journal
https://read.qxmd.com/read/38777126/ultrasound-induced-immune-responses-in-tumors-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Anne Rix, Helen Heinrichs, Céline Porte, Cathalijn Leenaars, André Bleich, Fabian Kiessling
Ultrasound is widely used in the diagnosis and therapy of cancer. Tumors can be treated by thermal or mechanical tissue ablation. Furthermore, tumors can be manipulated by hyperthermia, sonodynamic therapy and sonoporation, e.g., by increasing tumor perfusion or the permeability of biological barriers to enhance drug delivery. These treatments induce various immune responses in tumors. However, conflicting data and high heterogeneity between experimental settings make it difficult to generalize the effects of ultrasound on tumor immunity...
May 20, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38768662/in-situ-gelling-systems-for-ocular-drug-delivery
#2
REVIEW
Bakr Ahmed, Srishty Jaiswal, Srishti Naryal, Rohan M Shah, Raid G Alany, Indu Pal Kaur
In situ gelling systems represent a burgeoning paradigm in ocular drug administration, addressing intrinsic challenges posed by extant ocular formulations, such as compromised bioavailability and constraints in traversing the corneal barrier. This systematic review endeavours to comprehensively examine the contemporary landscape of research in this domain, focusing on the nuanced capabilities of in situ gelling systems to optimize drug delivery and enhance therapeutic outcomes, without much technological complexity...
May 18, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38768661/prostate-cancer-derived-extracellular-vesicles-metabolic-biomarkers-emerging-roles-for-diagnosis-and-prognosis
#3
REVIEW
Mahmoud Assem Hamed, Valerie Wasinger, Qi Wang, Peter Graham, David Malouf, Joseph Bucci, Yong Li
Prostate cancer (PCa) is a global health concern, ranking as the most common cancer among men in Western countries. Traditional diagnostic methods are invasive with adverse effects on patients. Due to the heterogeneous nature of PCa and their multifocality, tissue biopsies often yield false-negative results. To address these challenges, researchers are exploring innovative approaches, particularly in the realms of proteomics and metabolomics, to identify more reliable biomarkers and improve PCa diagnosis. Liquid biopsy (LB) has emerged as a promising non-invasive strategy for PCa early detection, biopsy selection, active surveillance for low-risk cases, and post-treatment and progression monitoring...
May 18, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38763389/softening-the-tumor-matrix-through-cholesterol-depletion-breaks-the-physical-barrier-for-enhanced-antitumor-therapy
#4
JOURNAL ARTICLE
Zhangwen Peng, Yunfei Yi, Yichu Nie, Tianqi Wang, Jia Tang, Sheng Hong, Yuanqi Liu, Wenxin Huang, Shengjie Sun, Hui Tan, Meiying Wu
The tumor develops defense tactics, including conversing the mechanical characteristics of tumor cells and their surrounding environment. A recent study reported that cholesterol depletion stiffens tumor cells, which could enhance adaptive T-cell immunotherapy. However, it remains unclear whether reducing the cholesterol in tumor cells contributes to re-educating the stiff tumor matrix, which serves as a physical barrier against drug penetration. Herein, we found that depleting cholesterol from tumor cells can demolish the intratumor physical barrier by disrupting the mechanical signal transduction between tumor cells and the extracellular matrix through the destruction of lipid rafts...
May 17, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38763388/photothermal-controlled-no-releasing-nanogels-reverse-epithelial-mesenchymal-transition-and-restore-immune-surveillance-against-cancer-metastasis
#5
JOURNAL ARTICLE
Junmei Zhang, Guizhi Miao, My Hanh Ta, Bingbing Zhao, Wei Wang, Yanran Xing, Hongliang Qian, Dechun Huang, Wei Chen, Yinan Zhong
Metastasis leads to high mortality among cancer patients. It is a complex, multi-step biological process that involves the dissemination of cancer cells from the primary tumor and their systemic spread throughout the body, primarily through the epithelial-mesenchymal transition (EMT) program and immune evasion mechanisms. It presents a challenge in how to comprehensively treat metastatic cancer cells throughout the entire stage of the metastatic cascade using a simple system. Here, we fabricate a nanogel (HNO-NG) by covalently crosslinking a macromolecular nitric oxide (NO) donor with a photothermal IR780 iodide-containing hyaluronic acid derivative via a click reaction...
