journal
https://read.qxmd.com/read/38380073/circulating-nucleic-acids-in-colorectal-cancer-diagnostic-and-prognostic-value
#1
REVIEW
Somayeh Igder, Mozhdeh Zamani, Shima Fakher, Morvarid Siri, Hassan Ashktorab, Negar Azarpira, Pooneh Mokarram
Colorectal cancer (CRC) is the third most prevalent cancer in the world and the fourth leading cause of cancer-related mortality. DNA (cfDNA/ctDNA) and RNA (cfRNA/ctRNA) in the blood are promising noninvasive biomarkers for molecular profiling, screening, diagnosis, treatment management, and prognosis of CRC. Technological advancements that enable precise detection of both genetic and epigenetic abnormalities, even in minute quantities in circulation, can overcome some of these challenges. This review focuses on testing for circulating nucleic acids in the circulation as a noninvasive method for CRC detection, monitoring, detection of minimal residual disease, and patient management...
2024: Disease Markers
https://read.qxmd.com/read/38292339/neutrophil-lymphocyte-and-platelet-lymphocyte-ratios-in-distinguishing-lung-cancer-in-people-with-hiv
#2
JOURNAL ARTICLE
Joseph Baruch Baluku, Sharon Namiiro, Brenda Namanda, Martin Nabwana, Irene Andia-Biraro, William Worodria, Robert Salata, Sayoki Mfinanga, Stanton Gerson, Bruce Kirenga
OBJECTIVE: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) demonstrate good diagnostic accuracy in distinguishing lung cancer patients from healthy individuals, primarily in HIV-negative populations. We determined the sensitivity (Se), specificity (Sp), and area under the curve (AUC) of the NLR and PLR in discriminating between people living with HIV (PLWH) with and without lung cancer. METHODS: This is a comparative analysis of secondary data...
2024: Disease Markers
https://read.qxmd.com/read/38222853/examining-the-association-of-rare-allelic-variants-in-urate-transporters-slc22a11-slc22a13-and-slc17a1-with-hyperuricemia-and-gout
#3
JOURNAL ARTICLE
Jiří Vávra, Kateřina Pavelcová, Jana Mašínová, Lenka Hasíková, Eliška Bubeníková, Aneta Urbanová, Andrea Mančíková, Blanka Stibůrková
Genetic variations in urate transporters play a significant role in determining human urate levels and have been implicated in developing hyperuricemia or gout. Polymorphism in the key urate transporters, such as ABCG2, URAT1, or GLUT9 was well-documented in the literature. Therefore in this study, our objective was to determine the frequency and effect of rare nonsynonymous allelic variants of SLC22A11 , SLC22A13 , and SLC17A1 on urate transport. In a cohort of 150 Czech patients with primary hyperuricemia and gout, we examined all coding regions and exon-intron boundaries of SLC22A11 , SLC22A13 , and SLC17A1 using PCR amplification and Sanger sequencing...
2024: Disease Markers
https://read.qxmd.com/read/38125390/retracted-efficacy-of-butylphthalide-in-combination-with-edaravone-in-the-treatment-of-acute-ischemic-stroke-and-the-effect-on-serum-inflammatory-factors
#4
https://read.qxmd.com/read/38125389/retracted-treatment-with-antiviral-drugs-will-significantly-inhibit-the-hiv-1-rna-pol-gene-expression-and-viral-load-in-aids-patients
#5
Disease Markers
[This retracts the article DOI: 10.1155/2023/9910542.].
2023: Disease Markers
https://read.qxmd.com/read/38125388/retracted-the-identification-and-clinical-value-evaluation-of-cycs-related-to-asthma-through-bioinformatics-analysis-and-functional-experiments
#6
https://read.qxmd.com/read/38125387/retracted-lifestyle-improvements-and-vitamin-d-supplementation-play-an-important-role-in-the-prevention-of-childhood-diabetes
#7
Disease Markers
[This retracts the article DOI: 10.1155/2022/6133908.].
2023: Disease Markers
https://read.qxmd.com/read/38125386/retracted-analysis-of-linc01314-and-mir-96-expression-in-colorectal-cancer-patients-via-tissue-microarray-based-fluorescence-in-situ-hybridization
#8
https://read.qxmd.com/read/38077938/retracted-cuproptosis-related-genes-cdk1-and-coa6-involved-in-the-prognosis-prediction-of-liver-hepatocellular-carcinoma
#9
Disease Markers
[This retracts the article DOI: 10.1155/2023/5552798.].
2023: Disease Markers
https://read.qxmd.com/read/38077937/retracted-alk7-knockdown-plays-a-protective-role-on-hg-stimulated-mcs-through-activation-of-the-nrf2-ho-1-pathway
#10
Disease Markers
[This retracts the article DOI: 10.1155/2022/4064733.].
