toyoda, Masanori Atsukawa, Tsunamasa Watanabe, Makoto Nakamuta, Haruki Uojima, Akito Nozaki, Koichi Takaguchi, Shinichi Fujioka, Etsuko Iio, Toshihide Shima, Takehiro Akahane, Shinya Fukunishi, Toru Asano, Kojiro Michitaka, Kunihiko Tsuji, Hiroshi Abe, Shigeru Mikami, Hironao Okubo, Tomomi Okubo, Noritomo Shimada, Toru Ishikawa, Akio Moriya, Joji Tani, Asahiro Morishita, Chikara Ogawa, Yoshihiko Tachi, Hiroki Ikeda, Naoki Yamashita, Satoshi Yasuda, Makoto Chuma, Akemi Tsutsui, Atsushi Hiraoka, Tadashi Ikegami, Takuya Genda, Akihito Tsubota, Tsutomu Masaki, Yasuhito Tanaka, Katsuhiko Iwakiri, Takashi Kumada
BACKGROUND: In clinical trials, a pangenotype direct-acting antiviral (DAA) regimen consisting of glecaprevir (GLE) and pibrentasvir (PIB) exhibited high virologic efficacy and tolerability in patients with hepatitis C virus (HCV) infection. This study sought to confirm these findings in real-world settings, focusing on patients with cirrhosis, history of DAA failure, or HCV genotype 3 who were treated with a 12-week regimen, in a large multicenter study from Japan. METHODS: In a nationwide multicenter prospective cohort study, we analyzed background characteristics, tolerability, and treatment outcome of patients who underwent a 12-week GLE/PIB regimen...
October 14, 2019: Journal of Gastroenterology and Hepatology
Chong Dong, Zhuolun Song, Jing Chen, Nan Ma, Xingchu Meng, Chao Sun, Keran Duan, Bowen Bi, Kai Wang, Hong Qin, Chao Han, Yang Yang, Fubo Zhang, Weiping Zheng, Wei Gao
AIMS: To investigate the risk factors of de novo hepatitis B virus (HBV) infection in pediatric liver transplantation recipients receiving hepatitis B core antibody (HBcAb) positive grafts and to evaluate the efficacy of our prophylactic strategies. METHODS: 139 pediatric recipients receiving HBcAb positive grafts operated from September 2016 to September 2018 were retrospectively enrolled, all the patients received prophylactic treatment to prevent de novo HBV infection...
October 14, 2019: Journal of Gastroenterology and Hepatology
Leonardo Zorron Cheng Tao Pu, Kenta Yamamoto, Takashi Honda, Masanao Nakamura, Takeshi Yamamura, Shun Hattori, Alastair D Burt, Rajvinder Singh, Yoshiki Hirooka, Mitsuhiro Fujishiro
BACKGROUND AND AIM: Microbiota have been associated with several diseases including colorectal cancer (CRC). This study aimed to evaluate the microbiota in early/invasive CRC utilising stool and cytological brushes to determine differences in relative abundance (RA). METHODS: Colonoscopy patients referred for endoscopic submucosal dissection or previous to CRC surgery were prospectively enrolled. Stool was collected pre-bowel preparation; and brush samples were taken during colonoscopy (3 regions)...
October 14, 2019: Journal of Gastroenterology and Hepatology
Z Hamarneh, E L Symonds, F Kholmurodova, C Cock
BACKGROUND: Fecal immunochemical tests (FIT) are used to screen asymptomatic individuals aged 50-74y for colorectal cancer (CRC) within the Australian screening program. Gastrointestinal symptoms or iron deficiency anemia (IDA) may also drive primary care physicians to request a FIT. This study aimed to examine factors that may increase neoplasia risk associated with a positive FIT, specifically age, gastrointestinal symptoms or IDA. METHODS: A retrospective audit was performed on colonoscopies performed in a single hospital in South Australia for a positive FIT (from all referral sources) between 2014-2017...
October 12, 2019: Journal of Gastroenterology and Hepatology
Maki Tobari, Estuko Hashimoto, Makiko Taniai, Kazuhisa Kodama, Tomomi Kogiso, Katsutoshi Tokushige, Masakazu Yamamoto, Nishino Takayoshi, Katagiri Satoshi, Araida Tatsuo
INTRODUCTION: We evaluated the characteristics of hepatocellular carcinoma (HCC) in patients who had non-alcoholic fatty liver disease (NAFLD) without cirrhosis. METHODS: We prospectively followed NAFLD patients at our University hospital. NAFLD was diagnosed from detection of steatosis by histology or imaging, no alcohol intake, and exclusion of other liver diseases. Cirrhosis was defined by histological features, imaging data, and symptoms. We compared NAFLD-related HCC with or without cirrhosis and non-cirrhotic NAFLD with or without HCC...
