journal
https://read.qxmd.com/read/38565395/all-stage-targeted-red-blood-cell-membrane-coated-docetaxel-nanocrystals-for-glioma-treatment
#21
JOURNAL ARTICLE
Yuan Ding, Qianzhu Xu, Zhilan Chai, Sunyi Wu, Weixia Xu, Jun Wang, Jianfen Zhou, Zimiao Luo, Yu Liu, Cao Xie, Linwei Lu, Weiyue Lu
Challenges for glioma treatment with nanomedicines include physio-anatomical barriers (the blood-brain barrier and blood-brain tumor barrier), low drug loading capacity, and limited circulation time. Here, a red blood cell membrane-coated docetaxel drug nanocrystal (pV-RBCm-NC(DTX)), modified with pHA-VAP (pV) for all-stage targeting of glioma, was designed. The NC(DTX) core exhibited a high drug loading capacity but low in vivo stability, and the RBCm coating significantly enhanced the stability and prolonged in vivo circulation...
April 3, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38575077/nanomodulators-targeting-endothelial-wnt-and-pericytes-to-reversibly-open-the-blood-tumor-barrier-for-boosted-brain-tumor-therapy
#22
JOURNAL ARTICLE
Rui Mu, Hang Sun, Yuteng Zeng, Yang Tong, Puxian Tang, Mei Zhao, Ziyan Lv, Ju Yu, Yanming Chen, Qing Lan, Xuechu Zhen, Liang Han
The blood-brain barrier (BBB)/blood-tumor barrier (BTB) impedes brain entry of most brain-targeted drugs, whether they are water-soluble or hydrophobic. Endothelial WNT signaling and neoplastic pericytes maintain BTB low permeability by regulating tight junctions. Here, we proposed nitazoxanide (NTZ) and ibrutinib (IBR) co-loaded ICAM-1-targeting nanoparticles (NI@I-NPs) to disrupt the BTB in a time-dependent, reversible, and size-selective manner by targeting specific ICAM-1, inactivating WNT signaling and depleting pericytes in tumor-associated blood vessels in breast cancer brain metastases...
April 2, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38575076/tumor-penetrating-irgd-facilitates-penetration-of-poly-floxuridine-ketal-based-nanomedicine-for-enhanced-pancreatic-cancer-therapy
#23
JOURNAL ARTICLE
Xingwei Li, Haiping Zhong, Shujing Zheng, Jingqing Mu, Na Yu, Shutao Guo
Efficient intratumoral penetration is essential for nanomedicine to eradicate pancreatic tumors. Although nanomedicine can enter the perivascular space of pancreatic tumors, their access to distal tumor cells, aloof from the vessels, remains a formidable challenge. Here, we synthesized an acid-activatable macromolecular prodrug of floxuridine (FUDR)-poly(FUDR-ketal), engineered a micellar nanomedicine of FUDR, and intravenously co-administered the nanomedicine with the tumor-penetrating peptide iRGD for enhanced treatment of pancreatic tumor...
April 2, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38575075/modulating-macrophage-phenotype-for-accelerated-wound-healing-with-chlorogenic-acid-loaded-nanocomposite-hydrogel
#24
JOURNAL ARTICLE
Shuangqing Wang, Yanhong Liu, Xusheng Wang, Liqing Chen, Wei Huang, Tianning Xiong, Nuoya Wang, Jianpeng Guo, Zhonggao Gao, Mingji Jin
Wound healing involves distinct phases, including hemostasis, inflammation, proliferation, and remodeling, which is a complex and dynamic process. Conventional preparations often fail to meet multiple demands and provide prompt information about wound status. Here, a pH/ROS dual-responsive hydrogel (OHA-PP@Z-CA@EGF) was constructed based on oxidized hyaluronic acid (OHA), phenylboronic acid-grafted ε-polylysine (PP), chlorogenic acid (CA)-loaded ZIF-8 (Z-CA), and epidermal growth factor (EGF), which possesses intrinsic antibacterial, antioxidant, and angiogenic capacities...
April 2, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38575074/enhanced-capillary-delivery-with-nanobubble-mediated-blood-brain-barrier-opening-and-advanced-high-resolution-vascular-segmentation
#25
JOURNAL ARTICLE
Roni Gattegno, Lilach Arbel, Noa Riess, Hila Shinar, Sharon Katz, Tali Ilovitsh
Overcoming the blood-brain barrier (BBB) is essential to enhance brain therapy. Here, we utilized nanobubbles with focused ultrasound for targeted and improved BBB opening in mice. A microscopy technique method assessed BBB opening at a single blood vessel resolution employing a dual-dye labeling technique using green fluorescent molecules to label blood vessels and Evans blue brain-impermeable dye for quantifying BBB extravasation. A deep learning architecture enabled blood vessels segmentation, delivering comparable accuracy to manual segmentation with a significant time reduction...
