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Journal of Controlled Release: Official Journal of the Controlled Release Society

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https://read.qxmd.com/read/30779951/continuous-alternative-to-freeze-drying-manufacturing-of-cyclodextrin-based-reconstitution-powder-from-aqueous-solution-using-scaled-up-electrospinning
#1
Panna Vass, Balázs Démuth, Attila Farkas, Edit Hirsch, Edina Szabó, Brigitta Nagy, Sune K Andersen, Tamás Vigh, Geert Verreck, István Csontos, György Marosi, Zsombor K Nagy
The aims of this study were to evaluate electrospinning as a continuous alternative to freeze drying in the production of a reconstitution injection dosage form, and to prove that aqueous electrospinning can be realized with a high production rate at room temperature. High-speed electrospinning with a novel continuous cyclone collection was used to manufacture a formulation of the poorly water-soluble antifungal voriconazole (VOR) with sulfobutylether-β-cyclodextrin (SBE-β-CD). The freeze-dried, marketed product of this drug substance, Vfend® also contains SBE-β-CD as excipient...
February 16, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30776396/co-delivery-of-mir-181a-and-melphalan-by-lipid-nanoparticles-for-treatment-of-seeded-retinoblastoma
#2
Seyed Nasrollah Tabatabaei, Rabeb Mouna Derbali, Chun Yang, Rosanne Superstein, Patrick Hamel, Jeanne Leblond Chain, Pierre Hardy
Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are short non-coding single-stranded RNAs that affect a vast range of biological processes. Previously, we focused on the regulatory role of miR-181a during cancer development and progression. In this manuscript, 171 nm switchable lipid nanoparticles (LNP) co-delivered melphalan and miR-181a with encapsulation efficiencies of 93%...
February 15, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30771414/two-dimensional-cancer-theranostic-nanomaterials-synthesis-surface-functionalization-and-applications-in-photothermal-therapy
#3
REVIEW
Chandran Murugan, Varsha Sharma, Rajesh Kumar Murugan, Gnanasekar Malaimegu, Anandhakumar Sundaramurthy
In recent years, novel two-dimensional (2D) nanomaterials are of great interest for diverse potential applications such as device fabrication, energy storage, sensing and theranostics because of their superlative physical features namely, large surface area, minimal thickness, tunable composition and easier surface modification methods. Rapid exploration in design and fabrication of 2D nano-structures have opened new avenue for cancer theranostics as it can encapsulate group of cancer cells and inflict major damage with great specificity in a non-invasive manner...
February 13, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30771413/sequential-activation-of-anticancer-therapy-triggered-by-tumor-microenvironment-selective-imaging
#4
Gayong Shim, Quoc-Viet Le, Juhan Suh, Sunhee Choi, Gunwoo Kim, Han-Gon Choi, Young Bong Kim, M B Macgregor, Yu-Kyoung Oh
The combination of imaging and anticancer therapy has recently emerged as a promising strategy. However, nonspecific imaging signals and distribution of anticancer drugs at normal tissues limit the specificity of the combination therapy. To overcome the challenges, we designed a system which can selectively visualize cancer tissues and initiate the subsequent action of therapeutic molecules in tumor microenvironment. Exploiting the overexpression of matrix metalloproteinase (MMP) in the tumor microenvironment, we designed a graphene oxide (GO)-based nanosheet system loaded with a pegylated MMP-cleavable imaging probe and an anticancer peptide shielded under the imaging probe...
February 13, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30771412/long-term-correction-of-hemophilia-b-using-adenoviral-delivery-of-crispr-cas9
#5
Calvin J Stephens, Elvin J Lauron, Elena Kashentseva, Zhi Hong Lu, Wayne M Yokoyama, David T Curiel
Hemophilia B (HB) is a life-threatening inherited disease caused by mutations in the FIX gene, leading to reduced protein function and abnormal blood clotting. Due to its monogenic nature, HB is one of the primary targets for gene therapy. Indeed, successful correction of HB has been shown in clinical trials using gene therapy approaches. However, application of these strategies to non-adult patients is limited due to high cell turnover as young patients develop, resulting in vector dilution and subsequent loss of therapeutic expression...
