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Diabetes Research and Clinical Practice

Michelle D Taylor, Thang S Han, Helen Ward, Clare Bradley
AIMS: To evaluate the Hypoglycaemia Symptom Rating Questionnaire (HypoSRQ© ) and relationships between self-reported hypoglycaemia and hypoglycaemia measured using blinded continuous glucose monitoring (CGM). METHODS: Diabetes outpatients (n=113) recruited from Ashford and St. Peter's Hospital completed the HypoSRQ (recent weeks version) and provided clinical information. Thirty participants used blinded CGM for six days and completed the HypoSRQ (24-hour version) for seven days, at the end of each week (7-day version), and after four weeks (recent weeks version)...
April 5, 2019: Diabetes Research and Clinical Practice
Dario Giugliano, Maria Ida Maiorino, Miriam Longo, Katherine Esposito
No abstract text is available yet for this article.
April 5, 2019: Diabetes Research and Clinical Practice
Johannes C Ehrenthal, Andreas Düx, Lara Baie, Markus Burgmer
AIMS: Psychosocial variables influence chronic diseases, such as type 2 diabetes mellitus. While there is evidence for a negative impact of depression, much less is known about stable, personality oriented factors. Aim of the study was to assess the impact of depression and personality functioning on glucose regulation in patients with type 2 diabetes. METHODS: Seventy-five adult individuals with a first diagnosis of type 2 diabetes were consecutively recruited in an outpatient medical practice...
April 5, 2019: Diabetes Research and Clinical Practice
Ji-Bin Yin, Ye Niu, Li-Yan Qian, Xin Zhang, Zhi-Ping Liu, Rui-Tao Wang
BACKGROUND: Patients with hepatocellular carcinoma (HCC) having pre-existing type 2 diabetes (T2DM) have a poorer prognosis than those without T2DM. Moreover, accumulating evidence reveals that activated platelets play a crucial role in tumor and T2DM. The mean platelet volume (MPV) indicates platelet activation and is altered in malignancies. The present study aimed to investigate the clinical significance of MPV in patients with HCC having T2DM. METHODS: This retrospective study performed between January 2010 and December 2013 included 331 patients with HCC (165 with T2DM and 166 without T2DM) ...
April 5, 2019: Diabetes Research and Clinical Practice
S Carter, P M Clifton, J P Keogh
AIMS: Two medication change protocols were tested, both based on haemoglobin A1c (HbA1c), with one protocol also accounting for hypoglycaemic events. The aim was to compare the two protocols during intermittent energy restriction (5:2 diet). METHODS: Forty-two adults with type 2 diabetes (HbA1c ≥7% [53 mmol/mol], BMI of ≥27kg/m2 ) treated with sulphonylureas and/or insulin were recruited and randomised 1:1 to fixed or adjusted medication protocols. Participants experiencing hypoglycaemia during a 2-week usual diet period then followed the 5:2 diet for 2 weeks (2 non-consecutive very-low-calorie days [500-600kcal] and 5 habitual eating days/week), following the allocated medication protocol...
April 5, 2019: Diabetes Research and Clinical Practice
Min Jeong Kwon, Yong Jae Lee, Hye Sook Jung, Hyun Mi Shin, Tae Nyun Kim, Soon Hee Lee, Byoung Doo Rhee, Mi-Kyung Kim, Jeong Hyun Park
AIMS: The direct effects of thiazolidinediones (TZDs) on pancreatic beta cells have been controversial. The aim of this study was to find out whether a novel TZD, lobeglitazone, has beneficial effects on pancreatic beta cells and db/db mice compared to those of other TZDs. METHODS: INS-1 cells were incubated at a high-glucose concentration with various concentrations of troglitazone, rosiglitazone, pioglitazone, and lobeglitazone. Apoptosis and proliferation of beta cells, markers for ER stress and glucose-stimulated insulin secretion (GSIS) were assessed...
April 4, 2019: Diabetes Research and Clinical Practice
Najat Abuhendi, Abeer Qush, Fozieh Naji, Hanan Abunada, Reeham Al Buainain, Zumin Shi, Hatem Zayed
AIMS: T2DM reach epidemic levels in the Arab countries. In this study, we aimed to perform a systematic review and meta-analysis to underline the susceptibility genetic profile of Arab patients with T2DM that result from SNPs. METHODS: We searched four literature databases (PubMed, Scopus, Science Direct and Web of Science) through January 2019. We included all SNPs in candidate genes with an OR>1 that were associated with T2DM among Arab patients with T2DM. Statistical programs such as software Review Manager (Version 5...
