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International Journal of Hyperthermia

Gennaro G Bellizzi, Tomas Drizdal, Gerard C van Rhoon, Lorenzo Crocco, Tommaso Isernia, Margarethus M Paulides
PURPOSE: Hyperthermia treatment quality determines treatment effectiveness as shown by the clinically derived thermal-dose effect relations. SAR based optimization factors are used as possible surrogate for temperature, since they are not affected by thermal tissue properties uncertainty and variations. Previously, target coverage (TC) at the 25% and 50% iso-SAR level was shown predictive for treatment outcome in superficial hyperthermia and the target-to-hot-spot-quotient (THQ) was shown to highly correlate with predictive temperature in deep pelvic hyperthermia...
April 11, 2019: International Journal of Hyperthermia
Emre Besler, Y Curtis Wang, Terence C Chan, Alan V Sahakian
BACKGROUND: Radiofrequency ablation is a minimally-invasive treatment method that aims to destroy undesired tissue by exposing it to alternating current in the 100 kHz-800 kHz frequency range and heating it until it is destroyed via coagulative necrosis. Ablation treatment is gaining momentum especially in cancer research, where the undesired tissue is a malignant tumor. While ablating the tumor with an electrode or catheter is an easy task, real-time monitoring the ablation process is a must in order to maintain the reliability of the treatment...
April 2, 2019: International Journal of Hyperthermia
Ravish Kapoor, Kristen Ashlee Robinson, Juan Pablo Cata, Pascal Owusu-Agyemang, Jose Miguel Soliz, Michael Hernandez, Paul Mansfield, Brian Badgwell
BACKGROUND: Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) has been used to treat various peritoneal malignancies. Cisplatin and mitomycin C (MMC) are agents commonly used in these procedures and, individually, each has been associated with acute kidney injury (AKI). There is limited literature on the complications associated with the use of both agents in HIPEC. Therefore, we sought to determine the incidence of nephrotoxicity and electrolyte abnormalities in patients undergoing laparoscopic HIPEC using this chemotherapeutic combination...
April 1, 2019: International Journal of Hyperthermia
Mehmet Salih Iyikesici
BACKGROUND: Previous evidence suggests that metabolically supported chemotherapy (MSCT), ketogenic diet, hyperthermia and hyperbaric oxygen therapy (HBOT) could all target vulnerabilities of cancer cells. This study aimed to evaluate the efficacy and the tolerability of this combination therapy in the treatment of stage IV non-small cell lung cancer (NSCLC). METHODS: Forty-four NSCLC patients with distant metastasis that received MSCT (administration of chemotherapy regimen following induced hypoglycemia) plus ketogenic diet, hyperthermia and HBOT combination were included in this retrospective study...
April 1, 2019: International Journal of Hyperthermia
Makoto Ihara, Kazuko Shichijo, Takashi Kudo, Kenzo Ohtsuka
PURPOSE: Mouse double-stranded DNA-dependent protein kinase (DNA-PK) activity is heat sensitive. Recovery of heat-inactivated DNA repair activity is a problem after combination therapy with radiation and heat. We investigated the mechanism of recovery of heat-inactivated DNA-PK activity. METHODS: Hybrid cells containing a fragment of human chromosome 8 in scid cells (RD13B2) were used. DNA-PK activity was measured by an in vitro assay. Immunoprecipitation of the nuclear extract was performed with an anti-Ku80 antibody...
March 28, 2019: International Journal of Hyperthermia
(no author information available yet)
No abstract text is available yet for this article.
March 28, 2019: International Journal of Hyperthermia
Yoko Miura, Eric Seifert, Josua Rehra, Katharina Kern, Dirk Theisen-Kunde, Michael Denton, Ralf Brinkmann
Objective/Purpose: In order to study the effects of hyperthermia and other temperature-related effects on cells and tissues, determining the precise time/temperature course is crucial. Here we present a non-contact optoacoustic technique, which provides temperatures during heating of cultured cells with scalable temporal and spatial resolution. METHODS: A thulium laser (1.94 µm) with a maximum power of 15 W quickly and efficiently heats cells in a culture dish because of low penetration depth (1/e penetration depths of 78 µm) of the radiation in water...
