journal
https://read.qxmd.com/read/37941528/melatonin-rescues-the-mitochondrial-function-of-bone-marrow-derived-mesenchymal-stem-cells-and-improves-the-repair-of-osteoporotic-bone-defect-in-ovariectomized-rats
#21
JOURNAL ARTICLE
Chao Gu, Quan Zhou, Xiayu Hu, Xiaoyang Ge, Mingzhuang Hou, Wenhao Wang, Hao Liu, Qin Shi, Yong Xu, Xuesong Zhu, Huilin Yang, Xi Chen, Tao Liu, Fan He
Osteoporotic bone defects, a severe complication of osteoporosis, are distinguished by a delayed bone healing process and poor repair quality. While bone marrow-derived mesenchymal stem cells (BMMSCs) are the primary origin of bone-forming osteoblasts, their mitochondrial function is impaired, leading to inadequate bone regeneration in osteoporotic patients. Melatonin is well-known for its antioxidant properties and regulation on bone metabolism. The present study postulated that melatonin has the potential to enhance the repair of osteoporotic bone defects by restoring the mitochondrial function of BMMSCs...
November 8, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37909654/safety-and-efficacy-of-melatonin-supplementation-as-an-add-on-treatment-for-infantile-epileptic-spasms-syndrome-a-randomized-placebo-controlled-double-blind-trial
#22
JOURNAL ARTICLE
Yulin Sun, Jian Chen, Xiuyu Shi, Zhichao Li, Lin Wan, Huimin Yan, Yuehao Chen, Jiaxin Wang, Jing Wang, Liping Zou, Russel Reiter, Bo Zhang, Guang Yang
This was a prospective, randomized, double-blind, single-center placebo-controlled trial to assess the efficacy and safety of melatonin as an add-on treatment for infantile epileptic spasms syndrome (IESS). Participants aged 3 months to 2 years with a primary diagnosis of IESS were recruited and assigned to two groups in a 1:1 ratio. Both treatment groups received a combination of adrenocorticotrophic hormone (ACTH) and magnesium sulfate (MgSO4 ) for 2 weeks, and the treatment group also received melatonin (3 mg) between 20:00 and 21:00 daily, 0...
November 1, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37846173/ramelteon-attenuates-hippocampal-neuronal-loss-and-memory-impairment-following-kainate-induced-seizures
#23
JOURNAL ARTICLE
Jung Hoon Park, Yeonggwang Hwang, Yen Nhi Doan Nguyen, Hyoung-Chun Kim, Eun-Joo Shin
Evidence suggests that the neuroprotective effects of melatonin involve both receptor-dependent and -independent actions. However, little is known about the effects of melatonin receptor activation on the kainate (KA) neurotoxicity. This study examined the effects of repeated post-KA treatment with ramelteon, a selective agonist of melatonin receptors, on neuronal loss, cognitive impairment, and depression-like behaviors following KA-induced seizures. The expression of melatonin receptors decreased in neurons, whereas it was induced in astrocytes 3 and 7 days after seizures elicited by KA (0...
October 17, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37814536/melatonin-suppresses-tumor-proliferation-and-metastasis-by-targeting-gata2-in-endometrial-cancer
#24
JOURNAL ARTICLE
Yangyou Liao, Ruiling Li, Jingyuan Pei, Juan Zhang, Bo Chen, Haojie Dong, Xiaoyu Feng, Hongshuo Zhang, Yuhong Shang, Linlin Sui, Ying Kong
Endometrial cancer (EC) is a reproductive system disease that occurs in perimenopausal and postmenopausal women. However, its etiology is unclear. Melatonin (MT) has been identified as a therapeutic agent for EC; however, its exact mechanism remains unclear. In the present study, we determined that GATA-binding protein 2 (GATA2) is expressed at low levels in EC and regulated by MT. MT upregulates the expression of GATA2 through MT receptor 1A (MTNR1A), whereas GATA2 can promote the expression of MTNR1A by binding to its promoter region...
