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Journal of Gastroenterology and Hepatology | Page 3

Zhixian Lan, Haiyan Hu, Rai Mandip, Wei Zhu, Wen Guo, Jing Wen, Fang Xie, Weiguang Qiao, Akshintala Venkata, Ying Huang, Side Liu, Yue Li
BACKGROUND: There is a lack of literature comparing linear endoscopic ultrasound (EUS) and radial EUS for the prediction of the depth of invasion in early gastric cancer (EGC). The aim of this study is to evaluate the accuracy of linear EUS for the diagnosis of submucosal (SM) invasion and compare linear EUS with radial EUS in suspected EGC patients. METHODS: Seventy-two consecutive patients with suspected EGC who underwent a preoperative assessment using linear EUS or radial EUS were prospectively enrolled...
August 4, 2019: Journal of Gastroenterology and Hepatology
Stella C M Heemskerk, Adriënne H Rotteveel, Jarno Melenhorst, Stéphanie O Breukink, Merel L Kimman, Carmen D Dirksen
BACKGROUND & AIMS: Standardizing evaluative outcomes and their assessment facilitates comparisons between clinical studies and provides a basis for comparing direct effects of different treatment options. The aim of this study was to systematically review types of outcomes and measurement instruments used in studies regarding treatment options for slow-transit constipation (STC) in adults. METHODS: In this systematic review of the literature we searched MEDLINE, EMBASE and PsycINFO from inception through February 2018, for papers assessing any STC-treatment in adult patients...
August 2, 2019: Journal of Gastroenterology and Hepatology
Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Daisuke Watanabe, Namiko Hoshi, Hirohumi Abe, Ryusuke Ariyoshi, Yoshiko Ohara, Toshitatsu Takao, Yoshinori Morita, Eiji Umegaki, Yuzo Kodama
BACKGROUND AND AIM: One of the main concerns related to peroral endoscopic myotomy (POEM) is postoperative gastroesophageal reflux (GER). The two penetrating vessels (TPVs) that are found at the boundary between the circular and oblique muscles in the posterior cardia wall have been suggested to be a good indicator of the optimal distal extent of POEM. However, the effect of performing myotomy using the TPVs as an anatomical reference on the frequency of post-POEM GER has not been studied...
August 1, 2019: Journal of Gastroenterology and Hepatology
Chung-Feng Huang, Ming-Lun Yeh, Ching-I Huang, Po-Cheng Liang, Yi-Hung Lin, Ming-Yen Hsieh, Kuan-Yu Chen, Yu-Min Ko, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu
BACKGROUND/AIMS: Ribavirin (RBV) remains crucial in difficult-to-cure chronic hepatitis C (CHC) patients receiving directly-acting antivirals (DAAs). The current study aimed to address whether RBV enhanced early viral kinetics in patients with DAAs. METHODS: Hepatitis C virus (HCV) genotype-1b patients were allocated to daclatasvir/asunaprevir +weight-based ribavirin (1000-1200 mg/day) for 12-24 weeks. HCV RNA levels were compared at day 1, week 1, week 2, and week 4 of treatment...
August 1, 2019: Journal of Gastroenterology and Hepatology
Yvonne Purcell, Riccardo Sartoris, Valérie Paradis, Valérie Vilgrain, Maxime Ronot
INTRODUCTION: To assess the influence of pre-treatment Tumour Growth Rate (TGR) on mRECIST objective response (OR) after a first session of selective trans-arterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). METHODS: 115 patients (101 men [88%], mean 65.1±10.5 years [range 26-87]) with 169 tumours (mean 34.2±29.3mm [10-160]), undergoing a first session of selective TACE for the treatment of HCC between 2011 and 2016, were included...
August 1, 2019: Journal of Gastroenterology and Hepatology
Eduardo Redondo-Cerezo, Francisco Vadillo-Calles, Adrian J Stanley, Stig Laursen, Loren Laine, Harry R Dalton, Jing H Ngu, Michael Schultz, Rita Jiménez-Rosales
BACKGROUND: Risk stratification for upper gastrointestinal bleeding (UGIB) is recommended. However, scoring systems accuracy is suboptimal and score calculation can be complex. Our aim was to develop a new score, the MAP (ASH) score, with information available in the emergency room (ER), and to validate it. METHODS: The score was built from a prospective database of patients with UGIB, and validated in an international database of 3,012 patients from six hospitals...
