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Journals Folia Histochemica et Cytobiol...

Folia Histochemica et Cytobiologica

https://read.qxmd.com/read/38407325/diagnostic-utility-of-immunocytochemistryby-using-liquid-based-cytology-lbc-slides
#1
JOURNAL ARTICLE
Ozben Yalcin, Senay Erdogan-Durmus, Enver Yarikkaya
INTRODUCTION: Cytological specimens, such as fine needle aspirations (FNAs) and exfoliative cytology samples, offer a minimally invasive avenue for diagnostic purposes. Liquid-based-cytology (LBC), initially designed for cervical cytology, has gained prominence as an alternative technique for nongynecological cytology. immunocytochemistry (ICC) is an ancillary method using mostly used entities exhibit morphological overlap, or cellular origin requires clarification. This study aims to assess ICC's diagnostic utility when applied to LBC slides and to evaluate its efficacy concerning residual material waiting time...
February 26, 2024: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/38073318/correlation-between-stromal-th-and-tc-lymphocytes-and-pd-l1-expression-in-early-breast-cancer-tumors
#2
JOURNAL ARTICLE
Jelena Vučinić, Ljiljana Vučković, Janja Raonić
INTRODUCTION: Prognostic and predictive value of PD-L1 as a biomarker in breast cancer remains controversial.While some studies suggest its association with negative prognostic parameters, others reported a highly significant association between PD-L1 expression and tumor-infiltrating lymphocytes, which are known to be an independent favorable prognostic factor. The aim of present study is to examine the relationship between immune response markers and PD-L1 expression in early breast cancer...
December 11, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/38073317/-periplaneta-americana-extract-attenuates-hepatic-fibrosis-progression-by-inhibiting-collagen-synthesis-and-regulating-the-tgf-%C3%AE-1-smad-signaling-pathway
#3
JOURNAL ARTICLE
Yi Chen, Yanwen Zhao, Liping Yuan, Ying He, Yongshou Yang, Peiyun Xiao
INTRODUCTION: Liver fibrosis is the damage repair response following chronic liver diseases. Activated hepatic stellate cells (HSCs) are the main extracellular matrix (ECM)-producing cells and key regulators in liver fibrosis. Periplaneta americana shows prominent antifibrotic effects in liver fibrosis; however, the underlying mechanisms remain undetermined. This study aimed to elucidate the therapeutic effects of P. americana extract (PA-B) on liver fibrosis based on the regulation of the TGF-β1/Smad signal pathway...
December 11, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/38013515/therapeutic-effect-of-autophagy-induced-by-rapamycin-versus-intermittent-fasting-in-animal-model-of-fatty-liver
#4
JOURNAL ARTICLE
Sara Adel Hosny, Mohammed Hafez Ahmed Moustafa, Fatma Mahmoud Mehina, Marwa Mohamed Sabry
INTRODUCTION: High-fructose, high-fat diet consumption (HFHF) is one of the primary causes of non-alcoholic fatty liver disease (NAFLD), which is due to impaired beta-oxidation or apolipoprotein secretion by hepatocytes. Activation of autophagy in hepatocytes could be a therapeutic method against hepatic complications. This study was designed to compare effects of rapamycin and intermittent fasting-inducing autophagy in rats with experimentally induced nonalcoholic fatty liver. MATERIAL AND METHODS: Male rats were divided into five groups: C (control, n = 6), the experimental group (EX) subdivided, EXIa (HFHF, n = 6), EXIb (recovery, n = 6), EXII (rapamycin, n = 6) and EXIII (intermittent fasting, n = 6)...
November 28, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37787036/inhibition-of-autophagy-promotes-sonodynamic-therapy-induced-apoptosis-of-pancreatic-cancer-cells
#5
JOURNAL ARTICLE
Xiaoxue Du, Jiaming Song, Ziwen Zhang, Jia Liu, Dan Xu
INTRODUCTION: Sonodynamic therapy (SDT), a promising non-invasive therapeutic modality, has attracted increasing attention in the treatment of pancreatic cancer (PC). At present, the role of autophagy in SDT of PC remains unclear. This study aims to explore the role of autophagy in SDT of PC and its effect on apoptosis of PC cells. MATERIAL AND METHODS: PC cells (Capan-1 and BxPC-3) underwent incubation with 5-aminolevulinic acid (5-ALA) or/and ultrasound (US) exposure (control, 5-ALA, US, and SDT groups), followed by measurement of cell apoptosis and autophagy...
