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Journals Journal of Gastroenterology an...

Journal of Gastroenterology and Hepatology

https://read.qxmd.com/read/38864669/the-association-between-proton-pump-inhibitor-use-and-recurrence-of-hepatocellular-carcinoma-after-hepatectomy
#1
JOURNAL ARTICLE
Chun-Ting Ho, Chia-Chu Fu, Elise Chia-Hui Tan, Wei-Yu Kao, Pei-Chang Lee, Yi-Hsiang Huang, Teh-Ia Huo, Ming-Chih Hou, Jaw-Ching Wu, Chien-Wei Su
BACKGROUND AND AIM: The association between long-term proton-pump inhibitors (PPIs) use and malignancies had long been discussed, but it still lacks consensus. Our study investigated the association between PPI use and hepatocellular carcinoma (HCC) recurrence following curative surgery. METHODS: We retrospectively enrolled 6037 patients with HCC who underwent hepatectomy. Patients were divided into four groups according to their PPI usage. (non-users: < 28 cumulative defined daily dose [cDDD]; short-term users: 28-89 cDDD; mid-term users: 90-179 cDDD, and long-term users: ≥ 180 cDDD, respectively)...
June 12, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38860525/idiopathic-myointimal-hyperplasia-of-the-mesenteric-veins-could-be-related-to-mesenteric-arteriovenous-malformation
#2
LETTER
D Huynh, P Hendy, M Mortimore
No abstract text is available yet for this article.
June 11, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38860418/analysis-of-autoimmune-hepatitis-with-acute-presentation-in-the-early-stage-of-illness
#3
JOURNAL ARTICLE
Keiichi Fujiwara, Yoshihiro Fukuda, Masahiko Sanada, Shuko Koizumi, Katsushi Seza, Masaya Saito, Osamu Yokosuka, Naoya Kato
BACKGROUND AND AIM: There is no gold standard for making the diagnosis of autoimmune hepatitis (AIH), and the diagnosis of acute onset AIH (A-AIH) is most challenging. A-AIH sometimes develops into acute liver failure with poor prognosis if the diagnosis is delayed. Therefore, it is most important for the better prognosis to diagnose non-severe A-AIH early and treat appropriately. However, features in the early stage of A-AIH are unclear. We examined initial characteristics of non-severe A-AIH in detail and tried to find novel clinical features for the early diagnosis...
June 11, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38860301/prevalence-of-functional-esophageal-disorders-and-associated-clinical-characteristics-in-patients-with-proton-pump-inhibitor-unresponsive-reflux-symptoms
#4
JOURNAL ARTICLE
Ming-Han Wei, Chien-Chuan Chen, Hui-Chuan Lee, Yi-Chia Lee, Hsiu-Po Wang, Ming-Shiang Wu, Jia-Feng Wu, Ping-Huei Tseng
BACKGROUND AND AIM: Patients with proton-pump-inhibitor (PPI)-unresponsive reflux symptoms, often caused by functional esophageal disorders (FED), are frequently encountered in clinical practice. We aimed to investigate the prevalence of FED and its associated clinical characteristics in patients with PPI-unresponsive reflux symptoms. METHODS: We retrospectively identified patients who were evaluated for persistent typical reflux symptoms, despite ≥8 weeks of PPI treatment, at the National Taiwan University Hospital from 2014 to 2023...
June 11, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38859699/gastrointestinal-involvement-in-neuromuscular-disorders
#5
REVIEW
Josef Finsterer, Walter Strobl
Although not often discussed, many of the neuromuscular disorders (NMDs) affect the gastrointestinal tract (GIT). Depending on the type of NMD, the prevalence of GIT involvement ranges from <5% (e.g. hereditary neuropathies, myofibrillar myopathies) to 100% (e.g. MNGIE, OPMD). Particularly in NMDs with multisystem affection, involvement of the GIT can dominate the clinical presentation or at least make up a significant part of the clinical picture. The most prominent representatives of NMDs with multisystem involvement are the mitochondrial disorders (MIDs) and the myotonic dystrophies...