July 29, 2019: Journal of Gastroenterology and Hepatology
Seyed Saeed Sarkeshikian, Mohammad Reza Ghadir, Faezeh Alemi, Seyed Mahdi Jalali, Ahmad Hormati, Abolfazl Mohammadbeigi
BACKGROUND AND AIM: Helicobacter pylori is one of the main causes of digestive diseases, which is difficult to treat and requires the administration of several antimicrobial agents. Considering the anti-inflammatory and antibacterial effect of atorvastatin, the present study aimed at adding this agent to a four-drug regimen in order to eradicate H. pylori. METHODS: A total of 220 patients with H. pylori infection were included in the current randomized controlled clinical trial...
July 29, 2019: Journal of Gastroenterology and Hepatology
Dong Kee Jang, Jungmee Kim, Wan Beom Park, Sun Young Yi, Jun Kyu Lee, Won Jae Yoon
BACKGROUND AND AIM: Biliary tract infections (BTIs) are a major cause of bacteremia. The prevalence of antibiotic-resistant pathogens in BTI patients is reported to be increasing. We used a nationwide database to evaluate the prevalence of, and risk factors for, BTIs caused by extended-spectrum beta-lactamase-producing organisms (ESBL-PO) in Korea. METHODS: Patients with a BTI diagnosis, an admission history, a history of a BTI-related procedure, and antibiotic use for ≥ 4 days between 2007 and 2016 were identified from the Health Insurance Review and Assessment Service database...
July 29, 2019: Journal of Gastroenterology and Hepatology
Xiumei Chi, Moli Wang, Yu Pan, Jing Jiang, Tao Jiang, Hongqing Yan, Ruihong Wu, Xiaomei Wang, Xiuzhu Gao, Junqi Niu
BACKGROUND: Polymorphisms of inosine triphosphate pyrophosphatase (ITPA) (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C (CHC) on ribavirin/interferon.Aim To investigate the associations of rs1127354, rs6051702, and rs12979860 with hemoglobin levels and SVR in patients on ribavirin/interferon.Methods Polymorphisms were detected by pyrosequencing. Levels of hemoglobin and hepatitis C virus (HCV) RNA were measured at weeks 2, 4, 12, 24, 36, 48, and 72 of treatment...
July 29, 2019: Journal of Gastroenterology and Hepatology
Hirotaka Furuhashi, Masaaki Higashiyama, Yoshikiyo Okada, Akinori Wada, Kazuki Horiuchi, Yoshinori Hanawa, Akinori Mizoguchi, Shin Nishii, Kenichi Inaba, Nao Sugihara, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Soichiro Miura, Ryota Hokari
OBJECTIVE: Dietary emulsifiers are widely used in processed foods and officially approved as safe for intake. However, recent studies have demonstrated that some emulsifiers alter the colonic microbiota, leading to colonic low-grade inflammation, in mice. The effect of dietary emulsifiers on small-intestinal microbiota, which is important for gut immunity, has not been studied. We aimed to investigate the effect of a representative dietary emulsifier, polysorbate-80 (P80), on the small-intestinal microbiota in normal mice...
July 29, 2019: Journal of Gastroenterology and Hepatology
Gabriel Stefani Leão, Guilherme John Neto, Raquel de Freitas Jotz, Angelo Alves Alves de Mattos, Ângelo Zambam de Mattos
BACKGROUND AND AIM: Bacterial infections are among the main causes of death in patients with cirrhosis. While there are unquestionable benefits of using albumin in patients with spontaneous bacterial peritonitis, the benefits of albumin are controversial for those with extraperitoneal infections. The aim was to compare the use of albumin associated to antibiotics and antibiotics alone in cirrhotic patients with extraperitoneal infections. METHODS: A systematic review was performed using MEDLINE and EMBASE databases...
July 28, 2019: Journal of Gastroenterology and Hepatology
S Fukunaga, A Mori, A Ohuchi, S Yoshioka, J Akiba, K Mistuyama, O Tsuruta, T Torimura
No abstract text is available yet for this article.
July 28, 2019: Journal of Gastroenterology and Hepatology
B Barberio, A Gubbiotti, L Albertoni, M Ghisa, E Savarino
No abstract text is available yet for this article.
July 24, 2019: Journal of Gastroenterology and Hepatology
T Kobayashi, S Yoshikawa, M Takeuchi, S Terai
No abstract text is available yet for this article.