February 13, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30763623/mechanistic-insights-into-the-ph-dependent-membrane-peptide-atram
#6
Vanessa P Nguyen, Loganathan Palanikumar, Stephen J Kennel, Daiane S Alves, Yujie Ye, Jonathan S Wall, Mazin Magzoub, Francisco N Barrera
pH-responsive peptides are promising therapeutic molecules that can specifically target the plasma membrane in the acidified extracellular medium that bathes cells in tumors. We designed the acidity-triggered rational membrane (ATRAM) peptide to have a pH-responsive membrane interaction. At physiological pH, ATRAM binds to the membrane surface in a largely unstructured conformation, while in acidic conditions it inserts into lipid bilayers forming a transmembrane helix. However, the molecular mechanism ATRAM uses to target and insert into tumor cells remains poorly understood...
February 11, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30763622/pegylated-peptide-to-tip1-is-a-novel-targeting-agent-that-binds-specifically-to-various-cancers-in-vivo
#7
Vaishali Kapoor, Abhay Kumar Singh, Buck E Rogers, Dinesh Thotala, Dennis E Hallahan
Targeted molecular imaging allows specific visualization and monitoring of tumors. Cancer-specific peptides have been developed for imaging and therapy. Peptides that specifically target cancer have several advantages including, ease of synthesis, low antigenicity, and enhanced diffusion into tissues. We developed the HVGGSSV peptide as a molecular targeting/imaging agent. HVGGSSV targets Tax interacting protein 1 (TIP1) which is a 14 kDa PDZ domain-containing protein that is overexpressed in cancer. We docked HVGGSSV in silico using the three-dimensional structure of TIP1 and found the binding energy was -6...
February 11, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30763621/involvement-of-planned-cell-death-of-necroptosis-in-cancer-treatment-by-nanomaterials-recent-advances-and-future-perspectives
#8
REVIEW
Majid Sharifi, Sara Haji Hosseinali, Ali Akbar Saboury, Eva Szegezdi, Mojtaba Falahati
With the expansion of the field of nanomedicine, the use of nanomaterials in cancer treatment has raised questions about their safety and unpredictable adverse effects. To date, the hazardous effects of nanomaterials have been investigated based on cell survival and cellular functionality, such as membrane integrity, mitochondrial activity and cell morphology. It is increasingly noted that more detailed analysis of regulated cell death pathways (RCD) triggered by nanomaterials is essential to understand their full mechanism of action...
February 11, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30742854/light-triggered-release-of-photocaged-therapeutics-where-are-we-now
#9
REVIEW
Joana M Silva, Eduardo Silva, Rui L Reis
The current available therapeutics face several challenges such as the development of ideal drug delivery systems towards the goal of personalized treatments for patients benefit. The application of light as an exogenous activation mechanism has shown promising outcomes, owning to the spatiotemporal confinement of the treatment in the vicinity of the diseased tissue, which offers many intriguing possibilities. Engineering therapeutics with light responsive moieties have been explored to enhance the bioavailability, and drug efficacy either in vitro or in vivo...
February 8, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30738975/nanoencapsulation-of-carotenoids-within-lipid-based-nanocarriers
#10
REVIEW
Hadis Rostamabadi, Seid Reza Falsafi, Seid Mahdi Jafari
Carotenoids, as promising functional components in human diet, are gaining immense importance todays. Apart from their pivotal importance in photosynthetic organisms or as natural pigments, they are typically referred to as health-promotional ingredients, which offer several beneficial attributes. However, their sensitivity against environmental and process stresses, low-water solubility, as well as low-bioavailability are the most shortfalls restricting pharmaceutical/food carotenoid applications. In this regard, lipid-based nano-delivery cargos i...
