Journals Diabetes Research and Clinical...

Diabetes Research and Clinical Practice
Barbara J Meyer, Colin Cortie, Marloes Dekker-Nitert, Helen L Barrett, Dilys J Freeman
AIMS: To compare maternal and fetal cord plasma and lipoprotein triglyceride (TG) concentrations in women with Gestational Diabetes Mellitus (GDM), with hyperglycaemia and hypertriglyceridaemia, and healthy women. METHODS: Fasted maternal blood at 28.6±3.4 (T1) and 36.2±1.0 (T2) [mean±S.D] weeks of gestation, and cord blood were collected. Plasma lipoprotein fractions underwent compositional analysis. RESULTS: Plasma glucose did not differ between GDM and healthy women...
September 30, 2023: Diabetes Research and Clinical Practice
Giuseppe Maltese, Theocharis Koufakis, Kalliopi Kotsa, Giorgio Basile, Richard Siow
No abstract text is available yet for this article.
September 29, 2023: Diabetes Research and Clinical Practice
Shitao Jiang, Junwei Zhang, Yaoge Liu, Ting Zhang, Han Zheng, Xinting Sang, Xin Lu, Yiyao Xu
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been linked to cognitive decline and neuropsychiatric conditions, implying a potential connection between NAFLD and brain health. However, the causal association between NAFLD and cortical changes remains uncertain. This study aimed to examine the causal impact of NAFLD on cortical structures using a two-sample Mendelian randomization (MR) approach. METHODS: Summary data from genome-wide association studies (GWAS) for NAFLD were gathered from large-scale cohorts...
September 29, 2023: Diabetes Research and Clinical Practice
Qiao Jin, Cindy Lo Kuen Lam, Eric Yuk Fai Wan
AIMS: The association of estimated glomerular filtration rate (eGFR) slope with progression of complications in people with type 2 diabetes (T2D) and early-stage chronic kidney disease (CKD) is less clear. METHODS: We identified 115,139 T2D participants without decreased eGFR (>60 mL/min/1.73 m2 ) between 2008 and 2015 from the electronic database of the Hong Kong Hospital Authority. eGFR slope calculated by linear-mixed effects model using 3-year eGFR measurements was categorized into quintiles...
September 29, 2023: Diabetes Research and Clinical Practice
Meghana D Gadgil, David M Herrington, Sukhmani K Singh, Namratha R Kandula, Alka M Kanaya
AIMS: We examined associations between lipoprotein subfractions and prevalent and incident T2D in two race/ethnically diverse cohort studies. METHODS: Adults self-identifying as White, Black, Chinese, Hispanic and South Asian-American without cardiovascular disease, with fasting serum, demographic, and clinical data at enrollment and after 5 years of follow-up were included. Lipoprotein subfractions were measured at enrollment using NMR spectrometry. LASSO regularized logistic regression models adjusted for age, sex, race/ethnicity, lipid-lowering agent use, and waist circumference assessed odds of incident T2D in pooled analyses...
September 28, 2023: Diabetes Research and Clinical Practice
Jemma Perks, Philip Mcbride, Harjeet Rayt, Tanya Payne, Charlotte Edwardson, Alex V Rowlands, Sarah Jane Messeder, Thomas Yates, Robert Sayers
INTRODUCTION: The aim of this study was to investigate the concept of an 8-week personalised activity plan, using short periods of physical activity to break up sitting time in people with Intermittent Claudication (IC), to improve walking ability, and reduce time spent sitting. METHODS: The study was designed as a single centre, single arm, before and after study and is registered with (NCT04572737). The co-primary outcomes are time spent sitting and walking ability measured via the walking impairment questionnaire...
September 27, 2023: Diabetes Research and Clinical Practice
Marco Witkowski, Yuping Wu, W H Wilson Tang, Stanley L Hazen
AIMS: Cardiovascular risk assessment beyond traditional risk factors in subjects with prediabetes is not well-established. Here, we evaluated the utility of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in predicting incident adverse cardiovascular outcomes in prediabetic subjects. METHODS: NT-proBNP was analyzed in 3,235 stable subjects with prediabetes undergoing cardiovascular risk evaluation and followed for both 3-year major adverse cardiac events (MACE; death, myocardial infarction, stroke), and 5-year all-cause mortality...
