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International Journal of Hyperthermia

Roberto Negro, Gabriele Greco
PURPOSE: Patients with toxic adenomas (TAs) that are too large to undergo radioactive iodine (RAI) treatment aimed at resolving hyperthyroidism and/or relieving mechanical pressure symptoms are referred to surgery. This prospective study aimed to assess the outcomes of combining laser ablation (LA) plus RAI vs lobectomy to treat large TAs in terms of clinical efficacy and the health-related quality of life (HRQoL). PATIENTS AND METHODS: Patients with TAs of volumes greater than 20 mL and a calculated therapeutic activity exceeding 600 Mbq were randomly assigned to undergo LA + RAI (Group A) or lobectomy (Group B)...
December 2019: International Journal of Hyperthermia
John Abraham
No abstract text is available yet for this article.
April 24, 2019: International Journal of Hyperthermia
Jiayun Jiang, Shihan Chen, Kun Li, Chang Zhang, Yunhua Tan, Qingsong Deng, Yuelong Chai, Xiaofei Wang, Geng Chen, Kai Feng, Leida Zhang, Chuan-Ming Xie, Kuansheng Ma
PURPOSE: Radiofrequency ablation (RFA) is widely accepted as a curative treatment for small hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can lead to rapid local recurrence. The underlying mechanisms remain poorly understood. This study aimed to elucidate the role and regulatory mechanisms of autophagy in the recurrence of HCC after IRFA. MATERIALS AND METHODS: SMMC7721 and Huh7 cells were exposed to sublethal heat stress to stimulate the transition zone of IRFA treatment...
April 22, 2019: International Journal of Hyperthermia
Xinhua Yang, Xiaofei Zhang, Bin Lin, Xiao Feng, Aixingzi Aili
OBJECTIVE: To evaluate the combined efficacy of high-intensity focused ultrasound (HIFU), gonadotropin-releasing hormone agonist (GnRH-a) and the levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of severe adenomyosis. METHOD: Four hundred and sixty-six patients with adenomyosis admitted to the Department of Gynecology of Shanghai First Maternity and Infant Hospital underwent HIFU treatment, and then were consecutively administered with GnRH-a 1 d, 1 month and 3 months after HIFU treatment...
April 17, 2019: International Journal of Hyperthermia
Valerio Belgrano, Jan Mattsson, Jonas Nilsson, Roger Olofsson Bagge, Dimitrios Katsarelias
BACKGROUND: Isolated limb perfusion (ILP) is a treatment option for unresectable in-transit melanoma metastases of the extremities. Approximately two-thirds of the patients have a complete response, and known predictive factors mainly regard tumor burden. In an attempt to identify subgroups with higher response rates, we retrospectively analyzed the predictive value of the BRAF V600E/K mutation for response at our institution. METHODS: Between January 2012 and December 2017, 98 consecutive patients underwent first-time ILP with melphalan for melanoma in-transit metastases and were included in the study...
April 15, 2019: International Journal of Hyperthermia
Gennaro G Bellizzi, Tomas Drizdal, Gerard C van Rhoon, Lorenzo Crocco, Tommaso Isernia, Margarethus M Paulides
PURPOSE: Hyperthermia treatment quality determines treatment effectiveness as shown by the clinically derived thermal-dose effect relations. SAR based optimization factors are used as possible surrogate for temperature, since they are not affected by thermal tissue properties uncertainty and variations. Previously, target coverage (TC) at the 25% and 50% iso-SAR level was shown predictive for treatment outcome in superficial hyperthermia and the target-to-hot-spot-quotient (THQ) was shown to highly correlate with predictive temperature in deep pelvic hyperthermia...
April 11, 2019: International Journal of Hyperthermia
Emre Besler, Y Curtis Wang, Terence C Chan, Alan V Sahakian
BACKGROUND: Radiofrequency ablation is a minimally-invasive treatment method that aims to destroy undesired tissue by exposing it to alternating current in the 100 kHz-800 kHz frequency range and heating it until it is destroyed via coagulative necrosis. Ablation treatment is gaining momentum especially in cancer research, where the undesired tissue is a malignant tumor. While ablating the tumor with an electrode or catheter is an easy task, real-time monitoring the ablation process is a must in order to maintain the reliability of the treatment...