October 9, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37794846/melatonin-alters-the-excitability-of-mouse-cerebellar-granule-neurons-by-inhibiting-voltage-gated-sodium-potassium-and-calcium-channels
#25
JOURNAL ARTICLE
Karolos-Philippos Pissas, Maria Schilling, Ahmet Korkmaz, Yuemin Tian, Stefan Gründer
Besides its role in the circadian rhythm, the pineal gland hormone melatonin (MLT) also possesses antiepileptogenic, antineoplastic, and cardioprotective properties, among others. The dosages necessary to elicit beneficial effects in these diseases often far surpass physiological concentrations. Although even high doses of MLT are considered to be largely harmless to humans, the possible side effects of pharmacological concentrations are so far not well investigated. In the present study, we report that pharmacological doses of MLT (3 mM) strongly altered the electrophysiological characteristics of cultured primary mouse cerebellar granule cells (CGCs)...
October 5, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37786974/erratum-to-mitochondrial-cytochrome-p450-cyp-1b1-is-responsible-for-melatonin-induced-apoptosis-in-neural-cancer-cells
#26
(no author information available yet)
No abstract text is available yet for this article.
October 3, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37786968/melatonin-prevents-eaac1-deletion-induced-retinal-ganglion-cell-degeneration-by-inhibiting-apoptosis-and-senescence
#27
JOURNAL ARTICLE
Chenyang Hu, Yanlin Feng, Guangyi Huang, Kaixuan Cui, Matthew Fan, Wu Xiang, Yuxun Shi, Dan Ye, Huiwen Ye, Xue Bai, Fan Xu, Yue Xu, Jingjing Huang
Normal tension glaucoma (NTG) is referred to as a progressive degenerative disorder of the retinal ganglion cells (RGCs), resulting in nonreversible visual defects, despite intraocular pressure levels within the statistically normal range. Current therapeutic strategies for NTG yield limited benefits. Excitatory amino acid carrier 1 (EAAC1) knockout (EAAC1-/- ) in mice has been shown to induce RGC degeneration without elevating intraocular pressure, mimicking pathological characteristics of NTG. In this study, we explored whether daily oral administration of melatonin could block RGCs loss and prevent retinal morphology and function defects associated with EAAC1 deletion...
October 3, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37753741/melatonin-a-potentially-effective-drug-for-the-treatment-of-infected-bone-nonunion
#28
JOURNAL ARTICLE
Han-Jun Qin, Si-Ying He, Ke Shen, Qing-Rong Lin, Yan-Jun Hu, Zi-Lin Chen, Bin Yu, Nan Jiang
Osteomyelitis (OM), characterized by heterogeneity and complexity in treatment, has a high risk of infection recurrence which may cause limb disability. Management of chronic inactive osteomyelitis (CIOM) without typical inflammatory symptoms is a great challenge for orthopedic surgeons. On the basis of data analysis of 1091 OM cases, we reported that latent osteogenic decline in CIOM patients was the main cause of secondary surgery. Our research shows that impairment of osteoblasts capacity in CIOM patients is associated with ferroptosis of osteoblasts caused by internalization of Staphylococcus aureus...
September 27, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37746893/orchestrated-feedback-regulation-between-melatonin-and-sex-hormones-involving-gper1-pka-creb-signaling-in-the-placenta
#29
JOURNAL ARTICLE
Xuan Shao, Yun Yang, Yanlei Liu, Yongqing Wang, Yangyu Zhao, Xin Yu, Juan Liu, Yu-Xia Li, Yan-Ling Wang
Maintaining placental endocrine homeostasis is crucial for a successful pregnancy. Pre-eclampsia (PE), a gestational complication, is a leading cause of maternal and perinatal morbidity and mortality. Aberrant elevation of testosterone (T0 ) synthesis, reduced estradiol (E2 ), and melatonin productions have been identified in preeclamptic placentas. However, the precise contribution of disrupted homeostasis among these hormones to the occurrence of PE remains unknown. In this study, we established a strong correlation between suppressed melatonin production and decreased E2 as well as elevated T0 synthesis in PE placentas...
