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Natural Product Reports

Kuan Zheng, Ran Hong
Covering: selected examples in the past three decades (up to 2018)The challenging structures and often potent biological activities of naturally occurring macrocycles have attracted much attention among the synthetic community. In a typical retrosynthetic disconnection, commonly used macrocyclization tactics, including macrolactonization, macrolactamization, ring-closing metathesis, olefination, and metal-mediated cross-coupling reactions, are invariably based on linear substrates in which all of the stereogenic centers have already been set forth...
February 13, 2019: Natural Product Reports
Zhong Jin, Guangmin Yao
Covering: July 2015 to June 2017. Previous review: Nat. Prod. Rep., 2016, 33, 1318-1343Recent progress on the isolation, identification, biological activity and synthetic studies of the structurally diverse alkaloids from plants of family Amaryllidaceae has been summarized in this review. In addition, the structurally related alkaloids isolated from Sceletium species are discussed.
February 1, 2019: Natural Product Reports
Teresa P Martins, Caroline Rouger, Nathaniel R Glasser, Sara Freitas, Nelly B de Fraissinette, Emily P Balskus, Deniz Tasdemir, Pedro N Leão
Covering: up to 2019Alkylresorcinols are amphiphilic metabolites, well-known for their diverse biological activities, produced by both prokaryotes and eukaryotes. A few classes of alkylresorcinol scaffolds have been reported from the photoautotrophic cyanobacteria, ranging from the relatively simple hierridins to the more intricate cylindrocyclophanes. Recently, it has emerged that cyanobacteria employ two different biosynthetic pathways to produce unique alkylresorcinol scaffolds. However, these convergent pathways intersect by sharing biosynthetic elements which lead to common structural motifs...
January 31, 2019: Natural Product Reports
Joshua J Kellogg, Mary F Paine, Jeannine S McCune, Nicholas H Oberlies, Nadja B Cech
Covering: up to the end of 2018Dietary supplements, which include botanical (plant-based) natural products, constitute a multi-billion-dollar industry in the US. Regulation and quality control for this industry is an ongoing challenge. While there is general agreement that rigorous scientific studies are needed to evaluate the safety and efficacy of botanical natural products used by consumers, researchers conducting such studies face a unique set of challenges. Botanical natural products are inherently complex mixtures, with composition that differs depending on myriad factors including variability in genetics, cultivation conditions, and processing methods...
January 25, 2019: Natural Product Reports
Fabrizio Alberti, Christophe Corre
Covering: up to December 2018This article aims to highlight advantages, drawbacks and issues that users should consider when implementing the use of CRISPR/Cas9-tools for genome editing in streptomycetes, the most prolific source of antimicrobial natural products to date. Here, we examine four toolkits that have so far been made available for streptomycete in vivo-engineering and one for in vitro-editing, and review how they have been applied over the last three years. Our critical evaluation of these toolkits intends to support potential users in determining what they could achieve, what they should consider and what system they should select/optimise for their application...
January 25, 2019: Natural Product Reports
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as vlasoulamine A from Vladimiria souliei.
January 22, 2019: Natural Product Reports
Anthony R Carroll, Brent R Copp, Rohan A Davis, Robert A Keyzers, Michèle R Prinsep
Covering: January to December 2017This review covers the literature published in 2017 for marine natural products (MNPs), with 740 citations (723 for the period January to December 2017) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1490 in 477 papers for 2017), together with the relevant biological activities, source organisms and country of origin...
January 21, 2019: Natural Product Reports
Nawaf Al-Maharik
Covering: Jan. 2012 to Dec. 2017This review describes the 391 new isoflavonoids isolated and identified from natural sources between January 2012 and December 2017, commenting on their sources, identification and biological activities. Due to the length of this review, the synthesis of isoflavonoids is not included. Furthermore, new applications of analytical techniques for the isolation and identification of isoflavonoids are also reviewed.
January 11, 2019: Natural Product Reports
Emily R Brown, Marisa R Cepeda, Samantha J Mascuch, Kelsey L Poulson-Ellestad, Julia Kubanek
Covering: January 2015 through December 2017This review focuses on recent studies on the chemical ecology of planktonic marine ecosystems, with the objective of presenting a comprehensive overview of new findings in the field in the time period covered. In order to highlight the role of chemically mediated interactions in the marine plankton this review has been organized by ecological concepts starting with intraspecific communication, followed by interspecific interactions (including facilitation and mutualism, host-parasite, allelopathy, and predator-prey), and finally the effects of plankton secondary metabolites on community and ecosystem-wide interactions...
January 8, 2019: Natural Product Reports
Liujie Huo, Joachim J Hug, Chengzhang Fu, Xiaoying Bian, Youming Zhang, Rolf Müller
Covering: 2013 to June 2018Heterologous expression of natural product biosynthetic pathways is of increasing interest in microbial biotechnology, drug discovery and optimization. It empowers not only the robust production of valuable biomolecules in more amenable heterologous hosts but also permits the generation of novel analogs through biosynthetic engineering. This strategy also facilitates the discovery of novel bioactive compounds following the functional expression of cryptic biosynthetic gene clusters (BGCs) from fastidious original producers or metagenomic DNA in surrogate hosts, thus facilitating genome mining in the post-genomic era...