October 9, 2019: Journal of Gastroenterology and Hepatology
Wing Yan Mak, Mirabella Zhao, Siew Chien Ng, Johan Burisch
BACKGROUND: The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. Exploring East versus West differences in the epidemiology of IBD could enhance our understanding of the multifactorial nature and heterogeneity of the disease. In this narrative review, we aim to compare the epidemiology of IBD between eastern and western countries by summarizing evidence from population-based cohort studies in the last ten years. METHODS: A thorough literature search on PubMed was conducted to identify studies reporting population-based data on the epidemiology of IBD...
October 9, 2019: Journal of Gastroenterology and Hepatology
Seung Wook Hong, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
BACKGROUND AND AIM: Epithelioid granuloma is one hallmark used to histologically diagnose Crohn's disease (CD). However, the clinical significance of granulomas in CD is unclear. Therefore, we performed a meta-analysis to compare the clinical features with CD according to the presence of granulomas. METHODS: A literature search in PubMed, EMBASE, and Cochrane databases was performed on manuscripts published until Oct 2018. We included studies that met the following inclusion criteria; (1) patient: patients with CD; (2) exposure: granulomas on the pathology; (3) comparator: no granulomas; (4) outcomes: disease location, disease behaviour, perianal disease, disease activity, use of biologics, and CD-associated hospitalization, surgery...
September 14, 2019: Journal of Gastroenterology and Hepatology
Shuang Zhao, Wen Xu, Yang-Xin Xie, Wei-Wei Chen, Min Zhao
OBJECTIVE: Hepatitis B associated liver cirrhosis (HBC) leads to profound alterations of immune systems, especially disruptions of B cell immune responses. CXCR5+CD4+ T cells (including T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr)) are responsible for the regulation of B cell functions. The aim of this study was to dissect the roles of CXCR5+CD4+ T cell subset in B cell disruption caused by HBC. METHODS: 41 patients with HBC and 15 healthy controls (HC) were enrolled in this study...
September 13, 2019: Journal of Gastroenterology and Hepatology
Ming-Ming Zhang, Ning Zhong, Xiang Gu, Xiao Wang, Xiu-Li Zuo, Rui Ji, Chang-Qing Li, Li-Xiang Li, Zhen Li, Yan-Bo Yu, Yan-Qing Li
BACKGROUND AND AIM: The effect of real-time analysis of needle-based confocal laser endomicroscopy (nCLE) for gastric subepithelial lesions (SELs) on the diagnostic value is unclear. The study aimed to investigate the diagnostic efficacy of real-time nCLE for gastric SELs and to assess the technical aspects and safety of real-time nCLE. METHODS: Consecutive patients with gastric SELs ≥ 1 cm were prospectively investigated by endoscopic ultrasound (EUS), followed by nCLE...
September 13, 2019: Journal of Gastroenterology and Hepatology
Yi-Ning Sun, Ming-Ming Zhang, Li-Xiang Li, Rui Ji, Xiao Wang, Peng Li, Yue-Yue Li, Meng-Qi Zheng, Guan-Qun Liu, Xiu-Li Zuo, Zhen Li, Yan-Qing Li
BACKGROUND AND AIM: Cresyl violet (CV) is a topical dye that allows simultaneous chromoendoscopy and in vivo confocal laser endomicroscopy (CLE) in identification of neoplastic changes of the lower GI tract without intravenous injection of fluorescein, but as yet no investigation has reported its application in the diagnosis of gastric intestinal metaplasia (GIM). This study aims to assess the feasibility as well as diagnosis accuracy of topical CV for in vivo diagnosis of GIM by using probe-based confocal laser endomicroscopy (pCLE)...
September 13, 2019: Journal of Gastroenterology and Hepatology
Dong Hyun Sinn, Danbee Kang, Yoosoo Chang, Seungho Ryu, Soo Jin Cho, Seung Woon Paik, Young Bin Song, Roberto Pastor-Barriuso, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak
BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease associated with an increased risk of cardiovascular disease (CVD), diabetes, and chronic kidney disease. Indeed, CVD is the most common cause of death in NAFLD patients. This study aimed to evaluate the association between NAFLD and the risk of incident myocardial infarction. METHODS: Thus is a retrospective cohort study involving 111,492 adults over 40 years old without history of CVD, liver disease or cancer at baseline who participated in a regular health screening exam between 2003 and 2013...
September 11, 2019: Journal of Gastroenterology and Hepatology
Philippe Godeberge, Parvez Sheikh, Evgeny Zagriadskiĭ, Varut Lohsiriwat, Abel Jalife Montaño, Pavle Košorok, Heiko De Schepper
BACKGROUND AND AIM: The CHORUS study (Chronic venous and HemORrhoidal diseases evalUation and Scientific research) was conducted to provide data on patients presenting with hemorrhoidal disease (HD) in clinical practice and to explore the frequency with which it coexists with chronic venous disease (CVD) and shared risk factors. METHODS: This international, noninterventional study enrolled adult patients attending a consultation for hemorrhoidal complaints. The questionnaire completed by physicians established the subjects' demographic and lifestyle characteristics and collected information on HD grade and symptoms and signs of CVD...