September 25, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37731275/corrigendum-to-melatonin-ameliorates-pm2-5-induced-cardiac-perivascular-fibrosis-through-regulating-mitochondrial-redox-homeostasis
#30
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37721126/biosynthesis-of-neuroprotective-melatonin-is-dysregulated-in-huntington-s-disease
#31
JOURNAL ARTICLE
Jinho Kim, Wei Li, Jingjing Wang, Sergei V Baranov, Brianna E Heath, Jiaoying Jia, Yalikun Suofu, Oxana V Baranova, Xiaomin Wang, Timothy M Larkin, William R Lariviere, Diane L Carlisle, Robert M Friedlander
Huntington's disease (HD) is a progressive neurodegenerative brain disorder associated with uncontrolled body movements, cognitive decline, and reduced circulating melatonin levels. Melatonin is a potent antioxidant and exogenous melatonin treatment is neuroprotective in experimental HD models. In neurons, melatonin is exclusively synthesized in the mitochondrial matrix. Thus, we investigated the integrity of melatonin biosynthesis pathways in pineal and extrapineal brain areas in human HD brain samples, in the R6/2 mouse model of HD and in full-length mutant huntingtin knock-in cells...
September 18, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37702245/ims-bmal1-mice-show-evident-signs-of-sarcopenia-that-are-counteracted-by-exercise-and-melatonin-therapies
#32
JOURNAL ARTICLE
José Fernández-Martínez, Yolanda Ramírez-Casas, Paula Aranda-Martínez, Alba López-Rodríguez, Ramy K A Sayed, Germaine Escames, Darío Acuña-Castroviejo
Sarcopenia is an age-related disease characterized by a reduction in muscle mass, strength, and function and, therefore, a deterioration in skeletal muscle health and frailty. Although the cause of sarcopenia is still unknown and, thus, there is no treatment, increasing evidence suggests that chronodisruption, particularly alterations in Bmal1 clock gene, can lead to those deficits culminating in sarcopenia. To gain insight into the cause and mechanism of sarcopenia and the protective effect of a therapeutic intervention with exercise and/or melatonin, the gastrocnemius muscles of male and female skeletal muscle-specific and inducible Bmal1 knockout mice (iMS-Bmal1-/- ) were examined by phenotypic tests and light and electron microscopy...
September 13, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37694761/correction-to-human-transporters-pept1-2-facilitate-melatonin-transportation-into-mitochondria-of-cancer-cells-an-implication-of-the-therapeutic-potential
#33
(no author information available yet)
No abstract text is available yet for this article.
September 11, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37650128/from-gestational-chronodisruption-to-noncommunicable-diseases-pathophysiological-mechanisms-of-programming-of-adult-diseases-and-the-potential-therapeutic-role-of-melatonin
#34
REVIEW
Natalia Méndez, Fernando Corvalan, Diego Halabi, Pamela Ehrenfeld, Rodrigo Maldonado, Karina Vergara, Maria Seron-Ferre, Claudia Torres-Farfan
During gestation, the developing fetus relies on precise maternal circadian signals for optimal growth and preparation for extrauterine life. These signals regulate the daily delivery of oxygen, nutrients, hormones, and other biophysical factors while synchronizing fetal rhythms with the external photoperiod. However, modern lifestyle factors such as light pollution and shift work can induce gestational chronodisruption, leading to the desynchronization of maternal and fetal circadian rhythms. Such disruptions have been associated with adverse effects on cardiovascular, neurodevelopmental, metabolic, and endocrine functions in the fetus, increasing the susceptibility to noncommunicable diseases (NCDs) in adult life...
August 31, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37649458/the-mammalian-gastro-intestinal-tract-is-a-not-a-major-extra-pineal-source-of-melatonin-in-mammals
#35
REVIEW
David J Kennaway
In 1992, a paper reported that the melatonin content of the rat duodenum was 24 000 ± 2000 pg/g tissue (range: 4000-100 000 pg/g) while the pineal melatonin content was 580 000 ± 36 000 pg/g. The data has been used for the last 30 years to infer that the gut produces 400 hundred times more melatonin than the pineal gland and that it is the source of plasma melatonin during the daytime. No-one has ever challenged the statement...