April 4, 2019: Diabetes Research and Clinical Practice
Javier Moreno-Ulloa, Aldo Moreno-Ulloa, María Martínez-Tapia, Jorge Duque-Rodríguez
No abstract text is available yet for this article.
April 4, 2019: Diabetes Research and Clinical Practice
Sergio Hernández-Jiménez, Ana Cristina García-Ulloa, Omar Yaxmehen Bello-Chavolla, Carlos A Aguilar-Salinas, David Kershenobich-Stalnikowitz
AIMS: To evaluate the effectiveness of a comprehensive care program to achieve and maintain goals in patients with type 2 diabetes. METHODS: The CAIPaDi program includes 9 interventions delivered in 7 hours. It seeks to achieve metabolic goals, identify and resolve barriers that would make implementation difficult, and provide self-efficacy and empowerment to patients by identifying personal profiles to establish individualized strategies. The program consists of a 4 intervention visits (1,2,3, and 4 months) and two follow up visits (12 and 24 months)...
April 4, 2019: Diabetes Research and Clinical Practice
Melawhy L Garcia, Sheila F Castañeda, Matthew A Allison, John P Elder, Gregory A Talavera
AIMS: We examined psychosocial- and social/economic factors related to low medication adherence, and sex differences, among 279 adults of Mexican heritage with Type 2 Diabetes. METHODS: Self-report and health record data were used for cross-sectional analyses. Bivariate analyses tested the association of demographic, psychosocial (depression, anxiety, stress) and social/economic factors (insurance type, health literacy, social support) and two medication adherence measures (Morisky Medication Adherence Scale -8, a self-report survey, and Proportion of Days Covered)...
April 4, 2019: Diabetes Research and Clinical Practice
Joseph C Engeda, Ashlyn Stackhouse, Mary White, Wayne D Rosamond, Stefan K Lhachimi, Jennifer L Lund, Thomas C Keyserling, Christy L Avery
AIMS: To conduct a meta-analysis of statin-associated type 2 diabetes mellitus (T2D) risk among randomized controlled trials (RCTs) and observational studies (OBSs), excluding studies conducted among secondary prevention populations. METHODS: Studies were identified by searching PubMed (1994-present) and EMBASE (1994-present). Articles had to meet the following criteria: 1) follow-up >one year; 2) >50% of participants free of clinically diagnosed ASCVD; 3) adult participants ≥30 years old; 4) reported statin-associated T2D effect estimates; and 5) quantified precision using 95% confidence interval...
April 4, 2019: Diabetes Research and Clinical Practice
Eu Jeong Ku, Dong-Hwa Lee, Hyun Jeong Jeon, Tae Keun Oh
AIMS: To directly compare the effectiveness and safety between two distinct sodium-glucose co-transporter 2 (SGLT2) inhibitors, empagliflozin and dapagliflozin, as part of a quadruple oral antidiabetic agents (OADs) in patients with inadequately controlled type 2 diabetes (T2D). METHODS: This study was an open-labeled, prospective, 52-week study conducted in T2D patients with glycated hemoglobin (HbA1c ) ranging 7.5-12.0% with metformin, glimepiride and dipeptidyl peptidase-4 inhibitors...
April 4, 2019: Diabetes Research and Clinical Practice
Waleed Mohammed, Hekmat M El Magdoub, Mona Schaalan
No abstract text is available yet for this article.
April 2, 2019: Diabetes Research and Clinical Practice
Elizabeth A Mann, Scott Lunos, Elijah Carrel, Trevor Omann, Alyssa Halper, Anne Kogler, Bradley S Miller, Muna Sunni, Melena D Bellin, Brandon M Nathan
AIMS: To establish the incidence and timing of hypoglycemia at a week-long residential diabetes camp for children. We hypothesized that hypoglycemia would occur more frequently during the first two days of camp and following evening all-camp games. METHODS: 225 children (mean age 12.0 +/- 2.3 years, 56% female, mean hemoglobin A1c 8.4% [71.6 mmol/mol]) had blood glucose (BG) levels obtained before meals, at bedtime, and as needed to detect hypoglycemia. Insulin adjustments were made by medical staff according to camp protocol and at the discretion of medical staff during camper check-in...
