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Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery

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https://read.qxmd.com/read/30783756/an-investigation-of-the-ocular-toxic-effects-of-levetiracetam-therapy-in-children-with-epilepsy
#1
Betul Diler Durgut, Adem Turk, Elif Acar Arslan, Tulay Kamasak, Sevim Sahin, Beril Dilber, Tugce Turkcan Soguksulu, Ali Cansu
OBJECTIVE: To investigate the potential toxic effects of levetiracetam monotherapy on ocular tissues in cases of pediatric epilepsy using optical coherence tomography (OCT). METHODS: Thirty epileptic children (group 1) receiving levetiracetam monotherapy at a dosage of 20-40 mg/kg/day for at least 1 year with a first diagnosis of epilepsy and 30 age- and gender-matched healthy children (group 2) were included in the study. In addition to a detailed eye examination, peripapillary retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal thickness (FT), and central corneal thickness (CCT) were measured in all children by means of spectral domain OCT...
February 20, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30783755/a-rare-concurrence-gelastic-seizures-in-a-patient-with-right-temporal-nongalenic-pial-arteriovenous-fistula
#2
Esra Sarigecili, Ezgi Caglar, Altan Yildiz, Cetin Okuyaz
INTRODUCTION: Gelastic seizures are the type of seizures that are most commonly seen in childhood and should be excluded definitely in the differential diagnosis of hypothalamic hamartomas. This seizure type may be accompanied by refractory seizures, cognitive decline, and early puberty. However, etiology may also include other causes different than hypothalamic hamartomas. The seizure may also arise from temporal and frontal region, in addition to hypothalamus. Different clinical findings may be observed based on origin and areas of spread...
February 19, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30778663/pediatric-parapharyngeal-infection-resulting-in-cervical-instability-and-occipital-cervical-fusion-case-report-and-review-of-the-literature
#3
Yi-Ren Chen, Jon Sole, Rashad Jabarkheel, Michael Edwards, Samuel Cheshier
Parapharyngeal infection is the most common deep neck space infection in children and, in rare instances, can result in bony destruction of the cervical spine. We report one such case that required occipital to cervical fusion and halo-vest fixation. We also review the literature and discuss the etiology, diagnosis, and treatment options for managing pediatric cervical bony destruction secondary to infection.
February 18, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30770994/unusual-radiological-and-histological-presentation-of-a-diffuse-leptomeningeal-glioneuronal-tumor-dlgnt-in-a-13-year-old-girl
#4
Nishant Tiwari, Benita Tamrazi, Nathan Robison, Mark Krieger, Jianling Ji, Di Tian
Diffuse leptomeningeal glioneuronal tumors (DLGNTs) are newly recognized as an entity in the 2016 revision of the WHO Classification of tumors of the central nervous system. They typically present as diffuse leptomeningeal infiltrates along the neuraxis with focal and superficial involvement of the parenchyma. Here, we report a DLGNT with unusual radiological and histological features. A 13-year-old girl presented with scoliosis and back pain. Magnetic resonance imaging demonstrated a syrinx from C2 to T11 and an intramedullary mass from T6 to T9-10...
February 15, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30770993/the-benefit-of-surveillance-imaging-for-paediatric-cerebellar-pilocytic-astrocytoma
#5
Ellen McAuley, Hannah Brophy, James Hayden, Benedetta Pettorini, Chris Parks, Shivaram Avula, Conor Mallucci, Barry Pizer
OBJECTIVES: Paediatric cerebellar pilocytic astrocytomas (PA) (WHO grade 1) are amongst the most common of childhood brain tumours and are generally amenable to resection, with surgery alone being curative in the majority of cases. There is, however, a lack of consensus regarding the frequency and duration of post-treatment MRI surveillance for these tumours. This is important, as follow-up imaging is a significant use of resources and often associated with patient and family anxiety...
February 15, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30758667/drug-resistant-epilepsy-in-indian-children-at-a-tertiary-care-public-hospital
#6
Prarthana Kharod, Devendra Mishra, Monica Juneja
BACKGROUND: Drug-resistant epilepsy (DRE), a condition in which seizures persist and seizure freedom is unlikely to be attained with further manipulation of anti-epileptic drugs, occurs in around 20% of children with epilepsy. This study was conducted with the aim to study the profile of Indian children with resistant epilepsy, using the new consensus definition of DRE. METHODS: All children who had been attending the Pediatric Neurology Clinic regularly for at least 6 months were reviewed between April and September 2015...
February 13, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30740633/pfeiffer-type-2-syndrome-review-with-updates-on-its-genetics-and-molecular-biology
#7
REVIEW
Rabjot Rai, Joe Iwanaga, Graham Dupont, Rod J Oskouian, Marios Loukas, W Jerry Oakes, R Shane Tubbs
INTRODUCTION: Pfeiffer syndrome is a rare autosomal dominant inherited disorder associated with craniosynostosis, midfacial hypoplasia, and broad thumbs and toes. The syndrome has been divided into three clinical subtypes based on clinical findings. METHODS: This review will specifically examine the most severe type, Pfeiffer syndrome type 2, focusing on its genetics and molecular biology. CONCLUSION: This subtype of the syndrome is caused by de novo sporadic mutations, the majority of which occur in the fibroblast growth factor receptor type 1 and 2 (FGFR1/2) genes...