August 31, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37649242/the-isl-lim-homeobox-2-transcription-factor-is-negatively-regulated-by-circadian-adrenergic-signaling-to-repress-the-expression-of-aanat-in-pinealocytes-of-the-rat-pineal-gland
#36
JOURNAL ARTICLE
Kuno M-J Mattern, Aurea S Blancas-Velázquez, Mikaella T Ngo, Signe Bille, Henrik Hertz, Tenna Bering, Martin F Rath
Melatonin is synthesized in the pineal gland during nighttime in response to nocturnal increase in the activity of the enzyme aralkylamine N-acetyltransferase (AANAT), the transcription of which is modulated by several homeodomain transcription factors. Recent work suggests that the homeodomain transcription factor ISL LIM homeobox 2 (ISL2) is expressed in the pineal gland, but its role is currently unknown. With the purpose of identifying the mechanisms that control pineal expression of Isl2 and the possible function of Isl2 in circadian pineal biology, we report that Isl2 is specifically expressed in the pinealocytes of the rat pineal gland...
August 30, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37602527/differentiation-of-t-cells-producing-interleukin-17-th17-against-the-background-of-exogenous-melatonin-during-pregnancy
#37
JOURNAL ARTICLE
Natalya Sergeevna Glebezdina, Irina Valerievna Nekrasova, Anna Alexandrovna Olina, Gulnara Kamilyevna Sadykova, Elena Michajlovna Kuklina
The population of T lymphocytes producing IL-17 (Th17) plays a dual role during pregnancy and its activity is tightly controlled during this period. One of the factors involved in this process may be the pineal hormone melatonin, which can effectively regulate this T cell population. Here we have shown that exogenous melatonin in pharmacological concentrations is able to enhance the differentiation of Th17 cells of pregnant women in vitro. The stimulatory effects of melatonin were limited to in the first trimester of pregnancy and were apparently mediated by both membrane and nuclear melatonin receptors...
August 21, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37584391/correction-to-high-sensitivity-of-melatonin-suppression-response-to-evening-light-in-preschool-aged-children
#38
(no author information available yet)
No abstract text is available yet for this article.
August 16, 2023: Journal of Pineal Research
https://read.qxmd.com/read/37055944/effect-of-melatonin-cream-on-acute-radiation-dermatitis-in-patients-with-primary-breast-cancer-a-double-blind-randomized-placebo-controlled-trial
#39
RANDOMIZED CONTROLLED TRIAL
Dennis Zetner, Claus Kamby, Camilla Christophersen, Sengül Gülen, Cecilie B Paulsen, Emily Piga, Bodil Hoffmeyer, Faisal Mahmood, Jacob Rosenberg
AIM: This was a double-blind, placebo-controlled randomized study investigating whether melatonin can protect against radiation dermatitis in women receiving radiation therapy for primary breast cancer. METHODS: Patients were included before radiation therapy and followed once weekly throughout treatment with a 3-week follow-up. Patients applied 1 g of cream to the irradiated skin twice daily, consisting of either 25 mg/g melatonin and 150 mg/g dimethyl sulfoxide, or placebo...
August 2023: Journal of Pineal Research
https://read.qxmd.com/read/37492880/efficacy-mechanism-and-safety-of-melatonin-loaded-on-thermosensitive-nanogels-for-rabbit-vx2-tumor-embolization-a-novel-design
#40
JOURNAL ARTICLE
Lei Chen, Tao Sun, Yongning Lv, Xin Lu, Xixuan Li, Hongsen Zhang, Kun Qian, Xiaopeng Guo, Bo Sun, Weihua Zhang, Licheng Zhu, Jia Huang, Yiming Liu, Huangxuan Zhao, Yanbin Zhao, Bin Liang, Chuansheng Zheng
Transarterial chemoembolization (TACE) has been widely used for hepatocellular carcinoma (HCC). Reducing hypoxia in the tumor microenvironment after TACE remains a challenge as tumor progression is common in post-TACE patients due to the hypoxic tumor microenvironment. In this study, melatonin loaded on p(N-isopropyl-acrylamide-co-butyl methylacrylate) (PIB-M) was used for tumor embolism. Two types of human hepatoma cell lines were used to explore the mechanism by which melatonin prevents the growth and metastasis of cancer cells in vitro...
July 26, 2023: Journal of Pineal Research
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