Syed Saad Salman, Balamurugan Thirunavukkarasu, Rajni Yadav, Vishal Singh Chauhan, Raja Shekar Peddinti, Shalimar, Shivanand Gamanagatti
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults occurring in a background of cirrhosis. Peritoneal dissemination of HCC is an unusual presentation with an incidence of 2%-16%. Peritoneal metastasis of an unruptured HCC is extremely uncommon. Despite low yield, ascitic fluid cytology serves as a valuable tool for diagnostic evaluation in a patient of cirrhosis with suspicion of malignant transformation. We present a rare case scenario in an elderly female with cirrhosis where the diagnosis of peritoneal metastasis was established on ascitic fluid cytology and confirmed by immunocytochemistry...
November 30, 2023: Diagnostic Cytopathology
Ghulam Ghous, Komal Ijaz, Magda Esebua, Lester J Layfield
BACKGROUND: Next generation sequencing (NGS) is standard of care for workup of many neoplasms including adenocarcinomas of the lung. Molecular testing of cytology samples is used for many types of neoplasms but the value of such testing for the selection of "first"- and "second-line" treatment protocols is incompletely understood. METHODS: Fifty-six sequentially performed cytology specimens (49 fine needle aspirates and 7 fluids) submitted for molecular analysis were reviewed by a medical oncologist to determine specimen adequacy and utility of results for therapy selection...
November 28, 2023: Diagnostic Cytopathology
Daisuke Hachisuka, Satsuki Nakano, Hiroshi Takase, Mio Sugiyama, Mariko Sugiura, Keiichiro Fujii, Ayako Masaki, Takayuki Murase, Hiroshi Inagaki
BACKGROUND: Periodic acid Schiff (PAS) staining which detects glycogen and mucosubstances is frequently used as an ancillary method for an accurate cytopathologic diagnosis. Unfortunately, cytologic slides for PAS stain are not routinely prepared. Aqueous 7-amino-4-methylcoumarin (AMC) is colorless and transparent under bright field illumination but exhibits strong fluorescence under ultraviolet (UV) light and can be used as a Schiff reagent. We recently reported that combining [author: Please define (H&E) in the first occurrence if necessary...
November 24, 2023: Diagnostic Cytopathology
Adam Kowalewski, Hubert Tissot, Nina Jehanno, Elwira Bakuła Zalewska, Olivier Choussy, Maria Lesnik, Nathalie Badois, Guillaume Rougier, Jerzy Klijanienko
Limited evidence exists regarding the 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (FDG) avidity of Warthin tumors, the second most common benign parotid gland tumor. This study aims to clarify this aspect by analyzing patients who underwent FDG positron emission tomography/computed tomography (PET/CT) and quantifying tumor standardized uptake values (SUV). Medical records of 29 patients with fine needle aspiration (FNA)-confirmed Warthin tumors who underwent FDG-PET/CT near the diagnosis of Warthin tumor were reviewed...
November 22, 2023: Diagnostic Cytopathology
Yubo Wu, Marcos Lepe
Fine needle aspirations (FNAs) are a valuable tool for the diagnosis of a wide variety of lesions. However, obtaining proficiency in performing FNAs and finding simulated scenarios where one can practice specimen adequacy and slide smearing can all be challenging. Benchtop FNAs of fresh surgical specimens offer a novel training opportunity that addresses these needs. In this study, we describe the feasibility and practicality of benchtop FNAs of fresh surgical specimens as a training tool. We performed benchtop FNAs on multiple specimen types, although most were partial and radical nephrectomies...
November 22, 2023: Diagnostic Cytopathology
Zhihua Lan, Jing Zhang, Jianping Li, Rongfang He
BACKGROUND: Ultrasound-guided fine-needle aspiration cytology (FNAC) is a routine preoperative method for evaluating suspicious axillary lymph nodes (ALNs) in patients with breast cancer. However, a range of reasons such as morphological pitfalls, technical artifacts, and sampling errors restrict the sensitivity and accuracy of FNAC. This retrospective study investigated the diagnostic value of GATA-binding protein 3 (GATA-3) immunocytochemistry for FNAC. METHODS: Breast cancer patients who underwent preoperative FNAC for suspicious ALNs, relevant GATA-3 immunocytochemistry, and postoperative status of ALNs were reviewed from the period of March 2020 to February 2022...