April 2, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38575073/the-predominant-quillaja-saponaria-fraction-qs-18-is-safe-and-effective-when-formulated-in-a-liposomal-murine-cancer-peptide-vaccine
#26
JOURNAL ARTICLE
Shiqi Zhou, Yiting Song, Anoop Nilam, Yuan Luo, Wei-Chiao Huang, Mark D Long, Jonathan F Lovell
Extracts of the Chilean soapbark tree, Quillaja Saponaria (QS) are the source of potent immune-stimulatory saponin compounds. This study compared the adjuvanticity and toxicity of QS-18 and QS-21, assessing the potential to substitute QS-18 in place of QS-21 for vaccine development. QS-18, the most abundant QS saponin fraction, has been largely overlooked due to safety concerns. We found that QS-18 spontaneously inserted into liposomes, thereby neutralizing hemolytic activity, and following administration did not induce local reactogenicity in a footpad swelling test in mice...
April 2, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38575072/a-blood-brain-barrier-and-blood-brain-tumor-barrier-penetrating-sirna-delivery-system-targeting-gliomas-for-brain-tumor-immunotherapy
#27
JOURNAL ARTICLE
Lin Tang, Rui Zhang, Yusi Wang, Mohan Liu, Die Hu, Yefeng Wang, Li Yang
Glioma is recognized as the most infiltrative and lethal form of central nervous system tumors and is known for its limited response to standard therapeutic interventions, high recurrence rate, and unfavorable prognosis. Recent progress in gene and immunotherapy presents a renewed sense of optimism in the treatment of glioblastoma. However, the barriers to overcome include the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB), as well as the suppressive immune microenvironment. Overcoming these barriers remains a significant challenge...
April 2, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38569943/adjuvants-in-cutaneous-vaccination-a-comprehensive-analysis
#28
REVIEW
Mariam Oladejo, Akeemat O Tijani, Ashana Puri, Lipika Chablani
Skin is the body's largest organ and serves as a protective barrier from physical, thermal, and mechanical environmental challenges. Alongside, the skin hosts key immune system players, such as the professional antigen-presenting cells (APCs) like the Langerhans cells in the epidermis and circulating macrophages in the blood. Further, the literature supports that the APCs can be activated by antigen or vaccine delivery via multiple routes of administration through the skin. Once activated, the stimulated APCs drain to the associated lymph nodes and gain access to the lymphatic system...
April 1, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38569942/disrupting-glycolysis-and-dna-repair-in-anaplastic-thyroid-cancer-with-nucleus-targeting-platinum-nanoclusters
#29
JOURNAL ARTICLE
Zongfu Pan, Xixuan Lu, Xi Hu, Ruixi Yu, Yulu Che, Jie Wang, Lin Xiao, Jianqiang Chen, Xiaofen Yi, Zhuo Tan, Fangyuan Li, Daishun Ling, Ping Huang, Minghua Ge
Cancer cells rely on aerobic glycolysis and DNA repair signals to drive tumor growth and develop drug resistance. Yet, fine-tuning aerobic glycolysis with the assist of nanotechnology, for example, dampening lactate dehydrogenase (LDH) for cancer cell metabolic reprograming remains to be investigated. Here we focus on anaplastic thyroid cancer (ATC) as an extremely malignant cancer with the high expression of LDH, and develop a pH-responsive and nucleus-targeting platinum nanocluster (Pt@TAT/sPEG) to simultaneously targets LDH and exacerbates DNA damage...
April 1, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38556217/studying-the-stability-of-polymer-nanoparticles-by-size-exclusion-chromatography-of-radioactive-polymers
#30
JOURNAL ARTICLE
Amrita Dikpati, Vanessa Dos Passos Maio, Ece Ates, Karine Greffard, Nicolas Bertrand
The properties of nanomedicines will influence how they can deliver drugs to patients reproducibly and effectively. For conventional pharmaceutical products, Chemistry, Manufacturing and Control (CMC) documents require monitoring stability and storage conditions. For nanomedicines, studying these important considerations is hindered by a lack of appropriate methods. In this paper, we show how combining radiolabelling with size exclusion chromatography, using a method called SERP, can inform on the in vitro degradation of polymers...
