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Diagnostic Cytopathology

Fumikazu Kimura, Takaki Kobayashi, Ryo Kanai, Yukihiro Kobayashi, Ohtani Yuhi, Hiroyoshi Ota, Masahiro Yamaguchi, Yoshiharu Yokokawa, Takeshi Uehara, Keiko Ishii
BACKGROUND: Lobular endocervical glandular hyperplasia (LEGH) was first described by Nucci et al. in 1999 and is believed to be a precancerous lesion of minimal deviation adenocarcinoma and gastric-type adenocarcinoma in the uterine cervix. LEGH lesions do not always exhibit apparent cellular and structural atypia, so are difficult to distinguish from normal endocervical cells (EC cells) with cytological examination. Therefore, we often struggle to make a definite diagnosis of LEGH. METHODS: We used microscopy images of cytological specimens that were diagnosed as EC cells and LEGH cells...
February 13, 2019: Diagnostic Cytopathology
Pooja Sharma, Priya Pathak, Aditi Goyal, Sonal Sharma
BACKGROUND: Scalp lesions are frequently encountered in clinical practice. Fine-needle aspiration cytology (FNAC) can characterize most of these lesions; however, there is little published work on cytology of scalp lesions. METHODS: Records of all the patients subjected to FNAC from January 2011 to August 2016 were retrieved from the archives of the Cytopathology section of our Institute. Out of the 71 852 cases reviewed, 896 patients, who presented with palpable scalp lesions, were included in the study...
February 13, 2019: Diagnostic Cytopathology
Estelle Dubruc, Maria Teresa Alvarez Flores, Yannick Bernier, Lucia Gherasimiuc, Alexandre Ponti, Patrice Mathevet, Massimo Bongiovanni
Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare uterine neoplasms of uncertain etiology that resemble the sex cord tumors of the ovary and display a combined sex cord, epithelial, and smooth muscle immunophenotype. Most tumors are associated with a benign clinical course. We report the first cytological description of uterine UTROSCTs in liquid-based cervical cytology (LBC). A menopausal woman was discovered to have a uterine intraluminal polypoid mass protruding through the vagina. A Pap test was performed, and the LBC preparation showed isolated tumor cells with scant cytoplasm and slightly irregular, ovoid nuclei with fine chromatin and small nucleoli...
February 13, 2019: Diagnostic Cytopathology
Kimiaki Okano, Tomoko Arimoto, Mitsuaki Ishida, Kaori Sandoh, Takuo Fujisawa, Hiroshi Iwai, Koji Tsuta
No abstract text is available yet for this article.
February 12, 2019: Diagnostic Cytopathology
Ryota Tanaka, Norihiko Sakamoto, Hitomi Suzuki, Keisei Tachibana, Kouki Ohtsuka, Koji Kishimoto, Masachika Fujiwara, Hiroshi Kamma, Junji Shibahara, Haruhiko Kondo
BACKGROUND: Liquid-based cytology (LBC) samples allow immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and molecular testing of nucleic acids to be performed in the remaining fixed cells. The current study aimed to examine the relationship between gene mutational status and cytomorphological features in primary lung adenocarcinoma (ADC) using LBC materials. METHODS: Forty consecutive patients with primary lung ADC underwent surgical resection in our hospital...
February 11, 2019: Diagnostic Cytopathology
Krithika Damodar Shenoy, Nicholas Stanzione, Justin E Caron, Gregory A Fishbein, Fereidoun Abtin, Gentian Lluri, Sharon L Hirschowitz
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare and aggressive subset of poorly differentiated squamous cell carcinoma that is defined by t(15,19) and typically presents in the midline structures of the head, neck, and mediastinum. We report two cases of NMC that presented uniquely with malignant pleural and pericardial effusions including one with cardiac tamponade at presentation. The first case is of a 25-year-old male patient who presented with progressive dyspnea associated with palpitations and dizziness on standing, found to have large bilateral pleural effusions...
