Canadian Journal of Cardiology

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BACKGROUND: Self-expanding pulmonary valve grafts have been designed for percutaneous pulmonary valve implantation (PPVI) in patients with native repaired right ventricular (RV) outflow tracts (RVOTs). However, their efficacy, in terms of RV function, and graft remodeling remain unclear. METHODS: Patients with native RVOTs who received Venus P-valve (N=15) or Pulsta valve (N=38) implants between 2017 and 2022 were enrolled. We collected data on patient characteristics and cardiac catheterization parameters as well as imaging and laboratory data before, immediately after, and 6-12 months after PPVI and identified risk factors for RV dysfunction...

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BACKGROUND: Substrate mapping-based identification of all ventricular tachycardia (VT) circuits (diastolic activation), including partial and complete diastolic circuits in clinical and non-clinical VT, could be beneficial in guiding VT ablation to prevent VT recurrence. The utility of extrasystole induced late potentials has not been compared to late potentials in sinus rhythm and RV pacing. METHODS: Intraoperative simultaneous panoramic endocardial mapping of 21 VTs in 16 ischemic heart disease patients was performed using a 112-bipole endocardial balloon...

INTRODUCTION: It remains unclear if racial and ethnic disparities for atherosclerotic cardiovascular disease (ASCVD) persists within universal healthcare systems. We aimed to explore long-term ASCVD outcomes within a single-payer healthcare system with extensive drug coverage in Quebec, Canada. METHODS: CARTaGENE (CaG) is a population-based prospective cohort study of individuals aged 40-69 years. We included only participants without prior ASCVD. The primary composite endpoint was time to the first ASCVD event (cardiovascular death, acute coronary syndrome, ischemic stroke/transient ischemic attack, or peripheral arterial vascular event)...

Cardiovascular disease (CVD) is the leading non-communicable disease and cause of premature mortality globally. Despite well-established evidence of a cause-effect relationship between modifiable lifestyle behaviours and the onset of risk of chronic disease, preventative approaches to curtail increasing prevalence have been ineffective. This has undoubtedly been exacerbated by the coronavirus disease 2019 (COVID-19) pandemic, which saw widespread national lockdowns implemented to reduce transmission and alleviate pressure on strained healthcare systems...

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Recurrent pericarditis (RP) is one of the most common complications of pericarditis, affecting 15-30% of patients after an initial episode and >40% after a first recurrence.[1, 2] Up to 5-10% of RP patients develop multiple recurrences that are difficult to treat and refractory to conventional anti-inflammatory therapy, suggestive of refractory corticosteroid-dependent, colchicine-resistant RP.[2, 3] Several treatment options are suggested for such patients, including interleukin-1 (IL-1) antagonists, which are currently off-label for treating pericarditis in Canada...

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One of the most uncommon presentations of lupus-associated vasculitis is coronary artery vasculitis (CAV). Cardiac involvement can be encountered even among asymptomatic patients without classical cardiovascular risk factors. Thus, making the correct diagnosis represents a clinical challenge. Here we present the case of a young female with history of SLE who presented to the ED with an acute coronary syndrome.

The WHO reports that more than 1.6 million healthy life-years are lost yearly from traffic-related noise in Western Europe. In addition, the number of studies reporting health side effects in response to traffic noise is steadily growing, mainly cardiovascular disease (CVD), such as acute and chronic ischemic heart disease, heart failure, arrhythmia, and stroke. Pathophysiologically nighttime noise has been shown to cause sleep disturbances, including too short sleep periods and frequent interruption of sleep leading to an increase in the levels of circulating stress hormones and subsequently to a significant increase in the production of reactive oxygen species (ROS; =oxidative stress) and inflammation in the vasculature and the brain...