Haichao Zhu, Hong Luo, Ruilong Chang, Yifan Yang, Dingkang Liu, Yue Ji, Hai Qin, Haibo Rong, Jun Yin
RNA-based therapeutics have emerged as promising approaches to modulate gene expression and generate therapeutic proteins or antigens capable of inducing immune responses to treat a variety of diseases, such as infectious diseases, cancers, immunologic disorders, and genetic disorders. However, the efficient delivery of RNA molecules into cells poses significant challenges due to their large molecular weight, negative charge, and susceptibility to degradation by RNase enzymes. To overcome these obstacles, viral and non-viral vectors have been developed, including lipid nanoparticles, viral vectors, proteins, dendritic macromolecules, among others...
September 21, 2023: Journal of Controlled Release