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JOURNAL ARTICLE
Toshifumi Tada, Takashi Kumada, Atsushi Hiraoka, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Fujimasa Tada, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Hisashi Kosaka, Atsushi Naganuma, Tomomitsu Matono, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa
BACKGROUND AND AIM: The study goal was to compare the outcomes of patients with unresectable hepatocellular carcinoma (HCC) who received atezolizumab plus bevacizumab (Atezo/Bev) as either first- or later-line systemic therapy. METHODS: A total of 430 patients with HCC treated with Atezo/Bev at 22 institutions in Japan were included. Patients treated with Atezo/Bev as first-line therapy for HCC were defined as the first-line group (n = 268) while those treated with Atezo/Bev as second- or later-line therapy were defined as the later-line group (n = 162)...
May 25, 2023: Journal of Gastroenterology and Hepatology
#2
REVIEW
A Holstein, C Michels, R W Bryson, B Schulz
No abstract text is available yet for this article.
May 25, 2023: Journal of Gastroenterology and Hepatology
#3
JOURNAL ARTICLE
Yutong Dong, Yuwei Liu, Xu Liu, Heming Ma, Yahui Liu, Guoyue Lv, Junqi Niu
BACKGROUND AND AIM: Hepatic fibrosis is a common pathogenic outcome of almost all chronic liver diseases and a growing public health problem globally. However, the key genes or proteins driving liver fibrosis and cirrhosis are not well understood. We aimed to identify novel hepatic fibrosis genes of human primary hepatic stellate cells (HSCs). METHODS: Human primary HSCs were isolated from surgically resected advanced fibrosis liver tissues (n = 6) and surgical resection of normal liver tissue around hemangioma (n = 5)...
May 24, 2023: Journal of Gastroenterology and Hepatology
#4
JOURNAL ARTICLE
Toshimitsu Tanaka, Keisuke Miwa, Yasutaka Shimotsuura, Sachiko Nagasu, Hirona Shigyou, Keisuke Hirota, Shunji Koya, Yoshito Akagi, Takumi Kawaguchi
BACKGROUND: Nivolumab extends the overall survival (OS) of patients with advanced gastric cancer (AGC). Intramuscular adipose tissue (IMAT) is associated with the prognosis of patients with various cancers. We investigated the effect of IMAT on OS in patients with AGC treated with nivolumab. METHODS: We enrolled patients with AGC treated with nivolumab (n = 58, 67 years old, men/women 40/18). The subjects were classified into long-term or short-term survival groups according to the median value...
May 24, 2023: Journal of Gastroenterology and Hepatology
#5
JOURNAL ARTICLE
Yusuke Takahashi, Yuya Seko, Kanji Yamaguchi, Kento Takeuchi, Kota Yano, Seita Kataoka, Michihisa Moriguchi, Yoshito Itoh
BACKGROUND AND AIM: Pemafibrate, a selective peroxisome proliferator activated receptor α modulator, has been shown to improve liver function among nonalcoholic fatty liver disease (NAFLD) patients with dyslipidemia. The aim of this retrospective study is to identify predictors of pemafibrate efficacy in NAFLD patients. METHODS: A total of 75 NAFLD patients with dyslipidemia who received pemafibrate twice per day for 48 weeks were enrolled in this study...
May 23, 2023: Journal of Gastroenterology and Hepatology
#6
JOURNAL ARTICLE
Seyed Aria Nejadghaderi, Ali-Asghar Kolahi, Maryam Noori, Mark J M Sullman, Saeid Safiri
BACKGROUND AND AIM: Globally, pancreatic cancer is recognized as one of the most lethal types of cancers. We report the burden of pancreatic cancer and its attributable risk factors in the Middle East and North Africa (MENA) region, from 1990 to 2019, by age, sex, and socio-demographic index. METHODS: Publicly available data from the Global Burden of Disease 2019 study were used to report the incidence, deaths, and disability-adjusted life years (DALYs) attributable to pancreatic cancer, as counts and age-standardized rates with 95% uncertainty intervals...
May 23, 2023: Journal of Gastroenterology and Hepatology
#7
JOURNAL ARTICLE
Claudia Wing-Kwan Wu, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Tsz-Fai Yam, Terry Cheuk-Fung Yip, Angus Chun-Hei Wong, Brian Wai-Nok Chan, Matthew Man-Lok Fong, Jimmy Che-To Lai, Yee-Kit Tse, Kit-Fai Lee, Tony Shu-Kam Mok, Henry Lik-Yuen Chan, Rashid Nok-Shun Lui, Stephen Lam Chan, Kelvin Kwok-Chai Ng
BACKGROUND: Baveno VII criteria for predicting varices needing treatment (VNT) have not been tested in hepatocellular carcinoma (HCC) population. We evaluated Baveno VII consensus for VNT in HCC patients of different stages according to Barcelona Clinic Liver Cancer (BCLC) stages undergoing curative hepatectomy. METHODS: This was a prospective cohort study of patients with HCC. Patients underwent transient elastography examination before HCC treatment and received at least one upper endoscopic examination afterwards...
