Arto Merivaara, Jooseppi Puranen, Amir Sadeghi, Natalia Zashikhina, Lea Pirskanen, Tatu Lajunen, Tetsuya Terasaki, Seppo Auriola, Kati-Sisko Vellonen, Arto Urtti
Lipid-based drug formulations are promising systems for improving delivery of drugs to ocular tissues, such as retina. To develop lipid-based systems further, an improved understanding of their pharmacokinetics is required, but high-quality in vivo experiments require a large number of animals, raising ethical and economic questions. In order to expedite in vivo kinetic testing of lipid-based systems, we propose a barcode approach that is based on barcoding liposomes with non-endogenous lipids. We developed and evaluated a liquid-chromatography-mass spectrometry method to quantify many liposomes simultaneously in aqueous humor, vitreous, and neural retina at higher than ±20% precision and accuracy...
April 12, 2024: Journal of Controlled Release