Siang-Ke Kong, Ming-Chieh Tsai, Chun-Lin Yeh, Yu-Cheng Tsai, Ming-Nan Chien, Chun-Chuan Lee, Wen-Hsuan Tsai
BACKGROUND: Excess parathyroid hormone (PTH) is associated with an increased risk of cardiovascular disease (CVD). PURPOSE: We aimed to evaluate the correlation between primary hyperparathyroidism (PHPT) and CVD or cardiovascular (CV) death. DATA SOURCES: Comprehensive searches of PubMed, Embase and until May 20, 2023 with the following keywords: "primary hyperparathyroidism," "cardiovascular disease," and "mortality." STUDY SELECTIONS: Cohort studies and randomized controlled trials comparing PHPT patients to the general population and those who had received parathyroidectomy (PTX) to those who did not...
May 23, 2024: Bone
Jiani Liu, Jixiao Wang, Wang Ziyao, Huiying Ren, Zijie Zhang, Yajing Fu, Lan Li, Zhiyuan Shen, Tianyi Li, Shuai Tang, Fulan Wei
The mechanosensitivity of inflammation can alter cellular mechanotransduction. However, the underlying mechanism remains unclear. This study aims to investigate the metabolic mechanism of inflammation under mechanical force to guide tissue remodeling better. Herein, we found that inflammation hindered bone remodeling under mechanical force, accompanied by a simultaneous enhancement of oxidative phosphorylation (OXPHOS) and glycolysis. The control of metabolism direction through GNE-140 and Visomitin revealed that enhanced glycolysis might act as a compensatory mechanism to resist OXPHOS-induced osteoclastogenesis by promoting osteogenesis...
May 22, 2024: Bone
Simon C Zhang, Tessa Makebeh, Jakub Mesinovic, Kevin Djopseu, Catherine Martin, Li-Yung Lui, Peggy M Cawthon, Andrea L C Schneider, Joseph M Zmuda, Elsa S Strotmeyer, Anne Schafer, Peter R Ebeling, Roger M Zebaze
Diabetes mellitus (DM) is associated with increased fracture risk in White adults. However, the impact of DM on fractures in Black adults is unknown. This systematic review and meta-analysis investigated the association between DM and fractures in adults of African ancestry. MEDLINE, Scopus, CINAHL and Embase databases were searched from their inception up to November 2023 for all studies in the English language investigating the epidemiology of fractures (prevalence, incidence, or risk) in Black men and women (age ≥ 18 years) with type 1 or type 2 DM...
May 22, 2024: Bone
Shivani Sharma, Saroj Kumar, Manendra Singh Tomar, Divya Chauhan, Chirag Kulkarni, Swati Rajput, Sreyanko Sadhukhan, Konica Porwal, Rajdeep Guha, Ashutosh Shrivastava, Jiaur R Gayen, Navin Kumar, Naibedya Chattopadhyay
Chronic kidney disease-induced secondary hyperparathyroidism (CKD-SHPT) heightens fracture risk through impaired mineral homeostasis and elevated levels of uremic toxins (UTs), which in turn enhance bone remodeling. Etelcalcetide (Etel), a calcium-sensing receptor (CaSR) agonist, suppresses parathyroid hormone (PTH) in hyperparathyroidism to reduce excessive bone resorption, leading to increased bone mass. However, Etel's effect on bone quality, chemical composition, and strength is not well understood. To address these gaps, we established a CKD-SHPT rat model and administered Etel at a human-equivalent dose concurrently with disease induction...
May 20, 2024: Bone
Debora M Grass, Gwladys Malek, Hubert M Taïeb, Eran Ittah, Helene Richard, Natalie Reznikov, Sheila Laverty
High cyclic strains induce formation of microcracks in bone, triggering targeted bone remodeling, which entails osteoclastic resorption. Racehorse bone is an ideal model for studying the effects of high-intensity loading, as it is subject to focal formation of microcracks and subsequent bone resorption. The volume of resorption in vitro is considered a direct indicator of osteoclast activity but indirect 2D measurements are used more often. Our objective was to develop an accurate, high-throughput method to quantify equine osteoclast resorption volume in μCT 3D images...
May 20, 2024: Bone
Alma B Pedersen, Reimar W Thomsen
No abstract text is available yet for this article.
