Journal of Gastroenterology and Hepatology | Page 2

Yichi Zhang, Tingting Su, Bing Han, Miao Huang, Xueshi Zhou, Jian Wang, Yuanwang Qiu, Yingbin Liu, Jinyang Gu
No abstract text is available yet for this article.
May 14, 2020: Journal of Gastroenterology and Hepatology
Xi-Hsuan Lin, Jiing-Chyuan Luo, Po-Hsiang Ting, Tien-En Chang, Yi-Hsiang Huang, Ming-Chih Hou, Fa-Yauh Lee
BACKGROUND AND AIM: The prospective, open-label, randomized study aims to compare the efficacy of lansoprazole, a fast orally-disintegrating proton pump inhibitor (PPI) and dexlansoprazole, a dual delayed release PPI in patients with atypical symptoms of gastro-esophageal reflux disease (GERD). METHODS: Patients with atypical GERD symptoms with a total Reflux Symptom Index (RSI) score >10 were eligible for enrollment. From Feb. 2018 to Dec. 2019, 232 subjects were randomly assigned (1:1 ratio) to receive oral lansoprazole, Takepron® OD 30 mg, once daily before breakfast or oral dexlansoprazole, Dexilant® 60 mg, once daily before breakfast for 8 weeks...
May 13, 2020: Journal of Gastroenterology and Hepatology
Y Mori, A Kurita, S Yazumi
No abstract text is available yet for this article.
May 11, 2020: Journal of Gastroenterology and Hepatology
Xiaocong Liu, Nagham Khouri-Farah, Catherine H Wu, George Y Wu
BACKGROUND & AIMS: Mitochondrial damage is commonly involved in liver injury. We have previously shown that normal mitochondria can be coated with a carrier protein to form complexes that are specifically taken up by liver cells in culture. The aim of the current study was to determine whether mitochondrial complexes could be specifically delivered to the livers of living rats by intravenous injection. METHODS: Mitochondria were harvested from fresh mouse liver, mixed with an asialoglycoprotein-based carrier, asialoorosomucoid-polylysine (AsOR-PL), and purified to form complexes...
May 9, 2020: Journal of Gastroenterology and Hepatology
Hytham K S Hamid
No abstract text is available yet for this article.
May 5, 2020: Journal of Gastroenterology and Hepatology
Hao Feng, Guohui Song, Shanrui Ma, Qing Ma, Xinqing Li, Wenqiang Wei, Christian Abnet, Youlin Qiao, Guoqing Wang
BACKGROUND AND AIM: This study aimed to evaluate effects of endoscopic screening method in different starting age groups and further confirm the optimum starting age for ESCC screening. METHODS: This study received IRB approval, and 6,825 residents aged 40 to 69 years in high prevalence communities were assigned to the screening group or the control (non-screening) group from Hebei province, China. Cumulative mortalities during the 14-year period, relative risks (RR) for participants underwent screening, numbers needed to invite for screening (NNS) to save one life were compared between the screening group and the control group of different starting age groups at 14-year follow-up...
May 4, 2020: Journal of Gastroenterology and Hepatology
Ka Wing Ma, Hoonsub So, Dong Hui Cho, Jin Sun Oh, Tan To Cheung, Do Hyun Park
BACKGROUND/AIMS: segregated right intrahepatic duct dilatation (IHD) results from complete obstruction of the biliary tract proximal to the hilar level. We aimed to evaluate long-term efficacy and safety of EUS-HDS in segregated right IHD. METHODS: Consecutive patients who had undergone EUS-guided HDS with a fully covered self-expandable metal stent (FCSEMS) in an academic tertiary center were recruited. All patients had segregated right hepatic duct and failed drainage by ERCP...
May 4, 2020: Journal of Gastroenterology and Hepatology
Huiyun Zhu, Pei Xie, Yuxin Wang, Zhendong Jin, Zhaoshen Li, Yiqi Du
BACKGROUND AND AIMS: The effect of solid debris on walled-off necrosis (WON) drainage remains unknown. Our study evaluated the role of solid debris in EUS-guided drainage of WON compared lumen-apposing metal stent (LAMS) with double-pigtail plastic stent (DPPS). METHODS: We retrospectively evaluated consecutive patients with WON underwent EUS-guided drainage in our endoscopic center over a 9-year period. The amount of solid debris in WON was assessed with CT/MRI and EUS images...
