Rong-rong Tao, Ji-Yun Huang, Xue-jing Shao, Wei-feng Ye, Yun Tian, Mei-hua Liao, Kohji Fukunaga, Yi-jia Lou, Feng Han, Ying-mei Lu
Clinical epidemiology has indicated that the endothelial injury is a potential contributor to the pathogenesis of ischemic neurovascular damage. In this report, we assessed S-nitrosylation and nitration of Keap1 to identify downstream nitric oxide redox signaling targets into endothelial cells during ischemia. Here, oxygen-glucose deprivation (OGD) exposure initiates the nuclear import of Keap1 in endothelial cells, which interacted with nuclear-localized Nrf2, as demonstrated through co-immunoprecipitation and immunocytochemical assay...
April 2013: Journal of Pineal Research