Lu Yang, Tingting Zhang, Penglu Wang, Wenting Chen, Wanmei Liu, Xiaoyu He, Yuxin Zhang, Shasha Jin, Zhijie Luo, Zunjian Zhang, Xinzhi Wang, Jun Liu
V-domain immunoglobulin suppressor of T-cell activation (VISTA), an important negative checkpoint protein, participates in immunoregulation. Systemic lupus erythematosus (SLE) is an autoimmune disease in which patients exhibit high levels of autoantibodies and multi-organ tissue injury, primarily involving the kidney and skin. In wild-type (WT) mice and Vsir-/- mice with pristane-induced lupus-like disease, we found that VISTA deficiency exacerbated the lupus-like disease in mice, possibly through aberrant activation of type I interferon (IFN-I) signaling, CD4+ T cell, and noncanonical nuclear factor-κB (NF-κB) pathway...
October 7, 2023: Cell Biology and Toxicology