May 22, 2023: Journal of Gastroenterology and Hepatology
#8
JOURNAL ARTICLE
Yichen Wang, Xiaoquan Huang, Mahesh Cheryala, Mark Aloysius, Beishi Zheng, Keming Yang, Bing Chen, Qianqian Fang, Sriram B Chowdary, Marwan S Abougergi, Shiyao Chen
OBJECTIVES: The US Preventive Services Task Force lowered the recommended starting age for colorectal cancer (CRC) screening in average-risk adults from 50 to 45 years. We aimed to estimate the global burden and trends of colorectal cancer in adults aged 20-49 years (early-onset CRC). METHODS: This is an analysis of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019). The GBD 2019 estimation methods were used to describe the incidence, mortality, and disability-adjusted life years (DALYs) of early CRC from 1990 to 2019...
May 21, 2023: Journal of Gastroenterology and Hepatology
#9
JOURNAL ARTICLE
Feini Zhou, Ting Mai, Ziren Wang, Zhaolong Zeng, Jingjing Shi, Fan Zhang, Ning Kong, Hao Jiang, Lingnan Guo, Maosheng Xu, Jiangnan Lin
BACKGROUND AND AIM: Curcumin may have promising application in the prevention and amelioration of inflammatory bowel disease (IBD). However, the underlying mechanisms underpinning the ability of curcumin to interact with the gut and liver in IBD remains to be defined, which is the exploration aim of this study. METHODS: Mice with dextran sulfate sodium salt (DSS)-induced acute colitis were treated either with 100 mg/kg of curcumin or phosphate buffer saline (PBS)...
May 20, 2023: Journal of Gastroenterology and Hepatology
#10
JOURNAL ARTICLE
Zheng Ma, Ruiqing Liu, Huasheng Liu, Longbo Zheng, Xuefeng Zheng, Yinling Li, Haoyu Cui, Chen Qin, Jilin Hu
BACKGROUND AND AIM: Postoperative complications are important clinical outcomes for colon cancer patients. This study aimed to investigate the predictive value of inflammatory-nutritional indicators combined with computed tomography body composition on postoperative complications in patients with stage II-III colon cancer. METHODS: We retrospectively collected data from patients with stage II-III colon cancer admitted to our hospital from 2017 to 2021, including 198 patients in the training cohort and 50 patients in the validation cohort...
May 18, 2023: Journal of Gastroenterology and Hepatology
#11
JOURNAL ARTICLE
Samantha Hodges, Chloe Attree, Sherman Picardo, Tiffany Faithfull, Adrian McElholm, Krish Ragunath
BACKGROUND AND AIM: There is a paucity of evidence regarding non-anemic iron deficiency as a predictor for colorectal cancer and therefore the indication for endoscopic evaluation. This study explores the rates of malignancy in adults with iron deficiency with and without anemia. METHODS: A retrospective multicenter diagnostic cohort study was conducted across two Australian health services. All cases that underwent both esophagogastroduodenoscopy and colonoscopy between September 1, 2018, and December 31, 2019, for the investigation of iron deficiency were included, and the cohort was divided into anemic and non-anemic arms...
May 17, 2023: Journal of Gastroenterology and Hepatology
#12
JOURNAL ARTICLE
Naoki Akizue, Kenichiro Okimoto, Yosuke Hirotsu, Kenji Amemiya, Tatsuya Kaneko, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Motoi Nishimura, Kazuyuki Matsushita, Hitoshi Mochizuki, Tetsuhiro Chiba, Makoto Arai, Jun Kato, Masao Omata, Naoya Kato
BACKGROUND AND AIM: Little is known about genetic mutations in the regenerated mucosa (RM) after endoscopic resection (ER) of esophageal carcinoma. Thus, this study investigates the status of genetic variation in RM after ER of esophageal squamous cell carcinoma (ESCC). METHODS: The study cohort included 19 patients with ESCC. We used an esophageal carcinoma panel to identify target sequences for squamous cell carcinoma (SCC), background mucosa (BM), and RM after ER of ESCC...