May 18, 2024: Bone
Josephine T Tauer, Tobias Thiele, Catherine Julien, Lior Ofer, Paul Zaslansky, Ron Shahar, Bettina M Willie
The traditional understanding of bone mechanosensation implicates osteocytes, canaliculi, and the lacunocanalicular network in biomechanical adaptation. However, recent findings challenge this notion, as shown in advanced teleost fish where anosteocytic bone lacking osteocytes are nevertheless responsive to mechanical load. To investigate specific molecular mechanisms involved in bone mechanoadaptation in osteocytic and anosteocytic fish bone, we conducted a 5-min single swim-training experiment with zebrafish and ricefish, respectively...
May 14, 2024: Bone
Lance L Frazer, Nathan Louis, Wojciech Zbijewski, Jay Vaishnav, Kal Clark, Daniel P Nicolella
Osteoporotic fractures, prevalent in the elderly, pose a significant health and economic burden. Current methods for predicting fracture risk, primarily relying on bone mineral density, provide only modest accuracy. If better spatial resolution of trabecular bone in a clinical scan were available, a more complete assessment of fracture risk would be obtained using microarchitectural measures of bone (i.e. trabecular thickness, trabecular spacing, bone volume fraction, etc.). However, increased resolution comes at the cost of increased radiation or can only be applied at small volumes of distal skeletal locations...
May 11, 2024: Bone
Xiang Zhang, Jin Xu
BACKGROUND: MicroRNAs (miRNAs) regulate osteogenic differentiation processes and influence the development of osteoporosis (OP). This study aimed to investigate the potential role of miR-466 l-3p in OP. METHODS: The expression levels of miR-466 l-3p and fibroblast growth factor 23 (FGF23) were quantified in the trabeculae of the femoral neck of 40 individuals with or without OP using quantitative reverse transcription-polymerase chain reaction (qRT-PCR)...
May 10, 2024: Bone
Shaobo Gu, Junzhuo Wang, Siyi Yu, Shunyao Zhang, Ting Gao, Deyi Yan, Runxiang Xie, Mengli Gu, Mengli Yu, Zongkai Zhang, Zhongze Lou, Xiaoyun Ding, Yi Chen, Chunxiao Li
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) may contribute to osteoporosis. Berberine is a traditional Chinese medicine and was recently shown to be beneficial in NAFLD. However, little is known about its impact on bone loss induced by NAFLD. AIM: We aimed to explore the role of berberine in bone loss and determine its underlying mechanisms in NAFLD. METHODS: C57BL/6 mice were fed a high-fat high-fructose high-glucose diet (HFFGD) for 16 weeks to establish a NAFLD mouse model...
May 7, 2024: Bone
Irving M Shapiro, Makarand V Risbud, William J Landis
This review examines the possible role of mitochondria in maintaining calcium and phosphate ion homeostasis and participating in the mineralization of bone, cartilage and other vertebrate hard tissues. The paper builds on the known structural features of mitochondria and the documented observations in these tissues that the organelles contain calcium phosphate granules. Such deposits in mitochondria putatively form to buffer excessively high cytosolic calcium ion concentrations and prevent metabolic deficits and even cell death...
April 30, 2024: Bone
Amida H Kuah, Lara H Sattgast, Kathleen A Grant, Steven W Gonzales, Rupak Khadka, John G Damrath, Matthew R Allen, David B Burr, Joseph M Wallace, Gianni F Maddalozzo, Mary Lauren Benton, Laura M Beaver, Adam J Branscum, Russell T Turner, Urszula T Iwaniec
Chronic heavy alcohol consumption is a risk factor for low trauma bone fracture. Using a non-human primate model of voluntary alcohol consumption, we investigated the effects of 6 months of ethanol intake on cortical bone in cynomolgus macaques (Macaca fascicularis). Young adult (6.4 ± 0.1 years old, mean ± SE) male cynomolgus macaques (n = 17) were subjected to a 4-month graded ethanol induction period, followed by voluntary self-administration of water or ethanol (4 % w/v) for 22 h/d, 7 d/wk...