February 11, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30726527/port-a-cath-and-ventriculoatrial-shunt-at-the-same-atrium-technical-note
#8
Mehmet Can Ezgu, Cahit Kural, Salih Guler, Yusuf Izci
Hydrocephalus is a rare complication of brain involving acute lymphoblastic leukemia (ALL). The standard treatment is ventriculoperitoneal (VP) shunting, while ventriculoatrial (VA) shunting is the second option in a case of VP shunt failure in young children. But the presence of port catheter at the right atrium restricts and makes a VA shunt difficult to place in the same atrium. We presented a 4-year-old boy who had the diagnoses of ALL and underwent chemotherapy through a port-a-cath. He also had hydrocephalus due to the brain invasion of the ALL...
February 6, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30726526/trophy-registry-study-design-a-prospective-international-multicenter-study-for-the-surgical-treatment-of-posthemorrhagic-hydrocephalus-in-neonates
#9
Ulrich-Wilhelm Thomale, Giuseppe Cinalli, Abhaya V Kulkarni, Sara Al-Hakim, Jonathan Roth, Andreas Schaumann, Christoph Bührer, Sergio Cavalheiro, Spyros Sgouros, Shlomi Constantini, Hans Christoph Bock
INTRODUCTION: Among children with hydrocephalus, neonates with intraventricular hemorrhage (IVH) and posthemorrhagic hydrocephalus (PH) are considered a group with one of the highest complication rates of treatment. Despite continued progress in neonatal care, a standardized and reliable guideline for surgical management is missing for this challenging condition. Thus, further research is warranted to compare common methods of surgical treatment. The introduction of neuroendoscopic lavage has precipitated the establishment of an international registry aimed at elaborating key elements of a standardized surgical treatment...
February 6, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30726525/an-unusual-presentation-of-bobble-head-doll-syndrome-in-a-patient-with-hydranencephaly-and-chiari-3-malformation
#10
Serge Eddy Mba, Aaron Musara, Kazadi Kalangu, Brighton Nyamapfene
Bobble-head doll syndrome is a rare movement disorder that is usually associated with lesions involving the third ventricle. It is characterised by stereotypical rhythmic up-and-down or side-to-side head movements. The pathophysiology and anatomical basis for this unusual manifestation is still a subject of intense scrutiny. The syndrome has never been described in a patient with both hydranencephaly and Chiari type 3 malformation. We describe a 2-year-old female patient who presented with congenital hydrocephalus, an occipital encephalocele and rhythmic bobbling of the head...
February 6, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30726524/establishing-reproducible-predictors-of-cerebellar-mutism-syndrome-based-on-pre-operative-imaging
#11
Heng Zhang, Zhiyi Liao, Xiaolei Hao, Zhe Han, Chunde Li, Jian Gong, Wei Liu, Yongji Tian
PURPOSE: To establish some explicit, feasible, and reproducible predictors for CMS. MATERIALS AND METHODS: This study was a retrospective case study. Data were obtained from 82 patients with medulloblastoma at a single center, Beijing Tiantan Hospital. Based on medical records, we created two independent samples: the CMS group comprising 23 patients and the non-CMS group comprising 23 patients. Pre-operative imaging was studied by performing quantitative assessments of specific indicators...
February 6, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30725177/human-tail-like-cutaneous-appendage-with-a-contiguous-stalk-of-limited-dorsal-myeloschisis
#12
Mio Sarukawa, Takato Morioka, Nobuya Murakami, Takafumi Shimogawa, Nobutaka Mukai, Noriko Kuga, Satoshi O Suzuki, Koji Iihara
PURPOSE: Limited dorsal myeloschisis (LDM) is characterized by a fibroneural stalk linking the skin lesion to the underlying spinal cord. On account of the external skin lesion, all LDMs are either flat (nonsaccular) or saccular, and a human tail-like cutaneous appendage has not been reported. METHODS: In our 14 LDM patients, 2 had tail-like appendages. We retrospectively analyzed the relationship between the appendage and the LDM tract from the clinicopathological findings of these 2 patients...
February 6, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30721351/hypertrophic-pachymeningitis-idiopathic-or-secondary
#13
LETTER
Indar Kumar Sharawat, Lesa Dawman
No abstract text is available yet for this article.