May 16, 2023: Journal of Gastroenterology and Hepatology
#13
JOURNAL ARTICLE
Sin-Ei Juang, Kuan-Chih Chung, Kung-Chuan Cheng, Kuen-Lin Wu, Ling-Chiao Song, Chien-En Tang, Hong-Hwa Chen, Ko-Chao Lee
BACKGROUND AND AIM: Morbid obesity is associated with poorer postoperative outcomes in colorectal cancer (CRC) patients. We aimed to evaluate short-term outcomes after robotic versus conventional laparoscopic CRC resection in morbidly obese patients. METHODS: This population-based, retrospective study extracted data from the US Nationwide Inpatient Sample during 2005-2018. Adults ≥ 20 years old, with morbid obesity and CRC, and undergoing robotic or laparoscopic resections were identified...
May 16, 2023: Journal of Gastroenterology and Hepatology
#14
JOURNAL ARTICLE
David Sooik Kim, Beom Kyung Kim, Jae Seung Lee, Hye Won Lee, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Nikolaos Pyrsopoulos, Seung Up Kim
BACKGROUND AND AIM: Hepatic decompensation is a major complication of liver cirrhosis. We validated the predictive performance of the newly proposed CHESS-ALARM model to predict hepatic decompensation in patients with hepatitis B virus (HBV)-related cirrhosis and compared it with other transient elastography (TE)-based models such as liver stiffness-spleen size-to-platelet (LSPS), portal hypertension (PH), varices risk scores, albumin-bilirubin (ALBI), and albumin-bilirubin-fibrosis-4 (ALBI-FIB-4)...
May 15, 2023: Journal of Gastroenterology and Hepatology
#15
REVIEW
H Hirata, N Ishiguro, K Ito, A Suga, N Yasuura, H Egami, T Kobayashi, T Kato
No abstract text is available yet for this article.
May 14, 2023: Journal of Gastroenterology and Hepatology
#16
LETTER
B Caron, L Peyrin-Biroulet
No abstract text is available yet for this article.
May 11, 2023: Journal of Gastroenterology and Hepatology
#17
REVIEW
D Fan, P Hu, L Liu
No abstract text is available yet for this article.
May 11, 2023: Journal of Gastroenterology and Hepatology
#18
JOURNAL ARTICLE
I Seul Park, Ji Hyung Kim, Jongwook Yu, YooJin Shin, Kibeom Kim, Tae Il Kim, Seung Won Kim, Jae Hee Cheon
BACKGROUND AND AIM: Bifidobacterium breve was the first bacteria isolated in the feces of healthy infants and is a dominant species in the guts of breast-fed infants. Some strains of B. breve have been shown to be effective at relieving intestinal inflammation, but the modes of action have yet to be elucidated. In this study, we investigated the mechanisms of action of B. breve CBT BR3 isolated from South Korean infant feces in relieving colitis in vitro and in vivo. METHODS: Colitis was induced in mice with dextran sodium sulfate (DSS) and dinitrobenzene sulfonic acid (DNBS)...
May 8, 2023: Journal of Gastroenterology and Hepatology
#19
JOURNAL ARTICLE
Fabio Salvatore Macaluso, Mauro Grova, Filippo Mocciaro, Roberto Di Mitri, Antonino Carlo Privitera, Maria Emanuela Distefano, Alessandro Vitello, Salvatore Camilleri, Concetta Ferracane, Dario Pluchino, Nunzio Belluardo, Emiliano Giangreco, Walter Fries, Anna Viola, Maria Cappello, Livia D'Amato, Carmelo Bertolami, Marco Ventimiglia, Sara Renna, Angelo Casà, Elvira D'Antonio, Simona De Vivo, Ambrogio Orlando
BACKGROUND AND AIM: Postoperative recurrence (POR) following ileocolonic resection is a major concern in patients with Crohn's disease (CD). The role of ustekinumab (UST) in this setting is poorly known. METHODS: All consecutive CD patients with a baseline colonoscopy at 6-12 months from ileocolonic resection showing POR (Rutgeerts score ≥ i2) who were treated with UST after the baseline colonoscopy and with an available post-treatment endoscopy, were extracted from the cohort of the Sicilian Network for Inflammatory Bowel Diseases (SN-IBD)...
May 6, 2023: Journal of Gastroenterology and Hepatology
#20
JOURNAL ARTICLE
Vítor Macedo Silva, Tiago Lima Capela, Marta Freitas, Tiago Cúrdia Gonçalves, Pedro Boal Carvalho, Bruno Rosa, José Cotter
INTRODUCTION: Foreign body (FB) ingestion is a common indication for urgent esophagogastroduodenoscopy (EGD). Nevertheless, most pass spontaneously through the gastrointestinal (GI) tract. Differently from GI bleeding, there is no validated score aiming to identify "low-risk" patients in suspected FB ingestion. We aimed to create a score able to discriminate patients who are candidates to emergent EGD in this scenario. METHODS: Retrospective study of consecutive patients admitted for suspected FB in the upper GI tract between 2016 and 2021...
May 4, 2023: Journal of Gastroenterology and Hepatology
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