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European Journal of Surgical Oncology

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https://read.qxmd.com/read/31006589/salvage-surgery-for-local-regrowths-in-watch-wait-are-we-harming-our-patients-by-deferring-the-surgery
#1
Irfan Nasir, Laura Fernandez, Pedro Vieira, Oriol Parés, Inês Santiago, Mireia Castillo-Martin, Hugo Domingos, Jose F Cunha, Carlos Carvalho, Richard J Heald, Geerard L Beets, Amjad Parvaiz, Nuno Figueiredo
BACKGROUND: Rectal cancer surgery conveys significant morbidity/mortality, long-term functional impairment and urinary & sexual dysfunction, especially if associated with neoadjuvant chemoradiotherapy (ChRT). Watch & Wait (W&W) is gaining momentum as an option for patients with clinical complete response (cCR) after ChRT. Approximately 30% will develop a local regrowth (RG) and need deferred surgery. Our study aimed to assess the short-term clinical outcomes after surgery for regrowths...
April 13, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/31005469/transhiatal-distal-esophagectomy-for-siewert-type-ii-cardia-cancer-can-be-a-treatment-option-in-selected-patients
#2
Rossella Reddavid, Paolo Strignano, Silvia Sofia, Andrea Evangelista, Giacomo Deiro, Gaspare Cannata, Paolo Chiaro, Fabio Maiello, Michela Mineccia, Alessandro Ferrero, Renzo Leli, Sergio Gentilli, Roberto Polastri, Felice Borghi, Michele Camandona, Renato Romagnoli, Mario Morino, Maurizio Degiuli
BACKGROUND: While surgical treatment of Siewert I and III (S1,S3) Esophagogastric Junction (EGJ) cancer is codified, the efficay of transhiatal procedure with anastomosis in the lower mediastinum for Siewert II (S2) still remains a dibated topic. METHODS: This is a large multicenter retrospective study. The results of 598 consecutive patients submitted to resection with curative intent from January 2000 to January 2017 were reported. Clinical and oncological outcomes of different procedures performed in S2 tumor were analyzed to investigate the efficacy of transhiatal approach...
April 13, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/31005471/transarterial-chemoembolization-versus-best-supportive-care-for-patients-with-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus%C3%AF-a-multicenter-study
#3
Xiao Xiang, Wan-Yee Lau, Zhen-Yu Wu, Chao Zhao, Yi-Long Ma, Bang-De Xiang, Ji-Ye Zhu, Jian-Hong Zhong, Le-Qun Li
BACKGROUND: This study aims to compare the efficacy and safety of treatment after transarterial chemoembolization(TACE) with best supportive care (BSC) in patients with hepatocellular carcinoma (HCC) with PVTT. METHODS: This retrospective study was conducted on 1,040 patients with HCC with PVTT who were treated either with TACE (n = 675) or BSC (n = 365). BSC did not include sorafenib. The two groups of patients were compared with or without propensity score matching...
April 12, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/31003722/time-trends-of-short-term-mortality-for-octogenarians-undergoing-a-colorectal-resection-in-north-europe
#4
Y H M Claassen, E Bastiaannet, E van Eycken, N Van Damme, A Martling, R Johansson, L H Iversen, P Ingeholm, V E P P Lemmens, G J Liefers, F A Holman, J W T Dekker, J E A Portielje, H J Rutten, C J H van de Velde
BACKGROUND: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (≥80 years) with colorectal cancer across four North European countries. METHODS: Patients of 80 years or older, operated for colorectal cancer (stage I-III) between 2005 and 2014, were included...
April 9, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/31003720/impact-of-spontaneous-rupture-on-the-survival-outcomes-after-liver-resection-for-hepatocellular-carcinoma-a-propensity-matched-analysis-comparing-ruptured-versus-non-ruptured-tumors
#5
Darren W Chua, Ye-Xin Koh, John C Allen, Chung-Yip Chan, Ser-Yee Lee, Peng-Chung Cheow, Premaraj Jeyaraj, Jin-Yao Teo, Pierce K Chow, Alexander Y Chung, London L Ooi, Brian K P Goh
INTRODUCTION: Spontaneous rupture of HCC (srHCC) is a life-threatening sequela of HCC characterized by a high mortality. Liver resection (LR) is the ideal therapeutic strategy as it not only arrests hemorrhage but also remove the offending tumour. We sought to determine the impact of spontaneous rupture on the survival outcomes of patients after LR by performing a propensity score matched (PSM) analysis comparing patients who underwent LR for srHCC versus non-ruptured (nrHCC). METHODS: From 2000 to 2015, a total of 67 patients who underwent LR for srHCC which met the study criteria were included...