February 7, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30738084/epidermal-micro-perforation-potentiates-the-efficacy-of-epicutaneous-vaccination
#11
Pierre-Louis Hervé, Véronique Dhelft, Camille Plaquet, Anaïs Rousseaux, Adeline Bouzereau, Laetitia Gaulme, Sylvain Tilleul, Mélanie Ligouis, Nathalie Donne, Paul-Henri Lambert, Pham Hong-Thai, Wassana Wijagkanalan, Hugh A Sampson, Lucie Mondoulet
The skin is an immune organ comprised of a large network of antigen-presenting cells such as dendritic cells, making it an attractive target for the development of new vaccines and immunotherapies. Recently, we developed a new innovative and non-invasive vaccination method without adjuvant based on epicutaneous vaccine patches on which antigen forms a dry deposit. Here we describe in mice a method for potentiating the efficacy of our epicutaneous vaccination approach using a minimally invasive and epidermis-limited skin preparation based on laser-induced micro-perforation...
February 6, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30731152/exploitation-of-the-bilosome-platform-technology-to-formulate-antibiotics-and-enhance-efficacy-of-melioidosis-treatments
#12
Riccardo V D'Elia, Stuart Woods, Wendy Butcher, Jonathan McGahon, Swapnil Khadke, Yvonne Perrie, E Diane Williamson, Craig W Roberts
Burkholderia pseudomallei is a Gram-negative intracellular bacterium which is recalcitrant to antibiotic therapy. There also is currently no licensed vaccine for this potentially fatal pathogen, further highlighting the requirement for better therapeutics to treat the disease melioidosis. Here we use an oral delivery platform, the bilosome to entrap already- licensed antibiotics. Bilosome-entrapped antibiotics were used to treat mice infected via the aerosol route with B. pseudomallei. When treatment was started by the oral route at 6 h post-infection and continued for 7 days, bilosome levofloxacin and bilosome doxycycline formulations were significantly more efficacious than free antibiotics in terms of survival rates...
February 4, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30731151/congruent-release-of-drug-and-polymer-a-sweet-spot-in-the-dissolution-of-amorphous-solid-dispersions
#13
Sugandha Saboo, Naila A Mugheirbi, Dmitry Y Zemlyanov, Umesh S Kestur, Lynne S Taylor
Liquid-liquid phase separation (LLPS) occurs following amorphous solid dispersion (ASD) dissolution when the drug concentration exceeds the "amorphous solubility", and is emerging as an important characteristic of formulations that may enhance the oral bioavailability of poorly soluble drugs. The purpose of this research was to identify criteria that impact the rate and extent of drug release and hence the occurrence or not of LLPS upon ASD dissolution. Specifically, the effect of drug log P, phase behavior of the hydrated but undissolved ASD matrix and the relative dissolution rates of drug and polymer were studied as a function of drug loading, using nilvadipine (Nil) (ClogP = 3...
February 4, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30731150/vaginal-rings-with-exposed-cores-for-sustained-delivery-of-the-hiv-ccr5-inhibitor-5p12-rantes
#14
John W McBride, Peter Boyd, Nicola Dias, David Cameron, Robin E Offord, Oliver Hartley, Vicky L Kett, R Karl Malcolm
Antiretroviral-releasing vaginal rings are at the forefront of ongoing efforts to develop microbicide-based strategies for prevention of heterosexual transmission of the human immunodeficiency virus (HIV). However, traditional ring designs are generally only useful for vaginal administration of relatively potent, lipophilic, and small molecular weight drug molecules that have sufficient permeability in the non-biodegradable silicone elastomer or thermoplastic polymers. Here, we report a novel, easy-to-manufacture 'exposed-core' vaginal ring that provides sustained release of the protein microbicide candidate 5P12-RANTES, an experimental chemokine analogue that potently blocks the HIV CCR5 coreceptor...
February 4, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30707902/therapeutic-vitamin-delivery-chemical-and-physical-methods-with-future-directions
#15
REVIEW
N Sanoj Rejinold, Hye Kyoung Kim, Abdel F Isakovic, Deborah L Gater, Yeu-Chun Kim
Vitamins are a diverse group of "life nourishing" molecules that are essential for proper childhood development, and for maintaining health throughout adulthood into old age. Vitamin supplementation is an important strategy for reducing the severe and chronic effects of malnutrition in subsets of the population of the developing world. Additionally, the precise role of many vitamins in certain conditions, including cancer and cardiovascular disease, remains an area of active research, although guidelines for vitamin supplementation in otherwise adequately nourished populations remain controversial...