April 2, 2019: International Journal of Hyperthermia
Ravish Kapoor, Kristen Ashlee Robinson, Juan Pablo Cata, Pascal Owusu-Agyemang, Jose Miguel Soliz, Michael Hernandez, Paul Mansfield, Brian Badgwell
BACKGROUND: Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) has been used to treat various peritoneal malignancies. Cisplatin and mitomycin C (MMC) are agents commonly used in these procedures and, individually, each has been associated with acute kidney injury (AKI). There is limited literature on the complications associated with the use of both agents in HIPEC. Therefore, we sought to determine the incidence of nephrotoxicity and electrolyte abnormalities in patients undergoing laparoscopic HIPEC using this chemotherapeutic combination...
April 1, 2019: International Journal of Hyperthermia
Mehmet Salih Iyikesici
BACKGROUND: Previous evidence suggests that metabolically supported chemotherapy (MSCT), ketogenic diet, hyperthermia and hyperbaric oxygen therapy (HBOT) could all target vulnerabilities of cancer cells. This study aimed to evaluate the efficacy and the tolerability of this combination therapy in the treatment of stage IV non-small cell lung cancer (NSCLC). METHODS: Forty-four NSCLC patients with distant metastasis that received MSCT (administration of chemotherapy regimen following induced hypoglycemia) plus ketogenic diet, hyperthermia and HBOT combination were included in this retrospective study...
April 1, 2019: International Journal of Hyperthermia
Makoto Ihara, Kazuko Shichijo, Takashi Kudo, Kenzo Ohtsuka
PURPOSE: Mouse double-stranded DNA-dependent protein kinase (DNA-PK) activity is heat sensitive. Recovery of heat-inactivated DNA repair activity is a problem after combination therapy with radiation and heat. We investigated the mechanism of recovery of heat-inactivated DNA-PK activity. METHODS: Hybrid cells containing a fragment of human chromosome 8 in scid cells (RD13B2) were used. DNA-PK activity was measured by an in vitro assay. Immunoprecipitation of the nuclear extract was performed with an anti-Ku80 antibody...
March 28, 2019: International Journal of Hyperthermia
(no author information available yet)
No abstract text is available yet for this article.
March 28, 2019: International Journal of Hyperthermia
Yoko Miura, Eric Seifert, Josua Rehra, Katharina Kern, Dirk Theisen-Kunde, Michael Denton, Ralf Brinkmann
Objective/Purpose: In order to study the effects of hyperthermia and other temperature-related effects on cells and tissues, determining the precise time/temperature course is crucial. Here we present a non-contact optoacoustic technique, which provides temperatures during heating of cultured cells with scalable temporal and spatial resolution. METHODS: A thulium laser (1.94 µm) with a maximum power of 15 W quickly and efficiently heats cells in a culture dish because of low penetration depth (1/e penetration depths of 78 µm) of the radiation in water...
March 28, 2019: International Journal of Hyperthermia
Matthew D Bucknor, Gabriela Beroukhim, Viola Rieke, Eugene Ozhinsky, Iryna Lobach
PURPOSE: Desmoid tumors are benign, locally aggressive soft tissue tumors derived from fibroblasts. Magnetic resonance-guided focused ultrasound (MRgFUS) is a safe and effective treatment for desmoid tumors. The purpose of this study was to retrospectively review the MRgFUS treatments of desmoid tumors at our institution to determine which technical treatment parameters contributed most significantly to the accumulation of thermal dose. MATERIALS AND METHODS: The study protocol was approved by the local IRB...