June 10, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38859685/potential-role-of-stem-cells-from-human-exfoliated-deciduous-teeth-in-inducing-liver-regeneration
#6
JOURNAL ARTICLE
Fatima Safira Alatas, Takayoshi Yamaza, Toshiharu Matsuura, Lukito Ongko, Muzal Kadim, Shouichi Ohga, Tomoaki Taguchi, Tatsuro Tajiri
BACKGROUND AND AIM: Even with advancement of medical technologies, liver transplantation still faces several major challenges. Hence, other treatment modalities are urgently needed for patients with end-stage liver disease. Stem cells from human exfoliated deciduous teeth (SHED) was discovered to have highly proliferative and pluripotent properties; including differentiation into hepatocyte-like cells. This study aims to investigate the capability of intrasplenic transplanted SHED and SHED-Hep cells in inducing proliferation of stem cells and native hepatocytes in order to accelerate liver regeneration in liver fibrosis mice models...
June 10, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38859657/small-gastric-subepithelial-lesions-a-sand-in-the-eye
#7
EDITORIAL
Tanyaporn Chantarojanasiri, Nikhil Sonthalia, Rashid N Lui
No abstract text is available yet for this article.
June 10, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38845460/efficacy-of-endoscopic-ultrasound-guided-gastroenterostomy-using-self-expandable-metallic-stent-for-afferent-loop-syndrome-a-single-center-retrospective-study
#8
JOURNAL ARTICLE
Yuya Hagiwara, Susumu Hijioka, Yoshikuni Nagashio, Yuta Maruki, Akihiro Ohba, Yuki Kawasaki, Kotaro Takeshita, Tetsuro Takasaki, Daiki Agarie, Hidenobu Hara, Shin Yagi, Soma Fukuda, Masaru Kuwada, Daiki Yamashige, Kohei Okamoto, Mark Chatto, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Masato Endo, Shunsuke Sugawara, Miyuki Sone, Yutaka Saito, Kiichiro Tsuchiya, Takuji Okusaka
BACKGROUND AND AIM: Endoscopic ultrasound-guided gastroenterostomy is a procedure used to connect the stomach and dilated afferent loop using a stent under endoscopic ultrasound for afferent loop syndrome. However, the actual efficacy and safety of this procedure remain unclear. Therefore, this retrospective study aimed to evaluate the efficacy and safety of endoscopic ultrasound-guided gastroenterostomy using a laser-cut-type fully covered self-expandable metallic stent and an anchoring plastic stent for afferent loop syndrome...
June 7, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38840444/prophylactic-use-of-a-self-assembling-peptide-hydrogel-for-preventing-delayed-bleeding-after-endoscopic-sphincterotomy-a-propensity-score-matched-analysis
#9
JOURNAL ARTICLE
Tadahisa Inoue, Rena Kitano, Mayu Ibusuki, Kazumasa Sakamoto, Satoshi Kimoto, Jun Arai, Yukiomi Nakade, Kiyoaki Ito
BACKGROUND AND AIM: Delayed endoscopic sphincterotomy-related bleeding (ES bleeding) is an unavoidable adverse event (AE) that can have serious ramifications. Intraoperative ES bleeding, which stops spontaneously in most cases, is a known risk factor for delayed bleeding. This study aimed to examine the preventive effect of a novel self-assembling peptide (SAP) for delayed ES bleeding in patients who attained spontaneous hemostasis after intraoperative ES bleeding. METHODS: A total of 1507 patients met the eligibility criteria for inclusion in this study...
June 5, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38837839/linas-score-prognostic-model-for-mortality-assessment-in-patients-with-cirrhotic-liver-and-infected-ascites
#10
JOURNAL ARTICLE
Silvia W├╝rstle, Tillman Schneider, Siranush Karapetyan, Alexander Hapfelmeier, Andriana Isaakidou, Fabian Studen, Roland M Schmid, Stephan von Delius, Kathrin Rothe, Rainer Burgkart, Andreas Obermeier, Julian Triebelhorn, Johanna Erber, Florian Voit, Fabian Geisler, Christoph D Spinner, Jochen Schneider, Laura Wagner
BACKGROUND AND AIM: Patients with liver cirrhosis often face a grave threat from infected ascites (IA). However, a well-established prognostic model for this complication has not been established in routine clinical practice. Therefore, we aimed to assess mortality risk in patients with liver cirrhosis and IA. METHODS: We conducted a retrospective study across three tertiary hospitals, enrolling 534 adult patients with cirrhotic liver and IA, comprising 465 with spontaneous bacterial peritonitis (SBP), 34 with bacterascites (BA), and 35 with secondary peritonitis (SP)...
