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Journal of Perinatology: Official Journal of the California Perinatal Association

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https://read.qxmd.com/read/30755719/differential-effects-of-the-retinopathy-of-prematurity-exam-on-the-physiology-of-premature-infants
#1
John B C Tan, Jennifer Dunbar, Andrew Hopper, Christopher G Wilson, Danilyn M Angeles
OBJECTIVE: To compare the differential effects of the retinopathy of prematurity (ROP) examination on the physiology of premature infants with and without oxygen support. STUDY DESIGN: We collected data from 42 premature infants (room air = 19, oxygen support = 23) and compared physiological metrics including heart rate (HR), systemic peripheral saturation (SpO2 ), mesenteric tissue oxygen saturation (StO2 ) and clinical events (oxygen desaturation episodes, bradycardia events, and gastric residuals)...
February 12, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30755718/tidal-volume-transmission-during-non-synchronized-nasal-intermittent-positive-pressure-ventilation-via-ram-%C3%A2-cannula
#2
David N Matlock, Shasha Bai, Michael D Weisner, Norman Comtois, Jennifer Beck, Christer Sinderby, Sherry E Courtney
BACKGROUND: Nasal intermittent positive pressure ventilation (NIPPV) is a widely used mode of support in neonates, during which ventilator inflations may or may not coincide with spontaneous breathing. OBJECTIVE: We tested the hypothesis that inflations delivered with NIPPV via RAM® cannula and not accompanied by patient effort produce minimal tidal volume as measured by respiratory inductance plethysmography. DESIGN/METHODS: Fourteen subjects were monitored while receiving NIPPV...
February 12, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723282/outcomes-of-preterm-infants-conceived-with-in-vitro-fertilization
#3
Kaashif Aqeeb Ahmad, Monica M Bennett, Polli Rayburn, C Andrew Combs, Reese H Clark, Veeral N Tolia
OBJECTIVES: To determine if there is increased risk of prematurity-related complications for in vitro fertilization (IVF)-conceived preterm infants compared to matched controls. STUDY DESIGN: Cohort study of 23-34 weeks' preterm infants from 329 US NICUs discharged from 2009 to 2016. Each IVF patient was matched to three controls. RESULTS: We identified 6,756 IVF-conceived preterm infants who were matched with 20,268 controls. IVF-conceived infants had no increase in non-respiratory morbidities but had significantly higher rates of bronchopulmonary dysplasia (8...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723281/feeding-during-transfusion-and-the-risk-of-necrotizing-enterocolitis-in-preterm-infants
#4
Monika Bajaj, Mirjana Lulic-Botica, Amber Hanson, Girija Natarajan
OBJECTIVE: To evaluate the effect of withholding feeds during transfusion on transfusion associated acute gut injury (TRAGI). STUDY DESIGN: Data were collected on 125 preterm infants before and after the practice of withholding feeds for 12-24 h during transfusion was instituted. Logistic regression was used to examine effects of withholding feeds on TRAGI rates. RESULTS: A total of 19 (15%) infants developed NEC; 6/19 (32%) had TRAGI. Postnatal hydrocortisone use was associated with TRAGI (OR 8...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723280/histological-chorioamnionitis-at-term-according-to-labor-onset-a-prospective-controlled-study
#5
Hadas Ganer Herman, Letizia Schreiber, Hadas Miremberg, Masha Ben Zvi, Jacob Bar, Michal Kovo
OBJECTIVE: To study the incidence of histological chorioamnionitis (HCA) in term pregnancies according to labor onset. STUDY DESIGN: During 2013-6, term pregnancy placentas were prospectively sent to histopathology evaluation, and compared between patients with spontaneous onset labor, pre-labor ROM, labor induction and elective cesarean deliveries. RESULTS: A total of 260 placentas were obtained, 65 from each group. Rates of HCA for the spontaneous labor, PROM, induction and CD groups were: 49, 32, 24 and 4%, respectively (p < 0...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723279/association-of-chorioamnionitis-and-its-duration-with-neonatal-morbidity-and-mortality
#6
Kartik K Venkatesh, Wesley Jackson, Brenna L Hughes, Mathew M Laughon, John M Thorp, David M Stamilio