March 28, 2019: International Journal of Hyperthermia
Matthew D Bucknor, Gabriela Beroukhim, Viola Rieke, Eugene Ozhinsky, Iryna Lobach
PURPOSE: Desmoid tumors are benign, locally aggressive soft tissue tumors derived from fibroblasts. Magnetic resonance-guided focused ultrasound (MRgFUS) is a safe and effective treatment for desmoid tumors. The purpose of this study was to retrospectively review the MRgFUS treatments of desmoid tumors at our institution to determine which technical treatment parameters contributed most significantly to the accumulation of thermal dose. MATERIALS AND METHODS: The study protocol was approved by the local IRB...
March 28, 2019: International Journal of Hyperthermia
Meng He, Jinghua Sun, Danyi Zhao, Hongmei He, Bing Wang, Lingling Xu, Yu Shang, Shanling Ren, Yang Zhang, Tao Wu
BACKGROUND: FOLFIRINOX chemotherapy displays significant survival improvements in patients with pancreatic cancer. However, toxicities have hampered enthusiasm for the use of FOLFIRINOX in full dose. In order to increase the tolerability, many researchers focused on the modification of FOLFIRINOX. On the other hand, hyperthermia (HT) has been considered as an effective ancillary treatment for cancer therapy. Up to now, there is no report evaluating combining deep regional hyperthermia (DRHT) with modified-FOLFIRINOX for pancreatic cancer patients...
March 27, 2019: International Journal of Hyperthermia
Haoran Huang, Jianbo Ran, Zhibo Xiao, Liping Ou, Xing Li, Jie Xu, Qi Wang, Zhibiao Wang, Faqi Li
OBJECTIVE: The objective of this study was to explore the correlations between the therapeutic effect of high intensity focused ultrasound (HIFU) and histopathological characteristics of excised uterine fibroids with different signal intensities as visualized on T2-weighted magnetic resonance imaging (MRI). METHODS: We collected 47 specimens of uterine fibroids after surgical resection and classified them into four groups according to preoperative T2-weighted MRI hypo-intense, isointense, heterogeneous intense and homogeneous hyper-intense...
March 27, 2019: International Journal of Hyperthermia
Ge Ma, Zequan Ding, Huaxing Huang, Wenbin Zhou, Shui Wang
No abstract text is available yet for this article.
March 26, 2019: International Journal of Hyperthermia
Enrico Papini, Claudio Maurizio Pacella, Luigi Alessandro Solbiati, Gaetano Achille, Daniele Barbaro, Stella Bernardi, Vito Cantisani, Roberto Cesareo, Arturo Chiti, Luca Cozzaglio, Anna Crescenzi, Francesco De Cobelli, Maurilio Deandrea, Laura Fugazzola, Giovanni Gambelunghe, Roberto Garberoglio, Gioacchino Giugliano, Livio Luzi, Roberto Negro, Luca Persani, Bruno Raggiunti, Francesco Sardanelli, Ettore Seregni, Martina Sollini, Stefano Spiezia, Fulvio Stacul, Dominique Van Doorne, Luca Maria Sconfienza, Giovanni Mauri
Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in the management of nodules causing local symptoms. In February 2018, the Italian MIT Thyroid Group was founded to create a permanent cooperation between Italian and international physicians dedicated to clinical research and assistance on MIT for thyroid nodules. The group drafted this list of statements based on literature review and consensus opinion of interdisciplinary experts to facilitate the diffusion and the appropriate use of MIT of thyroid nodules in clinical practice...
March 26, 2019: International Journal of Hyperthermia
Yu-Zhe Sun, Jia-Feng Li, Zhen-Dong Wei, Hang-Hang Jiang, Yu-Xiao Hong, Song Zheng, Rui-Qun Qi, Xing-Hua Gao
BACKGROUND: Hyperthermia has proved successful in treating cutaneous human papillomavirus infectious diseases such as plantar wart and condyloma acuminata (CA). Moreover, this treatment provides improved therapeutic efficacy in these conditions as compared with conventional therapies. OBJECTIVES: To investigate the global proteome changes in CA in response to hyperthermia and achieve a better understanding of the mechanisms of hyperthermia therapy against HPV-infectious diseases...
March 26, 2019: International Journal of Hyperthermia
Saurabh Singh, Pulathis Nilantha Siriwardana, Edward William Johnston, Jennifer Watkins, Steven Bandula, Rowland Oliver Illing, Brian Ritchie Davidson
No abstract text is available yet for this article.
