Zhenxing Jiang, Lizhao Yan, Shenghe Deng, Junnan Gu, Le Qin, Fuwei Mao, Yifan Xue, Wentai Cai, Xiu Nie, Hongli Liu, Fumei Shang, Kaixiong Tao, Jiliang Wang, Ke Wu, Yinghao Cao, Kailin Cai
Chemotherapy is not recommended for patients with deficient mismatch repair (dMMR) in colorectal cancer (CRC); therefore, assessing the status of MMR is crucial for the selection of subsequent treatment. This study is aimed at building predictive models to accurately and rapidly identify dMMR. A retrospective analysis was performed at Wuhan Union Hospital between May 2017 and December 2019 based on the clinicopathological data of patients with CRC. The variables were subjected to collinearity, least absolute shrinkage and selection operator (LASSO) regression, and random forest (RF) feature screening analyses...
2023: Disease Markers