September 27, 2023: Diabetes Research and Clinical Practice
P Genève, T Adam, A Delawoevre, S Jellimann, C Legagneur, M DiPatrizio, E Renard
AIMS: To evaluate the incidence of the skin reactions secondary to continuous subcutaneous insulin infusion (CSII) or continuous glucose monitoring (CGM), sensors and the characteristics of affected children with type 1 diabetes. METHODS: An observational, retrospective, single-centre study included 198 children with type 1 diabetes, (46% girls, mean age 11.75 years). A standardised questionnaire was completed with the patient during current care to evaluate the skin reactions (mean and percentage), the type of reaction, their impact and the treatment) and the characteristics of affected children with univariate and multivariate analysis...
September 26, 2023: Diabetes Research and Clinical Practice
Mohammed Abdu Seid, Mengistie Diress, Abdulwase Mohammed, Deresse Sinamaw
INTRODUCTION: Diabetes is one of the global public health concern and constipation is frequently seen among gastrointestinal symptoms in diabetes. Despite the fact that constipation is common, doctors and/or patients disregard it. This study aimed to determine the prevalence and contributing factors of constipation in patients with diabetes. METHODS: Multi-center cross-sectional study was carried out and the data was analyzed using STATA 14. Binary and multilevel logistic regressions were also carried out to identify associated to factors...
September 25, 2023: Diabetes Research and Clinical Practice
Ishant Khurana, Natasha J Howard, Scott Maxwell, Anelle Du Preez, Harikrishnan Kaipananickal, James Breen, Sam Buckberry, Jun Okabe, Keith Al-Hasani, Soontaree Nakasatien, Thep Himathongkam, Mark E Cooper, Louise Maple-Brown, Yotsapon Thewjitcharoen, Alex Brown, Assam El-Osta
AIMS: To investigate epigenomic indices of diabetic kidney disease (DKD) susceptibility among high-risk populations with type 2 diabetes mellitus. METHODS: KDIGO (Kidney Disease: Improving Global Outcomes) clinical guidelines were used to classify people living with or without DKD. Differential gene methylation of DKD was then assessed in a discovery Aboriginal Diabetes Study cohort (PROPHECY, 89 people) and an external independent study from Thailand (THEPTARIN, 128 people)...
September 23, 2023: Diabetes Research and Clinical Practice
Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini
AIMS: Subjects with type 2 diabetes (T2D) are characterized by a high cardiovascular morbidity and mortality. MG53, a marker of peripheral insulin resistance, has been linked with impaired β-cell function and decreased β-cell survival, and its circulating levels are increased in T2D. Its relationship with the cardiovascular risk profile and mortality in T2D is currently unknown. METHODS: In this longitudinal study, MG53 was measured in serum samples collected at baseline for 296 Caucasian participants in the MIND...
September 23, 2023: Diabetes Research and Clinical Practice
Shuoyi Li, Ying Chen, Liying Zhang, Ruiying Li, Ning Kang, Jian Hou, Jing Wang, Yining Bao, Feng Jiang, Ruifang Zhu, Chongjian Wang, Lei Zhang
AIM: To explore the influencing factors of Type 2 diabetes mellitus (T2DM) in the rural population of Henan Province and evaluate the predictive ability of non-invasive factors to T2DM. METHODS: A total of 30,020 participants from the Henan Rural Cohort Study in China were included in this study. The dataset was randomly divided into a training set and a testing set with a 50:50 split for validation purposes. We used logistic regression analysis to investigate the association between 56 factors and T2DM in the training set (false discovery rate < 5%) and significant factors were further validated in the testing set (P < 0...
September 23, 2023: Diabetes Research and Clinical Practice
Christos Chatzakis, Anna Eleftheriades, Eleftheria Demertzidou, Konstantinos Dinas, Nikolaos Vlahos, Alexandros Sotiriadis, Eleftheriades Makarios
AIMS: To assess the prevalence variation in pregnancy outcomes of the different phenotypes of gestational diabetes mellitus (GDM). MATERIALS: Cohort, cross sectional and case control studies grouping together pregnant women with GDM, based on the results of oral glucose tolerance test(OGTT) and reporting pregnancy outcomes in each group, were included. The primary outcomes were (i)large for gestational age and ii)hypertensive disorders of pregnancy (HDP). The secondary outcomes included (i)insulin treatment, ii)admission to neonatal intensive care unit, iii)preterm birth, iv)small for gestational age and v)caesarean section...