May 4, 2020: Journal of Gastroenterology and Hepatology
Tomoki Kobayashi, Keishi Kanno, Phuong Thao Nguyen, Akiko Sugiyama, Akihiro Kawahara, Yuichiro Otani, Nobusuke Kishikawa, Masanori Ito, Susumu Tazuma
BACKGROUND AND AIM: Nonalcoholic steatohepatitis (NASH) is characterized by hepatic steatosis, inflammation, and hepatocellular injury with varying degrees of fibrosis. There are currently no established treatment approaches for NASH other than lifestyle interventions. Periostin, a matricellular protein required for tissue remodeling and fibrosis, plays an important role in hepatic steatosis and fibrosis and could be a potential target for NASH treatment. Advances in molecular biology and biochemical engineering have led to the development of antisense oligonucleotides (ASOs) that can inhibit target genes with no significant toxic effects...
May 4, 2020: Journal of Gastroenterology and Hepatology
C Yang, H Yang, S Deng, Y Zhang
No abstract text is available yet for this article.
May 3, 2020: Journal of Gastroenterology and Hepatology
Kyung Mo Yoo, Hyo-Joon Yang, Soo-Kyung Park, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND AND AIMS: Sarcopenia has been suggested to be associated with chronic inflammation and insulin resistance. This study aimed to evaluate whether low muscle mass is associated with the incidence and recurrence of advanced colorectal adenoma. METHODS: We conducted a cohort study including 14,701 participants who underwent first-time screening colonoscopy between 2003 and 2012 and follow-up colonoscopy until 2017. Skeletal muscle mass was measured using a bioelectrical impedance analyzer and divided by body weight to calculate the skeletal muscle mass index (SMI)...
April 29, 2020: Journal of Gastroenterology and Hepatology
Montserrat Guasch, Fiorella Cañete, Ingrid Ordás, Eva Iglesias-Flores, Ariadna Clos, Javier P Gisbert, Carlos Taxonera, Isabel Vera, Miguel Mínguez, Jordi Guardiola, Montserrat Rivero, Pilar Nos, Fernando Gomollón, Jesús Barrio, Ruth de Francisco, Antonio López-Sanromán, M Dolores Martín-Arranz, Esther Garcia-Planella, Raquel Camargo, Santiago García-López, Luisa de Castro, Xavier Calvet, Maria Esteve, Míriam Mañosa, Eugeni Domènech
BACKGROUND AND AIM: Biological therapies may be changing the natural history of inflammatory bowel diseases (IBDs), reducing the need for surgical intervention. We aimed to assess whether the availability of anti-TNF agents impacts the need for early surgery in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Retrospective, cohort study of patients diagnosed within a 6-year period before and after the licensing of anti-TNFs (1990-1995 and 2007-2012 for CD; 1995-2000 and 2007-2012 for UC) were identified in the ENEIDA Registry...
April 29, 2020: Journal of Gastroenterology and Hepatology
Zien Vanessa Tan, Kiranmai Kosana, Jeffrey Savarino, Nicholas Croft, Sandhia Naik, Jess Kaplan, Edward Giles
BACKGROUND AND AIMS: Pediatric Crohn's disease (CD) has been shown to have a high recurrence rate following surgical resection. Risk factors for post-operative CD recurrence in children are not well known. The aim of this study was to identify factors influencing post-operative recurrence in pediatric CD. METHODS: Pediatric CD patients who underwent surgical resection with primary anastomosis with a minimum follow up of 2 years were identified from databases at the Royal London hospital and Massachusetts General Hospital...
April 28, 2020: Journal of Gastroenterology and Hepatology
Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Henry Lik-Yuen Chan, Yee-Kit Tse, Lilian Yan Liang, Vicki Wing-Ki Hui, Hye Won Lee, Grace Chung-Yan Lui, Alice Pik-Shan Kong, Vincent Wai-Sun Wong
BACKGROUND AND AIM: Male sex is a risk factor for hepatocellular carcinoma (HCC). Diabetes mellitus (DM) is associated with a doubled risk of HCC in patients with chronic hepatitis B (CHB). We examined the relationship between serum total testosterone and HCC risk in male CHB patients with DM. METHODS: We performed a retrospective cohort study of male CHB patients with DM between 2000 and 2017 using a territory-wide electronic healthcare database in Hong Kong. DM was defined by use of anti-diabetic medications, hemoglobin A1c ≥6...
