Allen J Wilcox, Jonathan M Snowden, Kelly Ferguson, Jennifer Hutcheon, Olga Basso
No abstract text is available yet for this article.
March 2, 2024: European Journal of Epidemiology
Louise A C Millard, George Davey Smith, Kate Tilling
Mendelian randomization may give biased causal estimates if the instrument affects the outcome not solely via the exposure of interest (violating the exclusion restriction assumption). We demonstrate use of a global randomization test as a falsification test for the exclusion restriction assumption. Using simulations, we explored the statistical power of the randomization test to detect an association between a genetic instrument and a covariate set due to (a) selection bias or (b) horizontal pleiotropy, compared to three approaches examining associations with individual covariates: (i) Bonferroni correction for the number of covariates, (ii) correction for the effective number of independent covariates, and (iii) an r2 permutation-based approach...
February 29, 2024: European Journal of Epidemiology
Christoffer Polcwiartek, Mikkel Porsborg Andersen, Helle Collatz Christensen, Christian Torp-Pedersen, Kathrine Kold Sørensen, Kristian Kragholm, Claus Graff
The electrocardiogram (ECG) is a non-invasive diagnostic tool holding significant clinical importance in the diagnosis and risk stratification of cardiac disease. However, access to large-scale, population-based digital ECG data for research purposes remains limited and challenging. Consequently, we established the Danish Nationwide ECG Cohort to provide data from standard 12-lead digital ECGs in both pre- and in-hospital settings, which can be linked to comprehensive Danish nationwide administrative registers on health and social data with long-term follow-up...
February 26, 2024: European Journal of Epidemiology
Guoqiao Zheng, Subhayan Chattopadhyay, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identified with expression quantitative trait loci in blood, which should be associated with systolic blood pressure to proxy for the effect of antihypertensive drug...
February 24, 2024: European Journal of Epidemiology
Jonathan Groot, Amélie Keller, Torben Sigsgaard, Steffen Loft, Anne-Marie Nybo Andersen
BACKGROUND: The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative rates. OBJECTIVES: To determine risk of RTIs in children ages 11 and 12 by residential exposures. METHODS: We included children in the Danish National Birth Cohort (DNBC) at ages 11 and 12. We estimated incidence risk ratios (IRR) and 95% confidence intervals (CI) for counts of RTIs within the last year by exposure to mold/dampness, gas stove usage, summer and winter candle-burning, fireplace usage, cats and dogs indoors, and farmhouse living...
February 23, 2024: European Journal of Epidemiology
Jochen K Lennerz, Nick Schneider, Karl Lauterbach
Health data integrity, as an emergent concept, stands to reshape the lifecycle of data-driven healthcare and research, ensuring a shared commitment to ethical practices and improved patient care.
February 15, 2024: European Journal of Epidemiology
Domantas Jasilionis, Alyson van Raalte, Sebastian Klüsener, Pavel Grigoriev
No abstract text is available yet for this article.
February 12, 2024: European Journal of Epidemiology
M Arfan Ikram, Brenda C T Kieboom, Willem Pieter Brouwer, Guy Brusselle, Layal Chaker, Mohsen Ghanbari, André Goedegebure, M Kamran Ikram, Maryam Kavousi, Rob J de Knegt, Annemarie I Luik, Joyce van Meurs, Luba M Pardo, Fernando Rivadeneira, Frank J A van Rooij, Meike W Vernooij, Trudy Voortman, Natalie Terzikhan
The Rotterdam Study is a population-based cohort study, started in 1990 in the district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the prevalence and incidence, unravel the etiology, and identify targets for prediction, prevention or intervention of multifactorial diseases in mid-life and elderly. The study currently includes 17,931 participants (overall response rate 65%), aged 40 years and over, who are examined in-person every 3 to 5 years in a dedicated research facility, and who are followed-up continuously through automated linkage with health care providers, both regionally and nationally...
February 7, 2024: European Journal of Epidemiology
Juha Luukkonen, Heta Moustgaard, Pekka Martikainen, Hanna Remes
The association between having older siblings and decreased risk for atopic symptoms is well-established. This has been interpreted as evidence for the microbiota hypothesis, i.e. that increased early-childhood microbial exposure caused by siblings protects from immune hypersensitivities. However, possible confounders of the association have received little attention. We used register data on Finnish cohorts born in 1995-2004 (N = 559,077) to assess medication purchases for atopic diseases: antihistamines, eczema medication, asthma medication and Epinephrine...
February 6, 2024: European Journal of Epidemiology
Michele Sassano, Giulia Collatuzzo, Federica Teglia, Paolo Boffetta
BACKGROUND: Diesel exhaust (DE) is human carcinogen with sufficient evidence only for lung cancer. Systematic evidence on other cancer types is scarce, thus we aimed to systematically review current literature on the association between occupational DE exposure and risk of liver and pancreatic cancers. METHODS: We performed a systematic literature review to identify cohort studies on occupational DE exposure and risk of cancers other than lung. We computed pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) for liver and pancreatic cancers using DerSimonian and Laird random-effects model...