June 5, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38822643/predictive-value-of-thrombin-antithrombin-iii-complex-and-tissue-plasminogen-activator-inhibitor-complex-biomarkers-in-assessing-the-severity-of-early-stage-acute-pancreatitis
#11
JOURNAL ARTICLE
Chushu Liao, Guanghua Liu, Lingqian Li, Juan Wang, Long Ouyang, Ping Lei, Shasha Fan
BACKGROUND AND AIM: The development of acute pancreatitis (AP) is strongly linked to blood clotting and fibrinolysis issues. Modern clinical practices now utilize advanced blood markers like thrombin-antithrombin III complex (TAT), plasmin-α2-plasmin inhibitor complex, thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (t-PAIC) to assess thrombosis risk. Our study used a highly sensitive chemiluminescence technique to measure these markers in AP patients, aiming to determine their early predictive value for AP severity...
June 1, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38818853/systematic-review-and-meta-analysis-of-endoscopic-versus-medical-management-of-peptic-ulcers-with-adherent-clots
#12
REVIEW
Daniel Tassone, Shamsul Kazi, Tanya Lee, Robert Gilmore, Nik Ding
Peptic ulcer disease is an important cause of upper gastrointestinal bleeding. Current guidelines recommend endoscopic treatment for ulcers with active bleeding or non-bleeding visible vessels, but the optimal management of ulcers with adherent clots is unclear. We performed a systematic review of the efficacy of endoscopic versus medical management of peptic ulcers with adherent clots. A systematic literature search was performed through September 2022 (MEDLINE, Embase, and CENTRAL). Randomized controlled trials (RCTs) comparing the effect of endoscopic versus medical management alone for peptic ulcers with adherent clots on the outcome of recurrent bleeding were incuded...
May 31, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38816902/association-between-diverticular-disease-and-subsequent-dementia
#13
LETTER
K Kostev, L Smith, N Veronese, P Soysal, S Krieg
No abstract text is available yet for this article.
May 30, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38816894/a-low-baseline-serum-myostatin-concentration-is-associated-with-poor-clinical-outcome-in-patients-with-primary-biliary-cholangitis
#14
JOURNAL ARTICLE
Manabu Hayashi, Kazumichi Abe, Tatsuro Sugaya, Yosuke Takahata, Masashi Fujita, Atsushi Takahashi, Hiromasa Ohira
BACKGROUND AND AIM: Primary biliary cholangitis (PBC) is an autoimmune-mediated cholestatic liver disease that can progress to biliary cirrhosis and liver-related death. The associations between baseline myostatin levels and clinical outcomes in PBC patients are unknown. We aimed to clarify the influence of myostatin levels on the clinical outcomes of PBC patients. METHODS: A total of 119 PBC patients were analyzed in this study. Myostatin levels were measured in stored sera before ursodeoxycholic acid treatment, and their associations with the clinical features and prognosis of PBC patients were analyzed...
May 30, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38812101/genomic-analysis-of-helicobacter-pylori-in-australia-antimicrobial-resistance-phylogenetic-patterns-and-virulence-factors
#15
JOURNAL ARTICLE
Jonathon P Schubert, Alfred Tay, Khui Hung Claire Lee, Lex E X Leong, Christopher K Rayner, Morgyn S Warner, Ian C Roberts-Thomson, Samuel P Costello, Robert V Bryant
BACKGROUND AND AIM: Rates of antimicrobial-resistant Helicobacter pylori infection are rising globally, but little is known about contemporary resistance patterns, virulence factors, and phylogenetic patterns of isolates within Australia. We aimed to characterize antimicrobial resistance and genetic mutations associated with adverse clinical outcomes. METHODS: Whole genome sequencing, culturing, and antibiotic sensitivity data for refractory H. pylori isolates at Australian centers were collected between 2013 and 2022...
