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Canadian Journal of Cardiology

Margot K Davis, Sean A Virani
No abstract text is available yet for this article.
December 26, 2018: Canadian Journal of Cardiology
Kevin Haddad, Jean-François Tanguay, Brian J Potter, Alexis Matteau, François Gobeil, Samer Mansour
No abstract text is available yet for this article.
December 6, 2018: Canadian Journal of Cardiology
Yu Liu, Yongyi Bi, Yingyao Chen, Lizheng Shi, Zhi-Jiang Zhang
No abstract text is available yet for this article.
November 29, 2018: Canadian Journal of Cardiology
Bobby Yanagawa, Subodh Verma, Girish Dwivedi, Marc Ruel
The clinical status of HIV infection has changed dramatically with the introduction of combined antiretroviral therapy. Patients with HIV are now living long enough to be susceptible to chronic illnesses, such as coronary disease and nonischemic cardiomyopathy, which can be consequences of the combined antiretroviral therapy treatment itself. Cardiovascular diseases are a major source of morbidity and mortality in HIV-positive patients. Increasingly, such patients might be candidates for the full range of cardiac surgical interventions, including coronary bypass, valve surgery, and heart transplantation...
November 20, 2018: Canadian Journal of Cardiology
Luca Baldetti, Matteo Pagnesi, Guglielmo Gallone, Alessandro Beneduce, Paolo Belardinelli, Francesco Melillo, Roberto Spoladore, Azeem Latib, Antonio Colombo, Francesco Giannini
No abstract text is available yet for this article.
February 2019: Canadian Journal of Cardiology
Hiroshi Kadowaki, Eisuke Amiya, Yasuhiro Hoshino, Maasa Tamura, Masae Uehara, Atsuko Nakayama, Kan Nawata, Yukako Domoto, Takako Saeki, Minoru Ono, Issei Komuro
We report the first case of coronary artery fistula with aneurysmal change in a patient with immunoglobulin G4-related disease (IgG4-RD). This case revealed concomitant coronary artery dilation, pericardial inflammatory nodules, and coronary-pulmonary fistula aneurysm in addition to several IgG4-RD lesions. Each of these features was located in close proximity to the thickened pericardium. These lesions might result from inflammation of the pericardial space, which extended to the coronary-pulmonary artery vessels, leading to aneurysmal formation...
February 2019: Canadian Journal of Cardiology
Kristy T Webster, Teimuraz Apridonidze, Prashanth R Mopala, Ariel E Sherman, Lakshmi N Potakamuri, Daniel R Storms, Alan T Kono, Bibhu D Mohanty
We describe the case of a 68-year-old woman presenting with stress cardiomyopathy (SCM), with concomitant cardiogenic shock, left ventricular outflow tract obstruction, and ventricular septal rupture. These complications have not simultaneously been reported in a single SCM case. The importance of early diagnosis of serial complications of SCM and using mechanical circulatory support as a treatment strategy are highlighted.
February 2019: Canadian Journal of Cardiology
Kerstin Piayda, Verena Veulemans, Katharina Hellhammer, Shazia Afzal, Alexander Blehm, Malte Kelm, Tobias Zeus
We present the case of a 71-year-old woman who showed recurrent signs of congestive heart failure with the need of rehospitalization after double valve (mitral and aortic) replacement. Extensive diagnostic workup revealed a moderate aortic stenosis and additionally a significant left ventricular outflow tract obstruction. The tissue overgrowth might be attributed to an inflammatory reaction with extensive pannus deposit after aortic valve surgery. With no-option for re-do surgery we performed the first-in-man off-label valve-in-left ventricular outflow tract procedure with an Edwards Sapien III 23 mm in deep orientation...
February 2019: Canadian Journal of Cardiology
Richard A Veldhoen, Winnie Chan, Ryan Mahaffey, Christine L D'Arsigny
Pulmonary hypertension is a known complication of high-flow arteriovenous fistulas (AVFs). We present a case of a 58-year-old man who sustained a gunshot wound 6.5 years before presentation for worsening pulmonary hypertension (PH). After diagnostic workup, the PH was attributed to a gunshot-related AVF. Exercise capacity and echocardiographic parameters improved after successful ligation of the AVF. This case highlights a rare and correctable cause of PH that requires careful investigation and multidisciplinary expertise for treatment...