April 28, 2020: Journal of Gastroenterology and Hepatology
Cheng-Hao Tseng, Chao-Ming Tseng, Jia-Ling Wu, Yao-Chun Hsu, Hashem B El-Serag
BACKGROUND & AIMS: Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have been shown to reduce incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). This systematic review aims to evaluate the magnitude, change over time, and prediction of residual HCC risks in CHB patients treated with ETV/TDF therapy. METHODS: Available literature was systematically reviewed through searches of PubMed and EMBASE databases from January 1, 2006, to September 1, 2019, to identify cohort studies that reported HCC incidence in CHB patients during ETV/TDF therapy...
April 28, 2020: Journal of Gastroenterology and Hepatology
Renyuan Gao, Zhiguo Wang, Hao Li, Zhan Cao, Zhiguang Gao, Hongqi Chen, Xiaohui Zhang, Dengdeng Pan, Rong Yang, Hui Zhong, Rongrong Shen, Lu Yin, Zhenyi Jia, Tongyi Shen, Nan Qin, Zhiqian Hu, Huanlong Qin
BACKGROUND AND AIM: The gut microbiota is associated with colorectal lesions in cases of precancer and colorectal cancer (CRC). However, there are apparent differences in studies on the gut microbiota in the pathogenic sequence from precancer to cancer. Here, we characterize the gut microbiota signatures of colorectal precancer and cancer and test their utility in detecting colorectal lesions in two independent Chinese cohorts. METHODS: Stool samples collected from patients with precancer and CRC were subjected to 16S rRNA gene sequencing and metagenomic shotgun sequencing analyses, which revealed the microbial signatures of the two disease stages...
April 26, 2020: Journal of Gastroenterology and Hepatology
Mohsen Mazidi, Richard Ofori-Asenso, Andre Pascal Kengne
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing public health problem. In this study, we explored the association between dietary patterns (DPs) and fatty liver and liver function tests. METHODS: This was a cross-sectional study using data from the US community-based National Health and Nutrition Examination Survey (NHANES). Participants with data on dietary intake, blood pressure and status for diabetes mellitus were analyzed...
April 26, 2020: Journal of Gastroenterology and Hepatology
Tsung-Po Chen, Michelle Lai, Wen-Yuan Lin, Kuo-Chin Huang, Kuen-Cheh Yang
BACKGROUND&AIMS: There are sparse data on the epidemiology of fatty liver in the elderly Asian population. We evaluated for predictors of fatty liver and high risk of advanced fibrosis in a community-based elderly population. METHODS: A total of 1091 participants (mean age was 74.6±6.3 years) were enrolled from 2017 to 2018. Subjects with age younger than 65 years, alcoholism, history of hepatitis B and hepatitis C were excluded. Fatty liver was diagnosed with abdominal ultrasound by using ultrasonographic fatty liver indicator (US-FLI), a semi-quantitative measurement grading the severity (normal, mild, moderate-to-severe)...
April 24, 2020: Journal of Gastroenterology and Hepatology
Henry Lik Yuen Chan, Satoshi Yasuda, Grace Lai Hung Wong, Toshifumi Tada, Carmen Ka Man Chan, Takashi Kumada, Yee Kit Tse, Vincent Wai Sun Wong, Hidenori Toyoda
BACKGROUND AND AIMS: Hepatitis B core related antigen (HBcrAg) has been shown to correlate with various viral markers in chronic hepatitis B, but its role in defining natural history is not well studied. We aimed to investigate the use of HBcrAg to define different phases of chronic hepatitis B. METHODS: Stored residual serum samples from longitudinal cohorts of chronic hepatitis B patients in Hong Kong and Japan were studied. Viral markers were measured in 3 serial serum samples for each patient...
April 15, 2020: Journal of Gastroenterology and Hepatology
Antonella Gallo, Cristina Cancelli, Emily Ceron, Marcello Covino, Ettore Capoluongo, Krizia Pocino, Gianluca Ianiro, Giovanni Cammarota, Antonio Gasbarrini, Massimo Montalto
BACKGROUND AND AIM: Faecal microbiota transplantation (FMT) has proven to be very effective in recurrent Clostridium difficile infection (CDI) when compared to standard antibiotic therapy. However, given the lack of validated criteria, decision regarding number and timing of infusions is currently based on the clinician's experience, severity of infection and clinical response. We performed a longitudinal assessment of fecal calprotectin concentration (FCC) in CDI patients undergoing FMT...
April 14, 2020: Journal of Gastroenterology and Hepatology
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