February 8, 2019: Diagnostic Cytopathology
Chie Hayakawa, Masahiro Hoshikawa, Johji Imura, Takahiko Ueno, Junki Koike
BACKGROUND: Benign and malignant cells need to be distinguished in any cytological examination of bile. Here, we report an original scoring system to improve the diagnostic accuracy of bile cytology. METHODS: The study used 158 bile aspiration samples obtained for cytological examination. Fourteen cytological findings were used to differentiate benign and malignant samples. Statistical significance tests and multivariate analysis were used to determine and quantify significant findings and develop a scoring system...
February 7, 2019: Diagnostic Cytopathology
Kimiaki Okano, Mitsuaki Ishida, Kaori Sandoh, Tomomi Mizokami, Masato Kita, Hidetaka Okada, Koji Tsuta
BACKGROUND: Carcinosarcoma of the endometrium is a relatively rare but aggressive neoplasm. Endometrial cytological features of this type of tumor have been rarely reported. This study aimed to clarify the usefulness of endometrial cytological examination in the diagnosis of endometrial carcinosarcoma. METHODS: Patients histopathologically diagnosed with endometrial carcinosarcoma who underwent preoperative endometrial or endocervical cytological examination were enrolled...
February 1, 2019: Diagnostic Cytopathology
Austin Blackburn Wiles, Adele O Kraft, Sandra M Mueller, Celeste N Powers
Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare primary cancer of the thyroid. This tumor is analogous to other primary tumors of the salivary glands, breast, pancreas, and esophagus. We present a case of this rare tumor with characteristic clinical features, ultrasound images, cytopathology, histopathology, and a heretofore undocumented somatic gene mutation. Additionally, we provide a succinct review of the controversial literature for this uncommon lesion.
January 24, 2019: Diagnostic Cytopathology
Sunayana Misra, R K Saran, Siddharth Srivastava, Sandip Barman, Amol Dahale
BACKGROUND: Pancreatic solid pseudopapillary tumor (SPN) and pancreatic neuroendocrine tumors (Pan-NET) have close resemblance on imaging and cytomorphology, though they differ in their prognosis and treatment strategy. SPNs are low-grade indolent tumors while Pan-NETs harbor malignant potential with propensity to metastasize. We aim to differentiate SPN from Pan-NET based on cyto-morphology; to classify nuclear membrane (NM) irregularities or nuclear folds into four grades and see whether they bear any difference with respect to the two entities...
January 24, 2019: Diagnostic Cytopathology
Nighat Hussain, Tummidi Santosh, Amit Bugalia
No abstract text is available yet for this article.
January 16, 2019: Diagnostic Cytopathology
Jordan E Baum, Lauren Soong, Theresa Scognamiglio, Elizabeth M Margolskee, Rana S Hoda, Rema Rao
BACKGROUND: The tall cell variant of papillary thyroid carcinoma (PTC-TC) has been associated with aggressive features including extrathyroidal extension, higher rate of lymph node and distant metastases, and higher recurrence rate. We aimed to evaluate the cytomorphologic features of PTC-TC on ThinPrep (TP) along with its diagnostic efficacy to detect PTC-TC. METHODS: Preoperative cytology samples from 30 cases of histologically-proven PTC-TC and 30 classical PTC controls were selected for this study...
January 16, 2019: Diagnostic Cytopathology
Manjari Kishore, Manju Kaushal, Sadhna Marwah, Megha Sharma, Nishi Sharma, Vishakha Mittal
Extramedullary hematopoeisis (EMH), also known as myeloid metaplasia can be seen in association with various hematological disorders. The common sites of EMH are liver, spleen and lymph nodes; but it can occur in almost any organ and in numerous locations. Involvement of the thyroid gland with EMH has rarely been reported. We present a case of EMH in the thyroid gland in an adult female diagnosed on fine-needle aspiration cytology (FNAC) which further helped in revealing an underlying myeloproliferative neoplasm; chronic myeloid leukemia (CML)...
January 15, 2019: Diagnostic Cytopathology
Juan B Laforga, Virginia A Cortés
We report the cytohistologic and immunohistochemical findings of an oncocytic variant of poorly differentiated thyroid carcinoma in a 76-year old man with a prior history of prostatic adenocarcinoma. The man complained of a palpable nodule in the right thyroid lobe and cervical lymph node. Fine-needle aspiration (FNA) in both cases yielded solid clusters of cells/insulae, microfollicles, and isolated atypical cells. Considering the patient's past history, an initial diagnosis of metastasis from prostate adenocarcinoma was considered...