April 9, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/31005470/long-term-outcome-after-minimally-invasive-and-open-warshaw-and-kimura-techniques-for-spleen-preserving-distal-pancreatectomy-international-multicenter-retrospective-study
#6
Salvatore Paiella, Matteo De Pastena, Maarten Korrel, Teresa Lucia Pan, Giovanni Butturini, Chiara Nessi, Riccardo De Robertis, Luca Landoni, Luca Casetti, Alessandro Giardino, Olivier Busch, Antonio Pea, Alessandro Esposito, Marc Besselink, Claudio Bassi, Roberto Salvia
BACKGROUND: The Warshaw (WT) and the Kimura (KT) techniques are both used for open or minimally invasive (MI) spleen preserving distal pancreatectomy (SPDP). Multicenter studies on long-term outcome of WT and KT are lacking. METHODS: Multicenter retrospective study with transversal follow-up moment, including patients who underwent SPDP from 2000 to 2017 at three high-volume centers in Italy and the Netherlands. Primary endpoint was the incidence of short and long term complications...
April 8, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30982656/poor-compliance-with-perioperative-chemotherapy-for-resectable-gastric-cancer-and-its-impact-on-survival
#7
Margreet van Putten, Valery E P P Lemmens, Hanneke W M van Laarhoven, Hans F M Pruijt, Grard A P Nieuwenhuijzen, Rob H A Verhoeven
BACKGROUND: In several Western European countries it is recommended to treat gastric cancer patients with perioperative chemotherapy if they are eligible for surgery. However, little is known about its use in daily clinical practice. This study examines the use of perioperative treatment and its impact on survival in the Netherlands. METHODS: Patients diagnosed with potentially resectable gastric cancer (cT1N+/cT2-T3,X any cN, cM0,X) between 2006 and 2014 were selected from the Netherlands Cancer Registry (N = 5824)...
April 6, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30981447/oncologic-outcomes-in-patients-treated-with-endoscopic-robot-assisted-simple-enucleation-erase-for-renal-cell-carcinoma-results-from-a-tertiary-referral-center
#8
Andrea Mari, Fabrizio Di Maida, Riccardo Tellini, Riccardo Campi, Simone Sforza, Andrea Cocci, Giampaolo Siena, Gianni Vittori, Agostino Tuccio, Lorenzo Masieri, Alberto Lapini, Maria Rosaria Raspollini, Marco Carini, Andrea Minervini
INTRODUCTION: Open Simple Enucleation (OSE) has been demonstrated to be an oncologically safe alternative to standard partial nephrectomy. We assessed the mid-term oncologic outcomes and predictors of disease recurrence in patients treated with Endoscopic Robot-Assisted Simple Enucleation (ERASE) verified through a standardized reporting system at a single institution. MATERIAL AND METHODS: The clinical data of patients treated with ERASE for renal cell carcinoma at our Institution from January 2012 to September 2018 were retrospectively reviewed...
April 4, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30982657/a-nomogram-to-predict-early-postoperative-recurrence-of-hepatocellular-carcinoma-with-portal-vein-tumour-thrombus-after-r0-liver-resection-a-large-scale-multicenter-study
#9
Xiu-Ping Zhang, Zhen-Hua Chen, Teng-Fei Zhou, Le-Qun Li, Min-Shan Chen, Tian-Fu Wen, Jie Shi, Wei-Xing Guo, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
BACKGROUND: Portal vein tumour thrombus (PVTT) is a significant poor prognostic factor for hepatocellular carcinoma (HCC). Patients with PVTT limited to a first-order branch or above of the main portal vein (MPV) could benefit from R0 liver resection (LR). A nomogram is needed to predict early postoperative recurrence (ER) in HCC patients with PVTT and to guide selection of these patients for adjuvant therapy to reduce postoperative recurrence risks. METHODS: HCC patients with PVTT limited to a first-order branch or above of the MPV after R0 LR as an initial therapy were included...