July 24, 2019: Journal of Gastroenterology and Hepatology
Stanley Khoo, Vincent Wai-Sun Wong, George Boon-Bee Goh, Jiangao Fan, Wah Kheong Chan, Wai-Kay Seto, Wan Cheng Chow
BACKGROUND & AIMS: NAFLD patients often have dyslipidemia, and optimal treatment of dyslipidemia lowers the risk of cardiovascular disease and mortality. We aimed to study the prescription of statin and low-density lipoprotein (LDL) cholesterol treatment targets in NAFLD patients. METHODS: Consecutive NAFLD patients attending five clinics in Asia were included in this study. The 10-year cardiovascular disease risk was calculated based on the Framingham Heart Study, and patients were categorized as moderate, high or very high risk for cardiovascular disease based on the American Association of Clinical Endocrinologist 2017 Guidelines...
July 23, 2019: Journal of Gastroenterology and Hepatology
Karen Margarete Vieira da Silva Franco, Waldonio Brito Vieira, Apio Ricardo Nazareth Dias, Aline Semblano Carreira Falcão, Luiz Fábio Magno Falcão, Juarez Antônio Simões Quaresma
BACKGROUND AND AIM: This study aimed to investigate the association between the findings of Doppler ultrasonography and transient elastography using FibroScan and to determine the cut-off points, sensitivity, and specificity of resistance indices, and pulsatility of the hepatic vessels to predict significant hepatic fibrosis. METHODS: This is a transversal, observational, and analytical study that includes 30 patients with chronic hepatitis C who were admitted at a public referral hospital...
July 23, 2019: Journal of Gastroenterology and Hepatology
Xiao-Dan Xu, Jian-Qing Qian, Jian-Jun Dai, Zhen-Xing Sun
BACKGROUND AND AIM: A few small retrospective studies recently found that endoscopic retrograde cholangiopancreatography (ERCP) in asymptomatic compared with symptomatic common bile duct stones (CBDSs) patients appeared to increase the risk of post-ERCP pancreatitis (PEP). This study aimed to determine the risk of ERCP in asymptomatic CBDS patients. METHODS: A total of 327 consecutive patients with native papilla were invited to participate into the study and divided into two groups: 53 in the asymptomatic group and 274 in the symptomatic group, who underwent CBDS removal by ERCP...
July 23, 2019: Journal of Gastroenterology and Hepatology
Salman Hussain, Ambrish Singh, Saima Zameer, Mohammad Chand Jamali, Harveen Baxi, Syed Obaidur Rahman, Mahtab Alam, Mohammad Altamish, Avinash Kumar Singh, Dasari Anil, Md Sarfaraj Hussain, Adil Ahmad, Abul Kalam Najmi
BACKGROUND AND AIM: A growing body of literature suggests the association between dementia risk and proton pump inhibitor (PPI) use. Therefore, we aimed to investigate the association between PPI use and dementia risk. METHODS: An extensive literature search was performed in PubMed, Embase, and Cochrane till March 31, 2019. All the studies (cohort and case-control) assessing the association between PPI use and dementia risk were eligible for inclusion. Articles were selected based on the screening of title and abstract, data were extracted, and risk of bias was assessed using Newcastle-Ottawa scale...
July 23, 2019: Journal of Gastroenterology and Hepatology
Kenichi Matsui, Kohei Funasaka, Ryoji Miyahara, Kazuhiro Furukawa, Masanobu Matsushita, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Osamu Watanabe, Kenichi Ohara, Yoshiki Hirooka, Hidemi Goto
BACKGROUND AND AIM: Magnifying endoscopy is useful for diagnosis of early gastrointestinal neoplasms by visualizing microvascular (MV) and microsurface (MS) structure of the mucosa when combined with image-enhanced endoscopy. However, precise control of the endoscope is needed because the depth of focus is narrow and the target may move. These problems may be overcome by the all-in-focus (AIF) technique, which was developed in the engineering field. The aim of the study was to evaluate magnifying endoscopic image with AIF algorithm...
July 23, 2019: Journal of Gastroenterology and Hepatology
Tarana Gupta, Dibya Lochan, Nipun Verma, Sahaj Rathi, Swastik Agrawal, Ajay Duseja, Sunil Taneja, Yogesh K Chawla, Radha K Dhiman
BACKGROUND AND AIM: The aim of this study is to evaluate the epidemiology and impact of bacterial infections at admission in patients with acute decompensation (AD) of cirrhosis. METHODS: A cohort with AD of cirrhosis (European Association for the Study of the Liver criteria) admitted at a tertiary center was evaluated between 2013 and 2014 for the presence of bacterial infections at admission. Clinical, demographic, and microbiological data were collected prospectively till death, transplant, or 90 days...
July 23, 2019: Journal of Gastroenterology and Hepatology
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