May 17, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38761856/phospholipids-of-inhaled-liposomes-determine-the-in-vivo-fate-and-therapeutic-effects-of-salvianolic-acid-b-on-idiopathic-pulmonary-fibrosis
#6
JOURNAL ARTICLE
Jianqing Peng, Qin Wang, Runbin Sun, Ke Zhang, Yi Chen, Zipeng Gong
Since phospholipids have an important effect on the size, surface potential and hardness of liposomes that decide their in vivo fate after inhalation, this research has systematically evaluated the effect of phospholipids on pulmonary drug delivery by liposomes. In this study, liposomes composed of neutral saturated/unsaturated phospholipids, anionic and cationic phospholipids were constructed to investigate how surface potential and the degree of saturation of fatty acid chains determined their mucus and epithelium permeability both in vitro and in vivo...
May 16, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38754633/small-extracellular-vesicle-mediated-crispr-cas9-rnp-delivery-for-cardiac-specific-genome-editing
#7
JOURNAL ARTICLE
Dasom Mun, Ji-Young Kang, Hyoeun Kim, Nuri Yun, Boyoung Joung
Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Although clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) gene editing holds immense potential for genetic manipulation, its clinical application is hindered by the absence of6 an efficient heart-targeted drug delivery system. Herein, we developed CRISPR-Cas9 ribonucleoprotein (RNP)-loaded extracellular vesicles (EVs) conjugated with cardiac-targeting peptide (T) for precise cardiac-specific genome editing...
May 14, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38754632/glycyrrhetinic-acid-loaded-in-milk-derived-extracellular-vesicles-for-inhalation-therapy-of-idiopathic-pulmonary-fibrosis
#8
JOURNAL ARTICLE
Bo Ran, Xiaohong Ren, Xueyuan Lin, Yupu Teng, Fangyuan Xin, Wuzhen Ma, Xiangyu Zhao, Mingwei Li, Jinghuang Wang, Caifen Wang, Lixin Sun, Jiwen Zhang
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and life-threatening lung disease for which treatment options are limited. Glycyrrhetinic acid (GA) is a triterpenoid with multiple biological effects, such as anti-inflammatory and anti-fibrotic properties. Herein, inhalable milk-derived extracellular vesicles (mEVs) encapsulating GA (mEVs@GA) were screened and evaluated for IPF treatment. The results indicated that the loading efficiency of GA in mEVs@GA was 8.65%. Therapeutic effects of inhalable mEVs@GA were investigated in vitro and in vivo...
May 14, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38744346/neoantigens-and-cancer-testis-antigens-as-promising-vaccine-candidates-for-triple-negative-breast-cancer-delivery-strategies-and-clinical-trials
#9
JOURNAL ARTICLE
RamaRao Malla, Mundla Srilatha, Veda Muppala, Batoul Farran, Virander Singh Chauhan, Ganji Purnachandra Nagaraju
Immunotherapy is gaining prominence as a promising strategy for treating triple-negative breast cancer (TNBC). Neoantigens (neoAgs) and cancer-testis antigens (CTAs) are tumor-specific targets originating from somatic mutations and epigenetic changes in cancer cells. These antigens hold great promise for personalized cancer vaccines, as supported by preclinical and early clinical evidence in TNBC. This review delves into the potential of neoAgs and CTAs as vaccine candidates, emphasizing diverse strategies and delivery approaches...
May 12, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38744345/current-status-and-advances-to-improving-drug-delivery-in-diffuse-intrinsic-pontine-glioma
#10
REVIEW
Lauren M Arms, Ryan J Duchatel, Evangeline R Jackson, Pedro Garcia Sobrinho, Matthew D Dun, Susan Hua
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma - DIPG), is the primary cause of brain tumor-related death in pediatric patients. DIPG is characterized by a median survival of <12 months from diagnosis, harboring the worst 5-year survival rate of any cancer. Corticosteroids and radiation are the mainstay of therapy; however, they only provide transient relief from the devastating neurological symptoms. Numerous therapies have been investigated for DIPG, but the majority have been unsuccessful in demonstrating a survival benefit beyond radiation alone...
May 12, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38744344/infant-friendly-adhesive-film-containing-glucose-for-neonatal-hypoglycemia
#11
JOURNAL ARTICLE
Meng Yu, Yanlv Chen, Jiapei Lei, Chengxian Ling, Junling Chen, Menghui Liu, Yang Sun, Ning Tan, Xin Peng
Neonatal hypoglycemia is a common disease in newborns, which can precipitate energy shortage and follow by irreversible brain and neurological injury. Herein, we present a novel approach for treating neonatal hypoglycemia involving an adhesive polyvinylpyrrolidone/gallic acid (PVP/GA) film loading glucose. The PVP/GA film with loose cross-linking can be obtained by mixing their ethanol solution and drying complex. When depositing this soft film onto wet tissue, it can absorb interfacial water to form a hydrogel with a rough surface, which facilitates tight contact between the hydrogel and tissue...