October 3, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37787035/therapeutic-effect-of-exosomes-derived-from-hepatocyte-growth-factor-overexpressing-adipose-mesenchymal-stem-cells-on-liver-injury
#6
JOURNAL ARTICLE
Liushenyan Yu, Junchao Xue, Yanyan Wu, Hanyu Zhou
UNLABELLED: Adipose mesenchymal stem cell-derived exosomes (ADMSC-Exo) are a new strategy for the treatment of liver injury. However, mesenchymal stem cells (MSCs) exert therapeutic effects mainly by secreting hepatocyte growth factor (HGF). Therefore, we investigated the role of exosomes derived from ADMSC that overexpress HGF (ADMSCHGF-Exo) on liver injury. MATERIAL AND METHODS: ADMSCs were isolated from young BALB/c female mice. Then exosomes derived from ADMSC transfecting negative control (ADMSCNC-Exo) and HGF overexpression (ADMSCHGF-Exo) were isolated and identified by quantitative polymerase chain reaction (qPCR), flow cytometry, western blot, transmission electron microscope and Nanosight particle tracking analysis...
October 3, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37787034/expression-of-cd105-but-not-of-e-cadherin-is-associated-with-malignancy-recurrence-and-disease-free-interval-in-laryngeal-cancer-in-men
#7
JOURNAL ARTICLE
Elvir Zvrko, Ljiljana Vuckovic
INTRODUCTION: In this study we analyzed CD105 (endoglin) and E-cadherin expression in laryngeal squamous cell carcinoma (LSCC) to evaluate their clinicopathologic significance. MATERIAL AND METHODS: Expression of CD105 and E-cadherin was examined immunohistochemically using paraffin-embedded archival tissues of 72 (35 glottic and 37 supraglottic) previously untreated LSCC male patients. The mean value of the positively-stained microvessels for CD105 counted in four hot spots for each case was used as the final intratumoralmicrovessel density (MVD)...
October 3, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37724035/inhibition-of-heat-shock-protein-47-suppressed-collagen-production-in-tenon-s-capsule-fibroblasts
#8
JOURNAL ARTICLE
Weiwei Wang, Haiyan lI
INTRODUCTION: Glaucoma is the leading cause of irreversible blindness worldwide, and conjunctival bleb scarring remains the most frequent reason for the failure of glaucoma filtration surgery. Excessive proliferation of fibroblasts from Tenon's capsule and excessive deposition of collagen contribute to the scarification of the conjunctival bleb. Heat shock protein 47 (HSP47) is assumed to act as a collagen-specific molecular chaperone, and thereby involved in the pathogenesis of fibrotic diseases...
September 19, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37724034/curcumin-exerts-protective-effects-on-the-thyroid-gland-in-propylthiouracil-treated-rats
#9
JOURNAL ARTICLE
Monika A Papiez
INTRODUCTION: Among the plant ingredients, some compounds interfere with the functions of the thyroid gland. However, there is limited research on the effect of curcumin (CMN) on the functions of this gland. The aim of this study was to analyze the effect of CMN on morphology, histochemical reactivity of cytochrome c oxidase (CCO) and secretion functions of the thyroid gland under conditions of hypothyroidism induced by propylthiouracil (PTU). MATERIAL AND METHODS: The rats were treated for 30 days by gavage with CMN (100 mg/kg b...
September 19, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/36880683/hdac6-inhibition-alleviates-acute-pulmonary-embolism-a-possible-future-therapeutic-option
#10
JOURNAL ARTICLE
Tao Zhou, Di Jia, Jiahui Han, Ce Xu, Xiaohong You, Xin Ge
INTRODUCTION: Acute pulmonary embolism (APE) is a clinical syndrome of pulmonary circulation disorder caused by obstruction of the pulmonary artery or its branches. Histone deacetylase 6 (HDAC6) has been reported to play an important role in lung-related diseases. However, the functional role of HDAC6 in APE remains unclear. MATERIAL AND METHODS: Male Sprague Dawley rats were used. The APE model was constructed by inserting an intravenous cannula into the right femoral vein and injecting Sephadex G-50 microspheres (12 mg/kg; 300 µm in diameter)...
