Rongjie Wu, Yuanchen Ma, Duanyong Chen, Mengyuan Li, Zeng Li, Zhantao Deng, Qiujian Zheng, Guangtao Fu
PURPOSE: To investigate the utility of serum C-terminal cross-linking telopeptides (β-CTX) and procollagen type I N propeptide (PINP) for predicting one-year mortality and walking ability in Chinese geriatric hip fracture patients who underwent surgical interventions. METHOD: Elderly patients (≥ 60 years) who underwent surgical interventions for unilateral low-energy hip fracture from 2015 to 2020 in our center were included. Demographic data was retrospectively retrieved from the electronic medical database...
September 27, 2023: Bone
Tatiana Kochetkova, Markus S Hanke, Michael Indermaur, Alexander Groetsch, Stefan Remund, Beat Neuenschwander, Johann Michler, Klaus A Siebenrock, Philippe Zysset, Jakob Schwiedrzik
Current clinical methods of bone health assessment depend to a great extent on bone mineral density (BMD) measurements. However, these methods only act as a proxy for bone strength and are often only carried out after the fracture occurs. Besides BMD, composition and tissue-level mechanical properties are expected to affect the whole bone's strength and toughness. While the elastic properties of the bone extracellular matrix (ECM) have been extensively investigated over the past two decades, there is still limited knowledge of the yield properties and their relationship to composition and architecture...
September 26, 2023: Bone
Floris K Hendriks, Michelle E G Weijzen, Joy P B Goessens, Antoine H G Zorenc, P Gijsen Annemie, Irene Fleur Kramer, Joop P W van den Bergh, Martijn Poeze, Taco J Blokhuis, Luc J C van Loon
BACKGROUND: All musculoskeletal tissues are in a constant state of turnover, with a dynamic equilibrium between tissue protein synthesis and breakdown rates. The synthesis of protein allows musculoskeletal tissues to heal following injury. Yet, impaired tissue healing is observed following certain injuries, such as geriatric hip fractures. It is assumed that the regenerative properties of femoral head bone tissue are compromised following an intracapsular hip fracture and therefore hip replacement surgery is normally performed...
September 26, 2023: Bone
Robert Kerberger, Giulia Brunello, Dieter Drescher, Bert van Rietbergen, Kathrin Becker
Implant migration has been described as a minor displacement of orthodontic mini-implants (OMIs) when subjected to constant forces. Aim of this study was to evaluate the impact of local stresses on implant migration and bone remodelling around constantly loaded OMIs. Two mini-implants were placed in one caudal vertebra of 61 rats, connected by a nickel‑titanium contraction spring, and loaded with different forces (0.0, 0.5, 1.0, 1.5 N). In vivo micro-CT scans were taken immediately and 1, 2 (n = 61), 4, 6 and 8 (n = 31) weeks post-op...
September 20, 2023: Bone
Lian-Hua Ji, Cheng-Long Zhao, Ya-Jin Wang, Zhong-Hua Fu
Fluoroquinolone antibiotics are known to induce serious tendinopathies and ligament disorders (TPLDs) on rare occasion, but it is less well-appreciated whether such adverse reactions result from the use of bisphosphonates (BPs). In this study, we assessed the correlation between TPLDs and the use of BPs via U.S. FDA Adverse Event Reporting System (FAERS) database. Bayesian and nonproportional analyses were applied to data retrieved from the FAERS database from the first quarter of 2004 to the third quarter of 2022...
September 20, 2023: Bone
Alexandra Arteaga, Claudia Cristina Biguetti, BhuvanaLakkasetter Chandrashekar, Javier La Fontaine, Danieli C Rodrigues
Chronic inflammation and hyperglycemia in diabetic patients increase the risk of implant failure and impaired fracture healing. We previously developed and characterized a titanium (Ti) coating strategy using an imidazolium-based ionic liquid (IonL) with a fully reduced, non-oxidizable High Mobility Group Box 1 (HMGB1) isoform (Ti-IonL-HMGB1) to immunomodulate tissue healing. In this study, we used an open reduction fracture fixation (ORIF) model in non-diabetic (ND) and diabetic (D) rats to further investigate the effectiveness of this Ti-IonL-HMGB1 coating on orthopedic applications...
