journal
https://read.qxmd.com/read/38744555/review-of-immunohistochemistry-techniques-applications-current-status-and-future-perspectives
#1
REVIEW
Dinku Yigzaw Mebratie, Gashaw Getaneh Dagnaw
The Hematoxylin and Eosin stain is a cornerstone in histopathology that facilitates the microscopic examination of tissue samples for identifying infections and tumors. However, challenges arise from the similar appearances of diseases and cells, prompting the emergence of Immunohistochemistry (IHC) as an important technique. This review summarizes the principles, procedures, and applications and future perspectives of IHC, a prevalent immunostaining method allowing the detection of specific proteins in tissue sections...
May 3, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38719707/diagnostic-clues-and-pitfalls-in-salivary-gland-fine-needle-aspiration-cytology
#2
REVIEW
Masato Nakaguro
Salivary gland tumors (SGT) display morphological diversity and pose diagnostic challenges. Preoperative fine needle aspiration cytology (FNAC) is a minimally invasive and efficient diagnostic test. However, due to the limited sample size, the final diagnosis may not be established based on FNAC alone. Although cytomorphology and architecture are usually preserved on FNAC, morphologic changes specific to FNAC can complicate the diagnosis. The Milan System for Reporting Salivary Gland Cytopathology categorizes complex FNAC interpretations...
May 3, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38734484/the-differential-diagnosis-of-lymphoepithelial-lesion-of-the-salivary-gland
#3
REVIEW
Makoto Urano, Masato Nakaguro
The differential diagnosis of salivary gland lesions with epithelial components and lymphoid stroma is often challenging. Salivary gland carcinoma with tumor-associated lymphoid proliferation, tumors composed of both epithelial and lymphoid components, lymphoid neoplasms in the salivary gland, and inflammatory lesions are all included in this category. It encompasses inflammatory lesions and neoplastic lesions. With the exception of Warthin tumors, these lesions are rare, making them more difficult to diagnose...
May 1, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38658249/high-grade-salivary-carcinomas-a-current-insight-on-diagnostic-pathology-and-the-key-to-clinical-decision-making
#4
REVIEW
Yoshitaka Utsumi, Masato Nakaguro, Yuichiro Tada, Toshitaka Nagao
High-grade carcinomas of the salivary glands are a group of several tumor entities with highly malignant histologic appearances, and have an aggressive biological behavior accompanied by poor a prognosis. In general, they require more intensive treatment than low- or intermediate-grade carcinomas. High-grade salivary carcinomas are rare and the microscopic features often overlap between different tumor types, making an appropriate diagnosis challenging in daily practice settings. However, with recent rapid advances in molecular pathology and molecular-targeted therapy in this field, there is a growing need to properly classify tumors, rather than just diagnosing the cases as "high-grade carcinomas"...
April 17, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38609754/expanding-the-cytological-and-architectural-spectrum-of-mucoepidermoid-carcinoma-the-key-to-solving-diagnostic-problems-in-morphological-variants
#5
REVIEW
Shinnichi Sakamoto, Kentaro Kikuchi
Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Varying sized cysts and sheets composed of three cell types (epidermoid, intermediate, and mucous cells) with varying degrees of atypia form the characteristic histological appearance of MEC. MEC frequently contains a wide variety of modified tumor cells and can be entirely cystic or completely solid. Under these circumstances, MEC requires critical differentiation from many mimickers, ranging from simple cysts and benign tumors to high-grade carcinomas...
April 3, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38341348/histopathologic-clues-to-the-etiopathogenesis-of-orbital-inflammatory-disease-idiopathic-igg4-related-neoplastic-autoimmune-and-beyond
#6
REVIEW
Anna M Stagner
Orbital inflammatory diseases represent a heterogenous group of idiopathic, autoimmune-related, and sometimes neoplastic conditions with overlapping clinical and histopathologic features, as well as variable levels of IgG4-positive plasma cells detected within tissue biopsies. Some histopathologic features, especially in an appropriate clinical context, may point to a specific diagnosis in a given patient. Diagnoses of non-specific orbital inflammation, orbital inflammation related to autoimmune diseases such as granulomatosis with polyangiitis and IgG4-related disease, lymphoma, and xanthogranulomatous diseases are discussed, contrasted and illustrated...