February 5, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30721350/intracranial-arterial-dolichoectasia-and-skull-damage-in-a-girl-with-jaffe-campanacci-syndrome-a-case-report
#14
Yong Han, Hangzhou Wang
ᅟJaffe-Campanacci is a rare syndrome characterised by axillary freckles, multiple non-ossifying fibromas of the long bones and jaw, and café-au-lait spots, associated with some features of neurofibromatosis type 1 (NF1). Cherix et al. and Colby and Saul suggested that Jaffe-Campanacci syndrome (JCS) might be a distinct form of NF1. Intracranial arterial dolichoectasia (IADE) is defined as an increase in the length and diameter of at least one intracranial artery. Affected intracranial arteries are dilated, elongated and sometimes tortuous...
February 5, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30707305/old-drugs-still-work-oral-etoposide-in-a-relapsed-medulloblastoma
#15
Marta Perez-Somarriba, Maitane Andión, Miguel A López-Pino, Cinzia Lavarino, Luis Madero, Alvaro Lassaletta
Medulloblastoma is the most common malignant brain tumor in children. Approximately 30% of children with medulloblastoma will progress or relapse despite being treated. New therapies have been proposed in recent years, including high-dose chemotherapy, immunotherapy, and targeted therapy. However, the best treatment for these patients remains unclear, and in this situation prognosis is poor. Oral etoposide has been used as a single agent or in combination for treating relapsed brain tumors since the 1990s. We report an 8-year-old patient with recurrent metastatic medulloblastoma who had an excellent response after treatment with oral etoposide, maintaining a great quality of life...
February 1, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30706133/pediatric-nodular-fasciitis-at-the-roof-of-the-optic-canal-causing-decreased-vision-case-report-and-review-of-the-literature
#16
Ako Matsuhashi, Kenichi Usami, Eitaro Ishisaka, Hideki Ogiwara
We present a 3-year-old girl with decreased visual acuity of the left eye. Radiological studies revealed a mass lesion at the roof of the left optic canal with bony erosion, which compressed the left optic nerve. Gross total resection of the mass and decompression of the optic canal were performed. Histopathological study was consistent with nodular fasciitis. This is the first report of nodular fasciitis at the roof of the optic canal in a young child. Nodular fasciitis compressing the optic nerve should be included in differential diagnoses of optic neuropathy in young children...
February 1, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30706132/diffuse-intrinsic-pontine-glioma-ventricular-peritoneal-shunt-metastasis-a-case-report-and-literature-review
#17
Chloé Louise Gelder, Cynthia Hawkins, Michal Zapotocky, Peter Dirks, Ute Bartels, Eric Bouffet
Dissemination of diffuse intrinsic pontine glioma (DIPG) outside the central nervous system is exceptional. Here, we present a child diagnosed with DIPG who developed seeding along the track of the ventriculoperitoneal shunt and review the literature on this unusual occurrence.
January 31, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30701299/eeg-lateralization-and-seizure-outcome-following-peri-insular-hemispherotomy-for-pediatric-hemispheric-epilepsy
#18
Ananth P Abraham, Maya Mary Thomas, Vivek Mathew, Karthik Muthusamy, Sangeetha Yoganathan, G Edmond Jonathan, Krishna Prabhu, Roy Thomas Daniel, Ari G Chacko
OBJECTIVE: To determine whether preoperative non-lateralizing scalp electroencephalography (EEG) influences seizure outcome following peri-insular hemispherotomy (PIH) in pediatric hemispheric epilepsy. METHODS: Retrospective data was collected on all 45 pediatric patients who underwent PIH between 2005 and 2016. All underwent a basic pre-surgical evaluation consisting of detailed history and examination, neuropsychological assessment, MRI, and EEG. SPECT/PET, fRMI, or Wada testing were done in only eight patients...
January 30, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30701298/microvascular-decompression-with-partial-occipital-condylectomy-in-a-case-of-pediatric-spasmodic-torticollis
#19
Patrick Graupman, Timothy Feyma, Thomas Sorenson, Eric S Nussbaum
Spasmodic torticollis is a rare, neurologic disorder that is caused by abnormal nerve compression of the 11th cranial nerve by blood vessels or bony protrusions. It is typically treated pharmacologically and, if necessary, with surgical intervention. We report a unique case of spasmodic torticollis in a 15-year-old female that involved abnormal compression of the left 11th cranial nerve (CN) by the left vertebral artery, displaced by a hypertrophic left occipital condyle. After treatment with Botox was unsuccessful, the patient was treated with microvascular decompression and occipital condylectomy that adequately relieved the abnormal compression of CN XI...
January 30, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/30694355/correction-to-congenital-pial-avf-along-the-falx-cerebri-with-complete-agenesis-of-the-corpus-callosum-and-bilateral-parasagittal-pachygyria-polymicrogyria-secondary-to-chronic-ischemia
#20
Pei Ing Ngam, Syed Shahzad Hussain, Ai Peng Tan
The article which was recently published contained error. Fig. 1 was incorrectly processed as Fig. 2, resulting to identical figures during the publication the paper. Given in this article are the correct figures.
January 29, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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