Yuki Tajima, Chun Y Seow, Shou-Jin Dong, Mai Tsutsui, Chung Y Cheung, Ian Welch, Laura Mowbray, Brittany Imlach, Rhonda Hildebrandt, Kayla Apperloo, Brian Ryomoto, Evan Goodacre, Corey Myrdal, Lindsay Machan, Kim Wolff, Eran Elizur, Dragos M Vasilescu, Don D Sin
Emphysema is one of the pathological hallmarks of chronic obstructive pulmonary disease. We have recently reported that radiofrequency therapy improves lung function in rodent models of emphysema. However, preclinical data using large animals is necessary for clinical translation. Here, we describe the work performed to establish a unilateral porcine emphysema model. Different doses of porcine pancreatic elastase (PPE) were instilled into the left lung of ten Yucatan pigs. Three additional pigs were used as controls...
September 28, 2023: Journal of Applied Physiology