May 12, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38740094/microenvironment-responsive-hydrogel-exerting-inhibition-of-cascade-immune-activation-and-elimination-of-synovial-fibroblasts-for-rheumatoid-arthritis-therapy
#12
JOURNAL ARTICLE
Yiqun Wu, Zhongshi Wang, Yu Ge, Ying Zhu, Tianli Tian, Jun Wei, Yu Jin, Yi Zhao, Qiang Jia, Jun Wu, Liang Ge
Rheumatoid arthritis (RA) is a progressive autoimmune disease and drug therapy has been restricted due to poor therapeutic efficacy and adverse effects. In RA synovium, dendritic cells present self-antigens to activate cascade immune pathway. Furthermore, downstream macrophages secrete high levels of pro-inflammatory cytokines; Hyperplasia of activated synovial fibroblasts (FLS) is responsible for hypoxic synovium microenvironment, secretion of cytokines/chemokines and erosion of bone/cartilage tissues. Positive feedback loop of inflammation between macrophages and FLS independent of antigen-presentation is constructed...
May 11, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38740093/electrically-activated-polymetallic-nanocrystals-for-long-term-tumor-suppression-via-oxygen-independent-ros-generation-and-electro-immunotherapy
#13
JOURNAL ARTICLE
Manchun Wang, Gui Chen, Ben Hu, Fengling Zhang, Qinqin Xu, Lei Li, Qiye Xi, Jun Liu, Zhiqiang Yu, Peng Cao, Yongxia Wang, Meng Yu
The low oxidation level and immunosuppressive microenvironment within hypoxic tumor tissue are critical factors contributing to the inefficacy of various anti-tumor strategies. Herein, we have designed a novel intravenous injection nanoplatform to conduct electro-immunotherapy, based on phospholipid-modified PtPd nanocrystals loaded with the immunoregulator IPI549 (LP@Pt-Pd@IPI549 nanoparticles, LPPI). LPPI responds to reactive oxygen species (ROS), triggering a cascade of therapeutic effects that overcome hypoxia-related resistance and effectively eradicate hypoxic tumors...
May 11, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38740092/radiation-primed-tgf-%C3%AE-trapping-by-engineered-extracellular-vesicles-for-targeted-glioblastoma-therapy
#14
JOURNAL ARTICLE
Ruyu Liang, Hongyu Lu, Haifeng Zhu, Gaofeng Liang, Junxia Zhang, Jun Gao, Tian Tian
The poor outcome of glioblastoma multiforme (GBM) treated with immunotherapy is attributed to the profound immunosuppressive tumor microenvironment (TME) and the lack of effective delivery across the blood-brain barrier. Radiation therapy (RT) induces an immunogenic antitumor response that is counteracted by evasive mechanisms, among which transforming growth factor-β (TGF-β) activation is the most prominent factor. We report an extracellular vesicle (EV)-based nanotherapeutic that traps TGF-β by expressing the extracellular domain of the TGF-β type II receptor and targets GBM by decorating the EV surface with RGD peptide...
May 11, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38735396/boarding-pyroptosis-onto-nanotechnology-for-cancer-therapy
#15
REVIEW
Weiyue Ban, Zhichao Chen, Tao Zhang, Tengda Du, Dianqiu Huo, Guorui Zhu, Zhonggui He, Jin Sun, Mengchi Sun
Pyroptosis, a non-apoptotic programmed cellular inflammatory death mechanism characterized by gasdermin (GSDM) family proteins, has gathered significant attention in the cancer treatment. However, the alarming clinical trial data indicates that pyroptosis-mediated cancer therapeutic efficiency is still unsatisfactory. It is essential to integrate the burgeoning biomedical findings and innovations with potent technology to hasten the development of pyroptosis-based antitumor drugs. Considering the rapid development of pyroptosis-driven cancer nanotherapeutics, here we aim to summarize the recent advances in this field at the intersection of pyroptosis and nanotechnology...