January 29, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30707901/intestinal-iontophoresis-from-mucoadhesive-patches-a-strategy-for-oral-delivery
#16
Amrita Banerjee, Renwei Chen, Shamsul Arafin, Samir Mitragotri
Biologics have limited permeability across the intestine and are prone to degradation in the acidic-proteolytic milieu of the gastrointestinal tract, leading to poor oral bioavailability. Iontophoresis is a promising technology that can substantially improve transport of drugs across biological barriers and has been particularly explored for skin. In this study, we investigated whether iontophoresis across the intestine can be utilized to improve oral insulin transport. Application of electric current to intestinal cells resulted in opening of the tight junctions in vitro and a consequent about 3-fold improvement in paracellular transport of insulin...
January 29, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30703391/thermosensitive-nanocomposite-gel-for-intra-tumoral-two-photon-photodynamic-therapy
#17
Lei Luo, Qi Zhang, Yonghuang Luo, Zhonggui He, Xiaohe Tian, Giuseppe Battaglia
We propose here a new approach to achieve intratumoral near-infrared (NIR) two-photon photodynamic therapy (PDT). We established a composite micellar thermosensitive hydrogel made of clinically approved methoxy poly(ethylene glycol)-polylactide copolymer (mPEG-PDLLA) and Pluronic (F127). The mPEG-PDLLA form micelles that can be loaded with two-photon absorption compound (T1) and photosensitizer (PS), The F127 micelles are liquid at room temperature and while forming an hydrogel at body temperature. This enables an in situ gelification upon injection providing long-term retentio within the tumor...
January 28, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30690106/silica-cloaking-of-adenovirus-enhances-gene-delivery-while-reducing-immunogenicity
#18
Ajay A Sapre, Gen Yong, Ya-San Yeh, Laura E Ruff, Justin S Plaut, Zeynep Sayar, Anupriya Agarwal, Jacqueline Martinez, Theresa N Nguyen, Yu-Tsueng Liu, Bradley T Messmer, Sadik C Esener, Jared M Fischer
Viral gene therapy is a means of delivering genes to replace malfunctioning ones, to kill cancer cells, or to correct genetic mutations. This technology is emerging as a powerful clinical tool; however, it is still limited by viral tropism, uptake and clearance by the liver, and most importantly an immune response. To overcome these challenges, we sought to merge the robustness of viral gene expression and the versatility of nanoparticle technology. Here, we describe a method for cloaking adenovirus (Ad) in silica (SiAd) as a nanoparticle formulation that significantly enhances transduction...
January 25, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30690105/a-nanoliter-resolution-implantable-micropump-for-murine-inner-ear-drug-delivery
#19
Farzad Forouzandeh, Xiaoxia Zhu, Ahmed Alfadhel, Bo Ding, Joseph P Walton, Denis Cormier, Robert D Frisina, David A Borkholder
Advances in protective and restorative biotherapies have created new opportunities to use site-directed, programmable drug delivery systems to treat auditory and vestibular disorders. Successful therapy development that leverages the transgenic, knock-in, and knock-out variants of mouse models of human disease requires advanced microsystems specifically designed to function with nanoliter precision and with system volumes suitable for implantation. Here we present results for a novel biocompatible, implantable, scalable, and wirelessly controlled peristaltic micropump...
January 25, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30690104/adhesive-nanoparticles-with-inflammation-regulation-for-promoting-skin-flap-regeneration
#20
Xiyuan Mao, Lili Liu, Liying Cheng, Ruoyu Cheng, Lu Zhang, Lianfu Deng, Xiaoming Sun, Yuguang Zhang, Bruno Sarmento, Wenguo Cui
Local drug delivery systems have become an important field of research as locally administration of medications may overcome most of the drawbacks associated with systemic drugs. Still, to assure continuous drug release and therapeutic drug levels, keeping the delivered drug in target area remains a physiological challenge. The aim of this study was to develop novel multipotent flap-protective adhesive mangiferin (MF)-loaded liposomes (A-MF-Lip), bioinspired in mussel architecture, for the promotion of random skin flap regeneration...
January 25, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
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