February 2019: Canadian Journal of Cardiology
Alexandra Saunders, Robert S Stevenson
A 70-year-old man with known coronary artery disease presented with crushing chest pain, diaphoresis, and pallor after consuming a marijuana lollipop; the pain began within 30 minutes of consumption. His troponin T increased from 94 ng/L to 216 ng/L, with slight ST changes but no gross ST elevations. Discharge diagnosis was non-ST-elevation myocardial infarction, and subsequent nuclear medicine wall motion studies showed worsening ejection fraction (40% to 31%). He also described worsening functional status and exercise capacity after the event...
February 2019: Canadian Journal of Cardiology
Ali Fatehi Hassanabad, Vishnu Vasanthan, William D T Kent
Aortic valve replacement (AVR) is the only definitive treatment for severe aortic stenosis. Options for valve replacement include surgical AVR (SAVR) and percutaneous transcatheter AVR. Although transcatheter AVR has recently been shown to be the optimal approach for high-risk patients, SAVR is the gold standard for patients with low and intermediate surgical risk. Advances in technique and innovations in rapid-deployment and sutureless valves have facilitated the development of a third alternative. Accumulating evidence suggests that minimally invasive SAVR can be performed as safely as conventional SAVR, and perhaps with less morbidity, allowing patients a quicker return to their productive lives...
February 2019: Canadian Journal of Cardiology
Guillaume St-Pierre, Christian Steinberg, Michelle Dubois, Mario Sénéchal
Mitochondrial diseases are a heterogeneous group of rare hereditary disorders that may manifest with single organ involvement or as multisystemic disease. The pathophysiology of mitochondrial disease is complex and related to mutations of genes encoding mitochondrial proteins that are crucial to the cellular respiratory chain. Given its almost exclusive aerobic metabolism, the heart is particularly susceptible to mitochondrial dysfunction and commonly involved in mitochondrial disorders. Various clinical presentations are described, making clinical recognition challenging...
February 2019: Canadian Journal of Cardiology
Steven L Rathgeber, Kevin C Harris
The growing awareness of Fontan-associated liver disease (FALD) in adults with Fontan physiology has provided the impetus to better understand the natural history of FALD and develop a reliable noninvasive method to diagnose and monitor liver health in this population. Biochemical and imaging tests have been investigated to determine their association with liver pathology. The congestive hepatopathy that develops after the Fontan procedure has made interpreting these tests challenging. We have reviewed and summarized the current understanding and ongoing challenges with respect noninvasive measures of liver health in Fontan patients including biochemical tests, elastography, hepatic ultrasound, cross-sectional imaging, and hemodynamics and how they relate to liver pathology...
February 2019: Canadian Journal of Cardiology
Wei Shuai, Bin Kong, Hui Fu, Caijie Shen, Xiaobo Jiang, He Huang
BACKGROUND: Myeloid differentiation protein 1 (MD1) is expressed in various tissues, including the heart. However, the role of MD1 in obesity-related atrial remodelling remains incompletely understood. Here, this study intends to determine the regulatory role and underlying mechanisms of MD1 in obesity-related atrial remodelling. METHODS: A high-fat diet (HFD) feeding was performed in 6-week-old MD1-knockout (MD1-KO) mice and wild-type (WT) littermates for 20 weeks...
February 2019: Canadian Journal of Cardiology
Julinda Mehilli, Jaya Chandrasekhar, Samantha Sartori, Alaide Chieffo, Anna S Petronio, Thierry Lefèvre, Patrizia Presbitero, Piera Capranzano, Didier Tchetche, Alessandro Iadanza, Gennaro Sardella, Nicolas M Van Mieghem, Emanuela Meliga, Nicolas Dumonteil, Chiara Fraccaro, Daniela Trabattoni, David Jochheim, Magda Zadrozny, Ghada W Mikhail, Samin Sharma, Maria C Ferrer, Christoph Naber, Peter Kievit, Kamilia Moalem, Usman Baber, Clayton Snyder, Madhav Sharma, Marie C Morice, Roxana Mehran
BACKGROUND: Several clinical and procedural factors determine outcomes after transcatheter aortic valve replacement (TAVR), but data are scarce on the impact of post-TAVR discharge disposition on long-term outcomes. We sought to analyse whether discharge location after TAVR is associated with 1-year outcomes in women undergoing contemporary TAVR. METHODS: The Women's INternational Transcatheter Aortic Valve Implantation (WIN-TAVI) registry is the first all-female TAVR registry to study the safety and performance of contemporary TAVR in women (n = 1019)...