April 2, 2019: Diabetes Research and Clinical Practice
Ebtesam M Ba-Essa, Mohammed Hassanein, Sahar Abdulrhman, Malak Alkhalifa, Zinab Alsafar
AIMS: To describe the experience and behavior of diabetes patients toward Ramadan fasting. A Secondary purpose was to describe diabetes treatment and hypoglycemia during Ramadan. METHODS: A prospective, non-randomized study for 2 years. Participants were stratified for fasting according to ADA recommendations. Results are presented using mean, standard deviation and percentages. RESULTS: Total of 400 participants, 10% with DM1 and 90% with DM2...
April 1, 2019: Diabetes Research and Clinical Practice
Pamela M Meharry, Olive Tengera, Stephen Rulisa, Adolphe Karegeya Byambu, Paul J Nietert, Samuel Byiringiro, Callixte Habimana, Crispin Gishoma, Louise R King
AIM: This study aimed to determine the prevalence of gestational diabetes mellitus (GDM) among women attending public health centers in Rwanda using the World Health Organization (WHO) 2013 diagnostic criteria. METHODS: A cross-sectional analysis was performed on 281 pregnant women attending antenatal care at urban and rural public health centers. Diagnostic testing was performed between 24 and 32 gestation using a 75 g oral glucose tolerance test. Venous plasma glucose was centrifuged within one hour and measured at one of two laboratories...
April 1, 2019: Diabetes Research and Clinical Practice
Qingchun Li, Ying Zhong, Tiansong Zhang, Ruiyun Zhang, Qi Zhang, Hangping Zheng, Lijin Ji, Wanwan Sun, Xiaoming Zhu, Shuo Zhang, Xiaoxia Liu, Bin Lu, Qian Xiong
AIMS: To examine and compare fully-automated and manually measured corneal nerve fiber parameters in type 2 diabetes mellitus (T2DM) patients with and without diabetic peripheral neuropathy (DPN) METHODS: A total of 128 T2DM subjects and 24 healthy controls underwent neuropathy assessment and bilateral corneal confocal microscopy (CCM). Five representative nerve fiber images were selected for each participant and analyzed manually and with fully-automated software. Corneal nerve fiber length (CNFL), branch density (CNBD), and fiber density (CNFD) were examined...
March 29, 2019: Diabetes Research and Clinical Practice
Yanqiong Gu, Xiujuan Su, Yuhong Li, Yuping Tang, Yirong Bao, Hao Ying
PURPOSE: The objective of this study was to estimate the combined effect of serum ferritin (SF) concentration and free thyroxine (fT4) levels on the risk of gestational diabetes mellitus (GDM). METHODS: Women presented for antenatal care at a tertiary hospital in Shanghai, China were included in this study from December 2012 to March 2014. Women were divided into six groups according to the SF and fT4 level. Multiple logistical regression model was used to estimate odds ratio (OR) among different groups...
March 29, 2019: Diabetes Research and Clinical Practice
Esmaeil Rahimi, Amirhossein Ahmadi, Mohammad Ali Boroumand, Bahram Mohammad Soltani, Mehrdad Behmanesh
AIMS: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder and its prevalence is rapidly increasing worldwide. Patients with T2DM suffer from an increased risk of vascular complications. Of these, the development of coronary artery disease (CAD) causes the most mortality in patients with T2DM, however, its underlying molecular mechanisms are not fully understood. Nutrient sensing pathways which play a key role in sensing cellular energy and nutrients levels are reported to dysregulated in metabolic disease like T2DM...
March 29, 2019: Diabetes Research and Clinical Practice
Nevena Chakarova, Rumyana Dimova, Greta Grozeva, Tsvetalina Tankova
The aim of the study was to assess glucose variability in subjects with prediabetes by means of CGM. MATERIAL AND METHODS: 32 subjects with prediabetes - mean age 56.6±9.6 years, mean BMI 30.3±5.3 kg/m2 and 18 subjects with normal glucose tolerance (NGT) - mean age 54.4±9.9 years, mean BMI 24.8±6.9 kg/m2 , were enrolled. Glucose tolerance was studied during OGTT. HbA1c was measured by NGSP certified method. CGM was performed with FreeStyle Libre Pro sensor. RESULTS: The following indices of glucose variability were significantly higher in the prediabetes group - CV (p<0...
March 29, 2019: Diabetes Research and Clinical Practice
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