March 29, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38554773/ros-responsive-sprayable-hydrogel-as-ros-scavenger-and-gata6-macrophages-trap-for-the-prevention-of-postoperative-abdominal-adhesions
#31
JOURNAL ARTICLE
Yanjuan Huang, Xiuling Dai, Yujun Gong, Lingling Ren, Yong Luo, Yue Sun, Meixu Chen, Jingwen Jiang, Zilin Guan, Chunshun Zhao
Postoperative abdominal adhesions are a common clinical problem after surgery and can cause many serious complications. Current most commonly used antiadhesion products are less effective due to their short residence time and focus primary on barrier function. Herein, we developed a sprayable hydrogel barrier (sHA-ADH/OHA-E) with self-regulated drug release based on ROS levels at the trauma site, to serve as a smart inflammatory microenvironment modulator and GATA6+ macrophages trap for non-adherent recovery from abdominal surgery...
March 28, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38554772/thermosensitive-polymer-prodrug-nanoparticles-prepared-by-an-all-aqueous-nanoprecipitation-process-and-application-to-combination-therapy
#32
JOURNAL ARTICLE
Léa Guerassimoff, Marianne Ferrere, Simon Van Herck, Samy Dehissi, Valérie Nicolas, Bruno G De Geest, Julien Nicolas
Despite their great versatility and ease of functionalization, most polymer-based nanocarriers intended for use in drug delivery often face serious limitations that can prevent their clinical translation, such as uncontrolled drug release and off-target toxicity, which mainly originate from the burst release phenomenon. In addition, residual solvents from the formulation process can induce toxicity, alter the physico-chemical and biological properties and can strongly impair further pharmaceutical development...
March 28, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38554771/nanodrug-modified-with-engineered-cell-membrane-targets-cdks-to-activate-apd-l1-immunotherapy-against-liver-metastasis-of-immune-desert-colon-cancer
#33
JOURNAL ARTICLE
Dongbing Ding, Rongpu Liang, Tan Li, Tianyun Lan, Yiquan Li, Shengxin Huang, Guanhui He, Jiannan Ren, Weibo Li, Zongheng Zheng, Tufeng Chen, Jiafeng Fang, Lijun Huang, Xintao Shuai, Bo Wei
Immunotherapy based on the PD-1/PD-L1 axis blockade has no benefit for patients diagnosed with colon cancer liver metastasis (CCLM) for the microsatellite stable/proficient mismatch repair (MSS/pMMR)) subtype, which is known as an immune-desert cancer featuring poor immunogenicity and insufficient CD8+ T cell infiltration in the tumor microenvironment. Here, a multifunctional nanodrug carrying a cyclin-dependent kinase (CDK)1/2/5/9 inhibitor and PD-L1 antibody is prepared to boost the immune checkpoint blockade (ICB)-based immunotherapy against MSS/pMMR CCLM via reversing the immunosuppressive tumor microenvironment...
March 28, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38554770/improved-pharmacokinetic-and-lymphatic-uptake-of-rose-bengal-after-transfersome-intradermal-deposition-using-hollow-microneedles
#34
JOURNAL ARTICLE
Sara Demartis, Giovanna Rassu, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Aaron R J Hutton, Akmal B Sabri, Helen O McCarthy, Paolo Giunchedi, Ryan F Donnelly, Elisabetta Gavini
The lymphatic system is active in several processes that regulate human diseases, among which cancer progression stands out. Thus, various drug delivery systems have been investigated to promote lymphatic drug targeting for cancer therapy; mainly, nanosized particles in the 10-150 nm range quickly achieve lymphatic vessels after an interstitial administration. Herein, a strategy to boost the lymphotropic delivery of Rose Bengal (RB), a hydrosoluble chemotherapeutic, is proposed, and it is based on the loading into Transfersomes (RBTF) and their intradermal deposition in vivo by microneedles...
March 28, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38552963/tumor-targeted-and-stimulus-responsive-polymeric-prodrug-nanoparticles-to-enhance-the-anticancer-therapeutic-efficacy-of-doxorubicin
#35
JOURNAL ARTICLE
Nuri Kim, Soonyoung Kwon, Gayoung Kwon, Nanhee Song, Hanui Jo, Chunho Kim, Sangjun Park, Dongwon Lee
Polymeric prodrug nanoparticles have gained increasing attention in the field of anticancer drug delivery because of their dual functions as a drug carrier and a therapeutic agent. Doxorubicin (DOX) is a highly effective chemotherapeutic agent for various cancers but causes cardiotoxicity. In this work, we developed polymeric prodrug (pHU) nanoparticles that serve as both a drug carrier of DOX and a therapeutic agent. The composition of pHU includes antiangiogenic hydroxybenzyl alcohol (HBA) and ursodeoxycholic acid (UDCA), covalently incorporated through hydrogen peroxide (H2 O2 )-responsive peroxalate...