April 3, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30981446/ct-response-of-primary-tumor-and-ca19-9-predict-resectability-of-metastasized-pancreatic-cancer-after-folfirinox
#10
Masayuki Tanaka, Max Heckler, André L Mihaljevic, Huihui Sun, Ulla Klaiber, Ulrike Heger, Markus W Büchler, Thilo Hackert
BACKGROUND: Effective chemotherapy protocols are currently changing the treatment options for metastasized pancreatic cancer. Survival benefits after synchronous metastasectomy have been reported for selected patients. We set out to assess predictive factors of resectability for synchronous metastases after FOLFIRINOX. METHODS: Consecutive patients with metastatic pancreatic cancer undergoing surgery after FOLFIRINOX between 2011 and 2017 were identified from a prospectively collected database...
April 3, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/31003721/long-term-survival-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-for-patients-with-peritoneal-metastases-of-urachal-cancer
#11
Laura S Mertens, Mark A Behrendt, Akash M Mehta, Laura Stokkel, Jeroen de Jong, Henk Boot, Simon Horenblas, Michiel S van der Heijden, Luc M Moonen, Arend G J Aalbers, Wim Meinhardt, Bas W G van Rhijn
INTRODUCTION: Urachal adenocarcinoma (UrAC) is a rare malignancy arising from persistent urachal remnants, which can cause peritoneal metastases (PM). Currently, patients with this stage UrAC are considered beyond cure. Our objective is to report long-term oncological outcome after cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with PM of urachal adenocarcinoma (UrAC). MATERIALS AND METHODS: We identified 55 patients with UrAC treated at our hospital between 1994 and 2017...
April 1, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30962045/lymphatic-spread-of-t2-gallbladder-carcinoma-regional-lymphadenectomy-is-required-independent-of-tumor-location
#12
Koji Toge, Jun Sakata, Yuki Hirose, Kizuki Yuza, Takuya Ando, Daiki Soma, Tomohiro Katada, Kohei Miura, Kazuyasu Takizawa, Takashi Kobayashi, Toshifumi Wakai
BACKGROUND: This study aimed to investigate the incidence and distribution of regional lymph node metastasis according to tumor location, and to clarify whether tumor location could determine the extent of regional lymphadenectomy in patients with pathological T2 (pT2) gallbladder carcinoma. METHODS: In total, 81 patients with pT2 gallbladder carcinoma (25 with pT2a tumors and 56 with pT2b tumors) who underwent radical resection were enrolled. Tumor location was determined histologically in each gallbladder specimen...
March 30, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30954354/pharmacokinetics-of-the-intraperitoneal-nanoparticle-pegylated-liposomal-doxorubicin-in-patients-with-peritoneal-metastases
#13
REVIEW
Paul H Sugarbaker, O Anthony Stuart
BACKGROUND: Peritoneal surfaces are a common site for the dissemination of gastrointestinal and gynecologic malignancy. Often, the surgeon can achieve a complete response. Unfortunately, current perioperative chemotherapy regimens fail to maintain control of cancer nodules within the abdomen and pelvis. More effective perioperative chemotherapy is needed. MATERIALS AND METHODS: The nanoparticle pegylated liposomal doxorubicin (PLD) was instilled directly into the peritoneal space in peritoneal metastases patients following maximal efforts of cytoreductive surgery to resect abdominal and pelvic disease...
March 29, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30954353/saved-by-the-evidence-hyperthermic-intraperitoneal-chemotherapy-still-has-a-role-to-play-in-ovarian-cancer
#14
EDITORIAL
Vincent Lavoué, Naoual Bakrin, Pierre Adrien Bolze, Sofiane Bendifallah, Pierre Collinet, Olivier Graesslin, Marcos Ballester, Cherif Akladios, Xavier Carcopino, Alexandre Bricou, Martin Koskas, Geoffroy Canlorbe, Charles Coutant, Lobna Ouldamer, Emile Daraï, Cyril Touboul, Cyrille Huchon
No abstract text is available yet for this article.