March 28, 2019: International Journal of Hyperthermia
Meng He, Jinghua Sun, Danyi Zhao, Hongmei He, Bing Wang, Lingling Xu, Yu Shang, Shanling Ren, Yang Zhang, Tao Wu
BACKGROUND: FOLFIRINOX chemotherapy displays significant survival improvements in patients with pancreatic cancer. However, toxicities have hampered enthusiasm for the use of FOLFIRINOX in full dose. In order to increase the tolerability, many researchers focused on the modification of FOLFIRINOX. On the other hand, hyperthermia (HT) has been considered as an effective ancillary treatment for cancer therapy. Up to now, there is no report evaluating combining deep regional hyperthermia (DRHT) with modified-FOLFIRINOX for pancreatic cancer patients...
March 27, 2019: International Journal of Hyperthermia
Ge Ma, Zequan Ding, Huaxing Huang, Wenbin Zhou, Shui Wang
No abstract text is available yet for this article.
March 26, 2019: International Journal of Hyperthermia
Yu-Zhe Sun, Jia-Feng Li, Zhen-Dong Wei, Hang-Hang Jiang, Yu-Xiao Hong, Song Zheng, Rui-Qun Qi, Xing-Hua Gao
BACKGROUND: Hyperthermia has proved successful in treating cutaneous human papillomavirus infectious diseases such as plantar wart and condyloma acuminata (CA). Moreover, this treatment provides improved therapeutic efficacy in these conditions as compared with conventional therapies. OBJECTIVES: To investigate the global proteome changes in CA in response to hyperthermia and achieve a better understanding of the mechanisms of hyperthermia therapy against HPV-infectious diseases...
March 26, 2019: International Journal of Hyperthermia
Saurabh Singh, Pulathis Nilantha Siriwardana, Edward William Johnston, Jennifer Watkins, Steven Bandula, Rowland Oliver Illing, Brian Ritchie Davidson
No abstract text is available yet for this article.
March 23, 2019: International Journal of Hyperthermia
Xuefeng Jiang, QiongLan Tang, Binjiang Yang, Fei Ye, Lei Cai, Xiaoyu Wang, Xin Luo, Hong Bu
OBJECTIVE: To evaluate the safety and feasibility of combined procedures: HIFU combined with systemic MTX followed by ultrasound-guided curettage or hysteroscopic resection while treating placenta accreta (PA). METHOD: This study included 21 patients diagnosed with retained PA with marked vascularity after abortion or delivery from July 2015 to December 2017. Patients with high serum β-hCG level (≥100 mIU/mL) received systemic MTX + HIFU treatment for 3 days and the ones with low β-hCG level (<100 mIU/mL) only received USgHIFU treatment for 3 days before ultrasound-guided curettage or hysteroscopic resection...
March 20, 2019: International Journal of Hyperthermia
Ping Liu, Shengguo Jia, Yue Lou, Kun He, Lisa X Xu
PURPOSE: We previously developed a novel cryo-thermal therapy to treat malignant mammary carcinoma and melanoma in a mouse model; long-term survival and CD4+ T cell orchestrating anti-tumor immune memory response were achieved. Moreover, cryo-thermal-induced CD4+ T cell differentiation into Th1 and CD4+ CTL sub-lineages, in which M1 macrophage polarization played a direct, important role. In particular, cryo-thermal therapy triggered M1 macrophage polarization with up-regulated expression of C-X-C motif ligand 10 (CXCL10) and Interleukin 6 (IL-6)...
March 20, 2019: International Journal of Hyperthermia
Karli Peña, Matthew Ishahak, Stacie Arechavala, Raymond J Leveillee, Nelson Salas
INTRODUCTION: Microwave ablation (MWA) uses heat to ablate undesired tissue. Development of pre-planning algorithms for MWA of small renal masses requires understanding of microwave-tissue interactions at different operating parameters. The objective of this study was to compare the performance of two MWA systems in in-vivo porcine kidneys. METHODS: Five ablations were performed using a 902-928 MHz system (24 W, 5 min) and a 2450 MHz system (180 W, 2 min)...
March 5, 2019: International Journal of Hyperthermia
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