OBJECTIVE: To investigate the association of chorioamnionitis, and secondarily its duration, on neonatal adverse outcomes for infants born <34 weeks vs. ≥34 weeks. STUDY DESIGN: A secondary analyss from the observational U.S. Consortium on Safe Labor Study. The exposure was chorioamnionitis, and secondarily, its estimated duration. The composite outcome included pneumonia, seizure, necrotizing enterocolitis, sepsis, periventricular/intraventricular/cerebral hemorrhage, mechanical ventilation, and neonatal death...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723278/association-of-antenatal-depression-with-oxidative-stress-and-impact-on-spontaneous-preterm-birth
#7
Kartik K Venkatesh, John D Meeker, David E Cantonwine, Thomas F McElrath, Kelly K Ferguson
OBJECTIVE: To determine whether antenatal depression is associated with oxidative stress and inflammation, and secondarily, whether the association between antenatal depression and spontaneous preterm birth (SPTB) is mediated by these biomarkers. STUDY DESIGN: The primary outcome included urine oxidative stress biomarkers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane and plasma inflammatory biomarkers measured at 10, 18, and 26 weeks and averaged within individual...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723277/aletheia-20-unconcealed-observations-from-quality-improvement-and-evidence-based-medicine
#8
Joseph W Kaempf, Gautham Suresh
Quality improvement (QI) and evidence-based medicine (EBM) activities ideally generate value (benefit/cost). Physicians and hospitals vary in ability to demonstrate efficiency despite common methodology available to all. Based upon our 60-some years of combined QI and EBM experience, we suggest reasoned consideration of meta-cognition-thinking about thinking. How do we observe, analyze, intuit, then share observations and learning with collaborative networks? The Greek word aletheia denotes disclosure of the essence of an object or event as its genuine nature, "unhidden, revealed, unconcealed"...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723276/umbilical-cord-milking-reduces-the-risk-of-intraventricular-hemorrhage-in-preterm-infants-born-before-32-weeks-of-gestation
#9
J D Toledo, S Rodilla, A Pérez-Iranzo, A Delgado, Y Maazouzi, M Vento
OBJECTIVE: Intraventricular hemorrhage (IVH) is a common complication in extremely preterm infants. We aimed to demonstrate that umbilical cord milking (UCM) would reduce the incidence of IVH in this at risk population. STUDY DESIGN: We compared the incidence of IVH in a prospective cohort of consecutively born preterm infants <32 weeks' gestation receiving UCM (n = 33) with a historical cohort that underwent immediate cord clamping (ICC) (n = 36). RESULTS: No significant differences regarding perinatal characteristics were present between both groups except for chorioamnionitis and preterm rupture of membranes which were more frequent in the UCM group...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30723275/hospital-acquired-viral-respiratory-infections-in-neonates-hospitalized-since-birth-in-a-tertiary-neonatal-intensive-care-unit
#10
Claudette L Poole, Bernard C Camins, Mark N Prichard, Ona Faye-Petersen, Cecelia Hutto
OBJECTIVE: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU. STUDY DESIGN: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. RESULTS: Seventy-four infants enrolled, with 5 (6.8%) testing positive for a virus (incidence rate of 1...
February 5, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692619/probiotics-for-preterm-infants-a-national-retrospective-cohort-study
#11
Balpreet Singh, Prakesh S Shah, Jehier Afifi, C David Simpson, Souvik Mitra, Kimberly Dow, Walid El-Naggar
OBJECTIVE: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. STUDY DESIGN: We conducted a retrospective cohort study of infants < 29 weeks' gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used...
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692618/should-we-target-higher-or-lower-oxygen-saturation-targets-in-the-preterm-infant
#12
Sarah Drennan, Edgardo Szyld
No abstract text is available yet for this article.
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692617/sutureless-closure-a-versatile-treatment-for-the-diverse-presentations-of-gastroschisis
#13
David F Grabski, Yinin Hu, Rick D Vavolizza, Sara K Rasmussen, Jonathan R Swanson, Eugene D McGahren, Jeffrey W Gander
OBJECTIVE: Case series have demonstrated sutureless closures to be safe for the correction of gastroschisis. We hypothesize that sutureless closure is efficacious in patients requiring silo reduction without need for intubation. STUDY DESIGN: We conducted a retrospective case control study of infants who underwent gastroschisis repair at our institution (January 2011-August 2018). Patient characteristics and clinical outcomes were compared between sutureless closure and primary fascial repair groups...