November 14, 2023: Diagnostic Cytopathology
Parikshaa Gupta, Sanjoli Chugh, Nalini Gupta, Kirti Gupta, Kushaljit Singh Sodhi, Nandita Kakkar, Radhika Srinivasan, Manish Rohilla, Reetu Kundu, Amita Trehan, Deepak Bansal, Nitin James Peters
INTRODUCTION: Pleuropulmonary blastoma (PPB) is a rare, aggressive, primary intrathoracic malignancy typically seen in infancy and early childhood. Accurate distinction from congenital cystic lung lesions is crucial due to significant prognostic and therapeutic differences. Cytologic features have rarely been described. Establishing a cytodiagnosis is challenging owing to its rarity, lack of awareness, and multiple morphologic mimics. MATERIALS AND METHODS: This was a retrospective study conducted over 8 years...
November 14, 2023: Diagnostic Cytopathology
G Anju, Meenakshi Rao, Aasma Nalwa, Dharma Ram Poonia
Secretory carcinoma is a relatively recently discovered low-grade salivary gland carcinoma with morphological similarities to its breast counterpart. The histopathological features of this entity are well established; however, the cytomorphological features are not well evaluated, leading to diagnostic challenges and pitfalls. We report a case of secretory carcinoma (SC) of the parotid gland, which was misdiagnosed as acinic cell carcinoma (ACC) on fine-needle aspiration cytology, to describe the cytological features...
November 11, 2023: Diagnostic Cytopathology
Gloria H Sura, Michael J Thrall, John Rogers, Parsa Hodjat, Paul Christensen, Trisha D Cubb, Helmi S Khadra, Jessica S Thomas, Elizabeth M Jacobi
INTRODUCTION: Thyroid malignancy is one of the most common types of cancer in developed nations. Currently, fine-needle aspiration cytology (FNAC) is the most practical screening test for thyroid nodules. However, cytologically indeterminate samples comprise approximately 15%-30% of cases. These include cases classified as atypia of undetermined significance (AUS), follicular neoplasm (FN), and suspicious for malignancy (SFM). Indeterminate cases can be sent for molecular testing for more definitive classification to help guide management and prevent overtreatment of benign thyroid nodules...
November 10, 2023: Diagnostic Cytopathology
Phiza Aggarwal, Uma Handa, Ranjeev Bhagat, Deepak Aggarwal
BACKGROUND: Malignancy in pleural effusion is an indication of poor prognosis. The distinction between malignant cells and reactive mesothelial cells in effusion cytology is sometimes difficult and requires ancillary techniques. Evaluation of morphological indicators of chromosomal instability (CI) like micronuclei (MN), chromatin bridging (CB), nuclear budding (NB), and multipolar mitosis (MM) on routine cytology smears is a promising tool to distinguish malignant from benign ascitic fluids...
November 9, 2023: Diagnostic Cytopathology
Ilias P Nikas, Soo-Young Park, Min Ji Song, Cheol Lee, Han Suk Ryu
AIM: To compare the immunochemical expression of EGFR, PD-L1, and the mismatch repair (MMR) proteins MLH1, PMS2, MSH2, and MSH6 between matched malignant effusions obtained before and following the administration of chemotherapy in patients with high-grade serous tubo-ovarian carcinoma (HGSC). METHODS: In the enrolled HGSCs, matched formalin-fixed and paraffin-embedded cell blocks (CBs) from effusions sampled before (treatment-naïve patients) and during recurrence (following chemotherapy administration), in addition to their matched HGSC tissues obtained from the ovaries at initial diagnosis (treatment-naïve patients), were subjected to EGFR, PD-L1, and MMR immunochemical analysis...
November 8, 2023: Diagnostic Cytopathology
Muzaffer Serdar Deniz, Merve Dindar
No abstract text is available yet for this article.
November 6, 2023: Diagnostic Cytopathology
Hinpetch Daungsupawong, Viroj Wiwanitkit
No abstract text is available yet for this article.