September 20, 2023: Bone
Sangyong Lee, Myoung Jun Kim, Seor I Ahn, Sung Kyung Choi, Keun Young Min, Wahn Soo Choi, Jueng Soo You
Recently improved techniques could provide snapshots of chromatin structure generated based on chromatin accessibility. Since chromatin accessibility determines transcriptional potential, it has been attempted in a variety of cell systems. However, there has been no genome-wide analysis of chromatin accessibility for the entire murine osteoclast (OC) differentiation process. We performed an Assay for Transposase-Accessible Chromatin (ATAC)-sequencing (seq) during RANKL-induced OC differentiation and found that global chromatin accessibility decreased, especially early in OC differentiation...
September 20, 2023: Bone
Susanne Hansen, Peter Schwarz, Jüri Rumessen, Allan Linneberg, Line Lund Kårhus
Celiac disease (CD) is an autoimmune disease caused by an abnormal immune response triggered by ingestion of gluten. Treatment of CD is a lifelong gluten-free diet. Both diagnosed and undiagnosed CD has been found to be associated with reduced bone mineral density, which can lead to an increased risk of fractures. We therefore aimed to investigate the association of CD and the risk of fractures and osteoporosis in Denmark in a nationwide registry-based study. We identified all patients with CD (ICD-10 code K90...
September 18, 2023: Bone
Brian-Tinh Duc Vu, Brandon C Jones, Hyunyeol Lee, Nada Kamona, Rajiv S Deshpande, Felix W Wehrli, Chamith S Rajapakse
BACKGROUND: Assessment of proximal femur trabecular bone microstructure in vivo by magnetic resonance imaging has recently been validated for acquiring information independent of bone mineral density in osteoporotic patients. However, the requisite signal-to-noise ratio (SNR) and resolution for interrogation of the trabecular microstructure at this anatomical location prolongs the scan duration and renders the imaging protocol clinically infeasible. Parallel imaging and compressed sensing (PICS) techniques can reduce the scan duration of the imaging protocol without substantially compromising image quality...
September 13, 2023: Bone
Ram N Yadav, Daniel J Oravec, Courtney K Morrison, Nick B Bevins, Sudhaker D Rao, Yener N Yeni
Despite effective therapies for those at risk of osteoporotic fracture, low adherence to screening guidelines and limited accuracy of bone mineral density (BMD) in predicting fracture risk preclude identification of those at risk. Because of high adherence to routine mammography, bone health screening at the time of mammography using a digital breast tomosynthesis (DBT) scanner has been suggested as a potential solution. BMD and bone microstructure can be measured from the wrist using a DBT scanner. However, the extent to which biomechanical variables can be derived from digital wrist tomosynthesis (DWT) has not been explored...
September 13, 2023: Bone
Ryohei Kozutsumi, Shinichiro Kuroshima, Farah A Al-Omari, Hiroki Hayano, Kazunori Nakajima, Hiroe Kakehashi, Takashi Sawase
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a potentially intractable disease with no definitive pathophysiology and no treatment and prevention strategies. This study aimed to investigate whether time-selective depletion of macrophages worsens BRONJ-like lesions in mice. A murine model of high-prevalence BRONJ-like lesions in combination with zoledronate/chemotherapeutic drug administration and tooth extraction was created according to the methods of our previous studies. Daily intra-oral submucosal administration of clodronate-loaded liposomes, which temporarily depletes systemic macrophages, was performed immediately after tooth extraction...
September 12, 2023: Bone
Beyhan Tüysüz, Esra Usluer, Dilek Uludağ Alkaya, Süheyla Ocak, Seha Saygılı, Ali Şeker, Hilmi Apak
BACKGROUND: Osteopetrosis and related osteoclastic disorders are a heterogeneous group of inherited diseases characterized by increased bone density. The aim of this study is to investigate the molecular spectrum and natural history of the clinical and radiological features of these disorders. METHODS: 28 patients and 20 families were enrolled in the study; 20 of them were followed for a period of 1-16 years. Targeted gene analysis and whole-exome sequencing (WES) were performed...
September 11, 2023: Bone
Ernesto Canalis, Magda Mocarska, Lauren Schilling, Paymaan Jafar-Nejad, Michele Carrer
Lateral Meningocele Syndrome (LMS) is a monogenic disorder associated with NOTCH3 pathogenic variants that result in the stabilization of NOTCH3 and a gain-of-function. A mouse model (Notch3em1Ecan ) harboring a 6691TAATGA mutation in the Notch3 locus that results in a functional outcome analogous to LMS exhibits cancellous and cortical bone osteopenia. We tested Notch3 antisense oligonucleotides (ASOs) specific to the Notch36691- TAATGA mutation for their effects on Notch3 downregulation and on the osteopenia of Notch3em1Ecan mice...