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38246802/igg4-related-kidney-disease-clinicopathologic-features-differential-diagnosis-and-mimics
#7
REVIEW
Sarwat I Gilani, Alessia Buglioni, Lynn D Cornell
IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial nephritis (IgG4-TIN), and then IgG4-related membranous glomerulonephritis (IgG4-MGN), we now recognize additional patterns of interstitial nephritis, glomerular disease, and vascular disease that can be seen as part of IgG4-RKD. The clinical presentation is variable and can include acute or chronic kidney injury, proteinuria or nephrotic syndrome, mass lesion(s), and obstruction...
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38238220/unraveling-the-complexities-of-igg4-related-disease-musings-from-a-histopathologist
#8
REVIEW
Vikram Deshpande
No abstract text is available yet for this article.
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38238218/mimickers-of-immunoglobulin-g4-related-hepatobiliary-disease-on-biopsy
#9
REVIEW
Byoung Uk Park, Hee Eun Lee, Lizhi Zhang
With the growing recognition of IgG4-related hepatobiliary disease, establishing a definitive diagnosis relies mainly on a combination of clinical findings, serological markers, and imaging modalities. However, the role of histopathological evaluation remains indispensable, particularly in cases necessitating differential diagnosis or malignancy exclusion. While diagnosing IgG4-related hepatobiliary disease through surgical resection specimens is often straightforward, pathologists encounter substantial challenges when evaluating biopsies...
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38185595/advancements-in-diagnosing-igg4-related-disease-of-the-head-and-neck-navigating-diagnostic-pitfalls
#10
REVIEW
Munita Bal, Vikram Deshpande
IgG4-related disease (IgG4-RD) is an immune-mediated condition affecting nearly any organ. This review focuses on the nuances of diagnosing IgG4-RD affecting the head and neck. Salivary gland involvement, especially of the submandibular glands, often permits a definitive diagnosis on biopsy. However, elevated IgG4+ plasma cells are nonspecific and can be seen in chronic sialadenitis, lymphoma, and other mimics. Careful correlation of clinical and pathological findings is essential. Given the significant overlap with chronic sinusitis, IgG4-RD of the sinonasal region is difficult to diagnose histologically...
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38184420/autoimmune-pancreatitis-biopsy-interpretation-and-differential-diagnosis
#11
REVIEW
Yoh Zen
Autoimmune pancreatitis (AIP) is classified into type 1 (IgG4-related) and type 2 (IgG4-unrelated) and the interpretation of pancreatic biopsy findings plays a crucial role in their diagnosis. Needle biopsy of type 1 AIP in the acute or subacute phase shows a diffuse lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis, and the infiltration of many IgG4-positive plasma cells. In a later phase, changes become less inflammatory and more fibrotic, making interpretations more challenging. Confirmation of the lack of 'negative' findings that are unlikely to occur in type 1 AIP (e...
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38000975/challenges-and-pitfalls-in-the-diagnosis-of-igg4-related-disease
#12
REVIEW
Adrian C Bateman, Emma L Culver
IgG4-related disease (IgG4-RD) is a relatively novel fibroinflammatory condition characterized typically by dense lymphoplasmacytic inflammation, storiform fibrosis and obliterative venulitis, together with prominent IgG4+ plasma cells and an IgG4+/IgG+ plasma cell ratio of >40 %. The diagnosis is usually made on a combination of clinical and serological features together with characteristic radiological and histological appearances. The condition may be limited to a single tissue/organ (e.g., autoimmune pancreatitis) or may be multicentric in nature - four clinical 'patterns' of disease distribution have recently been described...
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/37993385/differential-diagnosis-of-igg4-positive-plasma-cells-in-the-lung
#13
REVIEW
Sanjay Mukhopadhyay
The recognition of immunoglobulin G4-related disease (IgG4-RD) as an entity in the pancreaticobiliary tract was followed by a slew of papers describing inflammation and fibrosis containing IgG4-positive plasma cells in a variety of sites including the respiratory tract, leading to the hypothesis that these abnormalities were attributable to IgG4-RD. Predictably, pathologists began to see requests from clinicians to perform IgG4 immunohistochemistry in lung biopsies "to rule out IgG4-RD". Several years later, the notion that IgG4-RD would prove to be the underlying cause of a wide array of fibroinflammatory lesions in the lung has not panned out as promised...