March 7, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/36880682/focused-ultrasound-restrains-the-growth-of-orthotopic-colon-cancer-is-via-promoting-pyroptosis
#11
JOURNAL ARTICLE
Weixing Mo, Qingqing Yu, Jun Lou, Rongjun Tang, Ke Zhang, Lingdi Li, Linfang Zhao
INTRODUCTION: . Focused ultrasound (FUS) is a non-invasive tumor therapy technology emerging in recent years, which can treat various solid tumors. However, it is unclear whether FUS can affect the pyroptosis of colon cancer (CC) cells. Here, we analyzed the effect of FUS on pyroptosis in the orthotopic CC model. MATERIAL AND METHODS: . After an orthotopic CC mouse model was constructed by injecting CT26-Luc cells, BABL/C mice were allocated to the normal, tumor, FUS, and FUS + BAY11-7082 (pyroptosis inhibitor) groups...
March 7, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/36880681/periostin-in-ovarian-carcinoma-from-heterogeneity-to-prognostic-value
#12
JOURNAL ARTICLE
Ludmila Lozneanu, Irina-Draga Caruntu, Cornelia Amalinei, Mihaela Moscalu, Bogdan Gafton, Mihai Vasile Marinca, Andreea Rusu, Raluca Balan, Simona-Eliza Giusca
INTRODUCTION: Periostin (POSTN), an extracellular matrix protein, is involved in tumor-associated extracellular matrix (ECM) remodeling. However, its potential value as a prognostic and/or predictive factor has not yet been confirmed. The present study aims to assess POSTN expression separately in tumor cells and stroma of different ovarian carcinoma (OC) histological types, and its relationship with clinicopathological features. MATERIAL AND METHODS: 102 cases of different histological OC subtypes were immunohistochemically investigated, for POSTN expression assessment in both epithelial tumor cells and tumor stroma...
March 7, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/36734635/6-gingerol-attenuates-sepsis-induced-acute-lung-injury-by-suppressing-nlrp3-inflammasome-through-nrf2-activation
#13
JOURNAL ARTICLE
Quanli Pan, Peng Liu, Min Wan
INTRODUCTION: Sepsis is characterized by an inappropriate inflammatory response. Acute lung injury (ALI) is the most common type of organ injury in sepsis, with high morbidity and mortality. 6-Gingerol is the main bioactive compound of ginger, and it possesses anti-inflammatory bioactivity in different diseases. This study is aimed to explore the specific function of 6-Gingerol in sepsis-induced ALI. MATERIAL AND METHODS: Lipopolysaccharide (LPS) was intraperitoneally injected into Sprague-Dawley rats for establishing the ALI models in vivo...
February 3, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/36692115/morphology-and-immunohistochemical-characteristics-of-the-otic-ganglion-in-the-chinchilla-chinchilla-laniger-molina
#14
JOURNAL ARTICLE
Waldemar Sienkiewicz, Jacek Kuchinka, Agnieszka Dudek, Elżbieta Nowak, Jerzy Kaleczyc, Małgorzata Radzimirska, Aleksander Szczurkowski
INTRODUCTION: The available literature provides relatively little information on the morphology of the autonomic head ganglia in rodents including their neurochemical codding. MATERIAL AND METHODS: Morphological investigations of the otic ganglion of the chinchilla were performed using the modified acetylcholinesterase method. The cellular structure was investigated with histological techniques and neurochemical properties were studied with the double-labelling immunofluorescence method...
January 24, 2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/38258843/mirna-192-5p-targets-dyrk1a-to-attenuate-cerebral-injury-in-mcao-mice-by-suppressing-neuronal-apoptosis-and-neuroinflammation
#15
JOURNAL ARTICLE
Wei He, De-Long Meng, Dan Yang, Qing-You Chen, Li Li, Li-Hua Wang
INTRODUCTION: Ischemic stroke (IS) is a leading cause of disability and mortality worldwide. Several studies have demonstrated the involvement of microRNAs (miRNAs) in brain diseases. miRNA-192-5p is a regulatory molecule in neurodegenerative diseases and its expression was found to be significantly downregulated in the whole blood samples of IS patients, but the specific role of miRNA-192-5p in IS not fully understood. Here, we investigated the role of miRNA-192-5p in a murine model of acute cerebral injury after IS...