2023: Disease Markers
https://read.qxmd.com/read/38077936/retracted-the-use-of-cytotoxic-drugs-as-first-line-chemotherapy-for-egfr-nonsquamous-nsclc-a-network-meta-analysis
#11
Disease Markers
[This retracts the article DOI: 10.1155/2023/5272125.].
2023: Disease Markers
https://read.qxmd.com/read/38077935/retracted-keloid-core-factor-ctrp3-overexpression-significantly-controlled-tgf-%C3%AE-1-induced-propagation-and-migration-in-keloid-fibroblasts
#12
https://read.qxmd.com/read/38077934/retracted-the-nine-rna-methylation-regulatory-gene-signature-is-associated-with-the-pathogenesis-of-atrial-fibrillation-by-modulating-the-immune-microenvironment-in-the-atrial-tissues
#13
https://read.qxmd.com/read/38077933/retracted-meta-analysis-of-the-application-effect-of-different-modalities-of-thermal-ablation-and-surgical-treatment-in-papillary-thyroid-microcarcinoma
#14
https://read.qxmd.com/read/38077932/retracted-the-akt-mtor-signaling-pathway-was-mediated-through-the-linc00514-mir-28-5p-trim44-axis
#15
Disease Markers
[This retracts the article DOI: 10.1155/2022/1889467.].
2023: Disease Markers
https://read.qxmd.com/read/38077931/retracted-relationship-between-changes-in-blood-glucose-and-blood-lipid-levels-and-the-risk-of-thyroid-cancer-in-patients-with-type-2-diabetes-mellitus
#16
https://read.qxmd.com/read/38025665/arterial-hypertension-and-its-consequences-are-the-main-predictors-of-embolic-stroke-of-undetermined-source
#17
JOURNAL ARTICLE
Alexander B Berdalin, Daria D Namestnikova, Elvira A Cherkashova, Denis A Golovin, Ilya L Gubskiy, Vladimir G Lelyuk
METHODS: We performed a hospital-based prospective cohort study with 1,317 enrolled participants. We compared patients and healthy volunteers according to the main demographic, anthropometric parameters, stroke risk factors, comorbidities, and data of clinical and instrumental examination. In order to balance the study and the control groups for age and sex, the propensity score matching was performed. In order to generate the overall predictive model, a multivariate analysis was performed using the binary logistic regression method...
2023: Disease Markers
https://read.qxmd.com/read/37946798/retracted-neurotransmitters-and-electrophysiological-changes-might-work-as-biomarkers-for-diagnosing-affective-disorders
#18
Disease Markers
[This retracts the article DOI: 10.1155/2021/9116502.].
2023: Disease Markers
https://read.qxmd.com/read/37946797/exploration-of-metabolite-biomarkers-to-predict-the-efficacy-of-dupilumab-treatment-for-atopic-dermatitis
#19
JOURNAL ARTICLE
Shoko Miyamoto, Yasutomo Imai, Masako Matsutani, Makoto Nagai, Kiyofumi Yamanishi, Nobuo Kanazawa, Shin Nishiumi
Dupilumab (DUP) is the first biological agent used treating atopic dermatitis (AD). Notwithstanding its high cost, the type of patient group for which the drug is effective remains unclear. In this retrospective study, we aimed to identify novel and reliable biomarkers which can be measured before DUP administration and to predict the efficacy of DUP. Serum samples from 19 patients with AD treated with DUP were analysed by metabolome analysis using gas chromatography-mass spectrometry. Total 148 metabolites were detected, and the relative values of the metabolites were compared between the patient group that achieved 75% improvement in Eczema Area and Severity Index 16 weeks after administration of DUP (high responders: HR; n  = 11) and that did not (low responders: LR; n  = 8)...
2023: Disease Markers
https://read.qxmd.com/read/37937148/meta-analysis-of-assessment-of-total-oxidative-stress-and-total-antioxidant-capacity-in-patients-with-periodontitis
#20
REVIEW
Khadijah Mohideen, Krithika Chandrasekaran, Harsha Veeraraghavan, Shahul Hameed Faizee, Safal Dhungel, Snehashish Ghosh
BACKGROUND: Periodontitis is intricately linked to oxidative stress-antioxidant (redox) imbalance. The antioxidant system scavenges the oxygen free radicals in biological fluids in patients with periodontitis. However, little is still known about the free radicals mediated oxidative stress and reductive ability of the antioxidant system. Thus, the present meta-analysis aims to quantitatively review the literature that assessed the oxidative stress marker total oxidative stress (TOS) and total antioxidant capacity (TAC) in various biological fluids of patients with periodontitis...
2023: Disease Markers
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