March 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38627186/the-history-of-the-microscope-reflects-advances-in-science-and-medicine
#14
REVIEW
Caitlin A Noble, Andrew P Biesemier, Sarah F McClees, Aljunaid M Alhussain, Stephen E Helms, Robert T Brodell
Microscopes, more than any other instrument, reflect advances in clinical medicine over the past several hundred years. As the primary tool of the pathologist, they were, and continue to be, a key connector between the bedside and basic sciences. One specific example is the science of clinical dermatology, which relies on clinical-pathologic correlation to make a definitive diagnosis. The microscopes used by pathologists, however, are more than scientific artifacts. Many antique microscopes are hand-crafted works of art...
January 11, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38199878/mark-wick-contributions-to-pathology-of-the-mediastinum
#15
REVIEW
Horacio Maluf
Mark Wick made a wide range of contributions to the field of mediastinal pathology. Early papers amplified the spectrum of neuroendocrine carcinomas of the thymus and brought attention to the aggressive nature of this tumor, also highlighting the occurrence of coexisting carcinoid tumor and small cell carcinoma of this organ. The controversial issue of thymoma classification was addressed in several papers and editorial comments, while also reporting a case of metastatic thymoma. A series of thymic carcinomas as well a report on the unusual clear cell variant bear his name as one of the authors...
January 7, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38195331/pathology-of-hereditary-renal-cell-carcinoma-syndromes
#16
REVIEW
Chin-Lee Wu
No abstract text is available yet for this article.
January 7, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38242750/birt-hogg-dub%C3%A3-syndrome-in-an-overall-view-focus-on-the-clinicopathological-prospects-in-renal-tumors
#17
REVIEW
Jialong Wu, Jian Lu, Chin-Lee Wu, Min Lu
Birt-Hogg-Dubé syndrome (BHD) represents a rare autosomal dominant tumor predisposition syndrome characterized by skin lesions, lung cysts, and renal tumors. The predominant histological subtypes of BHD-related renal tumors include hybrid oncocytoma-chromophobe tumors, oncocytomas, and chromophobe renal cell carcinomas, all exhibiting eosinophilic/oncocytic features. Immunohistochemistry staining for KIT (CD117) and CK7 exhibits variability in these tumor types. Germline mutations in FLCN have been consistently identified...
January 6, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38336505/clinical-pathologic-correlation-the-impact-of-grossing-at-the-bedside
#18
REVIEW
C Alexis Noble, Chinmoy Bhate, Buu T Duong, Allison R Cruse, Robert T Brodell, Riley C Hanus
The unenlightened clinician may submit a skin specimen to the lab and expect an "answer." The experienced clinician knows that in performing skin biopsies, it is critical to select the most appropriate: 1) anatomic location for the biopsy1 , 2 ; 2) type of biopsy1 , 2 ; 3) depth and breadth of the biopsy; and 4) medium for hematoxylin and eosin staining (formalin) or direct immunofluorescence (Michel's Transport Medium or normal saline).2 Demographic information, anatomic location, clinical context, and differential diagnosis are all critical components of a properly completed requisition form...
January 5, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38238219/contributions-of-dr-wick-to-the-pathology-of-diseases-of-the-lung-and-pleura
#19
REVIEW
Saul Suster
The curriculum vitae of Dr. Mark R. Wick contains 57 peer-reviewed publications, 3 editorials, 6 book chapters and a whole book dedicated to diseases of the lung and pleura. It is remarkable that such productivity should represent only a small portion of the overall output of Dr. Wick, which includes (at last count) 341 original peer-review publications, 119 invited review articles, 93 book chapters, 42 editorials, 3 society-related position papers, 18 books and 2 interactive video disks. Yet, his contributions to the literature in pulmonary and pleural pathology have been significant and influential and have established for him a national and international reputation as one of the leading experts in pulmonary pathology...
January 5, 2024: Seminars in Diagnostic Pathology
https://read.qxmd.com/read/38228439/igg4-related-lymphadenopathy
#20
REVIEW
Wah Cheuk, Jacob R Bledsoe
IgG4-related lymphadenopathy is a nodal manifestation of IgG4-related disease (IgG4RD) which is characterized by increased polytypic IgG4+ plasma cells and IgG4+/IgG+ plasma cell ratio in lymph nodes and morphologically manifested as various patterns of reactive lymphadenopathy: Castleman disease-like, follicular hyperplasia, interfollicular expansion, progressive transformation of germinal centers and inflammatory pseudotumor-like. It typically presents with solitary or multiple, mild to moderate lymph node enlargement in otherwise asymptomatic patients...
January 5, 2024: Seminars in Diagnostic Pathology
journal
journal
28973
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.