2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37435900/rare-benign-lung-tumours-presenting-with-high-clinical-suspicion-for-malignancy-a-case-series-and-review-of-the-literature
#16
REVIEW
Katarina Popovic, Mirjana Miladinović, Ljiljana Vučković, Mirjana Nedović Vuković
INTRODUCTION: Incidentally discovered lung nodules can be worrisome for both the patient and their physicians. Although 95% of solitary lung nodules are benign, it is important to distinguish which nodules have high clinical suspicion for malignancy. Existing clinical guidelines do not apply to patients with signs and symptoms related to the lesion and with an increased baseline risk of lung cancer or metastasis. This paper highlights the vital role of pathohistological analysis and immunohistochemistry in the definitive diagnosis of such incidentally discovered lung nodules...
2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37435899/the-effectiveness-of-using-dye-models-for-small-tissue-biopsies-in-the-surgical-pathology-laboratory
#17
JOURNAL ARTICLE
Predaporn Nonsiri, Potchara Srivilai, Supatsorn Onkaew, Nontawat Benjakul
INTRODUCTION: Losing of small tissues during tissue preparatory steps may seriously affect pathological diagnostic performance. Using an appropriate tissue marking dye could be an alternative solution. Therefore, the aim of the study was to find a suitable tissue marking dye to enhance the observable ability of various types of small-size tissues during several steps of tissue preparation. MATERIAL AND METHODS: Various small-size samples of various organs and tissues (0...
2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37435898/cryptotanshinone-ameliorates-hemorrhagic-shock-induced-liver-injury-via-activating-the-nrf2-signaling-pathway
#18
JOURNAL ARTICLE
Jiahui Han, Di Jia, Hao Yao, Ting Lv, Xi Xu, Xin Ge
INTRODUCTION: Hemorrhagic shock (HS) is an important cause of high mortality in traumatized patients. Cryptotanshinone (CTS) is a bioactive compound extracted from Salvia miltiorrhiza Bunge (Danshen). The current study aimed to explore the effect and underlying mechanism of CTS on the liver injury induced by HS. MATERIAL AND METHODS: Male Sprague-Dawley rats were used to establish the HS model by hemorrhaging and monitoring mean arterial pressure (MAP). CTS was intravenously administered at concentration of 3...
2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37435897/myricetin-alleviates-h2o2-induced-senescence-and-apoptosis-in-rat-nucleus-pulposus-derived-mesenchymal-stem-cells
#19
JOURNAL ARTICLE
Tian Xie, Ruijie Pan, Wenzhuo Huang, Sheng Dong, Shizhen Wu, Yuhui Ye
INTRODUCTION: Transplantation of mesenchymal stem cells (MSCs) has been reported to be a novel promising target for the regeneration of degenerated intervertebral discs (IVDs). However, the culture and survival limitations of MSCs remain challenging for MSC-based biological therapy. Myricetin, a common natural flavonoid, has been suggested to possess antiaging and antioxidant abilities. Therefore, we investigated the biological function of myricetin, and its related mechanisms involving cell senescence in intervertebral disc degeneration (IDD)...
2023: Folia Histochemica et Cytobiologica
https://read.qxmd.com/read/37435896/immunocytochemical-localization-of-calbindin-d28k-calretinin-and-parvalbumin-in-the-mongolian-gerbil-meriones-unguiculatus-visual-cortex
#20
JOURNAL ARTICLE
Jae-Rim Son, Xin-Yu Kuai, Chang-Jin Jeon
INTRODUCTION: While most animals of the Muridae family are nocturnal, the gerbil displays diurnal activity and provides a useful model for visual system research. The purpose of this study was to investigate the localization of calcium-binding proteins (CBPs) in the visual cortex of the Mongolian gerbil (Meriones unguiculatus). We also compared the labeling of CBPs to those of gamma-aminobutyric acid (GABA)- and nitric oxide synthase (NOS)-containing neurons. MATERIAL AND METHODS: The study was conducted on twelve adult Mongolian gerbils (3-4 months old)...
2023: Folia Histochemica et Cytobiologica
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