January 13, 2019: Diagnostic Cytopathology
Hsiao-Ching Chen, Kuo-Ming Chang, Wen-Ko Su
Pharyngeal or Zenker's diverticulum is an infrequent disorder that results from an outpouching of pharyngeal mucosa through a weakened area in the posterior pharyngeal wall. As it may mimic a thyroid nodule on ultrasonography (US), accurate diagnosis is important to ensure appropriate treatment. Fine-needle aspiration (FNA) is recommended for the initial evaluation of thyroid nodules. We report the FNA diagnosis of two cases of Zenker's diverticulum that were suspected to be thyroid nodules on US. Pap stained aspirate smears showed findings characteristic of Zenker's diverticulum: benign squamous cells, bacteria, and vegetable debris and the absence of colloid and/or thyroid epithelial cells...
January 10, 2019: Diagnostic Cytopathology
Cheng-Chieh Chen, Yuh-Yu Chou
BACKGROUND: Anal intraepithelial neoplasia (AIN) refers to a precancerous lesion of anal squamous cell carcinoma (SCC). Human papillomavirus (HPV) is considered a crucial risk factor for AIN. Individuals with high-risk sexual behaviour, such as receptive anal intercourse and multiple sexual partners, as well as men who have sex with men exhibit a relatively high rate of AIN. The anal cytology is a screening method for AIN in high-risk individuals, and patients with abnormal anal cytology may benefit from high-resolution anoscopy...
January 3, 2019: Diagnostic Cytopathology
Yanlin Zhang, Xiaomeng Yu, Yan Yang, Yunhong Wang, Shuyuan Chen, Xiaoge Zhou
OBJECTIVE: This study aimed to investigate the diagnostic utility of immunohistochemistry (IHC) analysis (FNA) and Epstein-Barr virus- (EBV) encoded small RNAs (EBERs) in situ hybridisation analyses of cell block (CB) sections obtained using fine needle aspiration in nasopharyngeal carcinoma (NPC) with lymph node metastasis. METHODS: A total of 38 FNA biopsies were collected using a Youyi aspirator. The cytomorphology, CB-based histomorphology, IHC, and EBERs in situ hybridisation were observed and the sensitivity/final diagnostic rates were compared with those of simple smears and a combination of smears and CBs...
December 28, 2018: Diagnostic Cytopathology
Prih Rohra, Fatima Mir, Diana Murro Lin, Karina Furlan, Sara Javidiparsijani, David Lucero, Paolo Gattuso
BACKGROUND: Fine-needle aspiration (FNA) of superficial and deep-seated lesions has been used with high sensitivity and specificity in the diagnosis of neoplastic and nonneoplastic lesions. However, literature of FNA in posttransplant patients is sparse, especially in postliver transplant. We undertook a retrospective study to evaluate the utility of FNA in the clinical management of post liver transplant patients. METHODS: We searched our institution's surgical/cytologic databases (November1993-February2016) to identify liver transplant cases and FNA procedures performed on allograft liver recipients...
December 28, 2018: Diagnostic Cytopathology
Jian Jing, Jonathan Edwards, Timothy Harkin, Camille Hamula, Arnold H Szporn
No abstract text is available yet for this article.
December 28, 2018: Diagnostic Cytopathology
Shintaro Sugita, Terufumi Kubo, Tomoyuki Aoyama, Jun Moriya, Tsuyoshi Okuni, Masahiko Wanibuchi, Ken Yamashita, Maki Onodera, Mitsuhiro Tsujiwaki, Keiko Segawa, Taro Sugawara, Tadashi Hasegawa
Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade spindle cell sarcoma that predominantly affects middle-aged women with multiple tumors in the sinonasal tract. BSNS shows biphenotypic expression of neural and myogenic markers on immunohistochemistry (IHC) with a specific chimeric PAX3-MAML3 fusion. The cytological features of BSNS have so far not been reported. Here, we describe a case of BSNS including findings of imprint cytology, histology, IHC, and genetic analysis. A 30-year-old woman presented with a nodular tumor that completely occupied the ethmoid sinus...
December 27, 2018: Diagnostic Cytopathology
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