Vincent Roule, Farzin Beygui, Guillaume Cayla, Grégoire Range, Zuzana Motovska, Nicolas Delarche, François Jourda, Pascal Goube, Paul Guedeney, Michel Zeitouni, Mohamad El Kasty, Mikael Laredo, Raphaëlle Dumaine, Gregory Ducrocq, François Derimay, Eric Van Belle, Thibaut Manigold, Romain Cador, Nicolas Combaret, Eric Vicaut, Gilles Montalescot, Johanne Silvain
BACKGROUND: There is dated and conflicting data about the optimal timing of initiation of P2Y12 inhibitors in elective percutaneous coronary intervention (PCI). Peri-PCI myocardial necrosis is associated with poor outcome. We aimed to assess the impact of the P2Y12 inhibitor loading time on peri-procedural myocardial necrosis in the population of the randomized ALPHEUS trial which compared ticagrelor to clopidogrel in high-risk elective PCI patients. METHODS: 1809 patients of the ALPHEUS trial were divided into quartiles of loading time...
September 1, 2023: Canadian Journal of Cardiology