November 5, 2023: Diagnostic Cytopathology
Oindrila Das, Md Mohin, Soumya Dey, Anish Kar, Pankaj Singhania, Souvik Adhikari, Subhankar Chowdhury, Uttara Chatterjee
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm causing tumor-induced osteomalacia (TIO) and is characterized by secretion of FGF23, renal phosphate wasting and hypophosphataemia. It can be completely cured by resection and therefore its diagnosis is of utmost importance. Although the histology is well described, there is sparse literature on cytology of PMT and only three cases have been described so far. A 45-year-old lady presented with a non-tender mass in hard palate for 2 years from which fine-needle aspiration was done...
October 28, 2023: Diagnostic Cytopathology
Hiroe Niwa, Kazumi Mukai, Iyo Kimura, Johji Imura
Extranodal NK/T-cell lymphoma (ENKTL), nasal type, is often seen in the head and neck region, but there have been rare instances of this disease with initial presentation as a lesion in the oral mucosa. The patient, a woman in her seventh decade of life, presented with an ulcer in the maxillary gingiva, and scraping cytology and biopsy were performed. Cytological specimens showed solitary or small aggregating cells with marked atypia in a necrotic background. Tumor cells were detected that had various nuclear shapes and azure granules in the cytoplasm...
October 27, 2023: Diagnostic Cytopathology
Naoki Yamao, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Tomo Ishisaka, Akira Miyauchi, Takashi Akamizu
BACKGROUND: Medullary thyroid carcinoma (MTC) with papillary-like nuclear features has not been previously described. Here, we aimed to describe the unique features of MTC and examine their prognostic value as markers of high-grade MTC. METHODS: Of the 110 MTC patients reviewed, a total of five (4.5%) who exhibited MTC with papillary-like nuclear features based on observations from cytological preparations were included in this study. Papillary-like nuclear features were defined as exhibiting all of the following characteristics: ground-glass chromatin pattern, grooves, indented membrane, and lobulation...
October 16, 2023: Diagnostic Cytopathology
Yin Huei Pang, Li Yin Ooi
Squamoid cyst of pancreatic duct is a rare benign pancreatic lesion that is rarely encountered in fine-needle aspiration (FNA) and surgical resection specimens. Pancreatic stones can be seen in chronic pancreatitis, but stone-related crystals have previously not been described in pancreatic cytology. Presented here is a case report of a squamoid cyst of pancreatic duct with concurrent pancreatic duct stones. We describe the cytomorphology of this benign cyst, as well as the remarkable finding of polymorphous crystals on cyst fluid aspirate...
October 14, 2023: Diagnostic Cytopathology
Vanlal Hruaii, Balamurugan Thirunavukkarasu, Vindhya Prabha, Sandeep Mathur, Venkateswaran K Iyer, Aruna Nambirajan, Deepali Jain
BACKGROUND: Claudin-4, a tight junction associated protein expressed in epithelial cells, is purported as a highly specific and sensitive marker for epithelial malignancies. Our aim was to assess the sensitivity, specificity and real-time utility of claudin-4 immunocytochemistry (ICC) in the diagnostic work-up of suspected malignant effusions. METHODS: Claudin-4 (3E2C1 clone) ICC was performed prospectively in effusion cell blocks where other ICC markers were being performed as part of reporting over 3 months...
October 13, 2023: Diagnostic Cytopathology
Adil Aziz Khan, Sana Ahuja, Sufian Zaheer, Charanjeet Ahluwalia, Mukul Singh, Sachin Kolte, Sunil Ranga
BACKGROUND: Granulomatous mastitis (GM) is often clinico-radiologically misdiagnosed as breast malignancy. Tuberculosis, foreign body reactions, fungal and parastic infections, and autoimmune diseases can cause GM. The present study aimed to assess the spectrum of GM on fine-needle aspiration biopsy (FNAB) smears along with its histopathological and clinico-radiological findings. MATERIALS AND METHODS: It was a retrospective study which included all cases of GM diagnosed on FNAB over a period of 3 years...
October 13, 2023: Diagnostic Cytopathology
Archit Goel, Gargi Kapatia, Amber Parwaiz, Shruti Gupta
No abstract text is available yet for this article.
October 12, 2023: Diagnostic Cytopathology
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