April 26, 2024: Bone
Tzu-Yun Yen, Chan-Shien Ho, Yu-Cheng Pei, Tzuo-Yau Fan, Szu-Yi Chang, Chang-Fu Kuo, Yueh-Peng Chen
Osteoporosis is a common condition that can lead to fractures, mobility issues, and death. Although dual-energy X-ray absorptiometry (DXA) is the gold standard for osteoporosis, it is expensive and not widely available. In contrast, kidney-ureter-bladder (KUB) radiographs are inexpensive and frequently ordered in clinical practice. Thus, it is a potential screening tool for osteoporosis. In this study, we explored the possibility of predicting the bone mineral density (BMD) and classifying high-risk patient groups using KUB radiographs...
April 25, 2024: Bone
Riccardo Papa, Arinna Bertoni, Caterina Matucci-Cerinic, Enrico Drago, Francesca Liberatore, Anna Corcione, Marco Gattorno
No abstract text is available yet for this article.
April 19, 2024: Bone
Elina Tan, Laurence Guignat, Azeddine Dellal, Renaud Winzenrieth, Catherine Cormier, Eugénie Koumakis
CONTEXT: Hypercortisolism frequently induces trabecular bone loss, more pronounced at the lumbar spine, resulting in osteoporosis, and thus an increase in fracture risk. Several studies have shown bone mass recovery in patients with Cushing's disease (CD) after treatment. OBJECTIVE: To examine treatment effects on TBS (trabecular bone score) in addition to aBMD (areal bone mineral density) in a cohort of patients with CD. DESIGN AND SETTING: Single-center retrospective longitudinal study in patients diagnosed with CD and successfully treated following surgery and/or medical treatment...
April 19, 2024: Bone
Amy Creecy, Dyann Segvich, Corinne Metzger, Rachel Kohler, Joseph M Wallace
Osteogenesis imperfecta (OI) increases fracture risk due to changes in bone quantity and quality caused by mutations in collagen and its processing proteins. Current therapeutics improve bone quantity, but do not treat the underlying quality deficiencies. Male and female G610C+/- mice, a murine model of OI, were treated with a combination of raloxifene and in vivo axial tibial compressive loading starting at 10 weeks of age and continuing for 6 weeks to improve bone quantity and quality. Bone geometry and mechanical properties were measured to determine whole bone and tissue-level material properties...
April 17, 2024: Bone
Dennis Vinther, Reimar W Thomsen, Ove Furnes, Jan-Erik Gjertsen, Alma B Pedersen
PURPOSE: We investigated the incidence rates of a subsequent hip fracture (HF) and other subsequent fractures than HF after first incident HF, comparing patients with and without diabetes. METHODS: Using Danish medical databases, we identified 92,600 incident HF patients in the period 2004-2018. Diabetes exposure was examined overall, by type of diabetes (T2D and T1D), and by presence of diabetes complications. We estimated cumulative incidence of subsequent HFs and fractures other than HF within two years of the incident HF...
April 16, 2024: Bone
Siriporn Sasimontonkul, Jintana Sirivarasai
PURPOSE: There is some controversy regarding cytokines released from adipocytes, particularly adiponectin, leptin, and IL6 that regulate bone remodeling. In addition, IL6 is released from muscle contraction, which might have a distinct role in bone remodeling. Hence, this study investigated whether muscle contraction during a session of 40 min of high intensity interval training (40-min HIIT) and after 16 weeks of HIIT (16-wk HIIT) altered the release of those cytokines and bone remodeling in overweight women...
April 16, 2024: Bone
Saeed Jerban, Dina Moazamian, Hamidreza Shaterian Mohammadi, Yajun Ma, Hyungseok Jang, Behnam Namiranian, Soo Hyun Shin, Salem Alenezi, Sameer B Shah, Christine B Chung, Eric Y Chang, Jiang Du
High-resolution magnetic resonance imaging (HR-MRI) has been increasingly used to assess the trabecular bone structure. High susceptibility at the marrow/bone interface may significantly reduce the marrow's apparent transverse relaxation time (T2*), overestimating trabecular bone thickness. Ultrashort echo time MRI (UTE-MRI) can minimize the signal loss caused by susceptibility-induced T2* shortening. However, UTE-MRI is sensitive to chemical shift artifacts, which manifest as spatial blurring and ringing artifacts partially due to non-Cartesian sampling...
April 15, 2024: Bone
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