September 11, 2019: Journal of Gastroenterology and Hepatology
Chang Kyun Lee, Hyo Jung Ha, Shin Ju Oh, Jung-Wook Kim, Jung Kuk Lee, Hyun-Soo Kim, Soon Man Yoon, Sang-Bum Kang, Eun Soo Kim, Tae Oh Kim, Soo-Young Na, Jun Lee, Sang-Wook Kim, Hoon Sup Koo, Byung Kyu Park, Han Hee Lee, Eun Sun Kim, Jae Jun Park, Min Seob Kwak, Jae Myung Cha, Byong Duk Ye, Chang Hwan Choi, Hyo Jong Kim
BACKGROUND/AIMS: We conducted a nationwide validation study of diagnostic algorithms to identify cases of inflammatory bowel disease (IBD) within the Korea National Health Insurance System (NHIS) database. METHOD: Using the NHIS dataset, we developed 44 algorithms combining the Internal Classification of Diseases (ICD)-10 codes, codes for Rare and Intractable Diseases (RID) registration and claims data for healthcare encounters, and pharmaceutical prescriptions for IBD-specific drugs...
September 9, 2019: Journal of Gastroenterology and Hepatology
Alka Singh, Anil K Verma, Prasenjit Das, Shyam Prakash, Raja Pramanik, B Nayak, Siddhartha Datta Gupta, V Sreenivas, Lalit Kumar, Vineet Ahuja, Govind K Makharia
BACKGROUND: Demonstration of villous abnormalities is an essential component of diagnosis of celiac disease (CeD) which requires duodenal biopsies. There is a need for non-invasive biomarker(s) which can predict the presence of villous abnormalities. METHODS: Levels of plasma citrulline, plasma I-FABP, and serum Reg1α were estimated in treatment naïve patients with CeD and controls. The levels of these biomarkers and their cyclical pattern was validated in a predicted model of enteropathy...
September 9, 2019: Journal of Gastroenterology and Hepatology
Hironori Tsujimoto, Hiroyuki Horiguchi, Risa Takahata, Satoshi Ono, Yoshihisa Yaguchi, Shinsuke Nomura, Nozomi Ito, Manabu Harada, Hiromi Nagata, Yusuke Ishibashi, Keita Kouzu, Satoshi Tsuchiya, Yujiro Itazaki, Seiichiro Fujishima, Yoji Kishi, Hideki Ueno
BACKGROUND: High mobility group box chromosomal protein-1 (HMGB-1) is a potential late mediator of sepsis and a possible risk factor for postoperative pulmonary complications after esophagectomy. This study aimed to determine the relationship between HMGB-1 and clinicopathological factors and long-term prognosis after esophagectomy for esophageal cancer. METHODS: We measured perioperative serum HMGB-1 levels using enzyme-linked immunosorbent assay, and HMGB-1 protein by immunohistochemistry expression in resected specimens...
September 9, 2019: Journal of Gastroenterology and Hepatology
Masau Sekiguchi, Yasuo Kakugawa, Keiko Nakamura, Minori Matsumoto, Hiroyuki Takamaru, Masayoshi Yamada, Taku Sakamoto, Yutaka Saito, Takahisa Matsuda
BACKGROUND AND AIM: With the increasing necessity of colorectal cancer screening, observational screening colonoscopy during which only endoscopic observation and diagnosis is performed is worth consideration. However, whether detected lesions can be correctly identified at secondary colonoscopy performed for polypectomy is unclear. Further, whether new neoplastic lesions can be detected at secondary colonoscopy has not been fully examined. This study was performed to investigate the detectability of adenomatous polyps and advanced colorectal neoplasia (ACN) at secondary colonoscopy...
September 9, 2019: Journal of Gastroenterology and Hepatology
Anil Dhawan, Michael W Lawlor, George V Mazariegos, Patrick McKiernan, James E Squires, Kevin A Strauss, Digant Gupta, Emma James, Suyash Prasad
BACKGROUND AND AIM: Crigler-Najjar syndrome (CNS) results from biallelic mutations of UGT1A1 causing partial or total loss of uridine 5´-diphosphate glucuronyltransferase activity leading to unconjugated hyperbilirubinemia and its attendant risk for irreversible neurological injury (kernicterus). CNS is exceedingly rare and has been only partially characterized through relatively small studies, each comprising between two and 57 patients. METHODS: We conducted a systematic literature review to consolidate data on the patient, caregiver, and societal burden of CNS...
September 8, 2019: Journal of Gastroenterology and Hepatology
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