January 30, 2024: European Journal of Epidemiology
Michael Lawton, Yoav Ben-Shlomo, Apostolos Gkatzionis, Michele T Hu, Donald Grosset, Kate Tilling
Identifying factors that are causes of disease progression, especially in neurodegenerative diseases, is of considerable interest. Disease progression can be described as a trajectory of outcome over time-for example, a linear trajectory having both an intercept (severity at time zero) and a slope (rate of change). A technique for identifying causal relationships between one exposure and one outcome in observational data whilst avoiding bias due to confounding is two sample Mendelian Randomisation (2SMR). We consider a multivariate approach to 2SMR using a multilevel model for disease progression to estimate the causal effect an exposure has on the intercept and slope...
January 28, 2024: European Journal of Epidemiology
Mingyang Song, Michael Bretthauer
No abstract text is available yet for this article.
January 23, 2024: European Journal of Epidemiology
Rilla Tammi, Niina E Kaartinen, Kennet Harald, Mirkka Maukonen, Heli Tapanainen, Stephanie A Smith-Warner, Demetrius Albanes, Johan G Eriksson, Pekka Jousilahti, Seppo Koskinen, Maarit A Laaksonen, Sanna Heikkinen, Janne Pitkäniemi, Anne-Maria Pajari, Satu Männistö
OBJECTIVES: Shifting from animal-based to plant-based diets could reduce colorectal cancer (CRC) incidence. Currently, the impacts of these dietary shifts on CRC risk are ill-defined. Therefore, we examined partial substitutions of red or processed meat with whole grains, vegetables, fruits or a combination of these in relation to CRC risk in Finnish adults. METHODS: We pooled five Finnish cohorts, resulting in 43 788 participants aged ≥ 25 years (79% men)...
January 23, 2024: European Journal of Epidemiology
Andrew W Swartz
No abstract text is available yet for this article.
January 22, 2024: European Journal of Epidemiology
Marko Mandic, Hengjing Li, Fatemeh Safizadeh, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
No abstract text is available yet for this article.
January 17, 2024: European Journal of Epidemiology
Lei Clifton, Xiaonan Liu, Jennifer A Collister, Thomas J Littlejohns, Naomi Allen, David J Hunter
The UK Biobank has made general practitioner (GP) data (censoring date 2016-2017) available for approximately 45% of the cohort, whilst hospital inpatient and death registry (referred to as "HES/Death") data are available cohort-wide through 2018-2022 depending on whether the data comes from England, Wales or Scotland. We assessed the importance of case ascertainment via different data sources in UKB for three diseases that are usually first diagnosed in primary care: Parkinson's disease (PD), type 2 diabetes (T2D), and all-cause dementia...
January 16, 2024: European Journal of Epidemiology
Fabien de Oliveira, Lucas Léger, Vincent Costalat, Ihssen Belhadj, Maxime Pastor, Héléne de Forges, Jean-Paul Beregi, Thierry Boudemaghe, Julien Frandon
No abstract text is available yet for this article.
January 14, 2024: European Journal of Epidemiology
Aiping Fang, Yue Zhao, Ping Yang, Xuehong Zhang, Edward L Giovannucci
We summarized the current evidence on vitamin D and major health outcomes from Mendelian randomization (MR) studies. PubMed and Embase were searched for original MR studies on vitamin D in relation to any health outcome from inception to September 1, 2022. Nonlinear MR findings were excluded due to concerns about the validity of the statistical methods used. A meta-analysis was preformed to synthesize study-specific estimates after excluding overlapping samples, where applicable. The methodological quality of the included studies was evaluated according to the STROBE-MR checklist...
January 12, 2024: European Journal of Epidemiology
Marina Dehara, Susanna Kullberg, Marie Bixo, Michael C Sachs, Johan Grunewald, Elizabeth V Arkema
Sarcoidosis incidence peaks in women between 50 and 60 years old, which coincides with menopause, suggesting that certain sex hormones, mainly estrogen, may play a role in disease development. We investigated whether menopausal hormone therapy (MHT) was associated with sarcoidosis risk in women and whether the risk varied by treatment type. We performed a nested case-control study (2007-2020) including incident sarcoidosis cases from the Swedish National Patient Register (n = 2593) and matched (1:10) to general population controls (n = 20,003) on birth year, county, and living in Sweden at the time of sarcoidosis diagnosis...
January 12, 2024: European Journal of Epidemiology
Ben Schöttker, Bernd Holleczek, Sandra Hybsier, Josef Köhrle, Lutz Schomburg, Hermann Brenner
BACKGROUND: Selenium is an essential trace mineral. The main function of selenoprotein P (SELENOP) is to transport selenium but it has also been ascribed anti-oxidative effects. METHODS: To assess the association of repeated measurements of serum SELENOP concentration with all-cause and cause-specific mortality serum SELENOP was measured at baseline and 5-year follow-up in 7,186 and 4,164 participants of the ESTHER study, a German population-based cohort aged 50-74 years at baseline...
January 10, 2024: European Journal of Epidemiology
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