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692616/response-to-dr-kumar-s-letter
#14
LETTER
Meenakshi Girish, Zubair H Aghai
No abstract text is available yet for this article.
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692615/early-onset-sepsis-calculator-based-management-of-newborns-exposed-to-maternal-intrapartum-fever-a-cost-benefit-analysis
#15
Cynthia L Gong, Shom Dasgupta-Tsinikas, Kenneth M Zangwill, Michael Bolaris, Joel W Hay
OBJECTIVE: To determine potential net monetary benefit of an early onset sepsis calculator-based approach for management of neonates exposed to maternal intrapartum fever, compared to existing guidelines. STUDY DESIGN: We performed a cost-benefit analysis comparing two management approaches for newborns >34 weeks gestational age exposed to maternal intrapartum fever. Probabilities of sepsis and meningitis, consequences of infection and antibiotic use, direct medical costs, and indirect costs for long-term disability and mortality were considered...
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692614/vasa-previa-and-extreme-prematurity-a-population-based-study
#16
Amanda Yeaton-Massey, Anna I Girsen, Jonathan A Mayo, Yair J Blumenfeld, Yasser Y El-Sayed, David K Stevenson, Gary M Shaw
OBJECTIVE: To determine population-based risks of preterm birth associated with vasa previa. STUDY DESIGN: Included were 945,950 singleton, live birth cesarean deliveries with and without vasa previa (gestational ages 24-41 weeks) in California between 2007 and 2012. Odds ratios (ORs) of preterm birth were estimated using logistic regression. RESULTS: In total, 586 were complicated by vasa previa (0.06%). In total, 369 (63%) of those with vasa previa were delivered <37 weeks, compared with 91,662 (10%) of those without...
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692613/neuroimaging-and-bayley-iii-correlates-of-early-hand-function-in-extremely-preterm-children
#17
Andrea F Duncan, Carla M Bann, Allison G Dempsey, Ira Adams-Chapman, Roy Heyne, Susan R Hintz
OBJECTIVE(S): Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers. STUDY DESIGN: Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses...
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692612/intravenous-compared-with-oral-iron-for-the-treatment-of-iron-deficiency-anemia-in-pregnancy-a-systematic-review-and-meta-analysis
#18
REVIEW
Adam K Lewkowitz, Anjlie Gupta, Laura Simon, Bethany A Sabol, Carrie Stoll, Emily Cooke, Roxanne A Rampersad, Methodius G Tuuli
OBJECTIVE: To assess the effect of intravenous versus oral iron on hematologic indices and clinical outcomes for iron-deficiency anemia (IDA) in pregnancy. STUDY DESIGN: Searches in Ovid Medline, Embase, SCOPUS, Cochrane Database, and ClinicalTrials.gov identified randomized-controlled trials comparing intravenous to oral iron for treating IDA in pregnancy. Primary outcomes were maternal hematologic indices at delivery. Secondary outcomes were blood transfusion, cesarean delivery, neonatal outcomes, and medication reactions...
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30692611/elevated-umbilical-cord-arterial-lactate-at-birth-and-electronic-fetal-monitoring-characteristics-on-admission-and-in-the-active-phase
#19
Joshua I Rosenbloom, Molly J Stout, Methodius G Tuuli, Julia D López, George A Macones, Alison G Cahill
OBJECTIVE: To investigate the association between elevated umbilical arterial lactate at birth and electronic fetal monitoring (EFM) characteristics at admission and in the beginning of the active phase of labor. STUDY DESIGN: Nested case-control study within a prospective cohort of laboring patients at term who achieved active labor. Neonates with umbilical arterial lactate ≥ 4 mmol/L (cases, n = 119), were matched 1:1 to controls with lactate < 4 mmol/L...
January 28, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/30679823/data-electronically-extracted-from-the-electronic-health-record-require-validation
#20
Lisa M Scheid, L Steven Brown, Christopher Clark, Charles R Rosenfeld
OBJECTIVES: Determine sources of error in electronically extracted data from electronic health records. STUDY DESIGN: Categorical and continuous variables related to early-onset neonatal hypoglycemia were preselected and electronically extracted from records of 100 randomly selected neonates within 3479 births with laboratory-proven early-onset hypoglycemia. Extraction language was written by an information technologist and data validated by blinded manual chart review...
January 24, 2019: Journal of Perinatology: Official Journal of the California Perinatal Association
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