Xianzhi Zhang, Yuanchang Liu, Jeerapat Doungchawee, Laura J Castellanos-García, Kristen N Sikora, Taewon Jeon, Ritabrita Goswami, Stefano Fedeli, Aarohi Gupta, Rui Huang, Cristina-Maria Hirschbiegel, Roberto Cao-Milán, Prabin K D Majhi, Yagiz Anil Cicek, Liang Liu, D Joseph Jerry, Richard W Vachet, Vincent M Rotello
Bioorthogonal catalysis via transition metal catalysts (TMCs) enables the generation of therapeutics locally through chemical reactions not accessible by biological systems. This localization can enhance the efficacy of anticancer treatment while minimizing off-target effects. The encapsulation of TMCs into nanomaterials generates "nanozymes" to activate imaging and therapeutic agents. Here, we report the use of cationic bioorthogonal nanozymes to create localized "drug factories" for cancer therapy in vivo...
March 20, 2023: Journal of Controlled Release