February 2019: Canadian Journal of Cardiology
Mai Kimura, Takashi Kohno, Takashi Kawakami, Masaharu Kataoka, Takahiro Hiraide, Hidenori Moriyama, Sarasa Isobe, Toshimitsu Tsugu, Yuji Itabashi, Mitsushige Murata, Shinsuke Yuasa, Keiichi Fukuda
BACKGROUND: There is no consensus on the length of hospital stay (LOHS) and post-interventional management after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We examined temporal trends with respect to LOHS and requirement for intensive care for BPA and their relationship with the incidence of BPA-related complications. METHODS: From November 2012 to September 2017, a total of 123 consecutive patients with CTEPH who underwent BPA were enrolled (age: 66...
February 2019: Canadian Journal of Cardiology
Marni J Armstrong, Doreen M Rabi, Danielle A Southern, Alykhan Nanji, William A Ghali, Ronald J Sigal
BACKGROUND: Although suggested by practice guidelines, the need for pre-exercise stress testing in asymptomatic people with diabetes remains controversial. We examined the utility of screening with pre-exercise stress testing in patients with diabetes. METHODS: We completed a cohort study, evaluating patients with diabetes who attended an exercise program intake session between 2007 and 2012. The exposure of interest was referral for pre-exercise stress testing determined by an algorithm requiring sedentary patients with diabetes and ≥ 1 cardiac risk factor to undergo testing...
February 2019: Canadian Journal of Cardiology
Marie-A Chaix, Annie Dore, François Marcotte, Azadeh Shohoudi, Fabien Labombarda, Lise-Andrée Mercier, Anna Proietti, Réda Ibrahim, Anita W Asgar, Blandine Mondésert, Nancy Poirier, Paul Khairy, François-Pierre Mongeon
BACKGROUND: Echocardiographic evaluation of the systemic right ventricle (sRV) remains challenging in patients with transposition of the great arteries (TGA) corrected by an atrial switch (AS) and with congenitally corrected TGA (ccTGA). The aim of this study was to determine the interobserver and intraobserver variability of echocardiographic parameters for sRV size and systolic function. METHODS: Six independent observers retrospectively interpreted 44 previously acquired echocardiograms (25 patients with TGA/AS and 19 patients with ccTGA)...
February 2019: Canadian Journal of Cardiology
Andreu Porta-Sánchez, Andrew C T Ha, Xuesong Wang, Fahad Almehmadi, Peter C Austin, Hadas D Fischer, Atif Al-Qubbany, Diego Chemello, Vijay Chauhan, Eugene Downar, Douglas S Lee, Kumaraswamy Nanthakumar
BACKGROUND: Catheter ablation of ventricular tachycardia (VT) can reduce the burden of ventricular arrhythmia (VA) but its effect on health care utilization and costs after such therapy is poorly known. We sought to compare the rates of cardiovascular (CV)-related hospitalizations, survival, and health care costs in patients with recurrent VT treated either with VT ablation or with medical therapy. METHODS: One-hundred implantable cardioverter-defibrillator patients with structural heart disease who underwent VT ablation were included...
February 2019: Canadian Journal of Cardiology
Hanna Lee, Mary K Tan, Andrew T Yan, Paul Angaran, Paul Dorian, Claudia Bucci, Jean C Gregoire, Alan D Bell, Martin S Green, Peter L Gross, Allan Skanes, Charles R Kerr, L Brent Mitchell, Jafna L Cox, Vidal Essebag, Brett Heilbron, Krishnan Ramanathan, Carl Fournier, Bruce H Wheeler, Peter J Lin, Murray Berall, Anatoly Langer, Lianne Goldin, Shaun G Goodman
BACKGROUND: Physicians treating nonvalvular atrial fibrillation (AF) assess stroke and bleeding risks when deciding on anticoagulation. The agreement between empirical and physician-estimated risks is unclear. Furthermore, the association between patient and physician sex and anticoagulation decision-making is uncertain. METHODS: We pooled data from 2 national primary care physician chart audit databases of patients with AF (Facilitating Review and Education to Optimize Stroke Prevention in Atrial Fibrillation and Coordinated National Network to Engage Physicians in the Care and Treatment of Patients with Atrial Fibrillation Chart Audit) with a combined 1035 physicians (133 female, 902 male) and 10,927 patients (4567 female and 6360 male)...
February 2019: Canadian Journal of Cardiology
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