May 10, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38735395/hollow-microneedles-for-ocular-drug-delivery
#16
REVIEW
Shilpkala Gade, Katie Glover, Deepakkumar Mishra, Sanjiv Sharma, Owen Guy, Ryan F Donnelly, Lalitkumar Vora, Raghu Raj Singh Thakur
Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or as single needles. These MNs offer a minimally invasive approach to ocular drug delivery due to their micron size (reducing tissue damage compared to that of hypodermic needles) and overcoming significant barriers in drug administration. While various types of MNs have been extensively researched, significant progress has been made in the use of hollow MNs (HMNs) for ocular drug delivery, specifically through suprachoroidal injections...
May 10, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38735394/gold-core-ceo-2-halfshell-janus-nanocomposites-catalyze-targeted-sulfate-radical-for-periodontitis-therapy
#17
JOURNAL ARTICLE
Sijia Li, Qihang Ding, Lingling Zhang, Fangyu Shi, Chengyu Liu, Tingxuan Li, Yujia Shi, Manlin Qi, Lin Wang, Biao Dong, Shuyan Song, Jiao Sun, Jong Seung Kim, Chunyan Li
The sulfate radical (SO4 •- ), known for its high reactivity and long lifespan, has emerged as a potent antimicrobial agent. Its exceptional energy allows for the disruption of vital structures and metabolic pathways in bacteria that are usually inaccessible to common radicals. Despite its promising potential, the efficient generation of this radical, particularly through methods involving enzymes and photocatalysis, remains a substantial challenge. Here, we capitalized on the peroxidase (POD)-mimicking activity and photocatalytic properties of cerium oxide (CeO2 ) nanozymes, integrating these properties with the enhanced concept of plasma gold nanorod (GNR) to develop a half-encapsulated core@shell GNRs@CeO2 Janus heterostructure impregnated with persulfate...
May 10, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38729434/a-hyaluronic-acid-hydrogel-as-a-mild-photothermal-antibacterial-antioxidant-and-nitric-oxide-release-platform-for-diabetic-wound-healing
#18
JOURNAL ARTICLE
Changyuan He, Siwei Bi, Rongya Zhang, Chong Chen, Ruiqi Liu, Xueshan Zhao, Jun Gu, Bin Yan
Hyaluronic acid (HA)-based biopolymer hydrogels are promising therapeutic dressings for various wounds but still underperform in treating diabetic wounds. These wounds are extremely difficult to heal and undergo a prolonged and severe inflammatory process due to bacterial infection, overexpression of reactive oxygen species (ROS), and insufficient synthesis of NO. In this study, a dynamic crosslinked hyaluronic acid (HA) hydrogel dressing (Gel-HAB) loaded with allomelanin (AMNP)-N, N'-dis-sec-butyl-N, N'-dinitroso-1, 4-phenylenediamine (BNN6) nanoparticles (AMNP-BNN6) was developed for healing diabetic wounds...
May 10, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38734315/hydrophilic-biomaterials-from-crosslinked-and-self-assembled-hydrogels-to-polymer-drug-conjugates-and-drug-free-macromolecular-therapeutics
#19
JOURNAL ARTICLE
Jindřich Kopeček
This "Magnum Opus" accentuates my lifelong belief that the future of science is in the interdisciplinary approach to hypotheses formulation and problem solving. Inspired by the invention of hydrogels and soft contact lenses by my mentors, my six decades of research have continuously proceeded from the synthesis of biocompatible hydrogels to the development of polymer-drug conjugates, then generation of drug-free macromolecular therapeutics (DFMT) and finally to multi-antigen T cell hybridizers (MATCH). This interdisciplinary journey was inspiring; the lifetime feeling that one is a beginner in some aspects of the research is a driving force that keeps the enthusiasm high...
May 9, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38734314/-click-amphotericin-b-in-prodrug-nanoformulations-for-enhanced-systemic-fungemia-treatment
#20
JOURNAL ARTICLE
Dandan Guo, Changying Shi, Liye Suo, Xiaotian Ji, Hao Yue, Dekai Yuan, Juntao Luo
Severe nephrotoxicity and infusion-related side effects pose significant obstacles to the clinical application of Amphotericin B (AmB) in life-threatening systemic fungal infections. In pursuit of a cost-effective and safe formulation, we have introduced multiple phenylboronic acid (PBA) moieties onto a linear dendritic telodendrimer (TD) scaffold, enabling effective AmB conjugation via boronate chemistry through a rapid, high yield, catalysis-free and dialysis-free "Click" drug loading process. Optimized AmB-TD prodrugs self-assemble into monodispersed micelles characterized by small particle sizes and neutral surface charges...
May 9, 2024: Journal of Controlled Release
journal
journal
29304
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.