January 8, 2019: Natural Product Reports
Huijuan Guo, David Roman, Christine Beemelmanns
Covering: 2008 to 2018This review provides a comprehensive overview of newly discovered natural products containing a tropolonoid motif covering 2008 up to 2018 and depicts the ecological context in which they have been isolated. This review has a strong focus on describing the different analytical tools and molecular biological approaches used to identify the underlying biosynthetic pathways.
December 17, 2018: Natural Product Reports
Florence Lefranc, Aikaterini Koutsaviti, Efstathia Ioannou, Alexander Kornienko, Vassilios Roussis, Robert Kiss, David Newman
Covering: 1957 to 2017Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment. Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment. Because of their structural diversity and uniqueness, these molecules have recently gained a lot of interest for the identification of medicinally useful agents, including those with potential anticancer activities. In the current review, which is not a catalogue-based one, we first highlight the major biological events that lead to various types of cancer, including metastatic ones, to chemoresistance, thus to any types of current anticancer treatment relating to the use of chemotherapeutics...
December 17, 2018: Natural Product Reports
Alescia Cullen, Leanne A Pearson, Rabia Mazmouz, Tianzhe Liu, Angela H Soeriyadi, Sarah E Ongley, Brett A Neilan
Covering: up to 2018Marine and freshwater cyanobacteria produce a variety of toxic compounds that pose a threat to the health of humans, livestock and natural ecosystems world-wide. Significant research efforts have been directed towards understanding the biosynthesis of these cyanotoxins in an attempt to reduce their deleterious effects on water quality and, more recently, to harness their biotechnological potential. While a variety of complementary methods (such as bioinformatic analyses and isotope feeding studies) have been employed over the last three decades to address knowledge gaps in this field, this review focuses on the utility of heterologous expression and biochemical studies, including emerging technologies for engineering and expressing complete cyanotoxin gene clusters...
December 17, 2018: Natural Product Reports
Yaojun Tong, Tilmann Weber, Sang Yup Lee
Covering: up to February, 2018This review briefly introduces and summarizes current knowledge about the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) - CRISPR/Cas system and how it was engineered to become one of the most important and versatile genome editing techniques that are currently revolutionizing the whole field of molecular biology. It aims to highlight and discuss the applications and remaining challenges of CRISPR/Cas (mainly focusing on CRISPR/SpCas9)-based genome editing in natural product discovery...
December 14, 2018: Natural Product Reports
Xue Ming Wu, Ren Xiang Tan
Covering: 2000 to 2018 (October)Trillions of microbes, collectively termed as gut microbiota, reside in the gastrointestinal tract and are involved in the physiology of their hosts. In humans, disease incidence and medical therapy are found to be associated with gut microbiota composition. Since ethnomedicines are largely plant-derived and orally ingested, this review summarizes the interactions of gut microbiota with ethnomedicine constituents (overwhelmingly, natural phytochemicals) to highlight the knowledge accumulation in (1) the modulation of the gut microbiota profile by ingested natural compounds, and (2) the gut microbial conversion of natural products into the 'daughter molecules' with potent bioactivities...
December 11, 2018: Natural Product Reports
Guozhi Xiao, Xiaofei Shao, Dapeng Zhu, Biao Yu
Covering: 1989-2017Saponins are characteristic metabolites of starfish and sea cucumbers, and occasionally are also found in sponges, soft coral, and small fish. These steroid or triterpenoid glycosides often show remarkable biological and pharmacological activities, such as antifungal, antifouling, shark repellent, antitumor and anti-inflammatory activities. Over one thousand marine saponins have been characterized; the majority of them can be categorized into three major structural types, i.e., asterosaponins, polyhydroxysteroid glycosides, and holostane glycosides...
December 7, 2018: Natural Product Reports
Edward Owen Norman, James Lever, Robert Brkljača, Sylvia Urban
Covering: up to 2018The Haemodoraceae family is a monocotyledonous family in the order Commelinales consisting of 14 genera. Many species from the family are endemic to Australia and their use by the Aboriginal People of Australia as both pigments or remedies has been ethnobotanically documented. Phenylphenalenones are phenolic specialised metabolites consisting of a tricyclic phenalene nucleus with a ketone moiety and a lateral phenyl ring. Depending on their structural variance, four classes can be distinguished including the phenylphenalenones, oxabenzochrysenones, phenylbenzoisochromenones and phenylbenzoisoquinolinediones...
November 29, 2018: Natural Product Reports
Zhuang Chen, Mallesham Pitchakuntla, Yanxing Jia
Covering: 2000 to 2018Natural products containing the 2,3-dihydrobenzofuran (2,3-DHB) skeleton have been the focus of a substantial number of synthetic studies since 2000. Herein, we review the total syntheses of decursivine, serotobenine, lithospermic acid, linderol A, bisabosqual A, pterocarpans, conocarpan, heliannuols, and some resveratrol oligomers, with emphasis on the synthetic strategies employed.
November 29, 2018: Natural Product Reports
Wanping Chen, Yanli Feng, István Molnár, Fusheng Chen
Covering: up to June 2018Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the significant medical potential of these metabolites and their long history of widespread use as food colorants. However, a considerable progress has been made in recent years towards the elucidation of MonAzPs biosynthesis in various fungi...
November 28, 2018: Natural Product Reports
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as kadsuraol A from Kadsura longipedunculata.
November 26, 2018: Natural Product Reports
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