September 22, 2023: Diabetes Research and Clinical Practice
Hossein Saki, Farzad Nazem, Farnaz Fariba, Reza Sheikhsharbafan
OBJECTIVE: The purpose of this research is to investigate the effect of High Intensity Interval Training and Resistance training (HIITR) on heart rate variability (HRV), blood glucose, and plasma biomarkers levels in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: 24 boys with T1D (FBS: 274.66 ± 52.99, age: 15.2 ± 1.78 years, and BMI = 19.61 ± 1.11) and 12 healthy boys (FBS: 92.75 ± 5...
September 22, 2023: Diabetes Research and Clinical Practice
Li Wen, Ya Chen, Taihang Liu, Yingxiong Wang, Philip N Baker, Hongbo Qi, Lan Wang
AIMS: To determine whether different gestational diabetes mellitus (GDM) subtypes are associated with distinct perinatal outcomes in twin pregnancies. MATERIALS: This retrospective cohort study enrolled women with twin pregnancies who gave birth at a tertiary hospital between January 2017 and December 2022. GDM was diagnosed by the IADPSG diagnostic criteria. Three subtypes of GDM were defined as only abnormal fasting glucose (OAFG) values, only abnormal post-load glucose (OAPG) values and abnormal combined fasting and post-load glucose (ACFPG) values...
September 22, 2023: Diabetes Research and Clinical Practice
Panagiotis E Chatzistergos, Alfred Gatt, Cynthia Formosa, Jonathan K Sinclair, Nachiappan Chockalingam
INTRODUCTION: Optimising the cushioning stiffness of diabetic footwear/orthoses can significantly enhance their offloading capacity. This study explores whether optimum cushioning stiffness can be predicted using simple demographic and anthropometric parameters. METHODS: Sixty-nine adults with diabetes and loss of protective sensation in their feet were recruited for this cross-sectional observational study. In-shoe plantar pressure was measured using Pedar® for a neutral diabetic shoe (baseline) and after adding cushioning footbeds of varying stiffness...
September 22, 2023: Diabetes Research and Clinical Practice
Dai Wakabayashi, Sayaka Kato, Masashi Tanaka, Hajime Yamakage, Hisashi Kato, Naoki Ozu, Shu Kasama, Masato Kasahara, Noriko Satoh-Asahara
AIMS: This cohort study intended to elucidate the association between serum uric acid (SUA) levels and cardiovascular disease events in Japanese patients with obesity. METHODS: Altogether, 450 obese Japanese outpatients were enrolled in a multicenter prospective cohort Japan, the Japan Obesity and Metabolic Syndrome Study. Primary analysis regarding the measurements of cardiovascular risk factors, including SUA levels, and the occurrence of macrovascular complications was based on following the participants over a 5-year period...
September 22, 2023: Diabetes Research and Clinical Practice
McKenzie K Roddy, Andrew J Spieker, Lyndsay A Nelson, Robert A Greevy, Lauren M LeStourgeon, Erin M Bergner, Merna El-Rifai, Tom A Elasy, James E Aikens, Ruth Q Wolever, Lindsay S Mayberry
AIMS: Type 2 diabetes self-management occurs within social contexts. We sought to test the effects of Family/friends Activation to Motivate Self-care (FAMS), a self-care support intervention delivered via mobile phones, on psychosocial outcomes for persons with diabetes (PWDs) and their support persons. METHODS: PWDs had the option to enroll with a friend/family member as a support person in a 15-month RCT to evaluate FAMS versus enhanced usual care. FAMS included 9-months of monthly phone coaching and text message support for PWDs, and text message support for enrolled support persons...
September 22, 2023: Diabetes Research and Clinical Practice
Pascaline Cattrysse, Despoina Manousaki
No abstract text is available yet for this article.
September 21, 2023: Diabetes Research and Clinical Practice
Toni Mora, David Roche, Beatriz Rodríguez-Sánchez
AIMS: Using machine learning algorithms and administrative data, we aimed to predict the risk of being diagnosed with several diabetes-related complications after one-, two- and three-year post-diabetes diagnosis. METHODS: We used longitudinal data from administrative registers of 610,019 individuals in Catalonia with a diagnosis of diabetes and checked the presence of several complications after diabetes onset from 2013-2017: hypertension, renal failure, myocardial infarction, cardiovascular disease, retinopathy, congestive heart failure, cerebrovascular disease, peripheral vascular disease and stroke...
September 16, 2023: Diabetes Research and Clinical Practice
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