May 29, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38804845/hydronidone-induces-apoptosis-in-activated-hepatic-stellate-cells-through-endoplasmic-reticulum-stress-associated-mitochondrial-apoptotic-pathway
#16
JOURNAL ARTICLE
Zhongshang Sun, Yuecheng Guo, Xianjun Xu, Cui Zhou, Xin Luo, Zhenyang Shen, Bo Shen, Junjun Wang, Jingyi Lu, Qingqing Zhang, Feifei Shen, Lou Yu, Yanping Ye, Ling Zhang, Ying Luo, Ying Qu, Xiaobo Cai, Hui Dong, Lungen Lu
BACKGROUND AND AIM: Hydronidone (HDD) is a novel pirfenidone derivative developed initially to reduce hepatotoxicity. Our previous studies in animals and humans have demonstrated that HDD treatment effectively attenuates liver fibrosis, yet the underlying mechanism remains unclear. This study aimed to investigate whether HDD exerts its anti-fibrotic effect by inducing apoptosis in activated hepatic stellate cells (aHSCs) through the endoplasmic reticulum stress (ERS)-associated mitochondrial apoptotic pathway...
May 28, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38803139/total-flavone-of-abelmoschus-manihot-regulates-autophagy-through-the-ampk-mtor-signaling-pathway-to-treat-intestinal-fibrosis-in-crohn-s-disease
#17
JOURNAL ARTICLE
Dan Zhang, Jiali Liu, Lei Lv, Xiaopin Chen, Yunzhi Qian, Peizhen Zhao, Qiaofeng Zhang, Yugen Chen, Haihua Qian
BACKGROUND AND AIM: Drug therapy is the treatment of choice for Crohn's disease because it effectively controls or prevents intestinal inflammation. The purpose was to research the molecular mechanism of the total flavones of Abelmoschus manihot (TFA) on intestinal fibrosis in Crohn's disease. METHODS: A 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis model and IGF-1-treated intestinal fibroblasts were established. Then, TFA, 3-MA, and compound C were used treatments...
May 27, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38800890/immune-signature-and-therapeutic-approach-of-natural-killer-cell-in-chronic-liver-disease-and-hepatocellular-carcinoma
#18
REVIEW
Seung Kak Shin, Sooyeon Oh, Su-Kyung Chun, Min-Ji Ahn, Seung-Min Lee, Kayun Kim, Hogyeong Kang, Jeongwoo Lee, Suk Pyo Shin, Jooho Lee, Young Kul Jung
Natural killer (NK) cells are one of the key members of innate immunity that predominantly reside in the liver, potentiating immune responses against viral infections or malignant tumors. It has been reported that changes in cell numbers and function of NK cells are associated with the development and progression of chronic liver diseases (CLDs) including non-alcoholic fatty liver disease, alcoholic liver disease, and chronic viral hepatitis. Also, it is known that the crosstalk between NK cells and hepatic stellate cells plays an important role in liver fibrosis and cirrhosis...
May 27, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38783558/gastrointestinal-side-effects-of-somatostatin-analogs-in-neuroendocrine-tumors-a-focused-review
#19
REVIEW
Matteo Marasco, Elisabetta Dell'Unto, Alessandro Laviano, Davide Campana, Francesco Panzuto
Neuroendocrine tumors (NETs) are a group of well-differentiated heterogeneous neoplasms characterized by slow progression and distinct clinical and biological behavior. In the majority of patients with NET, first-line treatment is represented by somatostatin analogs (SSAs) that, despite being drugs with high tolerability (even at high doses) and providing to carcinoid symptoms control and anti-proliferative effects, may present some side effects, with potential impact on quality of life and nutritional status...
May 23, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38780349/short-chain-fatty-acids-bridges-between-diet-gut-microbiota-and-health
#20
REVIEW
Ling-Yun Wang, Li-Hong He, Li-Jun Xu, Shi-Bo Li
In recent years, gut microbiota has become a hot topic in the fields of medicine and life sciences. Short-chain fatty acids (SCFAs), the main metabolites of gut microbiota produced by microbial fermentation of dietary fiber, play a vital role in healthy and ill hosts. SCFAs regulate the process of metabolism, immune, and inflammation and have therapeutic effects on gastrointestinal and neurological disorders, as well as antitumor properties. This review summarized the production, distribution, and molecular mechanism of SCFAs, as well as their mechanisms of action in healthy and ill hosts...
May 23, 2024: Journal of Gastroenterology and Hepatology
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