September 11, 2023: Bone
Pernille van Dijk Christiansen, Christina Møller Andreasen, Bilal Mohamad El-Masri, Kaja Søndergaard Laursen, Jean-Marie Delaisse, Thomas Levin Andersen
BACKGROUND: Recruitment and proliferation of osteoprogenitors during the reversal-resorption phase, and their differentiation into mature bone-forming osteoblasts is crucial for initiation of bone formation during bone remodeling. This study investigates the osteoprogenitors' gradual recruitment, proliferation, and differentiation into bone-forming osteoblasts within intracortical remodeling events of healthy adolescent humans. METHODS: The study was conducted on cortical bone specimens from 11 adolescent human controls - patients undergoing surgery due to coxa valga...
September 10, 2023: Bone
Chihiro Kanno, Momoyo Kojima, Yu Tezuka, Sadanoshin Yaginuma, Yoshiaki Kanaya, Tetsuharu Kaneko
INTRODUCTION: Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is a serious adverse event associated with therapies for advanced cancer involving bone-modifying agents (BMAs). Although many studies have investigated the risk factors for ARONJ, none have provided sufficient clarifications. We aimed to determine whether there is a correlation between tooth extraction before BMA therapy and the development of ARONJ. PATIENTS AND METHODS: We included 511 patients who were admitted to our department before BMA therapy...
September 7, 2023: Bone
Laetitia Michou, Philippe Gamache, Jason R Guertin, Jean-Eric Tarride, Jacques P Brown, Sonia Jean
BACKGROUND: Paget's disease of bone (PDB) is a focal bone disorder characterized by an increased bone remodeling and an anarchic bone structure. A decline of prevalence and incidence of PDB has been observed in some countries. No epidemiological data are available on PDB in Canada. AIMS: We aimed at examining the evolution of the prevalence and incidence of PDB in Quebec (Canada) by analyzing health administrative databases. METHODS: PDB case definition relied on one or more hospitalizations, or one or more physician-billing claims with a diagnosis code of PDB...
September 6, 2023: Bone
Malinda Wu, Vin Tangpricha
No abstract text is available yet for this article.
September 5, 2023: Bone
Danielle E Whittier, Matthias Walle, Denis Schenk, Penny R Atkins, Caitlyn J Collins, Philippe Zysset, Kurt Lippuner, Ralph Müller
BACKGROUND: Recent applications of high resolution peripheral quantitative computed tomography (HR-pQCT) have demonstrated that changes in local bone remodelling can be quantified in vivo using longitudinal three-dimensional image registration. However, certain emerging applications, such as fracture healing and joint analysis, require larger multi-stack scan regions that can result in stack shift image artifacts. These artifacts can be detrimental to the accurate alignment of the bone structure across multiple timepoints...
September 2, 2023: Bone
Crystal Korff, Michele Adaway, Emily G Atkinson, Daniel J Horan, Angela Klunk, Brandy Suarez Silva, Teresita Bellido, Lilian I Plotkin, Alexander G Robling, Joseph P Bidwell
Severe osteoporosis is often treated with one of three Food and Drug Administration (FDA)-approved osteoanabolics. These drugs act by (1) parathyroid hormone (PTH) receptor stimulation using analogues to PTH (teriparatide) or PTH-related peptide (abaloparatide) or by (2) monoclonal antibody neutralization of sclerostin, an innate Wnt inhibitor (Scl-mAb, romosozumab-aqqg). The efficacies of both strategies wane over time. The transcription factor Nmp4 (Nuclear Matrix Protein 4) is expressed in all tissues yet mice lacking this gene are healthy and exhibit enhanced PTH-induced bone formation...
September 1, 2023: Bone
Wanbo Zhu, Dongdong Xu, Jiawei Mei, Baoliang Lu, Qiaojie Wang, Chen Zhu, Xianzuo Zhang, Xianlong Zhang
Diabetic patients suffer from delayed fracture healing and impaired osteogenic function, but the underlying pathophysiological mechanisms are not fully understood. Neutrophil extracellular traps (NETs) formed by neutrophils in high glucose microenvironments affect the healing of wounds and other tissues. Some evidence supports that NETs may inhibit osteogenic processes in the microenvironment through sustained inflammatory activation. In this study, we observed that high glucose-induced NETs led to sustained inflammatory activation of macrophages...
September 1, 2023: Bone
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