March 23, 2019: International Journal of Hyperthermia
Xuefeng Jiang, QiongLan Tang, Binjiang Yang, Fei Ye, Lei Cai, Xiaoyu Wang, Xin Luo, Hong Bu
OBJECTIVE: To evaluate the safety and feasibility of combined procedures: HIFU combined with systemic MTX followed by ultrasound-guided curettage or hysteroscopic resection while treating placenta accreta (PA). METHOD: This study included 21 patients diagnosed with retained PA with marked vascularity after abortion or delivery from July 2015 to December 2017. Patients with high serum β-hCG level (≥100 mIU/mL) received systemic MTX + HIFU treatment for 3 days and the ones with low β-hCG level (<100 mIU/mL) only received USgHIFU treatment for 3 days before ultrasound-guided curettage or hysteroscopic resection...
March 20, 2019: International Journal of Hyperthermia
Ping Liu, Shengguo Jia, Yue Lou, Kun He, Lisa X Xu
PURPOSE: We previously developed a novel cryo-thermal therapy to treat malignant mammary carcinoma and melanoma in a mouse model; long-term survival and CD4+ T cell orchestrating anti-tumor immune memory response were achieved. Moreover, cryo-thermal-induced CD4+ T cell differentiation into Th1 and CD4+ CTL sub-lineages, in which M1 macrophage polarization played a direct, important role. In particular, cryo-thermal therapy triggered M1 macrophage polarization with up-regulated expression of C-X-C motif ligand 10 (CXCL10) and Interleukin 6 (IL-6)...
March 20, 2019: International Journal of Hyperthermia
Chuanjun Xu, Lei Li, Wei Xu, Chao Du, Lixin Yang, Jinlong Tong, Yongxiang Yi
OBJECTIVE: The aims of this study were to compare the clinical outcomes between ultrasound-guided percutaneous microwave ablation (US-PMWA) and surgical resection (SR) in patients with recurrent intrahepatic cholangiocarcinoma (ICC) and to identify the prognostic factors associated with the two treatment methods. METHODS: This retrospective study was institutional review board approved. A total of 121 patients (102 men and 19 women) with 136 ICCs after hepatectomy from April 2011 to January 2017 were reviewed...
March 8, 2019: International Journal of Hyperthermia
Yangsean Choi, So Lyung Jung, Ja-Sung Bae, So-Hee Lee, Chan-Kwon Jung, Jinhee Jang, Na-Young Shin, Hyun Seok Choi, Kook-Jin Ahn, Bum-Soo Kim
PURPOSE: To compare the efficacy and complication rates of radiofrequency ablation (RFA) and repeat surgery in the treatment of locally recurrent thyroid cancers. MATERIALS AND METHODS: A total of 221 patients with locally recurrent thyroid cancers who underwent either RFA (n = 96) or repeat surgery (n = 125) between March 2008 and March 2017 were retrospectively enrolled (range of follow-up, 1-10 years). Each cohort consisted of 70 patients after propensity score adjustment...
March 5, 2019: International Journal of Hyperthermia
Karli Peña, Matthew Ishahak, Stacie Arechavala, Raymond J Leveillee, Nelson Salas
INTRODUCTION: Microwave ablation (MWA) uses heat to ablate undesired tissue. Development of pre-planning algorithms for MWA of small renal masses requires understanding of microwave-tissue interactions at different operating parameters. The objective of this study was to compare the performance of two MWA systems in in-vivo porcine kidneys. METHODS: Five ablations were performed using a 902-928 MHz system (24 W, 5 min) and a 2450 MHz system (180 W, 2 min)...
March 5, 2019: International Journal of Hyperthermia
Lucheng Zhu, Yasi Xu, Yuqiang Shan, Ruzhen Zheng, Zhibing Wu, Shenglin Ma
BACKGROUND: The peritoneum is the most frequent site of disease recurrence in gastric cancer, and the prognosis remains poor. This study assessed the role of adjuvant intraperitoneal (IP) chemotherapy with whole abdominal hyperthermia using external radiofrequency in gastric cancer patients after D2 dissection. METHODS: Patients with gastric cancer who underwent gastrectomy with D2 regional lymph node dissection were enrolled in the study. Patients received IP chemotherapy with whole abdominal hyperthermia...
March 4, 2019: International Journal of Hyperthermia
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