March 27, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38548064/continuous-iontronic-chemotherapy-reduces-brain-tumor-growth-in-embryonic-avian-in-vivo-models
#36
JOURNAL ARTICLE
Verena Handl, Linda Waldherr, Theresia Arbring Sjöström, Tobias Abrahamsson, Maria Seitanidou, Sabine Erschen, Astrid Gorischek, Iwona Bernacka-Wojcik, Helena Saarela, Tamara Tomin, Sophie Elisabeth Honeder, Joachim Distl, Waltraud Huber, Martin Asslaber, Ruth Birner-Grünberger, Ute Schäfer, Magnus Berggren, Rainer Schindl, Silke Patz, Daniel T Simon, Nassim Ghaffari-Tabrizi-Wizsy
Local and long-lasting administration of potent chemotherapeutics is a promising therapeutic intervention to increase the efficiency of chemotherapy of hard-to-treat tumors such as the most lethal brain tumors, glioblastomas (GBM). However, despite high toxicity for GBM cells, potent chemotherapeutics such as gemcitabine (Gem) cannot be widely implemented as they do not efficiently cross the blood brain barrier. As an alternative method for continuous administration of Gem, we here operate freestanding iontronic pumps - "GemIPs" - equipped with a custom-synthesized ion exchange membrane to treat a GBM tumor in an avian embryonic in vivo system...
March 26, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38538380/corrigendum-to-131-i-%C3%AE-pd-l1-immobilized-by-bacterial-cellulose-for-enhanced-radio-immunotherapy-of-cancer-journal-of-controlled-release-346-2022-240-249
#37
Zhongyuan Qi, Pei Pei, Yanxiang Zhang, Hua Chen, Sai Yang, Teng Liu, Yujuan Zhang, Kai Yang
No abstract text is available yet for this article.
March 26, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38537717/m-mdscs-mediated-trans-bbb-drug-delivery-for-suppression-of-glioblastoma-recurrence-post-standard-treatment
#38
JOURNAL ARTICLE
Tong Yu, Kai Wang, Jianwei Wang, Yupeng Liu, Tingting Meng, Fuqiang Hu, Hong Yuan
We found that immunosuppressive monocytic-myeloid-derived suppressor cells (M-MDSCs) were more likely to be recruited by glioblastoma (GBM) through adhesion molecules on GBM-associated endothelial cells upregulated post-chemoradiotherapy. These cells are continuously generated during tumor progression, entering tumors and expressing PD-L1 at a high level, allowing GBM to exhaust T cells and evade attack from the immune system, thereby facilitating GBM relapse. αLy-6C-LAMP is composed of (i) drug cores with slightly negative charges condensed by cationic protamine and plasmids encoding PD-L1 trap protein, (ii) pre-formulated cationic liposomes targeted to Ly-6C for encapsulating the drug cores, and (iii) a layer of red blood cell membrane on the surface for effectuating long-circulation...
March 25, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38522817/extracellular-vesicles-derived-from-dendritic-cells-loaded-with-vegf-a-sirna-and-doxorubicin-reduce-glioma-angiogenesis-in-vitro
#39
JOURNAL ARTICLE
Parisa Shamshiripour, Mehrana Rahnama, Mehdi Nikoobakht, Vahideh Farzam Rad, Ali-Reza Moradi, Davoud Ahmadvand
BACKGROUND: Numerous attempts have been devoted to designing anti-angiogenic agents as a strategy to slow tumor growth and progression. Clinical applications of conventional anti-angiogenic agents face some challenges, e.g., off-target effects for TKIs and also low solid tumor penetration for mAbs. Furthermore, although anti-angiogenic therapy provides a normalization window for better chemo-RT response, in long-term treatments, tumor hypoxia as a result of total removal of VEGF-A by mAbs from the TME or complete blockade of TK receptors induces over-activation of compensatory angiogenic pathways, causing escape...
March 22, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38522816/targeting-rock2-improves-macromolecular-permeability-in-a-3d-fibrotic-pancreatic-cancer-microenvironment-model
#40
JOURNAL ARTICLE
Hiroyoshi Y Tanaka, Takuya Nakazawa, Takuya Miyazaki, Horacio Cabral, Atsushi Masamune, Mitsunobu R Kano
Pancreatic cancer is characterized by a densely fibrotic stroma. The fibrotic stroma hinders the intratumoral penetration of nanomedicine and diminishes therapeutic efficacy. Fibrosis is characterized by an abnormal organization of extracellular matrix (ECM) components, namely the abnormal deposition and/or orientation of collagen and fibronectin. Abnormal ECM organization is chiefly driven by pathological signaling in pancreatic stellate cells (PSCs), the main cell type involved in fibrogenesis. However, whether targeting signaling pathways involved in abnormal ECM organization improves the intratumoral penetration of nanomedicines is unknown...
March 22, 2024: Journal of Controlled Release
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