March 29, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30954352/systemic-inflammatory-response-after-hyperthermic-intraperitoneal-chemotherapy-hipec-the-perfusion-protocol-matters
#15
Lilian Roth, Dilmurodjon Eshmuminov, Felix Laminger, Claudia Koppitsch, Marcel Schneider, Theresia Reding Graf, Anurag Gupta, Fritz Kober, Sebastian Roka, Philippe Gertsch, Kuno Lehmann
BACKGROUND: CRS/HIPEC gained acceptance as a treatment for selected patients with peritoneal metastasis. However, the pathophysiology behind HIPEC is poorly understood, and a variety of regimens are currently in use. In this study, we describe for the first-time changes in the postoperative systemic inflammatory reaction, highly different among HIPEC treatment protocols. METHODS: HIPEC was performed with three protocols, different with regard to perfusion times and drugs: (mitomycinC/doxorubicin, 90min), (cisplatin, 90min) (oxaliplatin, 30min)...
March 29, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30979508/defining-enhanced-recovery-after-resection-of-peri-hilar-cholangiocarcinoma
#16
L M Quinn, K Mann, R P Jones, S Bathla, S Stremitzer, D F Dunne, C Lacasia, S W Fenwick, H Z Malik
INTRODUCTION: Enhanced recovery after surgery (ERAS) for peri-hilar cholangiocarcinoma (pCCA) has not been described in the literature. This study examined patients undergoing pCCA resection within a standard post hepatectomy ERAS pathway to define achievable targets suitable for these patients. METHODS: Patients undergoing pCCA resection at University Hospital Aintree (January 2009-October 2017) were identified. Achievement of key ERAS outcomes was assessed. Patients were stratified on incidence of major complications and pre-operative cardiopulmonary exercise testing...
March 28, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30975447/frequency-of-surgical-resection-after-starting-neoadjuvant-chemoradiotherapy-in-patients-with-esophageal-cancer-a-population-based-cohort-study
#17
Alicia S Borggreve, Peter S N van Rossum, Stella Mook, Nadia Haj Mohammad, Richard van Hillegersberg, Jelle P Ruurda
BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) for resectable esophageal cancer is accompanied by the risk of treatment-related toxicity. The aim of this population-based cohort study was to provide insight in patients who do not proceed to surgical resection after starting nCRT. METHODS: Patients who started nCRT for primary esophageal cancer diagnosed in 2015 and 2016 were selected from the nationwide population-based cancer registry. Outcome measurements included omission from surgical resection, reasons for omission of surgical resection, mortality during nCRT (≤90 days after ending nCRT) and 1-year overall survival...
March 27, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30940421/prospective-validation-of-an-institutional-treatment-strategy-for-t1n0m0-glottic-carcinoma
#18
Simon Beyaert, Marc Hamoir, Aline Van Maanen, Vincent Grégoire, Sandra Schmitz
INTRODUCTION: The aim of this study was to assess the validity of a treatment strategy for T1N0 glottic squamous cell carcinoma. METHODS: One hundred and seventeen patients were prospectively treated according to institutional guidelines. using 1) laser microsurgery (L) for exophytic tumor, limited to one vocal cord, without extension to the anterior commissure or the vocal process of the arytenoid cartilage, 2) radiotherapy (RT) for large or infiltrative tumor reaching the anterior commissure or the vocal process of the arytenoid cartilage, poor endoscopic exposure and cT1b or 3) partial laryngectomy (PL) for tumor infiltrating the anterior commissure...
March 27, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30940422/clinical-impact-of-splenic-hilar-dissection-with-splenectomy-for-gastric-stump-cancer
#19
Masahiro Watanabe, Takahiro Kinoshita, Shinji Morita, Masahiro Yura, Masanori Tokunaga, Sho Otsuki, Yukinori Yamagata, Akio Kaito, Takaki Yoshikawa, Hitoshi Katai
BACKGROUND: Splenectomy for advanced gastric stump cancer (GSC) is performed in Japan, based on the concept that lymphatic flow toward the splenic hilum is dominant following initial gastrectomy. However, little has been reported on the therapeutic impact of complete splenic hilar dissection with splenectomy. MATERIAL AND METHODS: A total of 184 patients who underwent R0 total gastrectomy with or without splenectomy for GSC between 1998 and 2015 were included in this retrospective analysis...
March 26, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30935727/completion-thyroidectomy-indications-and-complications
#20
EDITORIAL
Ashok R Shaha, R Michael Tuttle
No abstract text is available yet for this article.
March 26, 2019: European Journal of Surgical Oncology
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